Here is a recap of my b vitamin trials. http://www.perskyfarms.com/phpBB2/viewt ... sc&start=0
The latest is as of around November 1 I've cut the folate (metafolin back from 2400 mcg per day to 800 mcg per day.) Everthing else on my regimen (the methylcobalamin and the P5P) stayed the same. I was getting a little "edginess or anxiety" which prompted me to try to cut the metafolin back. I'm not even sure if the edginess/anxiety was even tied out to the metafolin. On weekdays/workdays I'm doing fine on the computer. The last 6 weekends I either took zero b vitamins or took my old B complex "50" which has the less absorbable b's. I'm definitely not doing as well on the weekends. As I type (it's Sunday) I'm back to the transposed letter thing. I also have difficulty finding words during the weekend evenings. My brain seems to really need the metafolin version of folate. I've picked up some of the metafolin in 400 mcg dosage but will probably stay on the 800 mcg dose at least thru this week (tough biz trip ahead) and then will see how I respond to the 400 mcg dose of metafolin.
I have a question for Tex----is there such a thing as too much methylcobalamin B12 per day? I've been taking the 2000 mcg per day of the methylcobalamin. My last B12 score from Feb 7th 2012 ran 1358. PCP on appmt two weeks ago said I needed to cut back. Problem is I can function until around noon without it and then I crash. So....I wasn't sure if I should try 1000 mcg per day or if these thresholds really don't matter?
Marcia---on your next blood work take a look at your ferritin score. In reading about iron I'm learning that low ferritin can also cause short term memory issues.
I'm going to try Mom on the absorbable B's since she has short term memory issues and is celiac as well. She's kind of tiny--110 lbs-- so I'll probably try her on 1000 mcg of the methylcobalamin per day, either 800 or 400 mcg of the metafolin and 50 mg of the P5P.
Brandy
brandy's latest b vitamin update
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Hi Brandy,
That's interesting how your cognizance/memory fluctuates with the B vitamin supplementation.
Metanx contains:
3 mg (3,000 mcg) of L-methylfolate Calcium
35 mg (35,000 mcg) of Pyridoxal 5'-phosphate
2 mg (2,000 mcg) of Methylcobalamin
http://www.metanx.com/helpful-resources ... ick-facts/
Note that using generic substitutions for Metanx may not be equivalent:
The primary problem with the generics appears to be the use of a non-active form of folate. However, note that the proportions of these vitamins in the formulation is unique, and if they are not used in this same balance, the results may not be equivalent. For example, folate and cobalamin require a proper balance, in order for proper absorption and utilization of vitamin B-12.
I had my vitamin B-12 level checked about a month ago, and it was 989 (normal range 180–914). I've been taking Metanix for 3 years and 3 months, now, 1 tablet per day. After taking Metanx for so long, I was afraid that my B-12 level might be out of sight, but interestingly, it's not. I'm guessing that this may be because of the unique balance of the 3 vitamins from which Metanx is made.
As far as I'm aware, the risk of B-12 toxicity is rather low. It's such a non-issue that the FDA has not set an upper safe limit. Here's an article if you want to read more about it:
http://www.livestrong.com/article/45135 ... ity-level/
Tex
That's interesting how your cognizance/memory fluctuates with the B vitamin supplementation.
Metanx contains:
3 mg (3,000 mcg) of L-methylfolate Calcium
35 mg (35,000 mcg) of Pyridoxal 5'-phosphate
2 mg (2,000 mcg) of Methylcobalamin
http://www.metanx.com/helpful-resources ... ick-facts/
Note that using generic substitutions for Metanx may not be equivalent:
http://www.forthepeople.com/metanx-subs ... -2769.htmlMetanx is a medical food prescribed for the dietary management of endothelial dysfunction in patients suffering from diabetic peripheral neuropathy. Metanx is advertised as having a unique formulation providing the active forms of folate, vitamin B12, and vitamin B6 to manage the specific nutritional needs of patients suffering from numbness, tingling and burning sensations in their feet due to diabetic neuropathy. Reportedly, Folast, Neurpath-B and Duleek-Met do not contain this same unique formula, and therefore, are not therapeutically equivalent to the prescription version and should not be provided as Metanx substitutes.
The primary problem with the generics appears to be the use of a non-active form of folate. However, note that the proportions of these vitamins in the formulation is unique, and if they are not used in this same balance, the results may not be equivalent. For example, folate and cobalamin require a proper balance, in order for proper absorption and utilization of vitamin B-12.
I had my vitamin B-12 level checked about a month ago, and it was 989 (normal range 180–914). I've been taking Metanix for 3 years and 3 months, now, 1 tablet per day. After taking Metanx for so long, I was afraid that my B-12 level might be out of sight, but interestingly, it's not. I'm guessing that this may be because of the unique balance of the 3 vitamins from which Metanx is made.
As far as I'm aware, the risk of B-12 toxicity is rather low. It's such a non-issue that the FDA has not set an upper safe limit. Here's an article if you want to read more about it:
http://www.livestrong.com/article/45135 ... ity-level/
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Hi Brenda,
Yes, all B vitamins are water-soluble, so theoretically at least, any excess should be eliminated in urine. The body stores up to a 5-year supply in the liver (and a few other places), to tide us over the times when our diet is deficient, so if something goes wrong, there's a huge supply to draw from, and maybe this can somehow create a problem for some people. It appears that it's impossible for the blood level to reach a toxic amount from food, as long as the kidneys are working properly, but a few people apparently can reach excessive levels that trigger symptoms, if they take large supplemental doses for an extended period, (this may suggest a kidney problem, however).
Just having a high test result does not imply toxicity, because there is no apparent upper safe limit. If symptoms should develop, though, (such as excessive urination, diarrhea, increased thirst, skin flushing, palpitations, insomnia, and panic attacks), then it may be prudent to back off on any supplementation.
Tex
Yes, all B vitamins are water-soluble, so theoretically at least, any excess should be eliminated in urine. The body stores up to a 5-year supply in the liver (and a few other places), to tide us over the times when our diet is deficient, so if something goes wrong, there's a huge supply to draw from, and maybe this can somehow create a problem for some people. It appears that it's impossible for the blood level to reach a toxic amount from food, as long as the kidneys are working properly, but a few people apparently can reach excessive levels that trigger symptoms, if they take large supplemental doses for an extended period, (this may suggest a kidney problem, however).
Just having a high test result does not imply toxicity, because there is no apparent upper safe limit. If symptoms should develop, though, (such as excessive urination, diarrhea, increased thirst, skin flushing, palpitations, insomnia, and panic attacks), then it may be prudent to back off on any supplementation.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Hi, A relative was taking vitamin B" s supplements for a while a developed neuropathy in both her feet. She was tested and the levels were over 200. She went to many doctors and told her to stop the supplements. Her level dropped but now is higher then it was before. The neuropathy is worse. Is magnesium the trace mineral that is deficient as it helps control many kidney functions? Jon