http://articles.mercola.com/sites/artic ... L_artNew_1Demonstrating just how far-reaching the health impact of the bacterial balance in your gut can be, another recent study claims the key factor behind cancer appears to be ecological rather than genetic.
Published in the journal Science, the study suggests cancer may be due to a chain reaction that starts with inflammation that disrupts your gut ecosystems, allowing pathogens, such as E.coli, to invade your gut and cause cellular damage. The presence of E.coli was increased by a factor of 100 by inflammation, and 80 percent of germ-free mice infected with E.coli developed colorectal cancer, while germ-free mice inoculated with another common gut bacterium remained cancer-free, although these mice, like the others, did develop severe colitis (gut inflammation)
According to a press release by the University of North Carolina:
"In a series of experiments conducted with mice prone to intestinal inflammation, the researchers found that inflammation itself causes significant simplification in diverse communities of gut microbes and allows new bacterial populations to establish major footholds. Among the bacterial taxa invading the disturbed intestinal ecosystem, the research team found a greatly increased presence of E. coli and related bacteria.
By putting E. coli bacteria into mice that were raised under sterile conditions, the team also found that the presence of E. coli promoted tumor formation. When regions of the E. coli genome known to be involved in DNA damage were removed, the ability of the E. coli to cause tumors was substantially decreased.
The researchers noted that the mouse results may have implications for human health as well, as they also found an E. coli variant with the suspect genes in high percentages of human patients with colorectal cancer and irritable bowel disease.
...'As is usual in human studies, we didn't have cause and effect,' Fodor noted. 'We don't know if microbes are somehow causing conditions to shift in the gut that would cause cancer or if there are conditions that are associated with cancer that would increase the openness of the gut to particular microbes. A shift in the microbial community is associated with inflammation... It is interesting that the microbial community is actually changing with the disease state, which indicates that it is either responding to or contributing to the disease state.'"
Gut bacteria and cancer
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Gut bacteria and cancer
From a Dr. Mercola article...might have some implicationfor MC.
IMO,
Those gut bacteria population shifts are secondary to the real cause of cancer — inflammation caused by food sensitivities. Certain foods and the inflammation that results from a sensitivity to those respective foods, cause shifts in gut bacteria populations, not the other way around. Cancer did not exist in humans before the introduction of grains into the human diet during the neolithic period. On the other hand, gut bacteria have always existed, (they existed long before humans, and prior to the neolithic period, they apparently didn't cause cancer).
Tex
Those gut bacteria population shifts are secondary to the real cause of cancer — inflammation caused by food sensitivities. Certain foods and the inflammation that results from a sensitivity to those respective foods, cause shifts in gut bacteria populations, not the other way around. Cancer did not exist in humans before the introduction of grains into the human diet during the neolithic period. On the other hand, gut bacteria have always existed, (they existed long before humans, and prior to the neolithic period, they apparently didn't cause cancer).
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Tex,tex wrote:IMO,
Those gut bacteria population shifts are secondary to the real cause of cancer — inflammation caused by food sensitivities. Certain foods and the inflammation that results from a sensitivity to those respective foods, cause shifts in gut bacteria populations, not the other way around. Cancer did not exist in humans before the introduction of grains into the human diet during the neolithic period. On the other hand, gut bacteria have always existed, (they existed long before humans, and prior to the neolithic period, they apparently didn't cause cancer).
I humbly disagree.
We are not born with food sensitivities, just a genetic and bacterial make-up (from mom) that may predispose us to developing them. The food sensitivities develop after we have insulted our immune system in various ways - namely antibiotics as babies and kids, too much grain and processed food, infections and environmental toxins. I believe we first develop leaky gut and inflammation before we develop food sensitivities. Cancer's link to GI bacteria is probably a result of the bacteria we feed with our grain and poor diet choices, so yes, that would explain why cancer (caused by bacteria) did not exist before we ate grain. Our intestinal bacteria populations are determined by what we eat that feeds them, in addition to infections and antibiotic use. I suspect not all cases of colon cancer can be traced back to a food sensitivity, so other causes of inflammation play a role.
If grains were equally poisonous to all humans on the planet, we wouldn't have poeople living to 100+ without disease and GI trouble. Some people still manage to live relatively disease free and die of old age, despite their diet.
Zizzle,
You are basically correct (IMO), but if you will dig into the research articles, you will find that gluten is the key to the leaky gut, because everyone (yes, everyone — not just people who are sufficiently gluten-sensitive to present with clinical symptoms) responds to gluten by experiencing increased gut permeability on exposure to gluten. That trumps everything else, including drug-induced altered permeability, (because there is a good chance that initial drug-induced permeability (like other food sensitivities) may occur only in the presence of gluten in the diet).
Who said that grains were equally poisonous to all people on the planet? Everything exists in a spectrum, nothing is absolute in nature. Remember — the world is analog, not digital. People live to over 100 in spite of eating grains, not because of it. If grains had never been introduced into our diets, our species might be living to several hundred years of age now, instead of a fraction of it. Today, we are capped at about 115 years of age. If you research any longevity studies, you will find that we are falling far short of our potential, and IMO, it's because of our diet. Nothing else has as much influence in the long run.
