23andme DNA results and other reports

brandy · Post by **brandy** » Tue Dec 16, 2014 2:27 pm

Hi Jean,

I'm with you 100%. I'm doing well so why rock the boat. I'm at high risk for alzheimers and/or dementia and I think if I saw it in writing it would throw me into a 10 year depression. Instead of testing I'm concentrating on the low inflammation foods and working on my Salsa and Latin dance moves in my free time. I want to reread the recent alzheimers thread about 5 times to see what I'm missing but have not had the time.

Brandy

Sheila · Post by **Sheila** » Tue Dec 16, 2014 2:33 pm

Thanks Gabes. I've read through the results twice and some things are comprehensible and others, not so much. What is a methyl donor?

When I search the archives for "Methylation", I get back hundreds of conversations that have nothing to do with the subject. Is there a way to narrow the response when searching the archives?

Thank you for being so generous with your advice, Gabes. BTW, I have not heard whether I have Sjogren's or not. 23andme places me at lower risk and it will be interesting to find out if they are correct.

Sheila W

Gabes-Apg · Post by **Gabes-Apg** » Tue Dec 16, 2014 2:44 pm

Sheila
results on a search of 'MTHFR'

http://www.perskyfarms.com/phpBB2/viewt ... c&start=30
bottom of page 2 zizzle provides quite a few links

http://www.perskyfarms.com/phpBB2/viewt ... ight=mthfr

http://www.perskyfarms.com/phpBB2/viewt ... ight=mthfr

http://www.perskyfarms.com/phpBB2/viewt ... ight=mthfr

http://www.perskyfarms.com/phpBB2/viewt ... ight=mthfr

This is the best 'not too technical' info I have found about 'treatment' for A1298C issues
Hope this helps!
(Based on what the article below says, having a healthy digestion, that is healed and has minimal leaky gut issues affecting the liver is an important first step BEFORE taking treatment for A1298C)

http://www.fitzeefoods.com/tag/mthfr-treatment/
How do I fix the problem you ask? It’s relatively simple in many cases. You will want to avoid any supplements and foods fortified with folic acid or folate, since you are unable to metabolize it. The most important step is taking L-5-methyltetrahydrofolate, or L-5-MTHF. While some supplement companies have changed to this form, many are still using regular folic acid. Many people jump straight to just taking large doses of this vitamin. This is a HUGE mistake and can make you quite sick. Because the methylation pathway is a primary method of detoxing heavy metals and environmental chemicals, taking a large dose of this nutrient right away will result in toxins being dumped too quickly. And if your gut and liver are not functioning properly, you may recirculate toxins, moving them around instead of out! The older you are and the more toxins that you’ve been exposed to, the more slowly you must proceed with correcting your methylation pathways. If you’ve been on several rounds of anti-biotics, either in adulthood or as a child, it’s important for you to supplement with a high-quality probiotic. If you’re not having at least one bowel movement per day, you will want to not only supplement with a probiotic, but you should also likely pursue a stool test. A stool test will indicate what level of each of the good bacteria that you have, if there are any pathological bacteria present in the large intestine, any yeast that may be present, as well as any parasite infections. Why do you need this test? You want the gut functioning at a high level and emptying twice/day preferably before beginning any methylation protocol. As mentioned above, if this is not done, one will likely reabsorb toxins and experience an increase in symptoms. While optimizing gut health deserves an entirely separate article, suffice it to say that this must be addressed before moving on to fixing methylation. And remember, many times gut issues will not present as gastrointestinal symptoms, but may produce skin eruptions/rashes, fatigue, difficulty concentrating, etc. - See more at: http://www.fitzeefoods.com/tag/mthfr-tr ... Ui8i2.dpuf

http://www.stopthethyroidmadness.com/mthfr/
[quote]How to treat it
You can’t change a defective gene. But you can help it do its job better and minimize problems.

I am still researching the methyl donors status myself.
(i am just using google)
http://www.balancedconcepts.net/methyl_donors.pdf

I have a doctors apt on friday and I am going to ask for the homocysteine test - as this will determine what supps I need to use.

