research results - immune system attacking good gut bacteria

[Gloria]

There was one other woman who posted a few years ago about doing fecal transplants. The transplants only helped her for a few days, as I recall. I don't remember her board name, however. She didn't post very long, and sounded rather desperate. Her donor wasn't a spouse, because she wasn't married.

Gloria

[Zizzle]

Fecal transplants for pediatric UC in the news today!

http://www.medicaldaily.com/articles/14 ... isease.htm

Researchers have thought that bacteria in the gut may be the initiating factor. One of the reasons is that special mice which don't have any bacteria in their GI tract are not susceptible to some types of induced colitis. When bacteria are added to these mice the are then susceptible to colitis.

The current theory is that an imbalance in gut bacteria can perturb the immune system and set it off against a person's own organs.

The current study used the procedure on 10 children and teens aged 7-20. Stool samples were prepared in a lab from a healthy adult donor and infused into the intestines of patients by enema daily for 5 days.
The studies indicated that more than ¾ of the study participants had remission of symptoms after a week and more than 2/3 of the participants maintained a good outcome after one month.

[Gabes-Apg]

mmmm
i am going to raise an important fact to this discussion.

the health of the digestion system starts at the mouth and ends at the anus. using fecal transplants will have limited success if you are not fixing up the digestion system above this point...

if you have bacteria in your mouth, every time you eat or drink you are basically sending bacteria to attack the good flora.

If you have hiataus hernia, acid issues (either high or low acid) then the delicate chemisty of processing food is out of balance and this will affect any good flora that is starting to grow.
the foods you eat after the fecal transplant could affect the gut flora

IMO - fecal transplants have a very limited scope of success unless you start at the top and work down.

[gluten]

Hi, There are hundreds of different bacterias in the mouth. Some create bioflims in the mouth and result in plague. I agree with Gabes about the G.I tract and it also incudes the liver,gall bladder and pancreas. Jon

[ObsessedMrFixit]

Totally agree! You may notice I didn't say that FMT was my only treatment. :). I'm also addressing low stomach acid, an ulcer of unidentified origin, and malabsorption. :) hoping that all of it together gives me healing.

[tex]

I'm also addressing low stomach acid, an ulcer of unidentified origin, and malabsorption. :) hoping that all of it together gives me healing

.

What about food sensitivities? If you're not also avoiding your food sensitivities, then that's probably the main reason why the transplants are not helping.

Tex

[Zizzle]

Here's an interview and podcast with Moises Velasquez-Manoff, author of An Epidemic of Absence: A New Way of Understanding Allergies and Autoimmune Diseases.

http://chriskresser.com/the-hygiene-hyp ... 2710a6acd6

In this episode, they cover:

4:00 How Moises got into the hygiene hypothesis
7:23 The difference between the “hygiene hypothesis” and the “old friends hypothesis”
16:13 Why genes that predispose us to disease are selected for?
23:00 Does raw milk protect against asthma?
31:20 Could H. Pylori actually benefit humans?
36:50 Will Fecal Transplant become a common therapy in the future?
43:20 What are the risks associated with Helminthic and Hookworm Therapy?
54:14 How can we put these theories into practice with our children?

[Leah]

No probiotics for me either!
Leah

[Eric]

Here's an interview

Thanks for sharing Zizzle, interesting interview; good points regarding fecal transplants. Lucky for all of you, my LENGTHY post got timed out and erased so you'll get the condensed version. I like that he stressed prebiotics/synbiotics and other ways to enhance the existing flora but I feel there's a number of folks out there that face an unecessarily long and difficult battle to regain balance when a relatively immediate solution could be available. Unfortunately, I think they brushed over the major issue which is getting society/doctors to 1) foster the development of good flora from birth on and 2) maintain that flora throughout our lives. Until we have advanced medicines that disrupt communication between harmful bacteria, or find other ways to prevent their harmful effects without wiping out the beneficial bacteria in the process, we'll need effective ways to repopulate patients' gut flora. Maybe the "repoopulate" folks will fine tune their lab-grown bugs so future probiotics will be more effective but for the time being I strongly feel fecal microbial transplantation is an under-utilized, safe and effective practice that has potential to treat many conditions beyond C Diff.

[ObsessedMrFixit]

Bumping this thread in the hopes of getting Eric's attention. Did you ever try FMT?

[Zizzle]

I'm not sure if this belongs in this thread, but I've been thinking about this statement apparently taken from a video about the dangers of GMOs. It was posted in a soy allergy group on Facebook, along with a link to the movie which I haven't watched. Is this baseless propaganda, or could it be true? Could GMO soy be a cause of chronic GI system inflammation, even after we stop eating it??

"The only human feeding study ever published on GMO’s showed that the gene that was inserted into the soybean, transferred into the DNA of the bacteria living inside our intestines and continued to produce that protein. So if it happens to be an allergen and you’re allergic to it, you may be continuously triggered over and over again by the production of that allergen from inside your own intestine."

From "Seeds of Death: Unveling the Lies of GMOs"

http://www.youtube.com/watch?v=a6OxbpLw ... e=youtu.be

[Leah]

great

[Zizzle]

Pretty depressing if it's true! I just can't help but notice the connection between the introduction of GMO corn and soy in the 1990s and the sudden decline in our nation's gut health. Coincidence?

[tex]

"The only human feeding study ever published on GMO’s showed that the gene that was inserted into the soybean, transferred into the DNA of the bacteria living inside our intestines and continued to produce that protein. So if it happens to be an allergen and you’re allergic to it, you may be continuously triggered over and over again by the production of that allergen from inside your own intestine."

I would be very interested in seeing the research that is mentioned in that quote. I'm guessing that it does not actually exist.

A heck of a lot of things have happened to our food in the last 20 or 30 years, and GMO is only a tiny part of the changes. But GMO is a convenient whipping boy, because most people don't understand it, and it's easy to fear anything that we do not understand. (And it's easy to hate Monsanto — I'm not too fond of them myself. )

Tex

[ObsessedMrFixit]

Tex, if you do a search for GMO bacteria transfer, you'll find tons of hits. I think I found the study reffered-to in the video, but they want money for the paper, and I'm not that interested in it to give them money.

Anyway, I certainly think its plausible that GMO food gets into our gut bacteria, or even into our own cells and wreaks havoc. If true, it would certainly explain the huge rise in digestive diseases in this country.