Tex
You are basically correct (IMO), but if you will dig into the research articles, you will find that gluten is the key to the leaky gut, because everyone (yes, everyone — not just people who are sufficiently gluten-sensitive to present with clinical symptoms) responds to gluten by experiencing increased gut permeability on exposure to gluten. That trumps everything else, including drug-induced altered permeability, (because there is a good chance that initial drug-induced permeability (like other food sensitivities) may occur only in the presence of gluten in the diet).
http://www.ncbi.nlm.nih.gov/pubmed/16635908CONCLUSIONS: Based on our results, we concluded that gliadin activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules.
Who said that grains were equally poisonous to all people on the planet? Everything exists in a spectrum, nothing is absolute in nature. Remember — the world is analog, not digital. People live to over 100 in spite of eating grains, not because of it. If grains had never been introduced into our diets, our species might be living to several hundred years of age now, instead of a fraction of it. Today, we are capped at about 115 years of age. If you research any longevity studies, you will find that we are falling far short of our potential, and IMO, it's because of our diet. Nothing else has as much influence in the long run.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Well I suppose we should see some fervent paleo/GAPS diet converts living to 115. I hope so.
On another note, the "Healthy Home Economist" blogger stated that people can CURE celiac disease by healing their gut through whole foods, and can eventually not react to gluten, although she advocates a grain-free diet. She cited McBride's GAPS diet book as the evidence that people have been CURED of celiac disease. Is this possible?? I feel like natural health advocates are starting to go in a direction where everyone will be blamed for their chonic health conditions, because we choose not to eat a 100% organic/paleo/vegan/sugar free/grain free, etc. diet. Is EVERYTHING curable through extreme diet modification? Or do we believe once certains genes are triggered, we can't shut them off?
On another note, the "Healthy Home Economist" blogger stated that people can CURE celiac disease by healing their gut through whole foods, and can eventually not react to gluten, although she advocates a grain-free diet. She cited McBride's GAPS diet book as the evidence that people have been CURED of celiac disease. Is this possible?? I feel like natural health advocates are starting to go in a direction where everyone will be blamed for their chonic health conditions, because we choose not to eat a 100% organic/paleo/vegan/sugar free/grain free, etc. diet. Is EVERYTHING curable through extreme diet modification? Or do we believe once certains genes are triggered, we can't shut them off?
IMO, part of the problem is that these food sensitivities can cause cumulative damage to our genetics over the generations, and they can affect us in other ways (such as skipping a generation) by means of epigenetic effects. As long as our species continues to eat a faulty diet, it will continue to decline. (We might appear to be healthier, but that's an illusion, because we are not making any progress as far as our overall maximum longevity potential is concerned. The oldest individuals in our current society are no older now, than they were a hundred, or two hundred years ago, though more of us make it to that age cap because of the availability of more intensive health care to put out the little brush fires here and there that used to kill more people a few generations ago.
All this is discussed in my book, complete with references to back up my position.
Tex
No. Many people can gain tolerance to gluten, but they continue to produce antibodies, and continue to acrue damage, even in the absence of clinical symptoms. Dietary immunotherapy to "cure" food sensitivities and oral allergies is a cruel joke. There are no cures (though clinical symptoms can certainly be attenuated) and there are no free lunches).Zizzle wrote:Is this possible??
All this is discussed in my book, complete with references to back up my position.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
To me, the first few chapters seem pretty boring, so I'm guessing that kudos won't be forthcoming. 
Pleasant dreams.
Tex
Pleasant dreams.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
I was interested to read this in your book. I hadn't considered that. I had allergy shots (not oral) for years and it practically eliminated my symptoms.Dietary immunotherapy to "cure" food sensitivities and oral allergies is a cruel joke.
This might be a dumb question but is it possible for someone to get shots for food issues (I'm thinking someone with i.e. a fierce peanut allergy) and how do you think our bodies respond to that? Deb
Hi Deb,
As you will find in chapter 15 in the book, there is a team of researchers currently developing a vaccine for that purpose. Unfortunately, the vaccine will only be effect for the 3 most common peptides that cause a gluten reaction (and there are actually several hundred such antigens in wheat, rye, barley, and oats), so it remains to be seen how effective it will be. Probably it will help some people much more than others, because we all have different antigen responses.
Since the goal of a vaccine is to prompt the body to produce antibodies to a specific pathogen, vaccines, similar to oral immunotherapy, will cause antibodies to continue to be produced when an antigen is ingested, but it if works correctly, no clinical symptoms will develop. Recent research shows, however, that unfortunately, at least in the case of orally-induced immunotherapy, damage to the intestines continues. Much more research is needed, to define the extent of and the implications of that damage, and to determine whether it is also associated with other forms of immunotherapy.
