Now I'm sure it's histamines!

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tex
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Post by tex »

Linda,

Note that in Zyrtec, lactose monohydrate is the first listed inactive ingredient, meaning that it comprises the greatest percentage of the inactive ingredients. So there's a lot of it in there.

With the Claritin Redi-tabs, mannitol is the third (next to last) listed ingredient, indicating that it comprises a minor part of the inactive ingredients. But of course, that's because the sugar alcohols are very effective sweeteners, so less is required to provide the desired degree of sweetness.

Basically (as you are probably aware), there are two types of antihistamines, first generation, and second generation. You're already tried all of the second generation antihistamines (except Alavert, and it also contains mannitol), so the only remaining options are some of the first generation products.

First-Generation OTC Antihistamines

Brompheniramine (Dimetapp Cold and Allergy Elixir)
Chlorpheniramine (Chlor-Trimeton)
Dimenhydrinate (Dramamine)
Diphenhydramine (Benadryl Allergy, Nytol, Sominex)
Doxylamine (Vicks NyQuil, Alka-Seltzer Plus Night-Time Cold Medicine)

Second-Generation OTC Antihistamines

Loratadine (some brand names: Alavert, Claritin)
Cetirizine (one brand name: Zyrtec)
Fexofenadine (one brand name: Allegra)


Until it was removed from the OTC market (a few years ago), my favorite antihistamine was Chlor-Trimeton (chlorpheniramine maleate) in the 12 mg formulation. It was much more effective for me than any of the other antihistamines (for pollen allergies). It was effective for me for 24 hours. And it's generally less sedating than the other first generation antihistamines. Unfortunately, it contained lactose. The 4 mg (4-hour) version has always been available, and a 12 mg formulation is now available again. Unfortunately, they both contain lactose about mid-way down a long inactive ingredient list. :sigh:

http://www.walgreens.com/store/c/chlor- ... 0015878e71

http://www.chlorphen12.com/about-chlorphen-12/

It's even available on Amazon:

http://www.amazon.com/Chlorphen-Chlorph ... pc_title_2

And look at this price (for pets only):

http://www.vetrxdirect.com/product/view ... 7AodiHAAGQ

I can't help but wonder what the ingredients area, because there's a possibility that it might not contain a sweetener.

To be honest, I'm not aware of any OTC antihistamine that does not contain either some form of lactose, or a sugar alcohol (usually mannitol). I would assume that there is always the option of trying to find a compounding pharmacy that will compound a batch for you, to eliminate any ingredients that you need to avoid. If you can't find a local pharmacy, there are compounding pharmacies that will ship the formulations to you.

However, in order to arrange for a custom formulation, you would presumably need a prescription from your doctor (listing the ingredients, and the reason why this formulation is necessary), to authorize the pharmacy to produce the item. I'm not certain whether this is a requirement for OTC products though, so you might check with the compounding pharmacy first, to see if they would do it, and if they will, whether a prescription is required for an otherwise OTC product. (I suspect a prescription will be required).

Tex
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Post by Leah »

Can you take Benadryl during the day since it doesn't seem to make you drowsy?
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Post by ldubois7 »

Tex,

It seems like a 'no win' situation with the second generation antihistamines due to lactose or a sugar alcohol ingredient. The RediTabs may be worth a shot, due to the mannitol being further down in the inactive ingredients.
And, I never thought of having a compound made...that would be ideal, if it wasn't too expensive! :)

Leah,

I'm only taking 1/2 tablet of Benadryl (a whole one is 25 mg.) after dinner, and it does make me sleepy at first, but I don't get a restful nights sleep....waking many times through the night. Maybe I could play with taking it in mid afternoon, because I am really seeing a different even with such a low dose vs. the Allegra.

Thanks guys! Have a great weekend! It's absolutely beautiful here in Pennsylvania!

:)
Linda :)

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Post by Rubysmom »

Thank you so much Leah, for posting this. I, too, was just like you - no D, but no Norman either. I was stuck taking two Entocort a day with no hope of getting lower or off. I tried taking Claritin Red-Tabs because that was always my anti-histamine of choice, and low and behold, Norman has been hanging around since (3 days). I hadn't thought of histamines as the culprit, as I had no obvious symptoms. But even though the Claritin is non-drowsy, I am sleeping better, probably because my gut feels better. When I think back, I did have a few itches of unknown origin with no signs of bites, etc. And I thought that the itches on my scalp were residual itches from black fly bites....nope. They are going away. Unfortunately, the foods I am NOT sensitive to all contain either histamines or histamine releasers, so they have to stay in my diet. I have been taking the Claritin in the evening, and wondered if I should be taking it when I eat instead. I will have to experiment. That would mean three a day. I am now taking just one before bed with very happy results. I will also think about the Histame at mealtime. Another experiment!

Kathy Robbins
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Post by Gloria »

Tex wrote:However, in order to arrange for a custom formulation, you would presumably need a prescription from your doctor (listing the ingredients, and the reason why this formulation is necessary), to authorize the pharmacy to produce the item. I'm not certain whether this is a requirement for OTC products though
Back when I was experimenting with Benadryl, I went to a compounding pharmacy to see if they could make a pill without any dyes, additives, etc. They required a prescription from my Dr. first, and phoned the Dr. to get his approval to cut the dosage in half. They asked if it would be OK to use cornstarch as a filler. The gel capsule was made using bovine, as I recall. Each pill cost $1. The compounded formula gave me no improvement over the OTC version, so I've never gotten them again.

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Post by Leah »

You're welcome Kathy. I'm always happy when something I add in helps someone else :) To answer someone else's question... I really don't have any other histamine symptoms. In the Spring I sometimes get some itchy eyes and sneezes.

Leah
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Post by Gabes-Apg »

Leah,
like you, when I connected the dots, and realised that histamine/mast cell was a major trigger, it was kinda like how could something so simple cause so much chaos...

Be prepared, any change of season, having dental work, having your hair dyed can be histamine triggers, a bit like our mc eating triggers, when you remove one main one, a few weeks later another 'thing' may be the major histamine trigger...

The detective work may slow, but it never stops!!!
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Post by MaggieRedwings »

Well the Allegra Redi-Tabs seem to be helping but just into them for 4 days. Will keep you posted and thanks for the tip.

Love, Maggie
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Post by Gloria »

Good news, Maggie!

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