MS caused by Clostridia toxin?!

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Zizzle
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MS caused by Clostridia toxin?!

Post by Zizzle »

First they discover prevotella bacteria in RA, now they discover Clostridium perfrigens in MS. What infection will they discover in DM?? I can't wait to find out! I spend 3 days at the National Institutes of Health next month donating my live body to science!!

http://guardianlv.com/2014/03/multiple- ... s-answers/
1987 Mononucleosis (EBV)
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Post by gluten »

Hi Zizzle, Interesting. The day may soon be hear when they will link the different bacteria's, virus's and their toxins to the chronic diseases. How did you get to be a science subject for the NIH? Have you found any research why the nitric oxide levels are 100% higher in MC? I find that interesting because the amino acid arginine promotes viral replication and NO is produced from arginine. Jon
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Post by tex »

Jon,

FWIW, elevated nitric oxide levels are associated with all IBDs, including celiac disease.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by Zizzle »

Jon,
I have not come across anything related to nitric oxide. Regarding NIH, I've been accepted into two Dermatomyositis studies, the "new onset myositis study" and the "myositis natural history study." I initially volunteered for a DM sibling study, but I did not qualify because my sister has granuloma annulare, and she's supposed to be free of autoimmunity. I sent them photos of my rash and my rheumatologist sent medical records. They will poke and prod me for 3 days and have me vacuum dust from my home to send to them. I hope they check for lots of infections!
1987 Mononucleosis (EBV)
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
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Post by JenniferS »

Can y'all explain this article and your comments to the layman (i.e, me). :)

Good luck on the study, Zizzle! :)
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tex
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Post by tex »

Jennifer,

Basically, the researchers are proposing that a supposedly rare strain of a common bacteria found in soil, decaying vegetation, and the intestinal tract of almost every species living on this planet (from humans all the way down to insects), known as Clostridium perfrigens, sometimes produces a toxin (known as epsilon toxin) that may possibly be a trigger for multiple sclerosis. C. perfrigens is the third most common cause of food poisoning in this country (and others), but most strains apparently don't produce the epsilon toxin that's the focus of this study.

My take on the article is that while the toxin certainly appears to have the potential to do what is proposed (trigger MS), there's always the possibility that the presence of the toxin is merely coincidental. A lot more research will be required to prove that it is actually the cause, rather than just associated with MS, (IOW, an epidemiological association is not considered to be scientific proof).

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by gluten »

Hi Tex, I searched for the reason for high NO levels but of course no reliable explanation was given. However, they did mention the production of a toxin with chronic high levels of NO. Jon
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Post by tex »

Jon,

Almost anything you can think of, related to MC, has been discussed on this board previously. You might be interested in this old thread, especially since it mentions the observation that IBDs are apparently "muscle wasting" diseases:

Why Nitric Oxide, (NO), Is Associated With IBDs

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by Zizzle »

Than again, these researchers believe we may all be victims of a global borellia (Lyme Disease) pandemic. They think this form can be transmitted through sexual, congenital or gestational routes, not just through tick bites. This hypothesis was published in 2003 by a very respectable publisher (Elsevier).

Tex, this was based on a bunch of cases in Texas :shock:


http://home.comcast.net/~runagain/LymeD ... ndemic.pdf
1987 Mononucleosis (EBV)
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
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Post by Gabes-Apg »

Omg
I do hope the universe has my back, and other Aussie mc'ers.
According to the Aussie medical fraternity, Lyme disease doesn't exist?!?!
Gabes Ryan

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Post by tex »

Zizzle,

Thanks for the link. I read the entire paper, and I can't see anything out of order with the points that were made. The authors appear to be right on target.

So why is the CDC so out of touch with reality on this issue?

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by gluten »

Hi Tex, I always use the search option on your site to research what has been posted in the past and I did read the posts about nitric oxide. What, I have noticed about "Seneff" comments about Crohn's being a muscle wasting disease, is that many of the more severe cases of people with FSH muscle dystrophy all have a colitis. Jon
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Post by tex »

Jon,

Isn't FSH MD considered to be a connective tissue disease, or am I confused? CC, for example is clearly a connective tissue disease. I'm not sure about the other IBDs, but I have a hunch that they are also. IOW, these diseases all seem to be related.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by Zizzle »

So why is the CDC so out of touch with reality on this issue?
I work with the CDC...they are out of touch on a lot of issues, for many competing reasons. For starters, as the government, it takes them an average of 10 years to change anything after they figure out the problem. Then it might take more years to develop a commercially approved, affordable test for this form of borrelia. Next, they appropriate their resources according to Congressional mandates, so until enough members of Congress care to study this issue, it ain't happening on a large enough scale to matter. Finally, they have to be ready to deal with a public who finds out we are all infected with something very difficult to treat. Mass hysteria might ensue. Imagine the government suggesting many of us go on long-term antibiotics to treat this? The side effects of the mass antibiotic regimens might be worse than the autoimmune diseases some of us deal with.
1987 Mononucleosis (EBV)
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
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tex
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Post by tex »

Zizzle wrote:The side effects of the mass antibiotic regimens might be worse than the autoimmune diseases some of us deal with.
:iagree:

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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