http://www.ncbi.nlm.nih.gov/pubmed/19059394
This makes me wonder if going off Simvastatin a couple of years ago has any relationship with my present mast cell problem.
Gloria
Some Statins Inhibit Mast Cell Degranulation
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Some Statins Inhibit Mast Cell Degranulation
You never know what you can do until you have to do it.
Hmmmmmmmmm. Well that looks suspiciously like the likely reason why statins help to reduce the risk of cardiovascular events. I can't help but wonder why no one has bothered to point that out. Instead, they prefer to claim that it's the propensity of statins to reduce cholesterol levels, that reduces the risk of cardiovascular events, even in the face of an absolute absence of any proof that reduced cholesterol levels result in any benefits to cardiovascular risk. Of course, this observation/theory ignores the fact that pravastatin apparently is also effective at reducing cardiovascular risk. 
Regarding your wondering about whether or not this might be a factor in your current mast cell issues: That's a good question. I suppose it hinges on the question of whether or not dinitrophenol-human serum albumin is essential to the degranulation of mast cells, or if other mechanisms exist that do not rely on that protein in order to induce degranulation. I have no idea how many ways exist that can trigger the degranulation of mast cells, but it appears that this is just one way among many. I could certainly be wrong, though, since I'm not a mast cell expert.
Did your mast cell issues begin at the same time that you discontinued the statin, or shortly thereafter? I didn't realize that they went back that far.
Tex
Regarding your wondering about whether or not this might be a factor in your current mast cell issues: That's a good question. I suppose it hinges on the question of whether or not dinitrophenol-human serum albumin is essential to the degranulation of mast cells, or if other mechanisms exist that do not rely on that protein in order to induce degranulation. I have no idea how many ways exist that can trigger the degranulation of mast cells, but it appears that this is just one way among many. I could certainly be wrong, though, since I'm not a mast cell expert.
Did your mast cell issues begin at the same time that you discontinued the statin, or shortly thereafter? I didn't realize that they went back that far.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Hi Tex,
I've given up so many things over the years that I can't remember the exact dates. I read my "Weaning off Entocort" thread and noticed that last summer I thought going off statins helped me. But I also remember that I originally thought the statins helped me. I am probably not the example to use as proof of their effectiveness or non-effectiveness. I've had head sores during the past three summers. This summer, they didn't completely go away and the rash on my torso followed.
We are clearly at the embryonic stage of studying mast cells. I agree with you that they seem to be the root cause of many autoimmune diseases. If we could only get our doctors to recognize their importance. I have an appointment with my PCP tomorrow and am hoping he will recognize that mast cells are the source of my seemingly disconnected issues.
Gloria[/u][/list]
I've given up so many things over the years that I can't remember the exact dates. I read my "Weaning off Entocort" thread and noticed that last summer I thought going off statins helped me. But I also remember that I originally thought the statins helped me. I am probably not the example to use as proof of their effectiveness or non-effectiveness. I've had head sores during the past three summers. This summer, they didn't completely go away and the rash on my torso followed.
We are clearly at the embryonic stage of studying mast cells. I agree with you that they seem to be the root cause of many autoimmune diseases. If we could only get our doctors to recognize their importance. I have an appointment with my PCP tomorrow and am hoping he will recognize that mast cells are the source of my seemingly disconnected issues.
Gloria[/u][/list]
You never know what you can do until you have to do it.
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Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
Gloria
so far in Aus, no doctor i have seen (GI Specialist or GP) has heard of Mast Cells. nor are they interested in it.
mindful that if it doesnt show up in a blood test or a poop test it doesnt exist
if it isnt in a text book it doesnt exist
if big pharma has not developed a med to treat it, it doesnt exist....
so far in Aus, no doctor i have seen (GI Specialist or GP) has heard of Mast Cells. nor are they interested in it.
mindful that if it doesnt show up in a blood test or a poop test it doesnt exist
if it isnt in a text book it doesnt exist
if big pharma has not developed a med to treat it, it doesnt exist....
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Gabes,
I saw two doctors for my itching problem and neither suggested that I take an antihistamine. Their solution was a script for cortisone creams, which helped, but didn't get at the root of the problem. I think that Zizzle has had the same experience.
Gloria
I saw two doctors for my itching problem and neither suggested that I take an antihistamine. Their solution was a script for cortisone creams, which helped, but didn't get at the root of the problem. I think that Zizzle has had the same experience.
Gloria
You never know what you can do until you have to do it.