Hi Gabes,
I do have A1298C, MTRR A66G, MTRR H595Y and MTRR K350A mutations as well as V158M and H62H. I am taking methylated B12 and will add B6 pyridoxal-5-phosphate and B9 methyl folate, and L-Glutathione. I take D3 and a bunch of other supplements for Sjögren's and other vitamins.
I take Epsom baths and use magnesium cream as well. It takes a while to swallow all of this stuff with mineral water.
Thanks for reminding me to look at those 23andme results with the methylation addition.
Sheila W
Sjogrens and antihistamines
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
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Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
Sheila
in the methylation cycle, both types of mutations apply - the +/+ and the +/- (red and yellow ones) on the methylation reports...
if you are yellow for MAO or COMT or CBS this can affect approach for correcting some of the others - this type of info will indicate if NAC is good or bad for you.
this site offers some explanations of this
http://www.heartfixer.com/AMRI-Nutrigenomics.htm#MTR:
if you want any help -email me your methylation report and I am happy to have a look...
in the methylation cycle, both types of mutations apply - the +/+ and the +/- (red and yellow ones) on the methylation reports...
if you are yellow for MAO or COMT or CBS this can affect approach for correcting some of the others - this type of info will indicate if NAC is good or bad for you.
this site offers some explanations of this
http://www.heartfixer.com/AMRI-Nutrigenomics.htm#MTR:
if you want any help -email me your methylation report and I am happy to have a look...
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
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Greengoddess
- Adélie Penguin
- Posts: 170
- Joined: Thu Aug 28, 2014 3:30 pm
There was a dementia scare re anti-histamines in the media yesterday . Here is a balanced view of it from the NHS in the UK.
http://www.nhs.uk/news/2015/01January/P ... drugs.aspx
http://www.nhs.uk/news/2015/01January/P ... drugs.aspx
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Sheila
- Rockhopper Penguin
- Posts: 1150
- Joined: Wed May 18, 2011 5:10 am
- Location: Palm Beach Gardens, Fl
Wow, Gabes, that link is so, so good. It is going to take me a while to sort everything out but I won't be going to the Vitamin Shop today until I'm sure about my needs. I have methylation defects for sure but they are balanced by COMT +/+ mutations. I need to understand all of this and it is going to take me a while to do so. Thank you for your offer of help and I may very well need to take you up on it.
The 23andme health summary for me makes more sense now. Thanks so much for the link, Gabes.
Sheila W
The 23andme health summary for me makes more sense now. Thanks so much for the link, Gabes.
Sheila W
To get something you never had, you have to do something you never did.
A person who never made a mistake never tried something new. Einstein
A person who never made a mistake never tried something new. Einstein
Greengoddess,
Thanks for the link. It probably explains why my memory has been declining for years (surely it couldn't be old age
). In my opinion, in most cases it's not particularly easy to determine whether or not we might have an accumulated risk factor, because I'm guessing that most of us have used such products on an "as needed" basis, rather than to just take them every day for years.
I used chlorpheniramine maleate 12 mg during pollen season for decades. Figuring out my total accumulated usage level however, is not exactly easy to do. Since I only took it as needed, I rarely took it for more than 2 or 3 weeks at a time, whenever pollen was dense. Some years I used it for a significant number of days, but some years I used it only for a very limited number of days. There's a fair chance that I might have used it enough to at least add up to an accumulated 1-year daily dose level, but I'm not sure. So I'm not sure if I have accumulated a total exposure level that qualifies as an increased risk factor or not. Nor can I be sure what that risk level might be, since I have no idea what the total accumulated days of use might add up to. IOW, interpreting/applying that data isn't as easy as it appears to be.
I agree with the UK NHS — the story appears to be mostly a sensationalized media event, with somewhat limited useful information. After all, according to the study, the worst possible risk would be a hazard ratio of 1.54. Well heck, that's only a 54 % increased risk over the general population. While that's certainly not an insignificant risk increase, it's not exactly a death sentence, either.
Currently, the estimated lifetime risk of a woman developing Alzheimer's at age 65 is 1 in 6 (about 17 %), while for a man the risk is about 9 %. So the worst case scenario for using an anticholinergic medication increases those odds by another 9 % for women (to 26 %), and another 4 % for men (to 13 %).
I doubt that I'll be able to tell the difference.
Still, I probably will be checking the label for one more item before using antihistamines in the future.
Tex
Thanks for the link. It probably explains why my memory has been declining for years (surely it couldn't be old age
). In my opinion, in most cases it's not particularly easy to determine whether or not we might have an accumulated risk factor, because I'm guessing that most of us have used such products on an "as needed" basis, rather than to just take them every day for years.I used chlorpheniramine maleate 12 mg during pollen season for decades. Figuring out my total accumulated usage level however, is not exactly easy to do. Since I only took it as needed, I rarely took it for more than 2 or 3 weeks at a time, whenever pollen was dense. Some years I used it for a significant number of days, but some years I used it only for a very limited number of days. There's a fair chance that I might have used it enough to at least add up to an accumulated 1-year daily dose level, but I'm not sure. So I'm not sure if I have accumulated a total exposure level that qualifies as an increased risk factor or not. Nor can I be sure what that risk level might be, since I have no idea what the total accumulated days of use might add up to. IOW, interpreting/applying that data isn't as easy as it appears to be.
