I don´t understand,help me please

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Marijo
Posts: 9
Joined: Sun Dec 15, 2013 8:33 am

I don´t understand,help me please

Post by Marijo »

Laboratory Report
Date: 3/31/2014
Name: Julia Ferrandez, Maria Jose
DOB: 11/17/1964
Comprehensive Gluten/Antigenic Food Sensitivity Stool Panel

Fecal Anti-gliadin IgA 7 Units (Normal Range is less than 10 Units)

Fecal Anti-casein (cow’s milk) IgA 2 Units (Normal Range is less than 10 Units)

Fecal Anti-ovalbumin (chicken egg) IgA 4 Units (Normal Range is less than 10 Units)

Fecal Anti-soy IgA 4 Units (Normal Range is less than 10 Units)

Mean Value 11 Antigenic Foods 3 Units (Normal Range is less than 10 Units)

While all of the foods tested can be immune-stimulating, the hierarchy of reactions detected were as follows:

Food to which there was no significant immunological reactivity: Food to which there was some immunological reactivity (1+): Food to which there was moderate immunological reactivity (2+): Food to which there was significant and/or the most immunological reactivity (3+):
Corn
Oat
Rice
Beef
Chicken
Pork
Tuna
Almond
Walnut
Cashew
White potato
None None None


Yeast Sensitivity Stool Test

Fecal Anti-Saccharomyces cerevisiae (dietary yeast) IgA 1 Units (Normal Range is less than 10 Units)



TEST INTERPRETATION(S):


Interpretation of Fecal Anti-gliadin IgA: Intestinal antigliadin IgA antibody was below the upper limit of normal, indicating there is no ongoing gluten sensitivity. If you have a syndrome known to be associated with gluten sensitivity (of which there are many but mainly falling into six categories abbreviated as NAAAGS – neuropsychiatric, autoimmune, asthma, abdominal, glandular deficiencies/hyperactivity, or skin diseases) or symptoms of gluten sensitivity (such as abdominal symptoms - pain, cramping, bloating, gas, diarrhea and/or constipation, chronic headaches, chronic sinus congestion, depression, arthritis, chronic skin problems/rashes, fibromyalgia, and/or chronic fatigue), it is recommended that you continue a strict gluten-free diet.

If you have no syndrome or symptoms associated with gluten sensitivity, you may opt to stay gluten-free as a purely preventive measure. Being on a gluten-free diet or reduced gluten diet for many months or years at the time of testing, can (but not always) reduce your fecal antigliadin antibody level into the normal range despite underlying gluten sensitivity. (Usually it takes two or more years of a gluten-free diet to normalize a previously elevated fecal antigliadin antibody level, depending on the strictness of the diet; however, sometimes, this time period can be shorter, especially if the original value was only minimally elevated.)

For additional information on result interpretation, as well as educational information on the subject of gluten sensitivity, please see the "FAQ Result Interpretation", "FAQ Gluten/Food Sensitivity," and "Research & Education" links on our EnteroLab.com website.

Interpretation of Fecal Anti-casein (cow’s milk) IgA: A value less than 10 Units indicates that there currently is minimal or no immunologic reaction to milk, and hence no direct evidence of food sensitivity to this specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some immunocompetent people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, such as chronic headaches, abdominal symptoms (pain, cramping, bloating, gas, diarrhea and/or constipation), chronic sinus congestion, arthritis, chronic skin problems/rashes, fibromyalgia, and/or chronic fatigue, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test. If you have been on a diet reduced or devoid of the suspect food for many months or years (usually but not always requires two or more years), this can also (but will not always) reduce your fecal antibody level to that food into the normal range despite underlying ongoing sensitivity to that food.

Interpretation of Fecal Anti-ovalbumin (chicken egg) IgA: A value less than 10 Units indicates that there currently is minimal or no immunologic reaction to egg, and hence no direct evidence of food sensitivity to this specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some immunocompetent people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, such as chronic headaches, abdominal symptoms (pain, cramping, bloating, gas, diarrhea and/or constipation), chronic sinus congestion, arthritis, chronic skin problems/rashes, fibromyalgia, and/or chronic fatigue, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test. If you have been on a diet reduced or devoid of the suspect food for many months or years (usually but not always requires two or more years), this can also (but will not always) reduce your fecal antibody level to that food into the normal range despite underlying ongoing sensitivity to that food.

