I've been meaning to post this for some time, now, and I keep forgetting to do so. Sorry about that - there's always too much going on for my one-track mind to be expected to remember anything.
The topic of when and how to take Entocort comes up every so often, and for most people, the details may not matter, but for some of us, it does matter. Research shows that Entocort is almost 50% more effective at bringing remission, within a given time interval, if it is taken the same way that all corticosteroids are intended to be administered - namely, the full daily dose should be taken at one time. It's usually better to do this first thing in the morning, simply because the drug is less likely to interfere with sleep, this way, but timing is not critical to effectiveness.
The reason why this dosing works better, is because corticosteroids supplement, (and replace), the cortisol that the body naturally supplies, and cortisol usually peaks in mornings, and declines for the rest of the day. Corticosteroids are more effective at suppressing inflammatory effects, if they are applied in a manner which provides the maximum dose, at one time during the day, (to provide maximum "shock" value), and then allowed to decline, for the rest of the day. This is more effective than providing the same dose at an average, metered rate, at multiple times during the day. If you want to see a reference on this, here's a link:
Results—After eight weeks of treatment, remission occurred in 60% of patients receiving budesonide once daily or prednisolone and in 42% of those receiving budesonide twice daily
http://gut.bmj.com/content/41/2/209
Tex
Maybe they're so used to the idea that they forget to tell people- frustrating.
