http://www.precisionnutrition.com/gluten-sensitivity
If you choose to click on the link above it will send you to an article on gluten sensitivity; not Celiac Disease. It has a reference to Enterolab for the gluten sensitivity test.
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When I read it I was stunned to see how "mainstream" this knowledge has become since the summer of 2004 when I became ill. A few select people on this Forum (MC support) seemed to be the only people out there that had already discovered what the article describes and promotes. I am delighted to see that this information is becoming available to more people. As we all know, when you need to figure out what's wrong, this is exactly the knowledge, information, and support you need.
Enjoy reading! and Happy New Year!
Gluten Sensitivity - gone mainstream!
Moderators: Rosie, JFR, Dee, xet, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh, mbeezie
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TooManyHats
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Has anyone ever tried to take DPP IV (dipeptyl dipeptidase IV)? This sounds like a wonderful "insurance policy" for going out for dinner and the occasional cross contamination issues, although it looks like it's meant to be taken daily according to this article for those of us who are gluten sensitive rather than full blown Celiac disease.
http://www.kirkmanlabs.com/SiteSearchRe ... rch=DPP-IV
A description of what it does: http://www.kirkmanlabs.com/ViewProductD ... ID@86.aspx
I'm wondering whether anyone has ever tried this?
Being the mother of a child who has autism, I'm very familiar with the fact that some parents give quite a few vitamins and supplements to their children and follow the gf/cf diet. I went through a time when I gave my son some type of digestive aide (though I can't remember the name of it now because it was so long ago). Apparently, Kirkland Labs where I used to order from does in fact sell this enzyme.Additional Support
Once you’ve decided to avoid gluten, there are other things you can do to protect yourself.
Besides avoiding it everywhere you can, there have been a couple of novel enzymes found to help break down accidental exposure to gluten. However, it is not a license to eat gluten. Rather, if you know you are sensitive to gluten, you can take these enzymes on a daily basis to help avoid any gluten that may have snuck into your diet.
Research has shown that the digestion of proteins found in gluten requires an enzyme known as DPP IV (dipeptyl dipeptidase IV). This enzyme is normally found in intestinal cells and is known to be deficient in celiac patients. In non-Celiac patients, if there is any damage to the intestinal wall, DPP IV will be decreased, causing an increases susceptibility to gluten and therefore damage.
In gluten sensitive individuals following a gluten-free diet, it is recommended to take a few capsules of a supplement containing DPP IV daily to prevent damage from accidental exposure.
http://www.kirkmanlabs.com/SiteSearchRe ... rch=DPP-IV
A description of what it does: http://www.kirkmanlabs.com/ViewProductD ... ID@86.aspx
I'm wondering whether anyone has ever tried this?
As far as I can recall, no one has reported on trying any enzymes that specifically target gluten digestion. A few of us have tried various digestive enzyme supplements, with mixed results. In all honesty, since the source of MC reactions appears to be autoimmune reactions, (rather than just a case of poor digestion), I rather doubt that an enzyme will be able to successfully prevent a reaction, since many/most of us react to very tiny, (trace), amounts of our food sensitivities.
I once tried an enzyme supplement that was highly rated, and after taking the first capsule, within about 2 hours, I was nauseated, and later that day, I thought I was never going to stop vomiting. It took 4 days to get over it, so obviously, enzyme supplements don't benefit everyone.
FWIW, there are more than one research companies working on enzymes to specifically target the digestion of gluten. The leading company, (in Australia, I believe), is now in the human trial phase, and expected to receive approval and go to market within a year or so. The most promising "pill" treatment, (IMO), is an anti-zonulin pill, which is now in the final human trial stages, and will almost surely receive FDA approval, since it is on a fast-track program. It was developed by Dr. Fasano, at the University of Maryland Medical Center, who discovered that not only does zonulin regulate the tight junctions in the intestine, that control the absorption of nutrients, (and anything else, for that matter), but he also discovered that it is involved in the regulation of the blood-brain barrier. Looking at all the options that will soon become available, this one is by far the most promising, IMO, for anyone who wants a "pill" solution, for the type of situation that you describe, (sort of an "insurance policy").
Here's some recent information about it, (and the company that was formed to bring it to market), if you're interested:
http://www.prnewswire.com/news-releases ... 27992.html
IMO, this treatment will eventually prove to be beneficial for virtually all autoimmune diseases.
Tex
I once tried an enzyme supplement that was highly rated, and after taking the first capsule, within about 2 hours, I was nauseated, and later that day, I thought I was never going to stop vomiting. It took 4 days to get over it, so obviously, enzyme supplements don't benefit everyone.