Interpretation of Fecal Anti-soy IgA: A value less than 10 Units indicates that there currently is minimal or no immunologic reaction to soy, and hence no direct evidence of food sensitivity to this specific food. However, because 1 in 500 people cannot make IgA at all, and rarely, some immunocompetent people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, such as chronic headaches, abdominal symptoms (pain, cramping, bloating, gas, diarrhea and/or constipation), chronic sinus congestion, arthritis, chronic skin problems/rashes, fibromyalgia, and/or chronic fatigue, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test. If you have been on a diet reduced or devoid of the suspect food for many months or years (usually but not always requires two or more years), this can also (but will not always) reduce your fecal antibody level to that food into the normal range despite underlying ongoing sensitivity to that food.

Interpretation of Mean Value 11 Antigenic Foods: With respect to the 11 foods tested, a mean value of 3 Units indicates that overall, there was no significant detectable evidence of immunological reactivity to these antigenic foods in terms of fecal IgA production.

Many foods besides gluten, milk, egg, and soy are antigenic in their own right; the main classes of which include other grains, meats, nuts, and nightshades (potatoes being the primary food eaten from this latter class). Minimizing exposure to antigenic foods is an important component of an anti-inflammatory lifestyle to optimize immune system health. This is especially important for those with chronic abdominal symptoms and/or chronic immune/autoimmune syndromes, or for those who want to prevent them.

For immunologic food sensitivity testing, the actual numeric value (in Units) for any given food or for the overall average of a group of foods is important mainly for determining: 1) if the immune reaction is present or absent, and 2) the immune reaction in relative terms to different foods tested in a given individual at a given point in time. It is not a score, per se, to be interpreted as a measure of clinical or immunological severity for that individual or between individuals. This is because the amount of IgA antibody made by a given person is particular for the immune function of that person. Furthermore, sometimes a person can display what can be viewed as immunological and nutritional “exhaustion,” whereby a more significant and symptomatic immunologic food sensitivity is accompanied by a lower positive measured anti-food antibody value (rather than a higher positive). In such an instance, following clinical improvement and improved nutritional status (while the suspect antigenic foods are withdrawn), values can actually be higher for a time before finally falling into the negative range after several years.

Thus, the overall average food sensitivity antibody value for this panel is an assessment of your overall humoral immunologic food reactivity, which can help determine if dietary elimination trials may help you. If the mean value is less than 10 Units, the humoral immune reactions can be considered clinically insignificant (negative); if greater than or equal to 10 Units, they can be considered clinically significant (positive). Rather than reporting the absolute value of a positive result for each individual food, since it cannot be considered as an assessment of severity, the results are reported in semi-quantitative terms between the foods tested (1+, 2+, or 3+). This provides you with the knowledge of which foods are stimulating the most immune response which, in turn, is indeed the most practically applied information to dietary elimination trials.

Dietary Recommendation Based on Test Results to Individual Foods:

Although there was no detectable evidence of immunologic sensitivity to these antigenic foods, if you have an autoimmune or chronic inflammatory syndrome, or just want to pursue an optimally healthy diet and lifestyle, avoiding all grains, meats, and nightshades can optimize an anti-inflammatory diet despite a negative result on food testing. As nuts and seeds are a very healthful source of vegetarian protein and heart-protective oils and minerals, rather than avoiding all nuts and seeds, you can render nuts and seeds less antigenic, more digestible, and more easily tolerated by choosing the few that you seem to best tolerate overall, soaking a one-day supply in a glass jar filled with clean water for 4-8 hours (or for ease, overnight), and pouring off the water and rinsing before eating. The resultant soaked nuts or seeds can be eaten as is (alone or with fresh or dried fruit), blended into nut butters (by adding some water), or added to “smoothies.”

If you do decide to undertake dietary elimination trials, we discourage dietary changes that involve removing too many foods at once. This can lead you to feel too hungry too often, especially if adequate healthful replacement foods are not readily available. Dietary elimination (beyond gluten-free, dairy-free, and soy-free) is best approached over a period of weeks to months and sometimes years, removing one or two additional foods at a time, rather than removing many foods at once.

Finally, since 1 in 500 people cannot make IgA at all, and rarely, some immunocompetent people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have a syndrome or symptoms known to be associated with food sensitivity, such as chronic headaches, abdominal symptoms (pain, cramping, bloating, gas, diarrhea and/or constipation), chronic sinus congestion, arthritis, chronic skin problems/rashes, fibromyalgia, and/or chronic fatigue, avoiding antigenic foods may help you despite a negative test. If you have been on a diet reduced or devoid of the suspect food for many months or years (usually but not always requires two or more years), this can also (but not always) reduce your fecal antibody level to that food into the normal range despite underlying ongoing sensitivity to that food. If you have no syndrome or symptoms associated with food sensitivity, and have been eating any or all of these suspect foods, you can continue to follow your normal diet and retest in 3-5 years.

