with courier costs from Aus - the 23andme testing cost me $180 (i think it is about $120-130 from within the USA) the data from 23andme came through 2 weeks after they receipted my sample.
If you were to print the data that you receive from 23andme it would be over 2200 pages of data!!
Hence you need to use the reporting tools available on the net to turn this data into usable information regarding your health and wellness.
The methylation report from Genetic Genie (free) was very interesting - explained why I have always had adrenal fatigue, and issues clearing heavy metals. This information in consultation with my nutritionist/naturopath will help to know which supplements will overcome the issues.
the report from Promethease is very interesting - it is over 200 pages!!! 18537 genotypes annotated.
At first some of the information seems contradictory. It takes a bit of time to read through and translate the info in the report to viable information. There is no 'quick easy summary' persay that will give you the shortcut to fixing your health...
Keep in mind that the reports come with disclaimer that they are info only and not formal medical opinion /diagnosis type thing.... and they wont answer everything...
it has some good interesting basics, about your metabolism, (i metabolise coffee fast), whether you would lose weight with low fat diet, mine had that I have a low Vit B6 blood concentration, and that I have the gene alleles to be an early riser!
the report links gene +variation, your allele result to the outcomes of various medical studies.
ie sample of how things are linked to your results
2.1x increased risk of Crohn's disease
rs1050152(T;T)Magnitude: 2.1
Frequency: 11.5%
Repute:Bad
References:24
rs1050152, a SNP in the SLC22A4 gene known as L503F, has been associated with an autoimmune disease, in this case, Crohn's disease, odds ratio = 2.1 (CI = 1.31–3.39, p = 0.002), based on a study of 203 cases and 200 controls. The risk allele is rs1050152(T). A nearby SNP (rs2631367) in the promoter region of the SLC22A5 gene defines a haplotype along with rs3792876, with odds ratio reported as similar for either SNP or the haplotype. Referring to the TC risk haplotype, the population risk attributable to heterozygotes was 19%, and for homozygous haplotype carriers, 27%. [PharmGKB:Non-Curated Higher gabapentin exposure and lower renal clearance/tubular secretion in individuals carrying this variant] [OMIM:?]
As we know, not all studies are reliable, so all the interpretations in the Promethease report may not be fully reliable. It will take a fair bit of discernment to know if the basis of the heightened risk is a concern for each individual item. Some of the risk factors are based on the collective data of 23andme....5.2x risk of rheumatoid arthritis
rs6457617(T;T)Magnitude: 2.1
Frequency: 26.5%
Repute:Bad
References:20
rs6457617 has been reported in a large study to be associated with rheumatoid arthritis. This SNP is reported to be the most statistically significant of many SNPs similarly located in the MHC region. The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 2.36 (CI 1.97-2.84), and for homozygotes, 5.21 (CI 4.31-6.30). [GWAS:Rheumatoid arthritis]
It has a section on Medications - and summary of medical conditions (which is a kinda sorta summary of the report)
My interpretation of things thus far, is that genetics is not fate. This data, these reports are giving us the strong hint as to the root cause of an issue, why our cells went dodgy.... with the right approach (diet, supplements, lifestyle, environment etc) we can fix some of the issues.
I think this information goes towards explaining why some people respond well to one medication, when for another it can cause chaos.
Why some people benefit from a vaccine, why some people have issues and are not protected by the vaccine.
And why when some people take the medication that is supposed to help, other issues occur, as the complexity of our systems, our cells, our deficiencies, the wrong thing at the wrong time causes chaos.
Would I recommend it??
I am very happy with information thus far. It feels like I am only into the first chapter of the first book of a 5 book trilogy! to do this type of genetic testing in Aus ordered by my Doctor would have cost $2000. Bloody good value and it has explained some second layer methylation issues.. (linked to mast cell issues) which is fixable by taking the right amount of the right supplement.
For anyone with multiple issues, that mainstream testing is not finding the reasons, this process could very well provide some of the answers of the root causes.... keep in mind - it does not provide a quick direct solution...
if you are not savy with research about chemical processes in our bodies etc, you may need a nutritionist/wholistic practitioner to help translate what you should do.
For anyone that has more hassles with medications than benefits, this too could provide the reasons why. Again, it wont give direct solutions.. but it can aid with making better informed decisions.
It hasnt answered ALL my health issues thus far...
regardless, the solutions for issues highlighted are linked to strict diet, supplement protocol, environmental influences, lifestyle changes. (if only I had this info 15-20 years or more ago! )
For anyone that is concerned their children are already having wellness - AI type issues, then I would recommend the tests, making required changes early could save them from issues even starting!!
I don't know enough about it to be messin' with your post.