Gluten Sensitivity Gene Test Results

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dfpowell
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Gluten Sensitivity Gene Test Results

Post by dfpowell »

After reading the lab explanation, I'm not sure how to interpret the results. They did say I had one of the main genes that predisposes to gluten sensitivity and celiac (HLA-DQB1*0201).
But I'm not sure what the Serologic Equivalents HLA-DQ 2,3 (Subtype 2,7) mean. Any thoughts?

Gluten Sensitivity Gene Test
HLA-DQB1 Molecular analysis, Allele 1 0201

HLA-DQB1 Molecular analysis, Allele 2 0301

Serologic equivalent: HLA-DQ 2,3 (Subtype 2,7)

Thanks,
Donna

Diagnosed with CC August 2011
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tex
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Post by tex »

Hi Donna,

Your other allele, (HLA-DQB1*301) predisposes to microscopic colitis, but not to celiac disease

The serologic equivalent form is just an older format for reporting gene test results. DQ2 is the traditional way to refer to the most common celiac gene. The other celiac gene, as you are probably aware, is DQ8.

IOW, if your test results had been as follows:

HLA-DQB1 Molecular analysis, Allele 1 0301
HLA-DQB1 Molecular analysis, Allele 2 0302

the serologic equivalent would be written as:

HLA-DQ 3,3 (Subtype 7,8)

Or if your results had been:

HLA-DQB1 Molecular analysis, Allele 1 0201
HLA-DQB1 Molecular analysis, Allele 2 0302

then the serologic equivalent would be written as:

HLA-DQ 2,3 (Subtype 2,8)

Do you mind if I add your results to our list here?

Tex
:cowboy:

It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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dfpowell
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Post by dfpowell »

Tex,

Yes, add my results to the list.

Thank You!
Donna

Diagnosed with CC August 2011
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Zizzle
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Post by Zizzle »

My son has the same result as you.
1987 Mononucleosis (EBV)
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
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dfpowell
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Post by dfpowell »

Zizzie,

What have you seen in your son as a result of this genetic profile? Does he have a diagnosis or food sensitivities?
Donna

Diagnosed with CC August 2011
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Zizzle
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Post by Zizzle »

He had D as a baby, but he's regular now. He does have mild lactose intolerance. And he wets the bed nightly! (doubt any connection there...) I assume he got the DQ2 from me and the 3,7 from his dad, who is also gluten sensitive as of this year. My husband has more neurologic symptoms than GI (headaches, fatigue). My son does complain of headaches and/or tummy ache after gorging on LOTS of junkfood (pizza and ice cream at birthday parties, etc). He's also a slow grower compared to my daughter, but we're all short.
1987 Mononucleosis (EBV)
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
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