Interpretation of Fecal Anti-Saccharomyces cerevisiae (dietary yeast) IgA: The level of intestinal Anti-Saccharomyces cerevisiae (dietary yeast) IgA antibody was below the upper limit of normal, indicating that the main immunologic reaction specific to the diagnosis of Crohn’s disease is absent. This stool test alone cannot rule out Crohn’s disease however. Further gastroenterological and/or serological testing is warranted if you have any of the following symptoms chronically: moderate to severe abdominal pain; blood, mucus, or pus in stools; diarrhea; partial or complete intestinal obstruction at any time; and/or signs of ongoing chronic systemic inflammation such as fever, weight loss, arthritis, or fatigue. Furthermore, because 1 in 500 people cannot make IgA at all, and rarely, some immunocompetent people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if there are any suspicious symptoms or signs of Crohn’s disease consult your health care practitioner for further diagnostic testing. And if you think you may be immunologically sensitive to dietary yeast even without these symptoms, we recommend avoiding foods and beverages with added Saccharomyces cerevisiae yeast (i.e., foods/beverages made with baker’s or brewer’s yeast) or high concentrations of this yeast naturally (like wine).
NOW WHAT DO I DO?, COULD BE INVALID SAMPLE?
Polly
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Post by Polly »

Hi Marijo!

Your tests were normal!!! No evidence of significant food sensitivity. The most important comment in your report is the next to last paragraph:

"Finally, since 1 in 500 people cannot make IgA at all, and rarely, some immunocompetent people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have a syndrome or symptoms known to be associated with food sensitivity, such as chronic headaches, abdominal symptoms (pain, cramping, bloating, gas, diarrhea and/or constipation), chronic sinus congestion, arthritis, chronic skin problems/rashes, fibromyalgia, and/or chronic fatigue, avoiding antigenic foods may help you despite a negative test. If you have been on a diet reduced or devoid of the suspect food for many months or years (usually but not always requires two or more years), this can also (but not always) reduce your fecal antibody level to that food into the normal range despite underlying ongoing sensitivity to that food. If you have no syndrome or symptoms associated with food sensitivity, and have been eating any or all of these suspect foods, you can continue to follow your normal diet and retest in 3-5 years."

Some people who do have food sensitivities will show a false negative on the tests if they are deficient in IgA. If you are continuing to have symptoms of colitis/food sensitivities, then I would recommend that you ask your doctor to test you for IgA. It is a simple blood test. In other words, if you do not have enough IgA in your body, then these test results might be wrong.

I'm not sure if an "invalid sample" could be the problem - I know you had to send it a long distance. Did you ask the lab about that? I would email the lab and ask them about that if I were you.

Does this help? Feel free to ask more questions.

Polly
Blessed are they who can laugh at themselves, for they shall never cease to be amused.
Marijo
Posts: 9
Joined: Sun Dec 15, 2013 8:33 am

Post by Marijo »

Hi Polly:
in reality if I analyze the entire panel, well I think that it fits the reality.I have not noticed a reaction with any food, just eliminating gluten and lactose not even casein and from this I have noticed very good results.The panel may be correct, I do not react to soy, and egg... just notice improvement to the gluten.Anyway I hare IgA test, but as the determination of gluten is so complicated that if seaq reactive to other antibodies.The laboratory not told me anything that the shipment could be incorrect.Thank you
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tex
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Post by tex »

Hola Marijo,

Para añadir a lo que Polly escribió:

Los resultados son decepcionantes, porque indican que es posible usted puede tener que la deficiencia selectiva de IgA.. Aproximadamente 1 de cada 500 personas tienen deficiencia selectiva de IgA, y las estadísticas muestran que entre las personas que son sensibles al gluten, aproximadamente 1 de cada 300 personas tienen deficiencia selectiva de IgA. Alguien que tiene deficiencia selectiva de IgA no puede producir cantidades normales de inmunoglobulina A. Esto es importante porque las pruebas médicas que miden la producción de anticuerpos IgA darán resultados falsos negativos para alguien que tiene deficiencia selectiva de IgA. Por ejemplo, el análisis de sangre que utilizan los médicos para detectar la sensibilidad al gluten en el diagnóstico de la enfermedad celíaca, producirá un resultado falso negativo en pacientes con deficiencia selectiva de IgA. Las pruebas Enterolab también darán resultados negativos falsos para una muestra tomada de una persona que tiene deficiencia selectiva de IgA.