Gabes-Apg · Post by **Gabes-Apg** » Tue Dec 16, 2014 2:47 pm

For any of the health issues that we are 'high risk' 'medium risk' or 'low risk' for, my theory is, if we are following a low inflammation lifestyle, optimising the health of our gut (ie healed leaky gut, no candida or sibo etc), correcting any deficiencies, clearing any toxins/heavy metals etc - we have majorily reduced the risk of any of the health issues identified in the health report...

with the data about the genes linked to methylation, making some slight adjustments to supplement protocol to suit this will provide a MAJOR level of protection for those health issues..

another gift that comes with MC, it got us on the right path to minimise these major health issues

brandy · Post by **brandy** » Tue Dec 16, 2014 2:55 pm

Hi Gabes,

another gift that comes with MC, it got us on the right path to minimise these major health issues

Very true!

Sheila · Post by **Sheila** » Tue Dec 16, 2014 3:54 pm

Thanks, Gabes. I'll spend this evening researching these interesting genes. I am allergic to sulfur and there it is on a CBS mutation.

Thanks for the information and the direction, Gabes.

Sheila W

brandy · Post by **brandy** » Tue Dec 16, 2014 4:06 pm

Hi Gabes,

I'm not saying I'll never do the testing, it is just not where I am now. Probably down the road I'll be like "I'm really glad Gabes posted all of this.".

Brandy

Gabes-Apg · Post by **Gabes-Apg** » Tue Dec 16, 2014 6:19 pm

Brandy
thats how this site works!!! and what makes it awesome.... it was the same for me and mast cells 3 years ago....

Post by **tex** » Tue Dec 16, 2014 8:30 pm

Sheila and Gabes,

In chemistry, a methyl donor is simply any substance that can transfer a methyl group [which is a carbon atom attached to three hydrogen atoms (written as CH3, if you recall any of your old chemistry courses)] to another substance.

Tex

Sheila · Post by **Sheila** » Tue Dec 16, 2014 8:37 pm

Thanks, Tex. I've been reading this evening and more or less understand the problem. I will look for methylfolate and methylcobalamin, remembering it is important to NOT take too much of the methylfolate. However, my head may explode.

Sheila W

mcnomore · Post by **mcnomore** » Tue Dec 23, 2014 5:01 pm

I did the gene test with 23andme last March. It was very accurate about my ancestry, hair color and eyes so I suspect much of the rest might be accurate as well. I have the 677 MFTHR mutation also. I have a gene that supposedly protects me from the norovirus, hope that's true.

The functional docs use this test, but I found, after speaking with several, that they all want to prescribe the same protocol. That felt a little weird to me so I'm holding off on following the protocol. My functional doc wanted me to take 20 drops of methyl folate which probably, from what I hear, have caused a major reaction in my body. Too much too soon. So I am treading carefully.

I think the medication list is very useful.

One tip: if you don't have a lot of saliva it will take quite awhile to fill up the tube so don't give up too soon.

nerdhume · Post by **nerdhume** » Wed Dec 24, 2014 5:10 am

One tip: if you don't have a lot of saliva it will take quite awhile to fill up the tube so don't give up too soon.

I did mine yesterday. I always seem to generate too much saliva at the dentist. It took me a while to get enough. This test isn't as disgusting as the Enterolab tho

Sheila · Post by **Sheila** » Wed Dec 24, 2014 8:06 am

Not much is more disgusting than a box of poop in the freezer.

It took me a very long time to produce enough saliva for the test. In hindsight, Sjogren's must have reared it's ugly head when I was the sickest with MC. The massive amount of inflammation caused by celiac and MC brings to life dormant auto-immune genes. I'm hoping that controlling inflammation will quiet the worst of the Sjogren's symptoms.

Sheila W

nerdhume · Post by **nerdhume** » Thu Dec 25, 2014 4:15 am

Sheila wrote:Not much is more disgusting than a box of poop in the freezer.

Absolutely!!!!

nerdhume · Post by **nerdhume** » Sun Jan 11, 2015 5:59 am

Got my results this morning. Paid $2 to Promethease for faster results and go the interpretation in about 30 minutes.

Will spend this afternoon after church trying to understand it.