Tex,
I will post my Enterolab results over the weekend. I am on my way out and the results just came. The surprise was eggs! That is why I relaspe! I really do not understand the interpretation of the gene results. Can you explain how they know which genes gens are predispose to gluten sensitivity?
Thank You!!!
HLA-DQB1 Molecular analysis, Allele 1 0601
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 1,1 (Subtype 6,6)
Interpretation Of HLA-DQ Testing: Although you do not possess the main HLA-DQB1 genes predisposing to celiac sprue (HLA-DQB1*0201 or HLA-DQB1*0302), HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having two copies of a gluten sensitive gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe. This test was developed and its performance characteristics determined by the American Red Cross - Northeast Division. It has not been cleared or approved by the U.S. Food and Drug Administration.
Gene Test - Question
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Gene Test - Question
Denise
Dr. Fine sorted those out 12 to 15 years ago. I can't locate a reference on it at the moment, but basically, the only genes that have been shown to not predispose to gluten sensitivity are the DQ4 genes, and those genes are very uncommon. In fact, if I recall correctly, the odds of having a double DQ4 gene configuration are approximately 0.04%. That suggests that 99.96% of the population has at least one gene that predisposes to MC.Can you explain how they know which genes gens are predispose to gluten sensitivity?
You have a very unusual gene arrangement. The 0602 allele is somewhat common, but you are the only person tested so far (unless I overlooked someone) who has the 0601 allele. Note that you have a double DQ1 combination. This is an uncommon arrangement and please be aware that research suggests that any double DQ1, DQ2, or DQ3 gene combinations typically result in higher sensitivity levels and above average numbers of food sensitivities. Our accumulated experiences here on the board seem to verify that this effect is real. IOW, in general, the members of this board who have the greatest number of food sensitivities, and who experience the most difficulty in achieving remission, typically have double DQ genes.
Do you mind if I add your results to our list?
Thanks,
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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draperygoddess
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Denise,
I am also a double DQ1. I have one 0602, like you, and one 0609, which is much less common and usually found in people of African or Mediterranean descent (I didn't know I was either). I will attest to the multiple intolerances this pattern can cause! Because my children automatically inherited a DQ1 gene from me, we did a GF trial with all of them earlier this year, but so far they do not seem to be reacting.
I am also a double DQ1. I have one 0602, like you, and one 0609, which is much less common and usually found in people of African or Mediterranean descent (I didn't know I was either). I will attest to the multiple intolerances this pattern can cause! Because my children automatically inherited a DQ1 gene from me, we did a GF trial with all of them earlier this year, but so far they do not seem to be reacting.
Cynthia
"Can we fix it? YES WE CAN!" -Bob the Builder
"Can we fix it? YES WE CAN!" -Bob the Builder
Hi Denise, I am a double DQ1 0501 and 0604.
My daughter tested negative for everything at Enterolab (didn't do the DNA test) but has had some issues (eczema, lactose?). Now my six year old granddaughter has been getting an upset stomach and gluten and dairy appear to be likely culprits.
DD took her to Mayo and our PCP was pretty sure it was food related (hallelujah!) but did some blood work just in case. Recommended an elimination diet (as did MOM :)
Tex, I'm pretty sure my DD will eventually test positive for some of this. Has Dr. Fine shown any data/time frames about people testing negative but then crossing the line into positive?
Sorry to have hijacked your thread, Denise.
My daughter tested negative for everything at Enterolab (didn't do the DNA test) but has had some issues (eczema, lactose?). Now my six year old granddaughter has been getting an upset stomach and gluten and dairy appear to be likely culprits.
DD took her to Mayo and our PCP was pretty sure it was food related (hallelujah!) but did some blood work just in case. Recommended an elimination diet (as did MOM :)
Tex, I'm pretty sure my DD will eventually test positive for some of this. Has Dr. Fine shown any data/time frames about people testing negative but then crossing the line into positive?
Sorry to have hijacked your thread, Denise.
Hi Deb,
Unfortunately, I'm not aware of any research data regarding the elapsed time between positive food sensitivity test results and the actual development of MC or celiac disease. That probably depends on a lot of factors that may be difficult to pin down. Most people order those tests after a disease has already developed.