FWIW, there are more than one research companies working on enzymes to specifically target the digestion of gluten. The leading company, (in Australia, I believe), is now in the human trial phase, and expected to receive approval and go to market within a year or so. The most promising "pill" treatment, (IMO), is an anti-zonulin pill, which is now in the final human trial stages, and will almost surely receive FDA approval, since it is on a fast-track program. It was developed by Dr. Fasano, at the University of Maryland Medical Center, who discovered that not only does zonulin regulate the tight junctions in the intestine, that control the absorption of nutrients, (and anything else, for that matter), but he also discovered that it is involved in the regulation of the blood-brain barrier. Looking at all the options that will soon become available, this one is by far the most promising, IMO, for anyone who wants a "pill" solution, for the type of situation that you describe, (sort of an "insurance policy").
Here's some recent information about it, (and the company that was formed to bring it to market), if you're interested:
http://www.prnewswire.com/news-releases ... 27992.html
IMO, this treatment will eventually prove to be beneficial for virtually all autoimmune diseases.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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TooManyHats
- Rockhopper Penguin
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- Joined: Fri Jan 14, 2011 9:30 pm
- Location: New Jersey
That does sound promising. The "trick" would be getting my doctor to prescribe it since in her opinion, I don't have Celiac disease and all I need to do is take an anti-inflammatory drug and Nexium.
I would love to find scientific studies other than Dr Fine to support the connection between food sensitivities and MC because of his patent on the Entero Lab testing. I am equally skeptical of the D.A.N. protocol for the treatment of autism because of the same exclusivity and lack of scientific studies. This doesn't mean that for some patients it doesn't work, but it gets hard to sit there and talk to any M.D. without a copy of a scientific study in your hand. Can you tell I work in the medical field? LOL!
I would love to find scientific studies other than Dr Fine to support the connection between food sensitivities and MC because of his patent on the Entero Lab testing. I am equally skeptical of the D.A.N. protocol for the treatment of autism because of the same exclusivity and lack of scientific studies. This doesn't mean that for some patients it doesn't work, but it gets hard to sit there and talk to any M.D. without a copy of a scientific study in your hand. Can you tell I work in the medical field? LOL!
Are you aware of the research articles that Marliss posted links to in her first post in this thread?TooManyHats wrote:I would love to find scientific studies other than Dr Fine to support the connection between food sensitivities and MC because of his patent on the Entero Lab testing.
http://www.perskyfarms.com/phpBB2/viewtopic.php?t=12988
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
also toomanyhats there is a lot to find on www.glutenandbeyond.org
"As the sense of identity shifts from the imaginary person to your real being as presence awareness, the life of suffering dissolves like mist before the rising sun"
It's so helpful that more and more people are learning about gluten intolerance. It took me years of going doctor to doctor before I was diagnosed with Celiac's. Back then, few doctors knew about it and no one ever talked about it. It took lots of time, and lots of HSA spending to get diagnosed properly. The fact that this intolerance has gained mainstreamed awareness has made my life much easier. I love being able to order off of gluten free menus on restaurants, for example. I don't really trust an enzyme to help me process gluten, but it is an intriguing idea.
Hi Polly,
Welcome to the board. We have quite a few members here with both a celiac diagnosis, and MC. Do you also have MC?
Tex
Welcome to the board. We have quite a few members here with both a celiac diagnosis, and MC. Do you also have MC?
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Have you ever had a colonoscopy that included biopsies that ruled out MC? The only way to diagnose or rule out MC is by examining slides of biopsy samples from the colon, under the microscope, to search for the markers of MC. Most people with IBS have undiagnosed MC, simply because their GI doc either failed to take biopsies, or the pathologist wasn't sufficiently familiar with the disease to be able to recognize the markers of some of the more difficult to diagnose types of MC. As we say around here, "what's the difference between MC and IBS? In most cases, the answer is "biopsies".
Even if you had biopsies taken, most pathologists do not routinely look for the markers of mastocytic colitis, (an elevated mast cell count in the colon), because that procedure requires a special stain that most pathology labs don't normally stock. Therefore, unless the gastroenterologist specially requests that the pathologist rule out mastocytic enterocolitis, those markers will be overlooked virtually every time. It's possible to have mast cell issues, though, because of food sensitivities, even if mastocytic enterocolitis is not present.
Whether you have MC or not, you're certainly welcome, and I hope that you can find the information that you're seeking, to make living with these issues much easier.
Tex
Even if you had biopsies taken, most pathologists do not routinely look for the markers of mastocytic colitis, (an elevated mast cell count in the colon), because that procedure requires a special stain that most pathology labs don't normally stock. Therefore, unless the gastroenterologist specially requests that the pathologist rule out mastocytic enterocolitis, those markers will be overlooked virtually every time. It's possible to have mast cell issues, though, because of food sensitivities, even if mastocytic enterocolitis is not present.
Whether you have MC or not, you're certainly welcome, and I hope that you can find the information that you're seeking, to make living with these issues much easier.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.