Tex
As you will find in chapter 15 in the book, there is a team of researchers currently developing a vaccine for that purpose. Unfortunately, the vaccine will only be effect for the 3 most common peptides that cause a gluten reaction (and there are actually several hundred such antigens in wheat, rye, barley, and oats), so it remains to be seen how effective it will be. Probably it will help some people much more than others, because we all have different antigen responses.
Since the goal of a vaccine is to prompt the body to produce antibodies to a specific pathogen, vaccines, similar to oral immunotherapy, will cause antibodies to continue to be produced when an antigen is ingested, but it if works correctly, no clinical symptoms will develop. Recent research shows, however, that unfortunately, at least in the case of orally-induced immunotherapy, damage to the intestines continues. Much more research is needed, to define the extent of and the implications of that damage, and to determine whether it is also associated with other forms of immunotherapy.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Tex,
Well, I started off with Section II/Part II because I was tired...and I got through 6 pages before passing out for the night. Sorry!! I missed Clinton's speech too. I'm having an AI flare -- the itchy rash just developed on my right buttock, and the fatigue is increasing.
It feels like I have 5 moquito bites on my buttcheek and it's hot to the touch, so I spend the day grabbing by butt for relief . I'll start my Rx steroid cream tonight in earnest. So strange that I seem to have a right-sided autoimmune disease. Is that even possible? Most AI diseases are bilateral and even symmetrical. I have enlarged lymphnodes on the right side of my neck, rash on my right elbow, rash on my right hand, and now my right butt. I do have rash on both sides on my back and chest. Could this be an infection of some kind?? I wish someone would do a needle biopsy of one of the nodes to find out what's hiding in there. Incidentally, my EBV and Mycoplasma tests came back negative.
Well, I started off with Section II/Part II because I was tired...and I got through 6 pages before passing out for the night. Sorry!! I missed Clinton's speech too. I'm having an AI flare -- the itchy rash just developed on my right buttock, and the fatigue is increasing.
It feels like I have 5 moquito bites on my buttcheek and it's hot to the touch, so I spend the day grabbing by butt for relief . I'll start my Rx steroid cream tonight in earnest. So strange that I seem to have a right-sided autoimmune disease. Is that even possible? Most AI diseases are bilateral and even symmetrical. I have enlarged lymphnodes on the right side of my neck, rash on my right elbow, rash on my right hand, and now my right butt. I do have rash on both sides on my back and chest. Could this be an infection of some kind?? I wish someone would do a needle biopsy of one of the nodes to find out what's hiding in there. Incidentally, my EBV and Mycoplasma tests came back negative.Very interesting. I usually zip through books pretty fast but I'm really taking my time absorbing yours, Tex. Fascinating. Thanks, DebAs you will find in chapter 15 in the book, there is a team of researchers currently developing a vaccine for that purpose. Unfortunately, the vaccine will only be effect for the 3 most common peptides that cause a gluten reaction (and there are actually several hundred such antigens in wheat, rye, barley, and oats), so it remains to be seen how effective it will be. Probably it will help some people much more than others, because we all have different antigen responses.
Zizzle,
Clinton gave a speech? Just kidding. Sorry that I caused you to miss his speech. It wasn't easy, but I managed to miss it also.
Just out of curiosity, what prompted you to skip all the way to section II? Did you read the introduction/how to use the book?
It's a shame that you aren't a professional musical entertainer. Grabbing yourself every so often would surely help to sell another million or so records. LOL.
Seriously, it sounds as though you have a lot of inflammation going on. Are you sure that you're not getting traces of gluten on a somewhat regular basis?
Tex
Clinton gave a speech?
Just kidding. Sorry that I caused you to miss his speech. It wasn't easy, but I managed to miss it also. Just out of curiosity, what prompted you to skip all the way to section II? Did you read the introduction/how to use the book?
FWIW, my arthritis symptoms associated with MC were mostly on my right side — right knee, and several fingers on my right hand. At one point, though, my left elbow was also inflamed, for about 6 months or so. The problems with my right knee and fingers lasted much longer, though.Zizzle wrote:So strange that I seem to have a right-sided autoimmune disease. Is that even possible?
It's a shame that you aren't a professional musical entertainer. Grabbing yourself every so often would surely help to sell another million or so records. LOL.
Seriously, it sounds as though you have a lot of inflammation going on. Are you sure that you're not getting traces of gluten on a somewhat regular basis?
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Deb,
I apologize, because I realized that the book was going to be somewhat tedious to read in a lot of places, but I felt the need to pack a lot of information into it, since it was the first one ever written about the disease.
I can't believe that the disease was around for over 35 years, and no one ever wrote a book about it. It's truly an orphan disease.
Tex
I apologize, because I realized that the book was going to be somewhat tedious to read in a lot of places, but I felt the need to pack a lot of information into it, since it was the first one ever written about the disease.
I can't believe that the disease was around for over 35 years, and no one ever wrote a book about it. It's truly an orphan disease.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
