Thanks Tex,
That is helpful. I think I will order it.
23&me people - do you have this particular TNF gene?
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
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Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
The extra $90 for other countries is that it goes International Courier (DHL) both ways.
Dont think the international post will allow saliva samples...
I agree with Tex, for the outlay and the subsequent reporting that you can do for next to nothing on the web, it provides good quality information about the 'root causes' for issues, individual to you...
in the case of Methylation, it is already published that there is a HUGE scientific link between Mast Cells and Methylation issues and Methylation and Thyroid issues.
Given the high percentage of MC'ers that have Mast Cell and/or Thyroid issues, my belief now, after all the reading i have done the past 6 months, to know your situation and adjusting eating/supplements to suit, is a key part of the attaining wellness stage of life with MC.
There are many here that with adjusting their supplements to help the methylation cycle, they have had improvement.
As the solution for these issues is supplements/adjustments to eating plan, Main Stream medicine will not embrace this testing, reporting and approach anytime soon..... so 'Informed Self Management' is needed.
I wish I had done this testing 10 years or more ago...I could have avoided or minimised quite a few of my health issues that turned chronic.
Dont think the international post will allow saliva samples...
I agree with Tex, for the outlay and the subsequent reporting that you can do for next to nothing on the web, it provides good quality information about the 'root causes' for issues, individual to you...
in the case of Methylation, it is already published that there is a HUGE scientific link between Mast Cells and Methylation issues and Methylation and Thyroid issues.
Given the high percentage of MC'ers that have Mast Cell and/or Thyroid issues, my belief now, after all the reading i have done the past 6 months, to know your situation and adjusting eating/supplements to suit, is a key part of the attaining wellness stage of life with MC.
There are many here that with adjusting their supplements to help the methylation cycle, they have had improvement.
As the solution for these issues is supplements/adjustments to eating plan, Main Stream medicine will not embrace this testing, reporting and approach anytime soon..... so 'Informed Self Management' is needed.
I wish I had done this testing 10 years or more ago...I could have avoided or minimised quite a few of my health issues that turned chronic.
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Can you all do me another favor? Deb especially? From what I read, the TNF gene tends to hang around with the HLA DQ 2 celiac gene.
But now I'm on to something else.... I have close to dangerously low WBC counts and I suspect a genetic cause, since my parents both have low WBCs. I know my supposed Lupus may be the cause, but I came across this research showing people with fewer C3 and C4 genes have a much greater likelihood of developing Lupus. I have low C3 and C4, which means I may have what's known as a Complement Disorder or hereditary complement deficiency. Unfortunately, there is little medicine can do about it.
Here's what you do.
1. Go to your 23&me raw data to browse, and select Chromosome 6.
2. Within Chromosome 6, search for C4a, then search for C4b (you must be looking in Chromosome 6 only)
3. Tell me how many of each you have (I only have one of each...apparently not good, you want 2 or more of each). My Dad only has one of each too.
I need this to confirm my theory and to help arm me if I have to go to a hematologist next!!
I will know in a few days what my latest re-check (CBC) looks like.
Thanks!!
But now I'm on to something else.... I have close to dangerously low WBC counts and I suspect a genetic cause, since my parents both have low WBCs. I know my supposed Lupus may be the cause, but I came across this research showing people with fewer C3 and C4 genes have a much greater likelihood of developing Lupus. I have low C3 and C4, which means I may have what's known as a Complement Disorder or hereditary complement deficiency. Unfortunately, there is little medicine can do about it.
http://www.sciencedirect.com/science/ar ... 9707610234Gene Copy-Number Variation and Associated Polymorphisms of Complement Component C4 in Human Systemic Lupus Erythematosus (SLE): Low Copy Number Is a Risk Factor for and High Copy Number Is a Protective Factor against SLE Susceptibility in European Americans
Here's what you do.
1. Go to your 23&me raw data to browse, and select Chromosome 6.
2. Within Chromosome 6, search for C4a, then search for C4b (you must be looking in Chromosome 6 only)
3. Tell me how many of each you have (I only have one of each...apparently not good, you want 2 or more of each). My Dad only has one of each too.
