Sheila W
A New Journey: LDN and Moi
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Bonjour, Monique!
Merci. Vous etes très gentille, mon amie.
This may actually be a moot question, since hopefully you will be able to reduce/eliminate the melamine soon. Is your thinking that the transdermal prep would have less effect on the liver? I think it would still be primarily metabolized in the liver, but at a slower rate (and it would avoid that "first pass" issue).
My guess would be that either prep (oral or transdermal) would not stress the liver enough to worry about. Of course, we don't really know, since I believe there have been no studies done on transdermal LDN. The best way to know would be for you to have a repeat blood test for liver function after you have been on the LDN for a while - maybe one or two months. As you know, it is a simple, cheap test......and would be the only way to truly know in your case.
I think you mentioned that someone heard that LDN may help diabetes. I can see how it might help type II, but it would REALLY be something if it helped type I. I think that people with certain AI diseases have been able to reduce their meds once on LDN......for example, thyroid meds for Hashimoto's thyroiditis. I just wanted to warn you to keep an eye out, in case your need for insulin should become less. It might require a change in your usual treatment regimen.
Love,
Polly
Leslie, LDN could certainly be a consideration. But keep in mind that a lot has been written about the fact the folks with PPS often have unusual/unexpected reactions to medication. xoxo
Merci. Vous etes très gentille, mon amie.
This may actually be a moot question, since hopefully you will be able to reduce/eliminate the melamine soon. Is your thinking that the transdermal prep would have less effect on the liver? I think it would still be primarily metabolized in the liver, but at a slower rate (and it would avoid that "first pass" issue).
My guess would be that either prep (oral or transdermal) would not stress the liver enough to worry about. Of course, we don't really know, since I believe there have been no studies done on transdermal LDN. The best way to know would be for you to have a repeat blood test for liver function after you have been on the LDN for a while - maybe one or two months. As you know, it is a simple, cheap test......and would be the only way to truly know in your case.
I think you mentioned that someone heard that LDN may help diabetes. I can see how it might help type II, but it would REALLY be something if it helped type I. I think that people with certain AI diseases have been able to reduce their meds once on LDN......for example, thyroid meds for Hashimoto's thyroiditis. I just wanted to warn you to keep an eye out, in case your need for insulin should become less. It might require a change in your usual treatment regimen.
Love,
Polly
Leslie, LDN could certainly be a consideration. But keep in mind that a lot has been written about the fact the folks with PPS often have unusual/unexpected reactions to medication. xoxo
Blessed are they who can laugh at themselves, for they shall never cease to be amused.
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wmonique2
- Rockhopper Penguin
- Posts: 1048
- Joined: Fri Aug 03, 2012 9:06 am
- Location: Georgia, U.S
- Contact:
A New Journey: LDN and Moi
Hello Friends,
I know that some of you are following me and eager to know more about this.
Today is day 5. So far, here's what I noticed:
NO PAIN nowhere in my body
I have tons of energy (I never had any mostly because I was in pain all the time and didn't move well)
Sleep wonderful.
In excellent mood. Happier.
No foggy head.
It is supposed to increase your endorphins---it does. No need for mood elevators, it does it.
I've spend tons of money on tests and supplements that haven't given me any of this but I am waiting to see the most important aspect of this: a REDUCTION in inflammation and an ELIMINATION of expensive, toxic meds like mesalamine and elavil. REMISSION is my goal.
Monique
I know that some of you are following me and eager to know more about this.
Today is day 5. So far, here's what I noticed:
NO PAIN nowhere in my body
I have tons of energy (I never had any mostly because I was in pain all the time and didn't move well)
Sleep wonderful.
In excellent mood. Happier.
No foggy head.
It is supposed to increase your endorphins---it does. No need for mood elevators, it does it.
I've spend tons of money on tests and supplements that haven't given me any of this but I am waiting to see the most important aspect of this: a REDUCTION in inflammation and an ELIMINATION of expensive, toxic meds like mesalamine and elavil. REMISSION is my goal.
Monique
Diagnosed 2011 with LC. Currently on Low Dose Naltrexone (LDN)
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wmonique2
- Rockhopper Penguin
- Posts: 1048
- Joined: Fri Aug 03, 2012 9:06 am
- Location: Georgia, U.S
- Contact:
A New Journey: LDN and Moi
Polly,
Thank you for responding. Yes, you're right. It maybe a moot question because if I reduce mesalamine then I wouldn't have to worry about liver enzymes.
I don't worry anymore about LDN and the liver because I am taking 4.5mg. The studies done with addicts that had elevated enzymes were at 300mg!
As for diabetes---not for type 1, maybe type 2. Although there was a study done for type 1 at the ONSET of the disease and they were able to stop its progression. Too late for me!
I am taking transdermal because I don't want any gut issues.
Monique
Thank you for responding. Yes, you're right. It maybe a moot question because if I reduce mesalamine then I wouldn't have to worry about liver enzymes.
I don't worry anymore about LDN and the liver because I am taking 4.5mg. The studies done with addicts that had elevated enzymes were at 300mg!
As for diabetes---not for type 1, maybe type 2. Although there was a study done for type 1 at the ONSET of the disease and they were able to stop its progression. Too late for me!
I am taking transdermal because I don't want any gut issues.
Monique
Diagnosed 2011 with LC. Currently on Low Dose Naltrexone (LDN)
LOL!I saunter out of bed
I love picturing that!!I too am having extra energy without added need for sleep. I just switched my LDN pill filler from lactose to Avicel (cellulose). Lactose wasn't bothering me, and it's the most recommended, so I may go back, we'll see.
