Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Gloria, that is great news. I have been following you and Zizzle.My rash seems to finally be gone. It took 3 months for it to disappear.
Zizzle, when my rash turned into dots, they started to dry up. I felt like it was healing when they did that. I hope it means that your rash is beginning to heal. I didn't apply cortisone cream yesterday and there were a couple of small rashes on my backside this morning. It looks like I'm going to have to keep applying the cream for a while. But the intense itching is gone, and I'm glad for that.Zizzle wrote:I now have red, raw dots on some of the roughest portions of my lower back. They hurt but don't ooze.
), that someone has discovered how it works in autoimmune disease. Are toll-like receptor issues my smoking gun, perhaps?? They certainly play a role in skin AND gut mucosa. They seem to be reacting to microbes and antigens (not truly to self). And lo-and-behold, they are tied to nickel allergy!!!!!!!!!!! Coincidence?Antimalarials are lipophilic weak bases and easily go through plasma membranes. The free base form accumulates in lysosomes (acidic cytoplasmic vesicles) and is then protonated,[8] resulting in concentrations within lysosomes up to 1000 times higher than in culture media. This increases the pH of the lysosome from 4 to 6.[9] Alteration in pH causes inhibition of lysosomal acidic proteases causing a diminished proteolysis effect.[10] Higher pH within lysosomes causes decreased intracellular processing, glycosylation, and secretion of proteins with many immunologic and nonimmunologic consequences.[11]These effects are believed to be the cause of a decreased immune cell functioning such as chemotaxis, phagocytosis and superoxide production by neutrophils.[12] Recently a novel mechanism has been described wherein hydroxychloroquine inhibits stimulation of the toll-like receptor (TLR) 9 family receptors. TLRs are cellular receptors for microbial products that induce inflammatory responses through activation of the innate immune system
Schmidt et al. demonstrated that TLR4 is involved in the development of contact allergy to nickel in humans.[31] By binding to two non-conserved histidines, H456 and H458, Ni2+ cross-links the two receptor monomers, TLR4, and MD2, triggering formation of a dimer that structurally resembles the one induced by Lipopolysaccharide. That, in turn, activates the proinflammatory intracellular signal transduction cascades.
And how do we prepare our other cat for the loss of her life-long companion? Does she know what's happening? I hate this!!As you probably recall, my position is that there is no such thing as autoimmune disease — all so-called autoimmune responses are caused by exogenous antigens, and the responses can be stopped by avoiding the exogenous antigens. By definition, that eliminates such responses from being classified as autoimmune responses.Zizzle wrote:They seem to be reacting to microbes and antigens (not truly to self). And lo-and-behold, they are tied to nickel allergy!!!!!!!!!!! Coincidence?
But in the meantime, here is the list of inactive ingredients. Any reason for concern?
magnesium stearatePEG is the basis of a number of laxatives (e.g., macrogol-containing products, such as Movicol and polyethylene glycol 3350, or SoftLax, MiraLAX, or GlycoLax). Whole bowel irrigation with polyethylene glycol and added electrolytes is used for bowel preparation before surgery or colonoscopy. The preparation is sold under the brand names GoLYTELY, GaviLyte C, NuLytely, GlycoLax, Fortrans, TriLyte, Colyte, Halflytely, Softlax, Lax-a-Day, ClearLax and MoviPrep
Yet their news feed reads more like a police blotter!(patent litigation, recalls, etc) They had to hire Mayor Guliani to help them get their drugs approved for import into the US!Ranbaxy is one of the world’s largest manufacturers of generic drugs, with production facilities in the United States and India.
They sound like a typical drug company.Zizzle wrote:Yet their news feed reads more like a police blotter!(patent litigation, recalls, etc) They had to hire Mayor Guliani to help them get their drugs approved for import into the US!
TMA Member: I was wondering if any study has been done to see if going on a gluten-free diet can alleviate the adverse symptoms from Dermatomyositis and Polymyositis of which I'm experiencing both ailments since 2008. I'm asking because I've read going on a gluten free and/or even vegan diet has helped other immune problems like Lupus and Sjogren's Syndrome (both of my siblings suffer from one of these symptoms). I did my own test since July and noticed a difference. Not only did I drop 20 lbs but my finger tips didn't profusely cut and bleed but started to heal. It didn't heal completely but I noticed some relief. Also my breathing seemed to stabilize (Polymyositis affects my lungs). I'm currently on 2000mg Cellcept, 5 mg Prednisone and 400mg/80mg Bactrim. I'm a 54 yr Asian female.
Dr. Oddis: Unfortunately, there are no good studies on this intervention. I wouldn't be surprised to know that some pts improve and this is a benign thing to do.
Sorry, I'm out of the loop. Do you know what's causing the eye pain and headaches? Do you have high BP? Have you had your ocular pressure checked? Could it be caused by the Entocort? Steroids are not great on the eyes. I just had my baseline eye exam and although my eyes were normal, I'm at increased risk for glaucoma because my grandpa had it, I'm now on steroids, and I had asymmetry of the optic nerve cupp (the opening to the optic nerve). More frequent eye exams...I need the horrible eye pain/headaches to stop
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832720/Genetic risk factors for the development of myositis include the alleles HLA-DRB1 *0301 and HLA-DQA1 *0501.
