Issues related to stress

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Deb
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Issues related to stress

Post by Deb »

and ways to help..
http://chriskresser.com/how-stress-wrea ... n-your-gut
The biochemical changes that occur in times of stress have significant and immediate impact on gut function.

A family of peptides called corticotrophin releasing factors (CRF) are responsible for coordinating the body’s response to stress, and CRFs have a potent effects on the gut through modulation of inflammation, increase of gut permeability, contribution to visceral hypersensitivity, increased perception to pain, and modulation of the gut motility. (5) This hormone affects the hypothalamic-pituitary axis (HPA) to eventually stimulate the secretion of cortisol from the adrenal glands.

Not only does stress affect the physiological function of the gut, but it has also been shown to actually cause changes in the composition of the microbiota, possibly due to the changes in neurotransmitter and inflammatory cytokine levels. (6) Research in mice has found that exposure to stress led to an overgrowth of certain types of bacteria while simultaneously reducing microbial diversity in the large intestine of the stressed mice. (7, 8) Furthermore, this disruption of the microbiota increased susceptibility to enteric pathogens.

Chronic exposure to stress may lead to the development of a variety of gastrointestinal diseases such as gastroesophageal reflux disease (GERD), peptic ulcer disease, IBD, IBS, and even food allergies.

That said, it goes without saying that a major component of a healthy lifestyle should include stress reduction techniques.

As I mentioned before, many of my colleagues at the Paleo f(x) Conference focused on reducing stress as a key component of weight loss, longevity, and mental health. Stress may even cause hypothyroid symptoms such as weight gain, blood sugar swings, fatigue, decreased immunity, and sleep disturbance. I highly recommend that anyone struggling with these types of symptoms evaluate the level of stress in their life, and incorporate different strategies for minimizing stress on a regular basis.

There are many ways to mitigate the impacts of stress, including meditation, yoga, taiji (“Tai Chi”), deep breathing and spending time in nature – to name a few. However, here are two options that I’ve found to be particularly helpful for healing the gut-brain axis:
•The Body Scan (Mindfulness-Based Stress Reduction, MBSR): MBSR was developed by clinical psychologist and long-time Buddhist practitioner Jon-Kabat Zinn to cultivate greater awareness of the ways the unconscious thoughts, feelings, and behaviors can undermine emotional, physical, and spiritual health. It has been studied extensively at the Stress Reduction Clinic at the University of Massachusetts Medical Center for over 30 years, and is clinically proven to relieve chronic pain and illness. You can download a free audio recording of the Body Scan here, and I recommend doing it once a day if possible. If you prefer more in-depth training, MBSR is offered as an 8-week intensive in hospitals and medical centers around the world. It is also offered as an online course, and can be done via home study with books and audio recordings.
•Rest Assured is marketed as a program for healing insomnia naturally – and it’s very effective for that purpose. However, the way this is accomplished is by maintaining a greater state of relaxation and ease throughout the day, which will improve not only sleep but other physiological processes like gut function. As I’ve shown in this article, operating in a state of constant hyper-arousal (which many of us do) is a sure-fire path to digestive problems. The Rest Assured program contains simple exercises that coordinate breath and movement. Many of the exercises can be performed in as little as 3-4 minute throughout the day, while some take 20-30 minutes and can be done when you have a little more time – or while you’re laying in bed before sleep. I’ve found these to be incredibly helpful myself, and my patients have as well.
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tex
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Post by tex »

Deb,

CRFs are actually neuropeptides, meaning that they are both polypeptide hormones and neurotransmitters. Here is how they are described on page 218 in the book:
Neuropeptides also appear to have a direct role in the stress response that leads to disease
Neuropeptides are beginning to be recognized as important components in the development of inflammatory bowel disease. It has long been suspected that corticotropin-releasing hormone (CRH) plays a vital role in certain aspects of immune system functioning.

In 1999, Santos et al. showed that CRH could induce a stress-related pattern of inflammation in the epithelia of the rat colon that involved the degranulation of mast cells.46 Note that CRH is thought to be responsible for preventing a mother’s immune system from rejecting a fetus in the womb. Without the presence of CRH, a spontaneous abortion would almost surely occur. CRH is a neuropeptide, meaning that it is both a polypeptide hormone, and a neurotransmitter.

Most CRH is produced in the hypothalamus, but it is also produced by endocrine cells in the intestines. It has been well established that CRH is involved in the development of inflammatory bowel disease, not only by research studies of animal models, but with human subjects as well.47 Wallon et al. (2008) even demonstrated that CRH is capable of causing increased intestinal permeability in human tissue, by inducing mast cell degranulation.48 Thus we have all the ingredients necessary to describe how stress can lead to inflammatory bowel disease and other autoimmune issues.
And here are references 46–48 from that quote:

46. Santos, J., Saunders, P. R., Hanssen, N. P. M., Yang, P.-C., Yates, D., Groot, J. A., &Perdue, M. H. (1999). Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat. American Journal of Physiology - Gastrointestinal and Liver Physiology, 277(2) 391–399. Retrieved from http://ajpgi.physiology.org/content/277/2/G391.full

47. Margolis, K. G., & Gershon, M. D. (2009) Neuropeptides and inflammatory bowel disease: Corticotropin-releasing hormone. Current Opinion in Gastroenterology, 25(6), 503–511. Retrieved from http://www.medscape.com/viewarticle/711402_5

48. Wallon, C., Yang, P.-C., Keita, A. V., Ericson, A.-C., McKay, D. M., Sherman, P. M. . . . Söderholm, J. D. (2008). Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro. Gut, 57(1), 50–58. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/17525093

Of course the book was published 2 years before Chris Kressor wrote his blog about the topic, so presumably he should have some additional insight on it. Thanks for the link.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Deb
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Post by Deb »

Tex, unfortunately my mind doesn't retain all this information. Sorry for not remembering that you had already addressed it. I wouldn't be surprised if Kresser has read your book (and hope he has). I am looking into his techniques for improving sleep.
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tex
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Post by tex »

Deb,

I didn't mean to imply that there was anything wrong with your post (because there wasn't). I was just trying to add some information to the definition of CRFs, and how they affect MC.

And I agree that improved sleep is definitely a key to improved health. Whenever I get a good night's sleep, my systolic BP the next day will consistently run around 100–105 mmHg. Mediocre sleep will usually lead to a systolic BP of around 105–115 mmHg, and significantly short sleep will typically result in 120 + readings. That has to mean something, IMO.

Please let us know how well those sleep techniques work.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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jmh
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Post by jmh »

Deb,
When I was getting off of the sleep aid Ambien, I needed something to help. It took a while to rid my body of the Ambien affects. Eventually, at the recommendation of my local health food store, I bought a product by Nature's Plus called Sleep-Assure. It helps you relax so you can fall asleep. The label says it's free from common allergens yeast, wheat, soy and milk. It works for me, perhaps it will work for you.

Judy
Deb
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Post by Deb »

Thanks, Judy. I will check it out. I am on LDN which has helped some, just started trying an earthing mat, Benedryl a couple of times a week, and a small amount of Ambien once or twice a week when I wake up in the middle of the night and HAVE to sleep. I'm sure, as Tex has stated above, that my sleep issues have contributed to my blood pressure issues. Deb
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