Tex, what do know about the Gene mutation C677T?

mcnomore · Post by **mcnomore** » Mon Apr 21, 2014 8:55 pm

I had genetic testing through 23andme.com ($99)(you have to upload their results to another site: promethease.com for free to get results you can read.

I did this at the request of my functional medicine doc. She wondered if I had this mutation which indicates a methylation issue.

Could this have anything to do with mc?

Gabes-Apg · Post by **Gabes-Apg** » Mon Apr 21, 2014 9:01 pm

What did your practitioner say about C677T and IBD's??

gluten · Post by **gluten** » Tue Apr 22, 2014 10:42 am

Hi, I am very interested in the mutation that causes methylation. I had DNA testing done with genetic researchers and have my results about methylation of the DNA. Did they find a mutation when you were tested? Jon

Post by **tex** » Tue Apr 22, 2014 10:57 am

As Sargent Schultz, of the old TV show, Hogan's Heros, used to say, "I know nothing". . . well, very little, anyway. About all I know about it is that it's commonly know as the MTHFR mutation, and it's associated with IBDs (and virtually all other autoimmune diseases). So yes, it's almost surely associated with MC, also. Here's a old reference (1999) that confirms the IBD association. So it's been common knowledge for at least 15 years.

CONCLUSIONS—There is an association between the thermolabile MTHFR C677T variant and IBD. This accounts in part for the raised plasma tHcy found in patients with IBD and may contribute to the increased incidence of thromboembolic complications. All patients with IBD should receive low dose folic acid and vitamin B12 therapy to protect against the thromboembolic complications of raised tHcy.

Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications

Over the years, the MTHFR gene mutation has been linked to just about every disease you can think of, from heart disease to alopecia areata in Turkey.

CONCLUSION: The results suggest that MTHFR gene C677T mutation may have an effect on the risk of alopecia areata in the Turkish population. This is the first study reporting the association between the MTHFR (C677T) genotype and AA.

Methylenetetrahydrofolate reductase C677T mutation in patients with alopecia areata in Turkish population.

This is such a common gene mutation that probably we should all be taking folic acid and vitamin B-12, if for no other reason, to help slow down the development of Azheimer's disese.

A commonly carried C677T polymorphism in a folate-related gene, MTHFR, is associated with higher plasma homocysteine, a well-known mediator of neuronal damage and brain atrophy.

Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment

How common is it?

Around 30% of Europeans, 10% of Africans, and 50% of Chinese people have the C677T version of the MTHFR gene.

What are the A1298C mutation and C677T mutation?

Tex

Fern · Post by **Fern** » Tue Apr 22, 2014 2:58 pm

I've been researching the heck out of this, too, ever since Gabes mentioned it in a post. I was curious about what MTHFR was and my jaw dropped when I read about it. It would explain so much. I had an anencephalic baby and another pregnancy with preeclempsia. I had to be super careful to take my prenatal vitamins. My sister had multiple miscarriages. My PCP just ordered the test for me yesterday. I have already started supplementing with methyl folate and B vitamins. I mainly wanted the test done, because the genetic mutation predisposes diabetics (of which I have 3) to complications.

Interesting stuff!

Gabes-Apg · Post by **Gabes-Apg** » Tue Apr 22, 2014 4:05 pm

my thoughts on MTHFR is;

MTHFR mutation is not a game changer or the only factor to IBD's. Like mast cells or Thyroid it is just one of the many elements as to why MC exists (and wasnt so prevelant 50-70 years ago)

Modifying B12, Folate delivery can minimise the intensity in the body
(like antihistamines for Mast Cell/histamine and getting T3 and T4 in balance for thyroid)

Like the various types of gene testing that is done, If a parent has that gene mutation, then testing children and modifying diet/supplements, lifestyle early in life may protect them against chronic forms of the health issues later in life.

Heady · Post by **Heady** » Wed Apr 23, 2014 11:28 pm

Yikes.... I wasn't aware of the relationship of folic acid and vit.B12 with Alzheimer's disease. Both my parents had Alzheimer's and I try to keep my brain busy with puzzles, reading,exercise,diet, etc. Sometimes I dread the thought of aging for fear of what future health challenges will present themselves. After I have had some healing time with Normans should I incorporate those one at a time?

Gabes-Apg · Post by **Gabes-Apg** » Wed Apr 23, 2014 11:44 pm

said in jest....
maybe Alzheimers with MC is not the worst thing.. you wont remember all the foods you used to eat, and dont eat now!

in seriousness,
like the 'truths' about the importance of Vit D etc, only now are some of the mysteries of auto immune conditions being solved, and in line with many discussions here on this forum, how one thing works for one person, but for another it can be a complete disaster, these underlying genetic situations are maybe part of that the puzzle. (the same for mast cells/histamines)

the reality is, having this information will not bring about the quick fix, magic potion or cure. It will help each person to make informed decisions about our diet, supplements, medications etc to optimise wellness (and help future generations...)

Heady · Post by **Heady** » Thu Apr 24, 2014 12:25 am

Gabes,...lol Alzheimer's, not remembering my diet and eating whatever would have catastrophic diaper results. Ewwwwww! I will have the results at my doc appt next week from my IgA and other tests with my GP . Anything I can do to optimize my present health and ward off future health crisis is a bonus. I would rather suffer with MC than Alzheimer's. Although at that age both could involve a diaper! LOL

Sheila · Post by **Sheila** » Thu Apr 24, 2014 8:05 am

I did the 23andme test a while ago and have been trying to find reference to MTHFR. Through one discussion group link, I found that I have 2 snps that are positive but can't find the reference on the site. How do you find a specific gene on the 23andme site? I did not have to upload to another site in order to read my results.

I have increased risk for ulcerative colitis, gout, CVD, hypothyroidism. On the HLA region there are 3 positives for celiac, increased risk of selective IgA deficiency, & increased risk of ulcerative colitis. I have a decreased risk of Crohns. Some of the findings are contradictory, as you would expect.

Thanks.

Sheila W