A Question For Those Who Have A MTHFR Gene Mutation

Post by **tex** » Wed Oct 22, 2014 11:45 am

Hi,

I'm curious about how common out-of-the-normal-range red cell counts might be with these gene mutations.

Thanks,
Tex

dfpowell · Post by **dfpowell** » Wed Oct 22, 2014 1:59 pm

I am homozygous for the MTHFR A1298C mutation and my RBC has always been high normal.

Zizzle · Post by **Zizzle** » Thu Oct 30, 2014 2:57 pm

I just ordered the test kit! But my red cell values are always normal. My white counts are always low.

Gabes-Apg · Post by **Gabes-Apg** » Thu Oct 30, 2014 4:00 pm

Interesting question...

just reviewed my results, and they are always in the HIGH range of normal...(for past 6 years)

I am not MTHFR 1298/677, but do have methylation issues.

Post by **tex** » Thu Oct 30, 2014 4:51 pm

Zizzle,

I sent 'em a tube of spit this morning.

Tex

Gabes-Apg · Post by **Gabes-Apg** » Thu Oct 30, 2014 5:11 pm

oohhhh cant wait to see what results people get!!!

AnnW · Post by **AnnW** » Thu Oct 30, 2014 5:46 pm

tex wrote:Hi,

I'm curious about how common out-of-the-normal-range red cell counts might be with these gene mutations.

Thanks,
Tex

Tex:

RBC counts are not greatly altered by MTHFR gene mutations unless there is a actual deficiency of folate or B12. It also depends on what other defects co-exist. More often these defects present with vague symptoms such as increased food/chemical sensitivties, elevations in homocysteine, tendency towards autoimmune disorders (no surprise there) and mood swings.

Dr. Ann

Post by **tex** » Thu Oct 30, 2014 6:41 pm

Thanks. The responses certainly seem to bear that out.

Tex

ldubois7 · Post by **ldubois7** » Thu Oct 30, 2014 6:47 pm

Tex,

I messed up your count. I hit the no, it's almost always low. Actually my RBC is high. But, in the breakdown .....my MCV, MCH, & MCHC are low & RDW-CV is high. So, am I both or high? Can you change my vote?

I am compound hetero. for 1298 & 677.

I also have Thallasemia.

Thanks for the info, Ann! Maybe my new test results will show the folate or B12 issues.

Post by **tex** » Thu Oct 30, 2014 9:45 pm

Hi Linda,

After a while, such data tend to become buried in the database and can be very difficult to track down, but since votes are recorded in the polls anonymously (without a direct reference to member IDs), that greatly simplifies the job of tracking down a poll vote, and since there weren't many votes yet, and this was the last poll entered, I was able to track down your vote and change it. I hope I changed it to the selection that you preferred.

Tex

ldubois7 · Post by **ldubois7** » Fri Oct 31, 2014 6:05 am

Yes, thank you Tex. That is more accurate.

brookevale · Post by **brookevale** » Sat Nov 01, 2014 4:48 pm

Are you all doing the 23andme? My naturopath ordered a MTHFR test. I am heterozygous for both A1298C and C677T. I can't mail out the 23andme test for all the other gene mutations until I visit my son at college in Vermont next weekend. New York State doesn't allow saliva samples to be sent out. Makes no sense. Anyhow, I tried methyl protocol and had a horrible time. I am showing classic signs of a COMT, SOD, and/or CBS mutation. I am especially finding that I am sensitive to sulfur foods, sulfites/sulfates. Therefore, it would make sense the methyl protocol didn't work. If there is a defect in the sulfation pathway (CBS), that needs to be addressed first before MTHFR can be addressed. For now I am doing a low sulfur diet but losing weight again. Not good. If this is what you are all talking about, I should have my results in a month.

Gabes-Apg · Post by **Gabes-Apg** » Sat Nov 01, 2014 8:58 pm

Brooke, it is the same for pyrrole, the treatment protocol causes issues if there are deficiencies / excess of toxins.
At least you are figuring out the puzzle, piece at a time.

irisheyes13 · Post by **irisheyes13** » Wed Nov 05, 2014 2:43 pm

I'm homozygous 677. RBC's are typically within normal range but tend to run on the low end of normal or slightly below normal with WBC.

Sorry I haven't posted in a long time but I do jump on to read posts every once in a while.

Post by **tex** » Wed Nov 05, 2014 3:25 pm

Hi Kelly,

It's good to see a post from you again, and thanks for the information for the poll.

How in the world are you doing these days? I'm hoping that your long absence is a sign that you are doing very well.

Tex

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A Question For Those Who Have A MTHFR Gene Mutation

Is your red cell count (and associated red cell test numbers) almost always in the normal range?

A Question For Those Who Have A MTHFR Gene Mutation

Re: A Question For Those Who Have A MTHFR Gene Mutation