23&me people - do you have this particular TNF gene?

Zizzle · Post by **Zizzle** » Thu Mar 12, 2015 11:04 pm

I think I finally found the genetic smoking gun for the skin manifestations of Dermatomyositis (and perhaps the LC). I have the dreaded TNF -308 polymorphism (rs1800629 in 23&me data), which means higher levels of TNF release and more cytokine release from sun exposure. It also means less likelihood of remission. Ugh.

Anyone else have this gene allele?

Interestingly, one of my meds, hydroxychloroquine, is known to interfere with TNF signaling and cytokine release. At last I understand why the medication may be helping me!

https://www.facebook.com/Autoimmunethec ... 98368076:0

http://onlinelibrary.wiley.com/doi/10.1 ... 8/abstract

http://onlinelibrary.wiley.com/store/10 ... 824456e5c5

Blueberry · Post by **Blueberry** » Fri Mar 13, 2015 2:09 pm

I have a 23andMe account. I looked in my health section but didn't find what you are mentioning. Where do I look?

Zizzle · Post by **Zizzle** » Fri Mar 13, 2015 2:21 pm

I ran my raw data through Promethease.com, but I think you can search your raw data on 23&me and look by Chromosome location: 6, then gene name: TNF, and narrow it down to the specific RS#, which is rs1800629. Apparently it's a pretty rare polymorphism, and it's frequently tied to my darn DQ2 celiac gene, so basically I'm screwed. My immune system is on permanent hyperdrive.

Blueberry · Post by **Blueberry** » Fri Mar 13, 2015 3:29 pm

I looked again on the sight, but didn't see anything helpful! I'm a bit worn down more than typical today from MC, so that isn't helping. Hope someone else is able to find the information!

Post by **tex** » Fri Mar 13, 2015 8:03 pm

Blueberry,

Open your Promethease results and go down to your Medical Conditions link and click on it to open it. Go down the list and look for Dermatomyositis. Then click on the "...more..." link to see if you have any entries there. I would assume that rs1800629 should be listed there if you have it. It's not listed on mine.

Tex

Gabes-Apg · Post by **Gabes-Apg** » Fri Mar 13, 2015 8:27 pm

My Promethease report has a different SNP listed under Dermatomyositis
it had RS7572733 T:T

going back to 23andme raw data and searching for RS1800629 - i was G:G - normal risk

Post by **tex** » Fri Mar 13, 2015 9:38 pm

Gabes,

So does mine. But there's no known risk assigned to it. Right?

Tex

Gabes-Apg · Post by **Gabes-Apg** » Fri Mar 13, 2015 9:51 pm

So does mine. But there's no known risk assigned to it. Right?

I 'believe' so.

When I went to http://www.snpedia.com/index.php/Rs1800629 - for 1800629 it gives a risk status for the adelles
but for RS7572733 it didnt....

If Zizzle has been doing some research on these particular SNP's I am hoping she will chime in and confirm...

Blueberry · Post by **Blueberry** » Sat Mar 14, 2015 5:00 am

I didn't locate the Promethease results. But I did find the 23andme raw data, and it mentions GG results.

Zizzle · Post by **Zizzle** » Thu Mar 19, 2015 9:43 pm

You guys are lucky. RS1800629 G:G is normal/no risk. Having an A adds significant risk, you don't even need 2 As. Wish I knew why this stupid gene still persists in the population? Seems like a sure fire path to early death.

Blueberry · Post by **Blueberry** » Fri Mar 20, 2015 7:40 am

That's a raw deal Zizzle! Sorry to hear that. I signed up for 23andMe testing years ago for the genealogy services. They seem to have a neat program with that, in some respects. That is why I am much less certain about the health testing side of things and how that works. When I researched the family tree, something I found that was neat and nice to see was how many people lived to ripe old ages and healthy too on both sides of the family. Not all were that way obviously, but many were. There was one group in particular that lived longer than normal. They resided in the highest elevated city in the state of Oregon. It's an eastern desert town where one could obtain lots of vitamin D3. At least that's my theory on why they had long lives, sun exposure and with that increased DNA telomers length! But then again something else could have been at play. There is so much uncertainty in medical matters I've come to find.

aquilegia · Post by **aquilegia** » Sun Mar 29, 2015 8:14 am

I am thinking of doing the 23andme testing, but I don't know if it is a rip off and it would be throwing $199.00 away.

Can anyone advise me about that?

JLH · Post by **JLH** » Sun Mar 29, 2015 9:52 am

https://store.23andme.com/en-us/cart/

Deb · Post by **Deb** » Sun Mar 29, 2015 10:38 am

Zizzle, I have the RS1800629 A;G GREAT!

Post by **tex** » Sun Mar 29, 2015 11:56 am

Joan,

I believe the 23andme tests are more expensive in other countries. I don't know why.

Aquilegia,

The test only costs $99 in the U.S., as Joan pointed out.

This is just my opinion, but as far as I can tell it is a huge bargain, even at $199. You will receive more valuable data than you have ever received from any other medical test at any price. The raw data doesn't mean much to us, but after we download our own raw data, we can submit it for analysis to various websites, or download programs that we can use to analyze the data. Some of those analyses produce many, many pages of useful information.

IOW the raw data from 23andme will tell us virtually nothing when we look at it. But some of the interpretations of those data can be very enlightening and quite valuable (IMO). These results won't tell you what is causing your health problems, or what to do about them, but they will tell you why certain things may be happening and in many cases they can suggest ways to avoid the problems that the genetic mutations are associated with. And of course, as with all tests, there are never any guarantees. Just because we have certain genetic mutations does not guarantee that we will be affected in any certain way, but the analyses can definitely offer some clues concerning the odds that they might affect us.

I just wish that I had ordered my test years ago. And remember that this is just my unprofessional opinion, based on my own experiences.

Tex