I agree with the UK NHS — the story appears to be mostly a sensationalized media event, with somewhat limited useful information. After all, according to the study, the worst possible risk would be a hazard ratio of 1.54. Well heck, that's only a 54 % increased risk over the general population. While that's certainly not an insignificant risk increase, it's not exactly a death sentence, either.
Currently, the estimated lifetime risk of a woman developing Alzheimer's at age 65 is 1 in 6 (about 17 %), while for a man the risk is about 9 %. So the worst case scenario for using an anticholinergic medication increases those odds by another 9 % for women (to 26 %), and another 4 % for men (to 13 %).
I doubt that I'll be able to tell the difference.Still, I probably will be checking the label for one more item before using antihistamines in the future.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
Tex / Greengoddess
I can not provide physical science, but my pondering is based on reading/research thus far, that the issue with clearing medications/toxins/dealing with excess inflammation - is all connected to the effectiveness of the methylation cycle.
as more deficiencies occur, and cell health degrades, the body can not do its normal clearing process.
That is why, even though people may have the genetic markers to be at risk for a medical condition, if they actually get it is linked to many factors such as lifestyle, stress, exposure to toxins etc. All of which is linked to the bodies ability to cope with the life it leads and clearing the toxins etc.
As the quality of nutrients in foods have degraded in the past 50 years, these issues have become more prevalent.
I can not provide physical science, but my pondering is based on reading/research thus far, that the issue with clearing medications/toxins/dealing with excess inflammation - is all connected to the effectiveness of the methylation cycle.
as more deficiencies occur, and cell health degrades, the body can not do its normal clearing process.
That is why, even though people may have the genetic markers to be at risk for a medical condition, if they actually get it is linked to many factors such as lifestyle, stress, exposure to toxins etc. All of which is linked to the bodies ability to cope with the life it leads and clearing the toxins etc.
As the quality of nutrients in foods have degraded in the past 50 years, these issues have become more prevalent.
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
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Sheila
- Rockhopper Penguin
- Posts: 1150
- Joined: Wed May 18, 2011 5:10 am
- Location: Palm Beach Gardens, Fl
Hey Gabes,
I spent the afternoon reading the link you sent to me. I've been taking NAC and it does contain sulphur, something contraindicated by my Methylation results. I've contacted Jarrow (manufacture NAC) and asked about sulphur in the product. It is taken by people with Sjogrens because it helps with lubrication in the eye.
Before I start any new supplements I want to be sure I'm doing the right thing. I got 26 results for methyl cycle gene issues and have 13 with abnormalities. COMT V158M and COMT H62H are both +/+ which are actually good results but makes it difficult to figure the B vitamins.
I'm going to stop the NAC right away. Thanks again, Gabes.
Sheila W
I spent the afternoon reading the link you sent to me. I've been taking NAC and it does contain sulphur, something contraindicated by my Methylation results. I've contacted Jarrow (manufacture NAC) and asked about sulphur in the product. It is taken by people with Sjogrens because it helps with lubrication in the eye.
Before I start any new supplements I want to be sure I'm doing the right thing. I got 26 results for methyl cycle gene issues and have 13 with abnormalities. COMT V158M and COMT H62H are both +/+ which are actually good results but makes it difficult to figure the B vitamins.
I'm going to stop the NAC right away. Thanks again, Gabes.
Sheila W
To get something you never had, you have to do something you never did.
A person who never made a mistake never tried something new. Einstein
A person who never made a mistake never tried something new. Einstein
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Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
Sheila
before I got my methylation results, I too had got some NAC.
then reading the info on that site, I have stopped the NAC. I am keen to spend a few months correcting methylation cycle issues and then maybe see if i need it.
In my hand written notes, with my COMT status and MTRR status, I need both forms of B12..
before I got my methylation results, I too had got some NAC.
then reading the info on that site, I have stopped the NAC. I am keen to spend a few months correcting methylation cycle issues and then maybe see if i need it.
In my hand written notes, with my COMT status and MTRR status, I need both forms of B12..
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Greengoddess,
Thanks for posting the above link. I've been taking too much benadryl as a sleep aid. Your link will motivate me to use it sparingly. I have a WAG that Alzheimers and/or dementia is caused by a number of things and can be incremental......gene turned on, being overweight, not exercising, eating processed foods, too much benadryl, long term reliance on benzos (valium) over 50, eating low fat etc. Each item alone might cause 5 or 10 percent increased risk but having a number of the factors could be disastrous. This is my theory. Brandy
Thanks for posting the above link. I've been taking too much benadryl as a sleep aid. Your link will motivate me to use it sparingly. I have a WAG that Alzheimers and/or dementia is caused by a number of things and can be incremental......gene turned on, being overweight, not exercising, eating processed foods, too much benadryl, long term reliance on benzos (valium) over 50, eating low fat etc. Each item alone might cause 5 or 10 percent increased risk but having a number of the factors could be disastrous. This is my theory. Brandy
Brandy,
IMO a high-carb, low-fat diet, and the use of statins are probably the biggest items in the equation.
Tex
IMO a high-carb, low-fat diet, and the use of statins are probably the biggest items in the equation.Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.