Infection Revealed in Genova Diagnostics Testing - Advice?

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mbozard
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Infection Revealed in Genova Diagnostics Testing - Advice?

Post by mbozard »

Today I got the results from the Genova Diagnostics Stool Profile. The most alarming thing I learned is that I have a bacterial infection, Yersinia enterocolitcia. The recommendation is that I treat with Ciprofloxacin which I started today. This is very unnerving because I wonder if this has been a major contributor to my issues. I also am fearful that I will get further gut trouble from the Cipro. I am taking a probiotic to try to minimize the damage from the Cipro. Has anyone else got any experience with this or general advice about it?
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Gabes-Apg
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Post by Gabes-Apg »

Polly posted this a week or so ago;

http://www.perskyfarms.com/phpBB2/viewtopic.php?t=20892

I think some others have used SB Boullardi while taking antiobiotics -

as some of those people are not as active on the board as they used to be, a good approach would be do a search of the archives on Cipro or probiotics and read previous discussions

hope this helps
Gabes Ryan

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UkuleleLady
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Post by UkuleleLady »

Hi mbozard,

I am on cipro right now, for a sinus/bronchial infection. My mornings have been more normal the last few days and I'm wondering why? I was on prednisone for a few days last week but stopped Sunday because I couldn't sleep on it. Not sure if this is a holdover effect from the steroids but at least the cipro isn't affecting me adversely.

Hopefully you won't be negatively affected by it.

Nancy
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tex
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Post by tex »

The risk from Cipro is not digestive upset. To the contrary, it puts most of us into remission during the time that we are taking it.

The risk from Cipro (or any of the other fluoroquinolones) is tendonitis or torn ligaments, and/or peripheral neuropathy. My peripheral neuropathy either came from years of untreated gluten sensitivity, or it was caused by 2 almost back-to-back treatments with Cipro, each lasting 2 weeks, with about a week in between.

Cipro is the least-likely antibiotic to cause D for someone who has MC. It's the other risks that are serious.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by mbozard »

Thanks for the info. An alternative to the Cipro for this infection is Trimethoprim/Sulfa. Should I consider asking my doctor to put me on that instead? I've only had one dose of the Cipro.
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Post by tex »

Well, there's no way of predicting the risk in any individual case. Many of us have taken Cipro (especially back before they added the black box warnings to the label) without any ill effects. Most other antibiotics will cause us to relapse, or at least have D for a while.

Unless you are an athlete, the risk of tendonitis or a torn ligament is relatively small, but still a possibility of course, especially with repeat doses. I didn't have any tendinitis or ligament problems when I took it, and I'm more inclined to believe that my peripheral neuropathy was caused by years of untreated gluten sensitivity. I believe that in most cases where peripheral neuropathy can be traced to Cipro, repeated treatments or extended use was involved.

Trimethoprim/sulfamethoxazole has a higher incidence of adverse effects, including allergic responses, and because of that its use has been restricted in many countries to very specific circumstances where trials have demonstrated that it has improved efficacy over other options.

We're almost always between a rock and a hard place whenever an antibiotic is needed. Looking at some old research evidence, in the study referenced at the link below, Cipro was 100 % effective at treating Yersinia enterocolitcia infections, whereas Trimethoprim was 85 % effective. However, for all I know, the combination of Trimethoprim with sulfamethoxazole may well boost the effectiveness of the combination up to 100 % also. :shrug:

Antibiotics in Yersinia enterocolitica infections.

If I were in that situation I would probably pick Cipro, because at least it will not antagonize the MC.

Good luck with your treatment, whichever one you choose.

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by mbozard »

Thanks everyone! Again, it really helps to have your support. I appreciate it!
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Post by karrazza »

I just started the sulpha tabs 2 days ago so far no major side effects I just hope it can get my condition under control if not in 6 weeks doc putting me on steroids now I don't really want that. With me eliminating certain foods I hope I can get over this awful feeling right now and be back to normal if I remember what normal is. I hate taking drugs but atm its better than the alternative.
Karen Moran
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