I need this to confirm my theory and to help arm me if I have to go to a hematologist next!!
I will know in a few days what my latest re-check (CBC) looks like.
Thanks!!
1987 Mononucleosis (EBV)
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
Zizzle,
Are you talking about the full genome of the raw data? Apparently the flu has scrambled my thinking abilities.
What am I doing wrong? I don't see any C4s anywhere. Where would C4a and C4b appear? In the position code? Those codes include various combinations of pairs of A, C, G, T and blanks, but I don't see any numbers (such as 4) anywhere in them (at least not for chromosome 6) in my raw data.
Tex
Are you talking about the full genome of the raw data? Apparently the flu has scrambled my thinking abilities.
What am I doing wrong? I don't see any C4s anywhere. Where would C4a and C4b appear? In the position code? Those codes include various combinations of pairs of A, C, G, T and blanks, but I don't see any numbers (such as 4) anywhere in them (at least not for chromosome 6) in my raw data.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
yes, the full genome raw data. They did not appear on my Promethease report, so I loggen in to 23&me and did a search. You select Chromosome 6, then in the search box, search by gene name" C4a", then "C4b"
1987 Mononucleosis (EBV)
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
I don't understand why that doesn't show up in the downloaded raw data. It's claimed to be complete.
Thanks.
Tex
Thanks.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
I have only 1 of each:
C4a CC
C4b AG
So does that mean we're both doomed, or maybe we're both OK after all.
Tex
C4a CC
C4b AG
So does that mean we're both doomed, or maybe we're both OK after all.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Tex,
I have:
C4A rs28357069 C or T CC
C4B rs28361044 A or G GG
Here's the article I found about it. It would certainly explain my Lupus blood and skin symptoms. But I can't be sure this gene search on 23&me is producing the gene count described by the article.
http://www.sciencedirect.com/science/ar ... 9707610234
Gene Copy-Number Variation and Associated Polymorphisms of Complement Component C4 in Human Systemic Lupus Erythematosus (SLE): Low Copy Number Is a Risk Factor for and High Copy Number Is a Protective Factor against SLE Susceptibility in European Americans
And
http://www.ncbi.nlm.nih.gov/pubmed/8934926
The association between immunodeficiency and the development of autoimmune disease.
Tex, have you ever had a low WBC or low Lymphocyte count on a CBC? Have you ever had your C3 and C4 levels checked?
I have:
C4A rs28357069 C or T CC
C4B rs28361044 A or G GG
Here's the article I found about it. It would certainly explain my Lupus blood and skin symptoms. But I can't be sure this gene search on 23&me is producing the gene count described by the article.
http://www.sciencedirect.com/science/ar ... 9707610234
Gene Copy-Number Variation and Associated Polymorphisms of Complement Component C4 in Human Systemic Lupus Erythematosus (SLE): Low Copy Number Is a Risk Factor for and High Copy Number Is a Protective Factor against SLE Susceptibility in European Americans
And
http://www.ncbi.nlm.nih.gov/pubmed/8934926
The association between immunodeficiency and the development of autoimmune disease.
Abstract
There is a paradoxical relationship between immunodeficiency diseases and autoimmunity. While not all individuals with immunodeficiency develop autoimmunity, nor are all individuals with autoimmunity immunodeficient, defects within certain components of the immune system carry a high risk for the development of autoimmune disease. Inherited deficiencies of the complement system have a high incidence of systemic lupus erythematosus (SLE), glomerulonephritis, and vasculitis. Carrier mothers of children with chronic granulomatous disease, an X-linked defect of phagocytosis, often develop discoid lupus. Several antibody deficiencies are associated with autoimmune disease. Autoimmune cytopenias are commonly observed in individuals with selective IgA deficiency and common variable immune deficiency. Polyarticular arthritis can be seen in children with X-linked agammaglobulinemia. Combined cellular and antibody deficiencies, such as Wiskott-Aldrich syndrome, carry an increased risk for juvenile rheumatoid arthritis and autoimmune hemolytic anemia. Several hypothetical mechanisms have been proposed to explain the associations between autoimmunity and immunodeficiency. Immunologic defects may result in a failure to exclude microbial antigens, resulting in chronic immunologic activation and autoimmune symptoms. There may be shared genetic factors, such as common HLA alleles, which predispose an individual to both autoimmunity and immunodeficiency. Defects within one component of the immune system may alter the way a pathogen induces an immune response and lead to an inflammatory response directed at self-antigens. An understanding of the immunologic defects that contribute to the development of autoimmunity will provide an insight into the pathogenesis of the autoimmune process.
