23andme DNA results and other reports

Post by **tex** » Sun Jan 11, 2015 11:50 am

Theresa,

Cool!

Don't forget the methylation analysis available at the Genetic Genie. It's a much shorter report, and extremely useful, if you have any MTHFR gene mutations.

Methylation Analysis

Tex

nerdhume · Post by **nerdhume** » Mon Jan 12, 2015 5:49 am

OK, I ran that test and got some results. I am hoping my results might be useful to others deciding whether or not to get this done.
The two in red I guess are of most concern. The MAO tells me I'm OCD (aren't we all?). The VDR means I may not be able to utilize Vitamin D properly?
It's a huge file so I will just post the link:
http://www.chiefimaging.com/geneticgenie.pdf

Gabes-Apg · Post by **Gabes-Apg** » Mon Jan 12, 2015 8:32 am

My initial interpretation, happy to be corrected....

The combo of yellow and red items
- mast cell issues is heightened risk due to bh4 depletion.
- you will use more Vit D3 than some others, I would think you may always have to supplement with Vit D3
- do further reading about the one ADelle with 1298. That with some of the other results you may struggle to clear the lead, aluminium, ammonia etc. molybdenum, magnesium, Vit C and zinc supplementation may be required to assist clearance of these. ( clearance of these will also help with the Bh4 issues, and minimise mast cell issues)
- take the active forms of B6 and B12

Keep in mind that our low inflammation, 'clean and pure' mc eating plan minimises a lot of the issues that could occur, and that are mentioned in the other report...

I will do some further review of your report when at the computer with dual screens and my notes and other website links...

Gabes-Apg · Post by **Gabes-Apg** » Mon Jan 12, 2015 8:36 am

That acat1 snp - CoQ10 would help with this to help keep energy levels up.
Taking the right forms of B12 will also help.

nerdhume · Post by **nerdhume** » Mon Jan 12, 2015 9:11 am

thanks Gabes, you are such a wealth of information. I am already supplementing C, D3, B complex, zinc, magnesium on your recommendations. My energy levels are still down :-( maybe I will give the CoQ10 a try.

Gabes-Apg · Post by **Gabes-Apg** » Mon Jan 12, 2015 9:23 am

How long have you been taking the b complex?.
It will take a few months to correct B group deficiencies.

Now that you are off the uceris, have your eating plan figured out, inflammation is reduced, the body can really heal, and your cells 'recharge' per say.
Till now a lot of the supplementation you were doing, was dealing with the inflammation. Now ...you will be correcting deficiencies, getting a balanced methylation cycle and optimising cell health.

The CoQ10 is not a cheap supp per say.... especially to get soy free, but it's benefits do justify the cost, it helps gums, energy, kidney etc. and your combo of results I am pretty sure you will benefit.

Gabes-Apg · Post by **Gabes-Apg** » Mon Jan 12, 2015 9:27 am

Nb, I am not an expert with this stuff, and I am still learning.
My memory recall is average so am reliant on my notes etc

It will be much later before I provide expanded info. But I am super keen for people to find the key info to enhance wellness!!! Not only get their lives back, but get a super dooper awesome life back!!!

nerdhume · Post by **nerdhume** » Mon Jan 12, 2015 10:45 am

I've been taking the b complex and additional b-12 for about a year. I tried the CoQ10 several years back and didn't think it was helping and it is pricey.
I wake up feeling great most days and then like this morning I started laundry, cleaning, mopping and after a couple of hours I just felt like I had 'hit a wall'... just couldn't do any more had to go get in my recliner and rest.

JFR · Post by **JFR** » Mon Jan 12, 2015 11:00 am

I take a different approach to correcting possible deficiencies. I have not done the genetic testing and for me I don't think it would add much if anything. What I do instead is try to optimize my nutritional intake and use supplements where it seems to make sense. I do not know know whether or not I have methylation issues but I take only the active forms of b vitamins so it does not seem as if that knowledge would be critical for me. I use 2 websites where I can enter the foods I eat, Cron-O-Meter and Fitday, and get a break down of the nutritional content of the food I am eating daily. For those nutrients that I am getting what seems like less than optimal amounts I supplement. This works for me at least in part because I am now able to eat vegetables in rather large quantities so I can boost my nutrition that way. For 2 years I ate very few vegetables and in very small quantities, concentrating more on healing than on correcting deficiencies, as Gabes says. I guess, for me, I am just not that convinced that the gene testing would change anything I am already doing. I am not suggesting that my way is the better way, but that it is an alternative way to look at adjusting a diet for optimal nutrition. I am focusing more on the environmental side of the gene/environment interaction that determines our bodily well being. I also think it is important to remember that the knowledge we have of both genes and the environment is limited and that what is considered true today may be overturned tomorrow. One area where information seems sorely lacking is in the nutritional content of various meats. Can nutrient deficiencies be corrected by increased meat consumption rather than both the mainstream and the alternative emphasis on vegetables and fruits? More research is needed.

