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WOW. It all seems so much clearer to me now, and I KNOW I have some version of MCAD. I have SO MANY of the symptoms they mention, and they seem to be getting worse. My latest, besides the crazy skin rashes, is flushing after drinking wine -- I go looking for the thermostat because I'm sweating, but my core temp is still 97.6!
When Dr. Thomas Abell was at UTBowld Hospital in Memphis, his research team examined many full-thickness intestinal biopsies of patients with motility diseases and he has reported edema in the intestinal wall, an infiltration of lymphocytes, and often a high level of circulating non-specific auto-antibodies (Abell). While the lymphocytic infiltration may be indicative of some as yet unknown pathogen (Smalley), could it also be the result of the chemoattractant recruitment by mast cell mediators? Could the edema found in the intestinal wall be the result of histamine release and the subsequent tissue swelling that it is known to produce from blood vessel leakage? Are the circulating autoantibodies somehow related to autoimmune urticaria, which can be triggered by autoantibodies?
Yes, that's a good article. I believe Julie originally posted about it a year or so ago.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
MRT is a blood test and mast cells are not found in blood, so there is no direct measurement. However, the latest version of MRT measures basophil response, which is the next best thing. Basophils and mast cells have similar action and both degranulate and release histamine. My guess is that MRT can be useful in this situation.
Mary Beth
"If you believe it will work out, you'll see opportunities. If you believe it won't you will see obstacles." - Dr. Wayne Dyer
Yes, theoretically at least, MRT results should reflect effects of mast cell responses to the various foods and chemicals tested.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Thanks. I think I'll finally move ahead and get it done. My MCAD symptoms seem to go in waves, sometimes it's POTS symptoms, sometimes (now) it's skin hypersensitivity, lately it's worsening chemical sensitivities too. The article was interesting because it explained how one's chemical sensitivities or stress can result in D, something seemingly unrelated.
My MIL and BIL clearly have MCAD too. They have chronic urticaria and angioedema, lots of seasonal allergies, MIL is gluten intolerant, etc. But the urticaria happens in flares lasting for months, often years apart, then nothing. Why would the system take a break for so long??
Whoa! Mary Beth is right. (I just now noticed that we posted at the same time). I forgot that they are testing blood isolated from the body, so as she said, mast cell responses will not be reflected by the MRT results.
Sorry about that oversight.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Zizzle wrote:But the urticaria happens in flares lasting for months, often years apart, then nothing. Why would the system take a break for so long??
Chronic urticaria is connected with chronic stress.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