Tex
Unfortunately, I'm not aware of any research data regarding the elapsed time between positive food sensitivity test results and the actual development of MC or celiac disease. That probably depends on a lot of factors that may be difficult to pin down. Most people order those tests after a disease has already developed.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Hi Tex,
Results are below and you can post in the result section. At the time of the test I was G/D free for 10 months. I was surpised at the casein number. I did not expect the eggs and rice. I eat both of those items all the time.
Thanks
Mean Value 11 Antigenic Foods 7 Units (Normal Range is less than 10 Units)
Fecal Anti-gliadin IgA 18 Units (Normal Range is less than 10 Units)
Fecal Anti-casein (cow’s milk) IgA 11 Units (Normal Range is less than 10 Units)
Fecal Anti-ovalbumin (chicken egg) IgA 41 Units (Normal Range is less than 10 Units)
Fecal Anti-soy IgA 11 Units (Normal Range is less than 10 Units)
HLA-DQB1 Molecular analysis, Allele 1 0601
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 1,1 (Subtype 6,6)
Interpretation of Quantitative Microscopic Fecal Fat Score: Provided that dietary fat is being ingested, a fecal fat score less than 300 indicates there is no excessive malabsorbed dietary fat in stool, indicating that digestion and absorption of fat and other nutrients is currently normal.
While all of the foods tested can be immune-stimulating, the hierarchy of reactions detected were as follows:
Food toward which you displayed most immunologic reactivity: Oat, Rice
Food for which there was no significant immunologic reactivity: Chicken, Beef, Corn, Tuna, Pork, Cashew, White potato, Almond, Walnut
Within each class of foods to which you displayed multiple reactions, the hierarchy of those reactions detected were as follows:
Grains:
Grain toward which you displayed the most immunologic reactivity: Oat
Grain toward which you displayed intermediate immunologic reactivity: Rice
You can use the hierarchal results from each specific class of food, within which you reacted to multiple antigens, to make the wisest dietary decision when choosing which food(s) from that class to keep in your diet. Choose the food(s) to which you were least reactive (or in the case of potato, non-reactive).
Avoiding all grains, most antigenic meats (such as these), and nightshades is an important part of the most optimized anti-inflammatory diet.
Interpretation of Fecal Anti-gliadin IgA: The level of intestinal anti-gliadin IgA antibody was elevated, indicative of active dietary gluten sensitivity. For optimal health; resolution or improvement of gluten-induced syndromes (mainly falling into six categories abbreviated as NAAAGS – neuropsychiatric, autoimmune, asthma, abdominal, glandular deficiencies/hyperactivity or skin diseases); resolution of symptoms known to be associated with gluten sensitivity (such as abdominal symptoms - pain, cramping, bloating, gas, diarrhea and/or constipation, chronic headaches, chronic sinus congestion, depression, arthritis, chronic skin problems/rashes, fibromyalgia, and/or chronic fatigue); and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.
For additional information on result interpretation, as well as educational information on the subject of gluten sensitivity, please see the "FAQ Result Interpretation," "FAQ Gluten/Food Sensitivity," and "Research & Education" links on our EnteroLab.com website.
Interpretation of Fecal Anti-casein (cow’s milk) IgA: Levels of fecal IgA antibody to food antigens greater than or equal to 10 Units are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. It is recommended that for any elevated fecal antibody level to a highly antigenic food such as milk, that it be removed from your diet.
Interpretation of Fecal Anti-ovalbumin (chicken egg) IgA: Levels of fecal IgA antibody to food antigens greater than or equal to 10 Units are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. It is recommended that for any elevated fecal antibody level to a highly antigenic food such as egg, that it be removed from your diet.
Interpretation of Fecal Anti-soy IgA: Levels of fecal IgA antibody to food antigens greater than or equal to 10 Units are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. It is recommended that for any elevated fecal antibody level to a highly antigenic food such as soy, that it be removed from your diet.