Jean

Zizzle · Post by **Zizzle** » Mon Jan 12, 2015 12:10 pm

Theresa,
Your methylation profile is similar to mine. I was told to buy Ubiquinol instead of plain COQ10, because after age 40 your body is less able to convert COQ10 to the usable form. I was also told to start taking L-Carnitine (can't remember why!), but when i take them together I get a burst of energy. So much so that I can't take them at night. It causes crazy insomnia!

One good thing to note is that the VDRTaq mutation cancels out the COMT mutation, which might prevent ADHD or other supposed traits from those mutations. I have a double COMT mutation.

My mutations:
Homozygous (+/+)
COMT V158M
COMT H62H

Heterozygous (+/-)
MTHFR 03 P39P
MTHFR A1298C
VDR Bsm
VDR Taq
MAO A R297R
MTR A2756G
MTRR K350A
BHMT-02
CBS A360A

Zizzle · Post by **Zizzle** » Mon Jan 12, 2015 12:34 pm

I seem to share a lot of genetic features with Tex and Gabes too. I'm a rapid caffeine metabolizer...sucks...explains why my family can drink coffee right before bed. Can't get a jolt!! I also have the warfarin metabolism problem. And I don't metabolize NSAIDs properly. Good thing I haven't taken one in 8 years!! All meds seem to affect me the wrong way. I'm way too sensitive to cold medicines. I am a bitter taster, and I have the cilantro-loving gene. Lots of genes for autoimmune diseases, IBDs, diabetes, ADHD, and schizophrenia, but luckily I've dodged some of those bullets. My cancer genes seem to be outweighed by my cancer protective genes.

I'm trying to figure out which genes led to my lifelong dysautonomia and joint hypermobility/faulty collagen. I'm 16% Ashkenazi Jew, and they are prone to Familial Dysautonomia, but you need 2 genes, and it's a severe disease. I have a very mild version in comparison, but I'm pretty sure I was born with it. It started with breath-holding spells as a toddler.

Anyway, my way of addressing the MTHFR hetero mutation is by taking Pure Encapsulation's Nutrient 950 multivitamin, which contains all methylated forms f the B vits. However, I don't take the recommended 6 pills a day. That would be a megadose of most vitamins. I only take 2 pills/day, along with other single supplements like D, Zinc, mag, calcium, K, cod liver oil, etc.

Gabes-Apg · Post by **Gabes-Apg** » Mon Jan 12, 2015 11:10 pm

Theresa,
some further info...
I have been using this site as it sort of provides 'expanded info'

http://www.heartfixer.com/AMRI-Nutrigenomics.htm#MTR:
(as most of the review of methylation issues has been done by people who specialise in Autism, that is where you find the good info...)

takes a bit, i read, and reread to see how it applies to the combo of the individuals results.

Lets do your red +/+ first...

Re your VDR Taq +/+ mutution:
(taking into consideration the yellow status where mentioned)

Lowest dopamine levels
Poor tolerance to toxins and microbes
Needs and tolerates dopamine precursors and methyl donors
Lowest susceptibility to mood swings

In such an individual, we would utilize the methylated forms of Methyl Cycle intermediates, including methyl-B12 if n TR/MTRR defect is present. Dopamine precursors such as quercetin, ginkgo biloba, and the herb macuna puriens might be helpful, as would a diet high in tyrosine, the amino acid precursor to dopamine. Other methyl donors, including melatonin, TMG, turmeric, theanine, along with MSM and SAMe (the latter two only for CBS (-/-) individuals) would make sense. To support BHMT, instead of Phosphatidylserine, we would use Pedi-Activ, which contains Phosphatidylserine and DMAE, a methyl donor. Rather than using GABA to deal with excitotoxicity, we would use Zen, which combines GABA with the methyl donor threanine.

