Chinese herbs for treating food allergies

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Zizzle
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Chinese herbs for treating food allergies

Post by Zizzle »

I just read that Western doctors are now using a mix of Chinese herbs successfully to treat food allergies. From MedScape:
Herb formulas, containing a mixture of 14 different herbs, have been used in Chinese medicine for centuries and considered as a potential treatment for diseases such as asthma[150,151] or atopic dermatitis.[152] In FA, initial tests have been developed in a mouse model of peanut allergy, using an 11-herb formula (FAHF-1), demonstrating in treated mice reduced mast cell degranulation, reduced Th2 cytokine levels, decreased peanut-specific serum IgE levels and a reduced in vitro lymphocyte proliferation, with a protective effect against peanut-induced anaphylaxis and no systemic adverse reactions or toxic effects.[153] Given the protective effect shown and in an attempt to make the formula safer and simpler, the same group reduced the number of herbs and developed a nine-herb formula (FAHF-2), demonstrating, in the same mouse model, that this new formula can also induce protection, with similar immunological changes to those described for FAHF-1, with an upregulation of IFN-γ produced by CD8+ T cells.[154,155] Recently, a mouse model of multiple allergies (peanut-, codfish- and egg-sensitized mice) showed that treated mice had no anaphylactic symptoms after challenge with each allergen and this was accompanied by the same immunological changes as those described above.[156] Clinical trials with FAHF-2 have been approved in the USA[157] and a Phase I study was developed in 19 randomized, double-blinded, placebo-controlled, dose escalation patients with different FA. Of these, only one patient suffered an allergic reaction but it was not attributed to the herbal formula due to the high atopic status of the patient and the negative SPT to all the herbal components. These results showed the FAHF-2 formula to be a safe and tolerable treatment for FA patients and a Phase II study is currently ongoing.
Found a site that explains which herbs are used:
http://tinyurl.com/qxfmj says:
Herbs that fight nut allergy disclosed, By Terry Murray

NEW YORK ¨C The formula has been revealed, 12 months later¡ªthe
names of 11 Chinese herbs reported at the AAAAI meeting last year to
have a striking effect on peanut allergy in a mouse model.

Dr. Xiu-Min Li, assistant professor of pediatrics and clinical immunology
at the Mount Sinai School of Medicine here, told the conference last
year that the herbal formula reduced peanut-specific IgE levels in the
mice by more than 30% and protected the animals from anaphylaxis.
However, neither she nor another investigator on the project would
reveal the contents of the formulation (see Medical Post, April 17,
2001).

But in a seminar on alternative therapies in food allergy at this year's
conference, Dr. Li named the contents. She listed the components of
FAHF-1 (or food allergy herbal formula 1) first by their traditional
Chinese medicine designation (in Pinyin), followed by the equivalent
pharmaceutical name:

Lingzhi (Chi), or Ganoderma lucidum;
Fuzi (zhi), or Radix lateralis aconiti carmicaeli praeparata;
Wumei, or Fructus pruni mume;
Chuanjiao, or Pericarpium zanthoxyli bungeani;
Xixin, or Herba cum radice asari;
Huanglian (Chuan), or Rhizoma coptidis;
Huangbai, or Cortex phellodendri;
Ganjiang, or Rhizoma zingiberis officinalis;
Guizhi, or Ramulus cinnamomi cassiae;
Renshen (Hong), or Radix ginseng; and
Danggui (shen), or Corpus radix angelicae sinensis.

The Mt. Sinai researchers are working to standardize FAHF-1, to
explore the way in which it suppresses allergic reactions and to
determine the best combination of the 11 ingredients, Dr. Li said.
They have also moved " one step closer to clinical study " by starting to
evaluate FAHF-1 with human mucosal lymphocytes from four milk-
allergic patients, she added. But she said only that in cell culture, FAHF-
1 produced a " clear reduction " in proliferation and in IL-4 and IL-13, but
did not alter interferon-gamma production.

The ingredients, above, refer to FAHF-1. The version used in the US
trial (FAHF-2) removed Xixin & Fuzi, but that removel did not reduce the
anti-allergic effect.
http://nccam.nih.gov/news/newsletter...er/roundup.htm
I plan to ask my Chinese medicine doc about these!
1987 Mononucleosis (EBV)
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
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