Jon,
Thanks for reminding me about this thread. Given my long history of taking amoxycillin, cephalexin, bactrim and nitrofurantoin, I suspect the clostridia overgrowth might be a good probability. The fact that antibiotics give me temporary remission also make me think I'll do OK on Vancomycin. I'm still on the fence though. I need more clostridia research...
Study of the mucosa associated bacteria in two women with CC
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Hi Zizzle, A good site about Clostridia. " Commensal Clostridia: leading players in the maintenance of gut homeostasis. " www.gutpathogens.com/content/5/1/23 from Gut Pathogens 5/23/2013 Jon
Zizzle,
From the conclusions of the article cited by Jon:
The bottom line is that there is no evidence in your results listed in the GPL report (nor in the article that Jon cited) that indicates that you have an overgrowth of Clostridium bacteria that need to be wiped out. To the contrary, they need to be preserved.
The vancomycin treatment that has been proposed (assuming that it will be effective) will wipe them all out, with the exception of any antibiotic-resistant strains that you might have currently populating your gut. If any drug-resistant strains are indeed present (which is probably somewhat likely), then they will dominate the repopulation of your gut. Probiotics would not be able to prevent that from happening, since commensal bacteria are attached, and probiotic bacteria cannot attach to the gut.
Tex
From the conclusions of the article cited by Jon:
Notice how that appears to conflict with the interpretation of your test results offered by the Great Plains Lab. report, regarding HVA and VMA levels.Finally, Clostridia, enriched in β-glucuronidase activity, could be responsible for generating free catecholamines, including Norepinephrine (NE) and Dopamine (DA), from the glucuronide-conjugated biologically inactive form and could be involved in neuro-enteric system modulation.
The bottom line is that there is no evidence in your results listed in the GPL report (nor in the article that Jon cited) that indicates that you have an overgrowth of Clostridium bacteria that need to be wiped out. To the contrary, they need to be preserved.
The vancomycin treatment that has been proposed (assuming that it will be effective) will wipe them all out, with the exception of any antibiotic-resistant strains that you might have currently populating your gut. If any drug-resistant strains are indeed present (which is probably somewhat likely), then they will dominate the repopulation of your gut. Probiotics would not be able to prevent that from happening, since commensal bacteria are attached, and probiotic bacteria cannot attach to the gut.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