- definately take active form of B12,
- you would likely benefit from quercetin, tyrosine, melatonin, TMG, turmeric, theanine.
- Gaba or Gaba with threanine will help

(FYI- based on my methylation report results, I am now taking TMG, and GABA plus some other stuff, I got the now foods brand from iHerb)

MAO A R297R
the writer has limited info on this snp. I also have a +/+ for MAO R297R

MAO A: Monoamine Oxidase A
Monoamine Oxidase A breaks down serotonin, a neurotransmitter that is generated from the dietary amino acid tryptophan, in a BH4 requiring reaction. Many anti-depressant drugs, including the SSRIs (Serotonin Selective Reuptake Inhibitors) work by blocking the breakdown of serotonin. Defects in serotonin metabolism have been associated with mood and neurological disorders. How best to address the MAO A R297R abnormality is not clear to me. As serotonin metabolism is adversely affected, individuals with the R297R defect should avoid large doses of high tryptophan foods (see appendix). High doses of St. John’s Wort, often taken to address depression, could lead to mood swings as serotonin levels fluctuate. Dr. Yasko recommends frequent dosing in small amounts of St. John’s Wort, 5HTP (a tryptophan metabolite), and the Mood S RNA formula if serotonin support is needed. If serotonin production is impaired on the basis of BH4 deficiency secondary to a Methyl Cycle abnormality, as the abnormality itself is addressed, BH4 levels should stabilize, hopefully normalizing serotonin production.

my interpretation of this is that if we fix the other methylation issues (which fixes the BH4 issue) then no direct/major correction is needed
from another site, I have in my notes that MAO is needed to breakdown histamine - if IgE and increased IgG levels, allergies/sensitivies are a big issue - ie you will have exaggerated response to allergens.

while not always possible to avoid allergens 100% of the time, be prepared to use counter measures where necessary to minimise ongoing reactions (ie antihistamines etc)

Gabes-Apg · Post by **Gabes-Apg** » Tue Jan 13, 2015 12:05 am

Attn: theresa -now to the Yellows:

COMT V158M COMT H62H
the link above does not provide info for +/- status
(i am +/+, so my research has been focussed in this area)

MTHFR 1298C

Individuals with abnormalities in CBS and BHMT will be low in BH4, as it is being used up detoxifying ammonia that these defects have generated, so their combination with MTHFR A1298C leads to a BH4 deficiency double whammy.

DHPR is the enzyme that regenerates BH4 from BH2. It is poisoned by mercury, lead, and especially aluminum. These toxins are wide spread in our environment, and individuals with Methyl Cycle abnormalities have particular trouble dealing with them. The result is a progressive drain on BH4, a progressive impairment in neurotransmitter production, and conversion of arginine not in to nitric oxide but instead in to free radicals such as superoxide and peroxynitrite. We treat MTHFR A1298C with 5-methyl folate supplementation (aiming to push the reaction backwards) and, after your other Methyl Cycle challenges have been addressed, with nutritional doses of BH4. Metal detoxification will help here and with every other biochemical function in your body, and will be part of your overall program. We will also endeavor to decrease your need for BH4.

Keep up Zinc, Magnesium, Vit C to help clear mercury, lead and aluminium. Be aware of exposure to these metals (lead paints, using aluminium cookware etc)

MTRR A66G

MTRR generates the methyl-B12 needed by MTR and many other methyl-B12 requiring enzymes. Blood B-12 levels may be normal, but if MTRR is (+/+) or (+/-), methyl-B12 formation will be compromised, homocysteine levels will be elevated, methylation in general will be compromised, and your physiology will be compromised.

the need to supplement with active B12 is essential

BHMT 02 BHMT 08

TMG can be used to stimulate BHMT (but not in COMT (+/+) individuals, who will be sensitive to free methyl groups).

there is a longer story on the site. I got now brand TMG from iHerb. this will also help clear the excess metals mentioned above in MTHFR1298
(I am taking 2mg per day of TMG)

CBS A360A

A360A defects are associated with CBS up regulation. Homozygotes (+/+) will be more severely affected than will be individuals heterozygous (+/-) for a CBS abnormality.

We treat CBS ( +) individuals with dietary animal protein and sulfate restriction and supplements designed to neutralize ammonia and speed up clearance of sulfite/sulfate. Laboratory findings consist of an elevated urine sulfate level, a low or low normal blood homocysteine level, an elevated or high normal blood ammonia level, and positive findings of ammonia, sulfite, or sulfite upon Asyra testing.

be careful of high sulphite foods and drinks...

Sulfite is neurotoxic. Sulfite will be over produced by the CBS up regulation, and then requires conversion in to the less toxic sulfate molecule by the enzyme Sulfite Oxidase (SUOX). SUOX can easily be overwhelmed. Molybdenum is required for SUOX function, and is typically depleted in CBS (+/+) or (+/-) individuals. Molybdenum supplementation (3 drops or 75 mcg of e-lyte Molybdenum twice a day), Boron 3 mg/day, Vitamin E succinate 400 IU/day, and hydroxy-B12 2000 mcg/day are also utilized to speed up SUOX activity.