Tex, have you ever had a low WBC or low Lymphocyte count on a CBC? Have you ever had your C3 and C4 levels checked?
1987 Mononucleosis (EBV)
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
2004 Hypomyopathic Dermatomyositis
2009 Lymphocytic Colitis
2010 GF/DF/SF Diet
2014 Low Dose Naltrexone
Deb,
I wish I knew how far you are getting, but here's the procedure, at least on an older version of Firefox (the latest version where we are still allowed to move our tabs to the bottom of the toolbars, which is version 28):
They hide your raw data on 23andme and push the ancestral BS, one of the things that I don't like about the site. I'm pretty sure that all of my neanderthal relatives are probably long gone so it won't do much good to look for them at this point.
After you log in, look up to the right and locate your name. Click on that box to open a context menu and you should see "Browse Raw Data" listed as an option. Click on it.
Then on the sort of calendar-looking table that opens, click on "6" to select chromosome 6. On the page that opens, enter the name of the gene you want to search for (for example, C4a or C4b) in the search box on the left where it says "Jump to a gene". Click on "Go". Repeat for any other genes you want to search for.
Mine shows:
C4A 31963860 rs28357069 C or T CC
and
C4B 31997401 rs28361044 A or G AG
Be sure to click on chromosome "6" before searching for any genes (in this particular case).
Tex
I wish I knew how far you are getting, but here's the procedure, at least on an older version of Firefox (the latest version where we are still allowed to move our tabs to the bottom of the toolbars, which is version 28):
They hide your raw data on 23andme and push the ancestral BS, one of the things that I don't like about the site. I'm pretty sure that all of my neanderthal relatives are probably long gone so it won't do much good to look for them at this point.
After you log in, look up to the right and locate your name. Click on that box to open a context menu and you should see "Browse Raw Data" listed as an option. Click on it.
Then on the sort of calendar-looking table that opens, click on "6" to select chromosome 6. On the page that opens, enter the name of the gene you want to search for (for example, C4a or C4b) in the search box on the left where it says "Jump to a gene". Click on "Go". Repeat for any other genes you want to search for.
Mine shows:
C4A 31963860 rs28357069 C or T CC
and
C4B 31997401 rs28361044 A or G AG
Be sure to click on chromosome "6" before searching for any genes (in this particular case).
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Zizzle,
C4A 31963860 rs28357069 C or T CC
and
C4B 31997401 rs28361044 A or G AG
Looks like an identical match to me. So are we both doomed? Or both OK?
I don't recall any low WBC results. The level is always between 7.5 and 8.0, according to my records. My RBC has been consistently low since my last surgery (5 years ago), however.
That hospital visit included the transfusion of 11 units of blood (to make up for some of the blood lost prior to the surgery), and that could have been what caused the change.
Tex
C4A 31963860 rs28357069 C or T CC
and
C4B 31997401 rs28361044 A or G AG
Looks like an identical match to me. So are we both doomed? Or both OK?
I don't recall any low WBC results. The level is always between 7.5 and 8.0, according to my records. My RBC has been consistently low since my last surgery (5 years ago), however.
That hospital visit included the transfusion of 11 units of blood (to make up for some of the blood lost prior to the surgery), and that could have been what caused the change.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
