Attn those with MTHFR - Pyrrole - Methylation issues

[Gabes-Apg]

the world of MTHFR and active B12 can be overwhelming..

this collation of information is a good "summary" - most of all it explains why one week you can feel fantastic, and then the next week struggle and feel like crap.

you dont have to be diagnosed with MTHFR or Pyrrole for this information to be useful. Once MC is active our bodies are a very sensitive complex environment and getting the right supplements in the right forms is a big part of attaining wellness.

http://howirecovered.com/active-b12-therapy-faq/

one section of note:
for those that swap from B12 supp to Active B12 supplementation
things may get worse before they get better,

Has anyone else had increased inflammation from restarting the methylation cycle?

The Carmen Wheatley “Scarlett Pimpernel” papers I, II and III deal with this very issue. That with b12 there is first an increase in inflammation and then a neutralizing of the nitric oxide leading to a decrease in inflammation. This appears to happen as cell formation picks up with methylation starting up. There is no need to take prednisone. The inflammation will run it’s course and inflammation and pain will decrease. I had a lot of pain which wasn’t controlled by multiple medications. The pain decreased perhaps 90% allowing all but one medication to be discontinued. I had been taking 2400mg/day of ibuprofen. 9 months after starting mb12 the inflammation was gone and ibuprofen made no difference any more.

9 months after starting mb12 I was able to discontinue/taper Dilantin (for neurological pain and some spasm control). 9 months after starting mb12 I was able to start tapering benzos. 9 months after starting mb12 I was able to discontinue albuterol, Compazine suppositories, antihistamines, theophyllin, an anti-narcolepsy med and probably a few more in there. It took about 9 months to reach that point. However, some specific pains started fading by year 10.

[Gabes-Apg]

For those with low acid issues and or leaky gut.......
towards the bottom of the summary (which is about 50 pages in a word document)

How does the partial methylation cycle block affect the digestive system?

Rich: We know from the experience of many PWCs using the baking soda–burp test and salutary results of betaine-HCl supplementation that there is low stomach acid in many cases of CFS. According to the GD-MCB hypothesis, this is due to mitochondrial dysfunction in the parietal cells, which in turn results from glutathione depletion and the partial methylation cycle block.

We also know that digestion is often poor in PWCs. According to the GD-MCB hypothesis, this results from deficient secretion of pancreatic enzymes and/or bile. These in turn result from the lack of sufficient stomach acid to signal the need for the pancreatic enzymes and bile, and from deficiency of glutathione, which is necessary for bile production in the liver.

We also know that there is dysbiosis in most cases of CFS, as revealed by comprehensive stool testing. The lack of stomach acid allows pathogens that come in with the food to survive passage through the stomach and into the gut. In addition, there are abnormalities in peristaltic transport and cleaning of the gut, which allows small intestinal bacterial overgrowth (SIBO). These abnormalities are likely due to deficiencies in production of serotonin and acetylcholine by the gut, which in turn are due to the partial methylation cycle block.

We also know that there is leaky gut, which results from damage to the wall of the gut. The gut does not have its normal protection against oxidative stress, toxins and pathogens as a result of glutathione depletion. Also, the lack of folate inhibits the production of new DNA and RNA, which are needed for making new cells to replace those that die and are sloughed off the lining of the gut. Finally, the immune system is dysfunctional because of the lack of glutathione and folates, which are needed to support cell-mediated immunity in particular. Glutathione is also needed to control the oxidative stress generated by the immune system when it produces inflammation to attack pathogens.

In the other direction, problems in the digestive system can impact the methylation cycle, folate metabolism, and glutathione. For example, if the digestive system is unable to absorb enough B12, such as because of pernicious anemia or because of celiac disease, the methylation cycle will not have enough methylcobalamin as a cofactor for methionine synthase. If the digestion and absorption of other nutrients is poor, the other vitamins, minerals, amino acids and fatty acids needed by these parts of the metabolism can also become deficient. If dysbiosis is present, the gut flora may not be able to produce nutrients that it normally supplies for the body, including active folates. If there is leaky gut, the immune system will be occupied producing antibodies against food proteins, and this will take supplies and energy that may be needed for these other parts of the metabolism.

[tex]

If there is leaky gut, the immune system will be occupied producing antibodies against food proteins, and this will take supplies and energy that may be needed for these other parts of the metabolism.

That's an interesting observation, and it elucidates another reason why fatigue is so prevalent with MC — a lot of energy is wasted by the immune system on unproductive activities.

Tex

[Gabes-Apg]

Yes... one of the many elements for the fatigue
and maybe why people with AI issues /IBD's do better with activated forms of B6 and B12...
(ie - it doesnt just apply to MTHFR/Pyrrole)

[brookevale]

I have a double mutation of the MTHFR gene. I have a whole host of issues because of it and my fluoroquinolone toxicity. I tried out a glutathione IV push today at my naturopath's office (it is operated under a functional MD and has several RNs as well). I also get acupuncture there and signed up for a chakra yoga cleanse tomorrow. I've gone total hippy in the pursuit of healing. The glutathione made my liver area hurt. It still hurts. But I have a bunch of energy and clarity. I'll see how I do over the next week to determine if I want to get the glutathione again. By the way, the RN said I was the first person in their extremely busy practice who has both mutations. Lucky me. My naturopath has me on methyl-folate and sublingual methyl b12. Just started them this week.

[brookevale]

Just an update that the glutathione push made my liver area hurt for two days. Of course it has not been reported as a side effect. Like I said before. Lucky me. I do have an issue with constant stress on my bile duct and liver due to duodenal contents refluxing into my bile duct. This is the result of a surgery in which my pancreatic and biliary sphincters had to be sewn permanently open. Also, fluoroquinolone toxicity hits the liver hard. I did feel like I had more energy the past few days so maybe I'll try again in a few weeks but ask for a lower dose.

[tex]

Be careful Brooke. Remember that the liver is a vital organ.

Tex