Feel free to discuss any topic of general interest, so long as nothing you post here is likely to be interpreted as insulting, and/or inflammatory, nor clearly designed to provoke any individual or group. Please be considerate of others feelings, and they will be considerate of yours.
I'm no excuse expert (would that be an excusiologist?), but those sound like pretty good excuses to me. I've been spending a fair amount of time on yard work and tax-related record updating and paperwork myself, lately (no sewing, though. LOL).
One of the main problems with medical research is that if the only tests available are inadequate for accurate and reliable results, then the research is compromised before it's begun. IMO, that's the main reason why nothing meaningful has been accomplished to date. If an accurate and reliable test can be found, for detecting the presence of MAP, then maybe some meaningful research can be done on how it relates (or doesn't relate) to IBD.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Yes, an accurate way to test for hidden bacteria has been the problem and hopefully the test patented by UCF, that was used by Red Hill to develop the antibiotic is successful. I'm anxiously awaiting the results of this study, but imagine that even once completed, it will take some time before it's published.
SO close to being done with the taxes. Between my husband and myself, we have 14 W-2's, 3 - 1099's, both self-employed and 2 rentals. It's a nightmare every year despite how carefully I keep records. Thank goodness I have an accounting background.
Connie
Resolved MC symptoms successfully w/L-Glutamine, Probiotics and Vitamins, GF since 8/'09. DX w/MC 10/'09.
I took a probiotic strain of many Bifidobacteriums. This was 3 years ago. Things started going downhill at the same time I started taking those. Maybe just a coincidence but totally terrified of taking those again! They immediately gave me an increase in BM's for starters. And it was GF and DF.
I need to read up on the MAP.
Terri
Diagnosed with Lymphocytic Colitis in July, 2012 then with Celiac in November, 2012.
Terri, I had the same experience you did when I tried probiotics. So I have avoided them. I think the key will be when an individual gut bacterial analysis and interpretation becomes easily available. I know the test is available, but I doubt that anyone knows yet what the values mean or how to treat the results. Also I don't have time to look right now, but there are some really good old threads here about MAP and its unique characteristics.
Take care,
Polly
Blessed are they who can laugh at themselves, for they shall never cease to be amused.
@Polly...will have to check out the threads...thanks! I think IF I ever try a Probiotic again, it'll probably be Lactobacillus. Doing too good right now and don't want to risk a relapse at this time.
Terri
Diagnosed with Lymphocytic Colitis in July, 2012 then with Celiac in November, 2012.
Does this study about Interleukin-15 levels and their resulting lack of suppression of T cells add to our collective knowledge about the factors leading to MC and celiac?
Are researchers looking at drugs to suppress IL-15 specifically?
From Wikipedia:
This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells.
Notice the strange link to celiac and EPSTEIN BARR VIRUS!
Function
Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L).[6] In humans with celiac disease IL-15 similarly suppresses apoptosis in T-lymphocytes by inducing Bcl-2 and/or Bcl-xL.[14]
A hematopoietin receptor, the IL-15 receptor, that binds IL-15 propagates its function. Some subunits of the IL-15 receptor are shared in common with the receptor for a structurally related cytokine called interleukin 2 (IL-2) allowing both cytokines to compete for and negatively regulate each other's activity. CD8+ memory T cell number is controlled by a balance between IL-15 and IL-2. When IL-15 binds its receptor, JAK kinase, STAT3, STAT5, and STAT6 transcription factors are activated to elicit downstream signaling events.
Disease
Epstein-Barr virus
In humans with history of acute infectious mononucleosis (the syndrome associated with primary Epstein-Barr virus infection), IL-15R expressing lymphocytes are not detected--even 14 years after infection.[15]
Celiac disease
There have been recent studies suggesting that suppression of IL-15 may be a potential treatment for celiac disease and even presents the possibility of preventing its development. In one study with mice blocking IL-15 with an antibody led to the reversal of autoimmune intestinal damage.[16] In another study mice used were able to eat gluten without developing symptoms.[17]
[edit]Immunotherapy
Metastatic cancer
IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models.[18][19] A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.[20]
I've been spending a fair amount of time on yard work and tax-related record updating and paperwork myself, lately (no sewing, though. LOL).