Interpretation Of HLA-DQ Testing: Although you do not possess the main HLA-DQB1 genes predisposing to celiac sprue (HLA-DQB1*0201 or HLA-DQB1*0302), HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having two copies of a gluten sensitive gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe. This test was developed and its performance characteristics determined by the American Red Cross - Northeast Division. It has not been cleared or approved by the U.S. Food and Drug Administration.
Results are below and you can post in the result section. At the time of the test I was G/D free for 10 months. I was surpised at the casein number. I did not expect the eggs and rice. I eat both of those items all the time.
Thanks
Mean Value 11 Antigenic Foods 7 Units (Normal Range is less than 10 Units)
Fecal Anti-gliadin IgA 18 Units (Normal Range is less than 10 Units)
Fecal Anti-casein (cow’s milk) IgA 11 Units (Normal Range is less than 10 Units)
Fecal Anti-ovalbumin (chicken egg) IgA 41 Units (Normal Range is less than 10 Units)
Fecal Anti-soy IgA 11 Units (Normal Range is less than 10 Units)
HLA-DQB1 Molecular analysis, Allele 1 0601
HLA-DQB1 Molecular analysis, Allele 2 0602
Serologic equivalent: HLA-DQ 1,1 (Subtype 6,6)
Interpretation of Quantitative Microscopic Fecal Fat Score: Provided that dietary fat is being ingested, a fecal fat score less than 300 indicates there is no excessive malabsorbed dietary fat in stool, indicating that digestion and absorption of fat and other nutrients is currently normal.
While all of the foods tested can be immune-stimulating, the hierarchy of reactions detected were as follows:
Food toward which you displayed most immunologic reactivity: Oat, Rice
Food for which there was no significant immunologic reactivity: Chicken, Beef, Corn, Tuna, Pork, Cashew, White potato, Almond, Walnut
Within each class of foods to which you displayed multiple reactions, the hierarchy of those reactions detected were as follows:
Grains:
Grain toward which you displayed the most immunologic reactivity: Oat
Grain toward which you displayed intermediate immunologic reactivity: Rice
You can use the hierarchal results from each specific class of food, within which you reacted to multiple antigens, to make the wisest dietary decision when choosing which food(s) from that class to keep in your diet. Choose the food(s) to which you were least reactive (or in the case of potato, non-reactive).
Avoiding all grains, most antigenic meats (such as these), and nightshades is an important part of the most optimized anti-inflammatory diet.
Interpretation of Fecal Anti-gliadin IgA: The level of intestinal anti-gliadin IgA antibody was elevated, indicative of active dietary gluten sensitivity. For optimal health; resolution or improvement of gluten-induced syndromes (mainly falling into six categories abbreviated as NAAAGS – neuropsychiatric, autoimmune, asthma, abdominal, glandular deficiencies/hyperactivity or skin diseases); resolution of symptoms known to be associated with gluten sensitivity (such as abdominal symptoms - pain, cramping, bloating, gas, diarrhea and/or constipation, chronic headaches, chronic sinus congestion, depression, arthritis, chronic skin problems/rashes, fibromyalgia, and/or chronic fatigue); and prevention of small intestinal damage and malnutrition, osteoporosis, and damage to other tissues (like nerves, brain, joints, muscles, thyroid, pancreas, other glands, skin, liver, spleen, among others), it is recommended that you follow a strict and permanent gluten free diet. As gluten sensitivity is a genetic syndrome, you may want to have your relatives screened as well.
For additional information on result interpretation, as well as educational information on the subject of gluten sensitivity, please see the "FAQ Result Interpretation," "FAQ Gluten/Food Sensitivity," and "Research & Education" links on our EnteroLab.com website.
Interpretation of Fecal Anti-casein (cow’s milk) IgA: Levels of fecal IgA antibody to food antigens greater than or equal to 10 Units are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. It is recommended that for any elevated fecal antibody level to a highly antigenic food such as milk, that it be removed from your diet.
Interpretation of Fecal Anti-ovalbumin (chicken egg) IgA: Levels of fecal IgA antibody to food antigens greater than or equal to 10 Units are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. It is recommended that for any elevated fecal antibody level to a highly antigenic food such as egg, that it be removed from your diet.
