Detailed overview of Leaky Gut Syndromes

[Zizzle]

I came across this link in a forum where very sophisticated people were discussing MTHFR mutations, infections and the like. This is the most thorough overview of Leaky Gut Syndrome I've seen in a while. I'm not done reading it, but it really helps to tie all the pieces together. For example, I never understood why leaky gut led to liver conditions. Now I do!

http://www.mdheal.org/leakygut

[Gabes-Apg]

Zizzle
the link is not working for me

i would interested if any one else has tried it as it maybe a link that wont work for those outside of the USA
thanks

[LindyLou]

Is this it?

http://www.mdheal.org/leakygut.htm

[JFR]

Doesn't work for me either.

[Joefnh]

LindyLou you got it.

http://www.mdheal.org/leakygut.htm

Works

That website is using the older HTML 3 encoding which requires the explicit naming in its web links. In this case the .htm has to be added. Most websites these days do not require that level name matching.

Besides the technical mumbo jumbo, great article Zizzle, I did not realize how involved this topic is.

[JenniferS]

Zizzle, I'd say, "interesting," but first, I suspect I need to find a dictionary and try to read that article again. ;)

[DebE13]

Very interesting from what I've read so far. I believe I got the jist of it but did have to google a few words.

[Gabes-Apg]

long story short -

after chronic episodes of any IBD where there has been inflammation, villi damage etc. Focusing on healing the leaky gut is imperative for whole of body health.
leaky gut puts huge pressure on liver and kidney (long term leaky gut filtering done by the liver can damage it to the equivalent of having a constant fatty diet, alcohol etc)


focus on
low inflammation
low histamine - minimal mast cell
nurturing/healing eating plan

my theory is - things like pro-biotics will work once the leaky gut is healed. for the people that havent tolerated pro-biotics, maybe there is still too much inflammation/villi damage.

[jgivens]

Thank you, Zizzle! Fascinating and what a complicated process. It always amazes me and makes me think that it is a miracle that our bodies work at all--we are such finely tuned machines and make up for mechanic failures with all kinds of "back-up" systems--but when they fail in a big way, they really fail.

I have heard the phrase leaky gut for years and just accepted it as a condition, but this is a good explanation for what really is happening.

[Zizzle]

An easier must-read. A friend with an autistic daughter passed this on. Proves my point that autism exactly mirrors the epidemic of inflammatory disorders. It's a miracle my kids turned out ok!! Celiac in mom increases autism risk by 350%!?!!!!

http://www.nytimes.com/2012/08/26/opini ... d=all&_r=0

[Zizzle]

Incidentally, on the liver front, I've had anti-liver antibodies for 8 years, but thankfully no hepatitis yet. I have developed a tea drinking habit, and I'm now drinking one large mug of liver cleanse tea/detox tea per day. Are there any risks with this habit?

[Deb]

A fascinating article. Thanks, Zizzle. Deb

[tex]

Zizzle,

Here's a link to a Livestrong article that lists some of the Side Effects of Detox Tea.

Does the product you're using contain licorice? That one seems to pose the biggest risk, since it's contraindicated with corticosteroids and many other common medications.

Tex

[Stanz]

Passing this on to my niece with an autistic son.

[Zizzle]

Here is a fabulous interview with Dr. Fassano about leaky gut, autoimmunity, zonulin, a drug on the horizon to suppress zonulin, and an explanation of why some of us may make too much zonulin (regardless of gluten). I think I like Fassano again (I was unimpressed as his patient, but this gives me hope that he's on the right track to help people like me). Truly worth reading or listening to the whole interview.

http://chriskresser.com/pioneering-rese ... -leaky-gut

So what we understand is that at least for the zonulin pathway — and I’m sure there are going to be many others if they physiologically control the permeability — there are two major stimuli that we found to release zonulin in everybody — everybody. If you have bacteria in your small intestine, where supposedly they should not be there because we’ve been built so that bacteria will be confined in our intestinal tract all in the colon at the very end, where there are no nutrients anymore so they cannot steal. But if there are bacteria, they eventually will be able to colonize the small intestine by going through all these layers of defense that we have been evolving with as human beings, like saliva, the gastric juice defending from almost all bacteria, pancreatic juice, bile, glycocholic — in other words, if this bacteria will go through all of this and will land on the epithelial cells of the intestine and start to sit there and steal nutrients that we ingest with diet, if we have one last thing that we can do to get rid of these guys, enterocytes, i.e. these epithelial cells, when colonized by bacteria, they release a large amount of zonulin. They open this space, water comes in from underneath the intestine into the lumen, will dilute the toxins produced by these bacteria, but at the same time will flush them out so that they will be moved out and removed from the small intestine. This is one stimulus. The other stimulus — and I believe that this is more by mistake of evolution rather than planned design as for the proximal bile contamination — is gluten itself. We identified two fragments, one of the gluten components, it’s called gliadin, that when introduced to epithelial cells they induce, like for bacteria, zonulin release. And this, again, happens to everybody. What is the difference between everybody and the people that develop a problem with gluten like celiac disease is that while for me, for example, because I don’t have a problem. I eat a Big Mac. I have gluten in there. These fragments release zonulin, which increases permeability. Stuff comes through, including gluten. My immune system that is tuned to do the job right will clean up the mess, and I will not even know that all that happened. Also because this open-and-close is short. It’s a matter of minutes that it will open and a matter of minutes that will turn to be closed. People with celiac disease, on the other hand, when they do something like that, not only do they have much more zonulin produced than I do, but also the opening is much more prolonged because these doors get stuck open, and therefore you give much more time for substances from the environment, including gluten, to come through. And now on this other side, you find this immune system that is not tuned to do the job right, and when they see this enemy, they start to mount an immune response to attack your own body, and that leads to celiac disease.