23andme DNA results and other reports

[brandy]

Hi Theresa,

I react to turmeric in supplement form. I sprinkle the heck out of it and put it in mashed sweet potatoes along with black pepper cinnamon and coconut oil or olive oil. The black pepper makes the turmeric work better. Turmeric is supposed to help with alzehimers. I have this concoction around once per day.

If you take Ltheanine take it an hour before you go to bed. It will relax you. Not like a valium but maybe like 5% of a valium. This is part of my sleep regiimen.

Brandy

[Zizzle]

Apparently I may be at risk of systemic mastocytosis, among other scary things.

http://blog.23andme.com/23andme-researc ... neoplasms/

I also have the gene variant associated with lower levels of BH4. I'm wondering if I should supplement? It would totally explain my dysautonomia, and my grandfather's Parkinsons! I need more dopamine and norepinephrine! I'll do anything to get them!!

http://www.snpedia.com/index.php/Gs223

I also have the DRD4 gene which means less efficient Serotonin processing. My neurotransmitters are a mess!!

[Gabes-Apg]

The mc journey has many bumps in the road (and sometimes flooded rivers, whooping big trees across the road) the journey is worth it!!!

If it was me, for now I would
- minimise allergy reactions - take antihistamines before any risky task.
- minimise sulphides
- increase zinc, mag, Vit C to help clear excess metals and toxins
- start the CoQ10

Wait a Few weeks, start the GABA.
Turmeric is one of those things that you either tolerate it or you don't (bit like pro-biotics)
I would be more inclined to start the TMG

Info from my nutrient bible text book:
TMG - Betaine. Is a methyl donor. it protects cells, proteins and enzymes from environmental stress.
Betaine is the only molecule besides active B12, that provides methyl groups for homocysteine remethylation.
It assists digestion by increasing hydrochloride acid in the stomach, destroys detrimental bacteria in the stomach and small intestine.

[nerdhume]

Thanks for the advice gabes. I will follow it for now and let you know how it goes.

[brookevale]

I haven't been on here in a while as I've been doing pretty well. LDN helped me a lot but I recently went off it as I believe it was giving me stomach cramps. IV vitamin C has been miraculous and also effective is transdermal and IV glutathione. That being said, I did the whole 23andme and liked www.livewello.com the best. I also uploaded the raw data to genetic genie, mthfr support, and prometheus. I paid a genetic interpreter/consultant to go over the results with me via skype. There are a few people out there who do this. The woman I paid knew her stuff but hasn't followed through on sending me my report. This stuff if fascinating. The whole process of taking methyl folate and coenzymated b vitamins was a roller coaster. I would get overmethylated, then undermethylated. I think I am finally at a balance. My mutations revealed I cannot process NSAIDs and a few other drugs.

[DebE13]

It all sounds fascinating! Plan on looking into it myself.

[nerdhume]

I went to livewell.com and got my results. They are hard to understand, for instance RAG1 is +/+. The bold line is something I understand too well.

More info about RAG1 Genetic Health Reference Info Official name:
The official name of this gene is "recombination activating gene 1." RAG1 is the gene's official symbol. The RAG1 gene is also known by other names, listed below. Read more about gene names and symbols on the About page.
Normal function:
From NCBI Gene : The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008] From UniProt : Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as a E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. Mediates polyubiquitination of KPNA1.
Associated Health Conditions:
COMBINED CELLULAR AND HUMORAL IMMUNE DEFECTS WITH GRANULOMAS, SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, B CELL-NEGATIVE, NK CELL-POSITIVE, OMENN SYNDROME, ALPHA/BETA T-CELL LYMPHOPENIA WITH GAMMA/DELTA T-CELL EXPANSION, SEVERE CYTOMEGALOVIRUS INFECTION, AND AUTOIMMUNITY, RECOMBINATION-ACTIVATING GENE 1
Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them.
If your immune system cannot do its job, the results can be serious. Disorders of the immune system include Allergy and asthma - immune responses to substances that are usually not harmful Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake

[ldubois7]

I would appreciate any suggestions as to very knowledgeable professionals to go over my results with me. I have so many hetero & homo mutations...I'm spinning! (You aren't surprised, are you,Tex???)
I do like the visualization tool on Nutrahacker.....as well as, Amy Yasko's site.

