Study of the mucosa associated bacteria in two women with CC

gluten · Post by **gluten** » Wed Feb 19, 2014 9:39 pm

Hi, This study is from the World of Gastroentrology April 2012. " Mucosa-associated bacteria in two middle aged women diagnosed with collagenous colitis" Just type in the title to read the entire research report. The following is the summary " To the best of our knowledge, this is the first study of the intestinal microbiota in patients with a histologically diagnosis CC, by a culture-independent method. The overall compostion of the colonic microbiota was similar to a healhty one with dominance of Firmicutes and Bacteroidetes. Due to the fact that only two patients were analyzed, it is difficult to draw any conclusions, BUT IN BOTH PATIENTS A HIGH PROPORTION OF POTENTIALLY PATHOGENIC SPECIES OF BACTEROIDES AND CLONES RELATED TO CLOSTRIDIUM CLOSTRIDIOFORME WERE FOUND." Jon

Zizzle · Post by **Zizzle** » Thu Feb 20, 2014 8:58 am

Interesting. My doctor ordered an Organic Acids urine test to look for Clostridia bacteria (not c-diff, but others). If I have it, I'll take a one time treatment of Vancomycin to eradicate it.

http://www.greatplainslaboratory.com/ho ... ll_oat.asp

Polly · Post by **Polly** » Thu Feb 20, 2014 10:22 am

Hi Jon,

I have seen other articles that implicate bacteroides in colitis. Apparently it is normally in the colon but becomes altered somehow, which can lead to colitis. Maybe this is a reason that Cipro often improves MC - it is very active against bacteroides. Thanks for sharing.

Polly

Zizzle · Post by **Zizzle** » Thu Feb 20, 2014 10:34 am

This article is interesting...it seems Clostridria (one of 3 similar strains, often undifferentiated), are more common in stools of late onset autistic kids. It is often found in post-op wound infections, and as one might expect, it increases dramatically in the presence of amoxycillin (I'm assuming because other competing bacteria are wiped out).

http://bacteriaandautism.com/PDF/755.pdf

gluten · Post by **gluten** » Thu Feb 20, 2014 3:03 pm

Hi Zizzle, Amoxicilin is one of the antibiotics that has no effect against clostridium clostridioforme or the other species. Polly mentioned Cipro is effective against it. Amoxcillin kills the good bacteria and allows the clostridium to set-up an unbalanced gut microflora. The only antibiotic I was prescribed was amoxicillin. I had to take it for several days prior and after a dental procedure thirty years ago. Today, it is not prescribed anymore before dental work. Could this type of bacteria be responsible for the increase in gluten intolerance as the large study from Sweden has shown about the use of antibiotics? So as you have mentioned in some of your posts about a treatment with an antibiotic that could eliminate the clostridium, a good prebiotic while taking the antibiotic and a good probiotic after the antibiotic was finished to rebalanced the microflora. Jon

Zizzle · Post by **Zizzle** » Thu Feb 20, 2014 3:13 pm

The only antibiotic I was prescribed was amoxicillin. I had to take it for several days prior and after a dental procedure thirty years ago. Today, it is not prescribed anymore before dental work.

Jon,
I also took it before dental appointments for at least 10 years, after being diagnosed with Mitral Valve Prolapse. They no longer recommend it, and they also say my MVP is gone based on new guidelines.

gluten · Post by **gluten** » Sat Feb 22, 2014 6:08 pm

Hi Zizzle, I had two echo's looking for the MVP and they did not see anything. During the eighties they always thought it was only caused only by bacteria. Now, they have found other reasons including a magnesium deficiency. Jon

gluten · Post by **gluten** » Mon Feb 24, 2014 5:09 pm

Hi Polly, How long did the patients stay in remission with Cipro? Jon

Post by **tex** » Mon Feb 24, 2014 7:23 pm

Jon,

Many of us have personally experienced a Cipro remission. For example, I was prescribed a 2-week regimen of Cipro on 2 different occasions while I was reacting (my GI doc thought that I must have an infection). In both instances, Cipro brought almost immediate remission (within a day), and the remission lasted until roughly 2 days after the antibiotic was discontinued.

I didn't actually have normal BMs during those periods, but instead of having watery D many times each day, I had baby poop (yellow, semi-formed, and loaded with trapped gas bubbles) only a couple of times each day, and the urgency was greatly reduced. Compared with uncontrollable, watery D, at the time it seemed like a reasonable facsimile of remission.

Tex

gluten · Post by **gluten** » Tue Feb 25, 2014 11:00 am

Hi Tex, Thank you for your response. I had a one day remission and one normal stool after taking 2000 mgs of antibiotic one hour before a dental cleaning. Jon

Polly · Post by **Polly** » Tue Feb 25, 2014 11:23 am

Hi Jon,

I had Cipro a number of times for chronic sinus problems. Whenever I took it, my BMs returned to normal for that period of time. Within days of discontinuing it, the D returned. I never saw improvement on any other antibiotics. What antibiotic did you take for the dental cleaning?

Polly

Zizzle · Post by **Zizzle** » Tue Feb 25, 2014 12:35 pm

I always get improvement on Bactrim and Cephalexin.

gluten · Post by **gluten** » Wed Feb 26, 2014 10:14 am

Hi Polly, I took amoxicillin for the dental visits. In the eighties, when all this started it was two days before and two days after a dental visit. I had many dental visits and walked out of a hospital waiting room waiting for surgery after she told me I would have to take an antibiotic for ten days after the gum reduction treatment. Today, they do not recommend any antibiotic treatment. An interesting question was alway asked by a doctor when she spoke to a FSHD support group in the nineties. She asked " do you feel stronger or weaker when on an antibiotic ". While on an ten day course of antibiotic after a tooth extraction I did feel stronger and had no trouble climbing the stairs. But one week after finishing the treatment it was difficult to climb the stairs, could not make the last step and definitely felt weaker. So, I have a question for you, Tex and Zizzle. Different antibiotics were prescirbed and we all had remission while taking them. During the course of antibiotics were you taking a steriod or another drug to reduce inflammation? I was not. Jon

Zizzle · Post by **Zizzle** » Wed Feb 26, 2014 11:40 am

During the course of antibiotics were you taking a steriod or another drug to reduce inflammation?

Nope, I've never been on any sort of meds (other than birth control pills) until this past year. In my early IBS days, antibiotics would even temporarily cure my lactose intolerance. The colonoscopy cleanout also gave me more than a month of relief from the D.

Post by **tex** » Wed Feb 26, 2014 12:08 pm

Jon wrote:During the course of antibiotics were you taking a steriod or another drug to reduce inflammation?

No, I've never taken a steroid or any other oral anti-inflammatory drug for any reason that I'm aware of. The only medications I ever took for MC symptoms were less than 2 weeks of Pepto-Bismol (before I caved in and went to a doctor) and occasional Tylenol (as needed, for migraines or severe neck/spine aches and pains during severe reactions).

Tex