I started at 2.25 and went up to 4.5 mg 10 days later. There was a 2-3 day adjustment, but I'm fine now. Every morning I wake up to see my rash lightening every day. I love it! It does get redder by evening, but still much better overall.
Regarding MC symptoms, I've had a few questionable restaurant meals while in Florida this week, and it did cause mild D, but not explosive or frequent.
1987 Mononucleosis (EBV)
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
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mzh
- Rockhopper Penguin
- Posts: 615
- Joined: Fri Nov 12, 2010 8:03 pm
- Location: Upstate South Carolina
- Contact:
Monique, how did you get your doctor to write a scrip? I ask because I happened to have an appt with my shoulder surgeon today and asked him about LDN. He didn't feel comfortable writing a scrip for me b/c he didn't have a good medical reason although he thinks I should be able to have it. He thought my GP would be more likely to give it. And I was just at my GP last week. Argh!
Also have sleep apnea
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wmonique2
- Rockhopper Penguin
- Posts: 1048
- Joined: Fri Aug 03, 2012 9:06 am
- Location: Georgia, U.S
- Contact:
A New Journey: LDN and Moi
Mzh,
It's my GI doc. I went armed with clinical trials results and tons of info for him. I showed him the pictures of the clinical trial by Dr Jill Smith which clearly shows a decrease in inflammation in Crohn's. He knew nothing about LDN and I came ready to educate him. I supported my facts with evidence and I was speaking his language. You have to fight science with science. Not just anecdotal evidence. I overwhelmed him with info.
I showed him some abstracts which are short to read and he listened and said, OK. I'll write the script. I told him the dose I wanted, gave him the phone number of a pharmacist (an expert on the subject) who has like 10,000 people on LDN.
My doc is open-minded and easy-going. If he had refused I would have gone to a functional medicine doctor (they all know about it and prescribe it) or I would have ordered it from India and compounded it myself. No rx, no doc expenses. DIY. I have several sources where you can buy it without rx and the stuff is really cheap, no matter where you buy it.
Z. glad you're moving along swimmingly. And for the rest of the gang--thanks for the cheering
Monique
It's my GI doc. I went armed with clinical trials results and tons of info for him. I showed him the pictures of the clinical trial by Dr Jill Smith which clearly shows a decrease in inflammation in Crohn's. He knew nothing about LDN and I came ready to educate him. I supported my facts with evidence and I was speaking his language. You have to fight science with science. Not just anecdotal evidence. I overwhelmed him with info.
I showed him some abstracts which are short to read and he listened and said, OK. I'll write the script. I told him the dose I wanted, gave him the phone number of a pharmacist (an expert on the subject) who has like 10,000 people on LDN.
My doc is open-minded and easy-going. If he had refused I would have gone to a functional medicine doctor (they all know about it and prescribe it) or I would have ordered it from India and compounded it myself. No rx, no doc expenses. DIY. I have several sources where you can buy it without rx and the stuff is really cheap, no matter where you buy it.
Z. glad you're moving along swimmingly. And for the rest of the gang--thanks for the cheering
Monique
Diagnosed 2011 with LC. Currently on Low Dose Naltrexone (LDN)
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mzh
- Rockhopper Penguin
- Posts: 615
- Joined: Fri Nov 12, 2010 8:03 pm
- Location: Upstate South Carolina
- Contact:
Monique, thanks for the details. Do you happen to have links to the stuff in your pack of clinical trials?
I wouldn't mind compounding it myself if push came to shove though.
Tell me more about where to get it. PM me if you prefer.
It's weird. I had little to no pain when I was on 3 mg Entocort a day. Now that I'm on 3mg every 3 days, everything but my elbows hurts! If I take it more often than that I get constipated. This after 10 solid years of diarrhea!
MZH, aka Marcia
I wouldn't mind compounding it myself if push came to shove though.
Tell me more about where to get it. PM me if you prefer.It's weird. I had little to no pain when I was on 3 mg Entocort a day. Now that I'm on 3mg every 3 days, everything but my elbows hurts! If I take it more often than that I get constipated. This after 10 solid years of diarrhea!
MZH, aka Marcia
Also have sleep apnea
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wmonique2
- Rockhopper Penguin
- Posts: 1048
- Joined: Fri Aug 03, 2012 9:06 am
- Location: Georgia, U.S
- Contact:
A New Journey: LDN and Moi
Marcia,
For info about clinical trials, go to www.lowdosenaltrexone.org, you'll find results of Dr. Jill Smith. The NIH website has those trial results too. Look at the pics of inflammation in Crohnsies. There is tons of info on that website.
For purchasing LDN without rx: www.buyldn.com already compounded, just decide what dose you want. For compounding yourself www.alldaychemist.com in India. You can dissolve the 50mg pill (standard dose for addicts) with distilled water. The cheapest of all methods. If you decide to go this route, I'll give you directions on how to do it and there are directions all over the net on how to do it.
Monique
For info about clinical trials, go to www.lowdosenaltrexone.org, you'll find results of Dr. Jill Smith. The NIH website has those trial results too. Look at the pics of inflammation in Crohnsies. There is tons of info on that website.
For purchasing LDN without rx: www.buyldn.com already compounded, just decide what dose you want. For compounding yourself www.alldaychemist.com in India. You can dissolve the 50mg pill (standard dose for addicts) with distilled water. The cheapest of all methods. If you decide to go this route, I'll give you directions on how to do it and there are directions all over the net on how to do it.
Monique
Diagnosed 2011 with LC. Currently on Low Dose Naltrexone (LDN)