I also take molybdenum and soy free Vit E to help clear excess heavy metals
I have to get the Soy Free Vit E prepared by compounding pharmacy. I get the molybdenum from iHerb in tablet form.
(FYI - due to my high copper level, I was already taking take 1200mg per day of Vit E, 300mcg of molybdenum, with methylation results I will continue these intakes for quite a while)

While sulfate is less toxic than is sulfite, it will stimulate the adrenergic (fight or flight) limb of the autonomic nervous system and stimulate a cortisol stress response, revving you up into an unrelenting biochemical overdrive. If you have a CBS defect, we need to restrict your sulfur intake, at least until your urine sulfate (and your body sulfate burden) has decreased. The amino acids methionine, taurine, and cysteine all contain sulfur; they are concentrated in animal protein (thus the restriction on animal protein intake). Many nutritional supplements (MSM, N-acetyl cysteine, glutathione) that are good for most people are a problem for you.

Sulfites and Chronic Disease by Rick Williams (available at the office or at www.readingtarget.com/nosulfites)

Energy Production will falter. To generate ATP energy, you need Co-enzyme Q10 and Carnitine, but to manufacture these co-factors you need methyl groups, which tend to be in short supply in individuals with Methyl Cycle defects. To make matters worse, when energy is in short supply, homocysteine is shunted in to ammonia, hydrogen sulfide, and alpha-ketoglutarate, and not in to its one beneficial metabolic product, glutathione. NADH, Carnitine, Co-enzyme Q10, and its non-oxidizeable 1st cousin Idebenone will all help with ATP energy production, and their use makes sense in patients with CBS up regulations, especially if they have cardiovascular disease. (I am getting ahead of myself, so skip this entry if you wish, but the latter three agents also can serve as methyl donors. We will be more liberal with their use in individuals who are COMT (-/-), who need methyl donors, and more conservative in their dose in individuals who are COMT (+/+)

highlight was done by me. As you are COMT +/- if you are going to take CoQ10 go the midway dosage. min would be 150mg, max would be 300mg per day.

Hope this helps....
if you increase the Magnesium, Zinc, Vit C, and start the Molybdenum, Vit E to help clear excess metals etc, expect detox response.. ie extra pooping and weeing!!
go the pace that you can handle. it took me a couple of months to do the detox, hit me hard for a couple of weeks.
As I was not working, I did the detox a bit harder.

nerdhume · Post by **nerdhume** » Tue Jan 13, 2015 7:47 am

Wow, that's a lot of reading...I will have to look at the links a little at a time and take notes.
Gabes & Zizzle thanks so much for taking the time to help sort out the overwhelming information.
It's very confusing to me and I try to take less supplements (as advised by some sources) and then read I need to take several other supplements. It's all trial and error.

MAO is needed to breakdown histamine - if IgE and increased IgG levels, allergies/sensitivies are a big issue - ie you will have exaggerated response to allergens.

My allergies have gotten much worse as I have aged. I take Zyrtec year-round. Yesterday I repotted some plants and something in the old potting soil did me in (mold? mildew?). This started mucous from both ends :-( Then we had a private family issue which upset me and the mucous went straight to WD. I tried the 2 brazil nut source of Selenium yesterday morning before all this and that went through totally undigested. Today I will revert to my safest list and minimal supplements until this is better. I can understand why some newbies just give up, I know in my heart this is just a bump in the road. On the plus side I can still read!

definately take active form of B12,
- you would likely benefit from quercetin, tyrosine, melatonin, TMG, turmeric, theanine.
- Gaba or Gaba with threanine will help

already take: B12, melatonin, ordered Ubiquinol this morning

The food sources of these happen to be the few foods I eat a lot of:

Tyrosine: chicken, turkey, fish, peanuts, almonds, avocados, bananas
quercetin: red wine (could drink more), olive oil, grape juice

Will look into these for sure:
especially the ones found only in green tea as I hate green tea!
TMG, turmeric, theanine.
- Gaba or Gaba with threanine

Gabes-Apg · Post by **Gabes-Apg** » Tue Jan 13, 2015 9:36 am

Theresa,
As per my post a week or so ago, I am taking over 25 different supps!!!
As we heal, we can handle them ok.

If you re-read the info, avoiding certain things will be enough to help for now. Ie

-Re the red wine, I would stop it all together, sulphides are not your friend.
-minimising allergic reactions
-minimising contact with heavy metals