Colonic hormones involved in MC?

Zizzle · Post by **Zizzle** » Sun Jun 17, 2012 9:58 pm

This is brand new research, and I have no idea what it implies, but it is new information about the possible pathophysiology of LC. Endocrine hormones in the colon?

http://www.ncbi.nlm.nih.gov/m/pubmed/22699394/

Zizzle · Post by **Zizzle** » Sun Jun 17, 2012 10:14 pm

OK, so this info isn't so new. A study published in 2011 had similar findings. But what does this mean? Why is Chromogranin A, a substance commonly measured in blood for cancer diagnosis, involved in LC??

http://www.spandidos-publications.com/mmr/4/4/603

Could we have too much serotonin in our gut, as theorized by IBS-D researchers? Has anyone here had success with Lotronex?

http://www.health.harvard.edu/newsweek/ ... _bowel.htm

draperygoddess · Post by **draperygoddess** » Mon Jun 18, 2012 2:12 pm

Hmm, this is interesting--I wonder if there is any correlation to SSRI use?

Zizzle · Post by **Zizzle** » Mon Jun 18, 2012 6:57 pm

Cynthia,
I think you're on to something. Treatments aimed at reducing diarrhea use serotonin inhibitors, whereas more serotonin is needed to treat constipation. If you are treating depression by increasing serotonin levels with SSRIs, it's logical diarrhea would be the eventual outcome.

http://www.ncbi.nlm.nih.gov/m/pubmed/22 ... 02/related

draperygoddess · Post by **draperygoddess** » Tue Jun 19, 2012 8:35 am

It has long been my theory that my prolonged use of Zoloft was the catalyst for my (non) MC. Although I had occasional GI problems from my teens, after i started taking Zoloft they became progressively more frequent. By the time I broke down and went for a colonoscopy, I was waking up every day wondering, "Will I have D today? Will I be able to keep my client appointments? Should I eat this morning?" Going GF/DF/SF started me in the right direction, but I didn't see significant improvement until I stopped the Zoloft. Unfortunately, the damage has been done, apparently.