Two genes linked to inflammatory bowel disease

MBombardier · Post by **MBombardier** » Sun Apr 27, 2014 2:15 pm

http://www.sciencedaily.com/releases/20 ... 100103.htm

Scientists have done what is believed to be the first direct genetic study to document the important function for the Ron receptor, a cell surface protein often found in certain cancers, and its genetic growth factor, responsible for stimulating cell growth, in the development and progression of inflammatory bowel disease.

Post by **tex** » Sun Apr 27, 2014 9:00 pm

Hmmmm. This has nothing to do with the discovery, but I notice that the article has an interesting description of colitis:

Colitis is swelling of the large intestine (colon) and is a potentially pre-cancerous condition.

Technically, I suppose that description is correct, but I wouldn't recognized that it was describing colitis, if they hadn't said so.

Thanks for the link.

Tex

Gabes-Apg · Post by **Gabes-Apg** » Mon Apr 28, 2014 12:28 am

Marliss
hope you are doing ok, are you home or still with your dad??

There are quite a few Gene Mutations that include IBD's/IBS as an issue.
I have started to ponder if the frequent mention of IBD/IBS, is like the list of side effects with medications, where pretty much all of them have Diarrhea and Constipation listed.

Stay well

nerdhume · Post by **nerdhume** » Mon Apr 28, 2014 3:10 am

tex

Colitis is swelling of the large intestine (colon) and is a potentially pre-cancerous condition.

I have read your book and everything I can get my hands on and this is the first time I have heard it referred to as "pre-cancerous".
That is very scary to me.

Post by **tex** » Mon Apr 28, 2014 9:31 am

nerdhume wrote:I have read your book and everything I can get my hands on and this is the first time I have heard it referred to as "pre-cancerous".
That is very scary to me.

That remark is directed specifically at Crohn's disease and UC, because most doctors don't even recognize MC as an IBD.

They also don't tend to think of celiac disease as an IBD

There are no research data that link MC with any precancerous conditions. However, though undocumented, there is a good possibility that the association of MC with gluten sensitivity may slightly increase the risk of developing non-Hodgkins lymphoma, just as it does with celiac disease. That risk (if it exists at all) is very small, and to date, no member has ever reported developing NH lymphoma after their diagnosis. And of course the good news is that when gluten is removed from the diet, as the antibodies fade away, so does any increased risk of developing NH lymphoma.

Tex

Zizzle · Post by **Zizzle** » Mon Apr 28, 2014 9:31 am

Hmm, I wonder if this may be part of the reason Low Dose Naltrexone works so well in Crohn's? It's anti-cell proliferation effect, which is also helpful in cancer?

Zizzle · Post by **Zizzle** » Mon Apr 28, 2014 9:34 am

most doctors don't even recognize MC as an IBD. Rolling Eyes They also don't tend to think of celiac disease as an IBD

This is so true. My doctor at NIH, when completing my health history forms, really resisted checking the box for IBD on me. He thought MC didn't qualify, and having no biopsy-confirmed celiac wasn't enough. So I guess they will study me as a test subject with no history of intestinal problems. Ugh.

Post by **tex** » Mon Apr 28, 2014 9:42 am

Zizzle wrote:Hmm, I wonder if this may be part of the reason Low Dose Naltrexone works so well in Crohn's? It's anti-cell proliferation effect, which is also helpful in cancer?

That might be the case, because unlike MC, one of the markers of precancerous conditions such as Barrett's, Crohn's disease, etc. is crypt dysplasia (IOW, architectural changes to mucosal cellular histology).

Tex

Post by **tex** » Mon Apr 28, 2014 9:46 am

Zizzle wrote:So I guess they will study me as a test subject with no history of intestinal problems. Ugh.

Well that's a relief, to find out that you haven't actually been sick all these years.

I'm sure that when your data skews their results, they'll figure out a way to rationalize it in their reports.

Tex

Zizzle · Post by **Zizzle** » Mon Apr 28, 2014 9:51 am

I told a room full of world-reknowned myositis experts that one minor glutening episode caused one week of diarrhea and worsening skin rash. I also explained that the autoimmune paleo anti-inflammatory diet improved my rash 60% within a few weeks. They seemed a little shocked but were all ears... I hope I broadened their thinking.

Post by **tex** » Mon Apr 28, 2014 10:11 am

A lot of top-level experts seem so indifferent (blasé?) to real world events that if someone doesn't hit them up aside the head with a 2x4 to get their attention, they don't seem to even notice what goes on in the real world (outside of their research labs). Good for you.

Tex

gluten · Post by **gluten** » Mon Apr 28, 2014 10:44 am

Hi Zizzle, Years ago, I was selected to go before the top neurologists from all of the Boston Hospitals. It was me in my shorts and ten of them. During the two hours many items were discussed including diet and elimination of certain foods. The only thing I got out of the meeting was a challenge for a another muscle biospy without any pain. My first one was done without any pain meds. until they were stitching up the incision. Diet was never recognized and still is not considered. Jon

nerdhume · Post by **nerdhume** » Tue Apr 29, 2014 4:49 am

I was wondering about the inflammation causing cancer.
I know many people are convinced the purple pill will keep the inflammation from GERD from causing cancer.
I was on Prevacid for a few months, but stopped when I realized that could keep me from absorbing several vitamins, also likely that at my age my stomach was not making enough acid rather than too much.