Thanks!

[tex]

(You aren't surprised, are you,Tex???)

No, I reckon not, not with all your digestive system issues. I also have a lot of them that I can't decide whether or not I should be concerned about. Most health issues are associated with multiple SNPs, and many of the mutations show contradictory effects, so it's pretty tricky to sort out their relative importance, let alone assign a statistical significance to the combined effects of all of them.

Tex

[Sheila]

Check out the site Gabes posted. It is complicated but after reading it a few times, it has started to come together. Gabes gave me some invaluable pointers and I've been reading and rereading the information found on this site:

http://www.heartfixer.com/AMRI-nutrigenomics.htm#MTR

I just tried the link and it didn't work. The original link is located on a post about Sjogrens. Perhaps go to the heart fixer site and proceed from there.

Sheila W

[Gabes-Apg]

Most health issues are associated with multiple SNPs, and many of the mutations show contradictory effects, so it's pretty tricky to sort out their relative importance, let alone assign a statistical significance to the combined effects of all of them.

There is our mega maze! and has given foundation why what works for one person, does not work so well for another.

all we can do is listen to our bodies, what are the main symptoms and go from there....


Sheila, i find the website/link is not available frequently (about once a week)

[brookevale]

Theresa,

RAG1 is in the IGE group. You may have allergy/histamine issues. Stay away from high histamine foods and histamine releasing foods:

Histamine in Foods

There are many foods that contain histamine or cause the body to release histamine when ingested. These types of reactions are food intolerances, and are different from food allergy in that the immune system is not involved in the reaction. The symptoms, however, can be the same as a food allergy.

Foods that contain the chemical tyramine can trigger headaches. Foods that may have large amounts of tyramine include: fish, chocolate, alcoholic beverages, cheese, soy sauce, sauerkraut and processed meat.

Fermented foods may cause allergy symptoms because they are either rich in histamine or because yeast or mold is involved in the fermentation process.

Histamine-Rich Foods (including fermented foods):

Alcoholic beverages, especially beer and wine.
Anchovies
Avocados
Cheeses, especially aged or fermented cheese, such as parmesan, blue and Roquefort.
Cider and home-made root beer.
Dried fruits such as apricots, dates, prunes, figs and raisins (you may be able to eat these fruits - without reaction - if the fruit is thoroughly washed).
Eggplant
Fermented foods, such as pickled or smoked meats, sauerkraut, etc.
Mackerel
Mushrooms
Processed meats - sausage, hot dogs, salami, etc.
Sardines
Smoked fish - herring, sardines, etc.
Sour cream, sour milk, buttermilk, yogurt - especially if not fresh.
Soured breads, such as pumpernickel, coffee cakes and other foods made with large amounts of yeast.
Spinach, tomatoes
Vinegar or vinegar-containing foods, such as mayonnaise, salad dressing, ketchup, chili sauce, pickles, pickled beets, relishes, olives.
Yogurt
Histamine-Releasing Foods:

Alcohol
Bananas
Chocolate
Eggs
Fish
Milk
Papayas
Pineapple
Shellfish
Strawberries
Tomatoes

[Gabes-Apg]

Brooke
which practitioner did you use??

[brookevale]

Gabes, a lot of what I know is self taught. I'd rather not say who the genetic practitioner/consultant was I used as I am not pleased with her right now. There are others you can skype with who are costly. Well, all of them are costly. Here are a few I know are the most popular:

1. Dr. Armine or Shawn Bean can be obtained inside and outside the USA by: info@bio-individualmed.com. Phone: (610) 449-9716. Fill in contact form at www.bio-individualmed.com.

2. Cynthia Smith: info@lifezonewellness.com or by calling (312) 451-6504

There are others but I need to find their info. I would caution though that most genetic interpreters will recommend a ton of supplements. I disagree with that angle. I can say that methyl folate and the coenzymated versions of b vitamins have been helpful as have a few other vitamins/supplements I stagger. But, I don't believe in loading people up with all these supplements they recommend. I wanted the interpretation to learn about what the various mutations meant, not to load up on supplements.

I'll get back with the other names and info.

Brooke

[tex]