Existe la posibilidad de que los resultados de las pruebas podrían ser correctas, si usted no tiene deficiencia selectiva de IgA. Para determinar si usted tiene o no la deficiencia selectiva de IgA, el médico puede ordenar una prueba de sangre simple para descartar la deficiencia selectiva de IgA. Si la prueba de sangre demuestra que usted no tiene deficiencia selectiva de IgA, a continuación, los resultados de las pruebas Enterolab son correctas, y que probablemente no son sensibles a los alimentos. Si la prueba muestra que usted tiene deficiencia selectiva de IgA, sin embargo, a continuación, los resultados de las pruebas Enterolab son probablemente inválida, y no hay ninguna prueba disponible para determinar si usted es sensible a esos alimentos.

Eso sería muy lamentable, pero me ha pasado a varios otros miembros de este foro de discusión . Para esas personas, ya que las pruebas no son válidos, la única manera de que puedan determinar su sensibilidad a los alimentos es por ensayo y pruebas de error, usando una dieta de exclusión, y luego comer la comida en su dieta, uno a la vez, para ver si reaccionar a ellos. Pero no pueden hacer ese tipo de pruebas hasta que estén en remisión, por lo que el método de prueba requiere que siguen una dieta muy restrictiva hasta que estén en remisión.

Lamento que esto haya sucedido, pero si preguntará su médico para un prueba para la deficiencia selectiva de IgA, entonces después de que tenemos ese resultado, podemos decidir qué hacer a continuación.

Tex


Hello Marijo,

To add to what Polly wrote:

Those test results are disappointing, because they indicate that you may have selective IgA deficiency. Approximately 1 in 500 people have selective IgA deficiency, and statistics show that among people who are sensitive to gluten, approximately 1 in 300 people have selective IgA deficiency. Someone who has selective IgA deficiency cannot produce normal amounts of immunoglobulin A. This matters because medical tests that measure IgA antibody production will yield false negative results for someone who has selective IgA deficiency. For example, the blood test that doctors use to detect gluten sensitivity when diagnosing celiac disease, will produce a false negative result for patients who have selective IgA deficiency. The EnteroLab tests will also yield false negative results for a sample taken from a person who has selective IgA deficiency.

There is a possibility that the test results might be correct, if you do not have selective IgA deficiency. To determine whether or not you have selective IgA deficiency, your doctor can order a simple blood test to rule out selective IgA deficiency. If that blood test shows that you do not have selective IgA deficiency, then the EnteroLab test results are correct, and you probably are not sensitive to those foods. If the test shows that you do have selective IgA deficiency though, then the EnteroLab test results are probably invalid, and there is no test available to determine whether you are sensitive to those foods.

That would be very unfortunate, but it has happened to more than a few other members of this discussion board. For those people, since the tests are not valid, the only way they can determine their food sensitivities is by trial and error testing, using an exclusion diet, and then trying the foods in their diet, one at a time, to see if they react to them. But they cannot do that type of testing until they are in remission, so that method of testing requires that they follow a very restrictive diet until they are in remission.

I'm sorry that this has happened, but if you will ask your doctor to test you for selective IgA deficiency, then after we have that result, we can decide what to do next.

Tex
:cowboy:

It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Marijo
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Joined: Sun Dec 15, 2013 8:33 am

Post by Marijo »

I am quite disappointed after so much effort and money.It sought the IgA test and inform them.Thank you for everything
Leah
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Post by Leah »

Marijo, Sorry to hear that you got the same results as I did. I wish I had known to get the IgA blood test first. After my doctor ran the blood test, it turns out that I am not only IgA deficient, but I also don't make half of my IgG antibodies either. This is probably the reason I got MC to begin with. IgA antibodies are mainly to protest our mucus systems ( digestive being one of them).

I went on a very restrictive diet for about six months. Healed and then tested foods back in one at a time. I remain gluten, dairy, and soy free and still have issues with eating fruit in any quantity, but have been able to add many things back in. If yo have seen improvement with no gluten or lactose, then you already know two things you should stay away from. If you are still reacting, then you still have some detective work. It could be that you just haven't healed enough to be eating fiber ( raw fruits and veggies, beans and legumes) or too much sugar can give us problems also when we are still healing.

Good luck
Leah
Marijo
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Post by Marijo »

Leah thanks for your reply, soon encargare the IgA test to see the results. what may have other problems to be deficient in IgA?.Thank you.
Leah
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Post by Leah »

When someone is IgA deficient, they COULD have many upper respiratory infections. I don't though. I actually rarely get a cold.
However, if one does not show a tendency for upper respiratory infections, then one will most likely get autoimmune diseases instead….. hence, MC. I also have hypothyroid, and DIV ( all autoimmune). Otherwise, I'm fit as a fiddle :)

Leah

PS Make sure you ask your doctor to order a test for SELECTIVE IGA DEFICIENCY
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