Interpretation of Fecal Anti-soy IgA: Levels of fecal IgA antibody to food antigens greater than or equal to 10 Units are indicative of an immune reaction, and hence immunologic “sensitivity” to that food. It is recommended that for any elevated fecal antibody level to a highly antigenic food such as soy, that it be removed from your diet.
Interpretation Of HLA-DQ Testing: Although you do not possess the main HLA-DQB1 genes predisposing to celiac sprue (HLA-DQB1*0201 or HLA-DQB1*0302), HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having two copies of a gluten sensitive gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe. This test was developed and its performance characteristics determined by the American Red Cross - Northeast Division. It has not been cleared or approved by the U.S. Food and Drug Administration.
Denise
Hi Denise,
Because of this rating:
"Mean Value 11 Antigenic Foods 7 Units (Normal Range is less than 10 Units)"
And this:
"Grain toward which you displayed intermediate immunologic reactivity: Rice"
The resulting combination means that your actual sensitivity to rice is so low that it may never bother you.
41 is a very strong positive result on the eggs. My guess is that you have developed a tolerance for eggs, after eating them for a long time. I developed a tolerance for casein, in the same way. Not quite a year ago, I discovered that I produce antibodies to casein (my test result was 24).
No one knows what type of risks are involved if we continue to eat foods for which we produce antibodies, even though they don't cause clinical symptoms.
So whether or not we eat them has to be a personal decision, based on our best guess. I decided to stop eating casein, and I haven't touched it since then.
Tex
Because of this rating:
"Mean Value 11 Antigenic Foods 7 Units (Normal Range is less than 10 Units)"
And this:
"Grain toward which you displayed intermediate immunologic reactivity: Rice"
The resulting combination means that your actual sensitivity to rice is so low that it may never bother you.
41 is a very strong positive result on the eggs. My guess is that you have developed a tolerance for eggs, after eating them for a long time. I developed a tolerance for casein, in the same way. Not quite a year ago, I discovered that I produce antibodies to casein (my test result was 24).
No one knows what type of risks are involved if we continue to eat foods for which we produce antibodies, even though they don't cause clinical symptoms.
So whether or not we eat them has to be a personal decision, based on our best guess. I decided to stop eating casein, and I haven't touched it since then.Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Thanks Tex
I see the GI tomorrow and I am going to asked to be switched to Lialda to get over this flare due to high blood pressure Entocort causes. (plus Entocort is not working I received a few days of relief)
Should I discuss the 2 copies of HLA gene; he dismissed me over a year ago when I said I would like the test?
Anyones comments are welcome.
Thanks!
I see the GI tomorrow and I am going to asked to be switched to Lialda to get over this flare due to high blood pressure Entocort causes. (plus Entocort is not working I received a few days of relief)
Should I discuss the 2 copies of HLA gene; he dismissed me over a year ago when I said I would like the test?
Anyones comments are welcome.
Thanks!
Denise
If I were in your shoes, I wouldn't even bring it up, because he wouldn't know what those genes imply, anyway. I seriously doubt that he is even aware that certain genes are associated with the disease, and even if he were, currently there's no official medical opinion on how to relate that information to treatment decisions.Denise wrote:Should I discuss the 2 copies of HLA gene; he dismissed me over a year ago when I said I would like the test?
Good luck with your appointment.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
with Gabes.
That's just a generic swipe at nightshades, because eliminating them from the diet would indeed be a part of "the most optimized anti-inflammatory diet". Since Denise showed no reaction to them at all, there's no reason for her to invoke "the most optimized anti-inflammatory diet". A customized diet based on her test results should be fine.is an important part of the most optimized anti-inflammatory diet
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Being used to a food has nothing to do with it, because foods will not cause our immune system to produce antibodies unless we are sensitive to them. If we are sensitive to a food, then our immune system will produce antibodies to it. And if we continue to eat that food, then our antibody level will continue to increase.Lisa wrote:I'm confused by this. It sounds like it's being said that a high number, might mean you're used to a food, even though antibodies are high?
If we aren't sensitive to a food, then we won't produce antibodies to it, and there is no way that the antibody level could be high, no matter how much of it we eat. Does that clarify your concerns?
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.