An Important Reason Why We Should Be Using Magnesium

[tex]

Hi All,

I came across this a while ago, intended to post about it, and then forgot (my memory isn't what it used to be, especially when I have too many things going on, which is most of the time). I posted about this in another thread, but it deserves a thread of it's own, because I believe that everyone who has an IBD should be aware of this:

Here's another (very important) reason why all of us should probably be taking a magnesium supplement, or using a magnesium topical application:

Magnesium deficiency causes defective T cell development/expression (and of course, defective T cell activity is what causes the inflammation that results in the development of MC).

Abstract
The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free Mg2+ levels. Individuals with genetic deficiencies in MAGT1 have high levels of Epstein-Barr virus (EBV) and a predisposition to lymphoma. We show that decreased intracellular free Mg2+ causes defective expression of the natural killer activating receptor NKG2D in natural killer (NK) and CD8+ T cells and impairs cytolytic responses against EBV. Remarkably, magnesium supplementation in MAGT1-deficient patients restores intracellular free Mg2+ and NKG2D while concurrently reducing EBV-infected cells in vivo, demonstrating a link between NKG2D cytolytic activity and EBV antiviral immunity in humans. Moreover, these findings reveal a specific molecular function of free basal intracellular Mg2+ in eukaryotic cells.

That research obviously focused on the beneficial effects of magnesium in preventing/controlling Epstein-Barr virus activity, but it also appears to provide evidence that magnesium should be a part of any treatment program for all IBDs.

Also, some individuals believe (Zizzle, are you reading this?) that Epstein-Barr virus predisposes to MC and other AI issues, which may well be correct.

EPSTEIN-BARR VIRUS in MC and AUTOIMMUNITY!!

IOW, defective Killer T cells and CD8+ T cells are the inflammatory lymphocytes that infiltrate the mucosa of our intestines to promote the inflammation that results in the development of MC. So we can't necessarily conclude that a magnesium deficiency causes MC, but it certainly appears that magnesium supplementation might help to suppress the inflammation that causes it.[/quote]

Of course, I could be all wet, since this hasn't yet been verified (or even explored) by any dedicated RCTs.

Tex

[wmonique2]

Thanks Tex! Good info!


Love,


Monique

[tex]

Hi Monique,

How in the world are you doing these days? Great, I hope.

It's good to see a post from you again.

Love,
Tex

[wmonique2]

Hi Tex,

I am doing great Tex. Miss you guys! I've been a year now on LDN and I couldn't be happier about the results. No nausea, no cramps, no D, no C, nothing. Pretty much symptom free. Never knew it could be possible. I eat pretty much anything I want but I am still GF, SF and low fiber. I have no histamine issues at all. The Universe has been good to me.

I had a small setback in February. I had a thyroid cancer scare (they said it was "suspicious" of cancer) so they operated on me, took half my thyroid to biopsy while I was under (apparently that's how it's done) to find out that I never had any cancer. I was mad as hell (and still am sometimes) that they removed half my thyroid for naught. Modern medicine. So now I take a thyroid supplement because the other half is working too hard to keep up with my needs.

The operation did a number on me. But soon as I increased my LDN I went back to normal. Doing great now as long as I don't eat spicy Mexican food :)

Sometimes I visit the forum but don't post since I have nothing to contribute. I got some folks who contacted me after reading my success story on the board and I have been coaching them with LDN. I saw the FB page you started...great idea and Z. is perfect for it.

And how are you, my friend?

Love,

Monique

[Marcia K]

Thanks, Tex. Using topical magnesium helped me to sleep much better. I'm sure it helped with other things, too. I wish I had known about it sooner.

Marcia

[tex]

Monique,

It's good to hear that you're doing so well, especially after having to deal with the thyroid cancer scare, and recovery from the surgery. I certainly agree that removing half your thyroid gland rather than just a few biopsy samples seems rather Draconian. Makes you wonder if they just felt obligated to remove something, since they were already in there, and they were surgeons with plenty of scalpels ready to go. But of course, the main point is there wasn't any cancer.

As medical tests become more sensitive, false alarms are becoming more frequent, resulting in a lot of unnecessary stress, expense, and unnecessary procedures. And it's always the patients who foot the bill and suffer the inconveniences, because the hospitals and staff are going to be paid the same, whether the diagnosis was right or wrong. Hopefully they'll eventually figure out a way to fine tune their system, but as long as patients are footing the bill, and taking all the hits, there's probably no real sense of urgency in medical circles, to correct the situation.

I'm doing fine these days. I'm staying busy and definitely not enjoying all the humidity we're having this year due to the persistent wet weather. But at least everything is green and growing (trying to stay ahead of the mold and mildew. LOL).

Please try to drop by more often. We always benefit from your insight and your experiences.

Love,
Tex

[wmonique2]

Tex,

I feel the same way about the thyroid removal. They did take biopsies and the results were "inconclusive". So after talking to 4 doctors who all said take it out, I decided to do it. I waited like 4 months before I did it. My body was telling me that I was OK, didn't have anything but in the end I surrendered to the fear. Draconian is the right word for it. Primitive is another. And you and I know that medicine is a racket in this country as you said in your post. Everybody profits except the patient.



Love,

Monique

(I promise to drop by more frequently :)

[tex]

Monique,

I hear you about giving in and surrendering. I do the same thing in the name of stroke control. I don't believe that the TIAs on my record were actually TIAs, but I sure don't want to hear those guys telling me (if I survive a stroke), "I told you so!" So I take the Plavix and a BP med, just in case they were right.

Love,
Tex

The porch light is always on.

[wmonique2]

Tex!

Love and thanks for leaving the porch light on

Monique

[Sheila]

Hey Monique, I'm so glad you're doing so well, minus the thyroid scare. Are you hard at work on your next book? Let us know when you publish.

Sheila W

[wmonique2]

Hi Sheila,

Thank you so much for being one of my fans! Good to hear from you

I'll definitely will let everyone know about it when it happens. It's been a hard 3 years for accomplishing anything but I am doing great and maybe I should pick up where I left off.


Love to all,

Monique

[Leah]

Hi Tex, Monique, and Sheila. It's good to hear from all of you. I'm not on very much either. I have been really busy at work and have noticed that others have picked up where some of us have left off ( with giving great advice). I have also been doing great when it comes to my MC. I use topical magnesium spray, and also am taking LDN ( 1.5 mg) every other day. I don't know if I even need it any more. I am pretty much symptom free. I stay gluten free and mostly dairy and soy free, but I cheat with a spoon full of ice cream every once in a while :) I also try to help those on the FB forum, but tell the really lost people to join this great group. take Care
Leah

[tex]

Hi Leah,

It's good to hear that you're doing so well.

Thanks for the update.

Tex

[mzh]

Wow, I wish I knew that about magnesium and lymphoma; we lost a young greyhound to it this Spring.

Incidentally, my guts are just fine this year; I credit it to LDN - no Entocort needed anymore. It's very strange to have Normans but I'm still careful about gluten.

[Sheila]

Interesting about magnesium and lymphoma. People with Sjogrens are at greater risk for lymphoma, and I think celiacs are as well. I have to get a blood test twice a year because of my Sjogrens.
I'm wondering if LDN would help with the fatigue that comes with Sjogrens and does anyone know if LDN helps with arthritis pain?
BTW, I am taking magnesium glycinate 3x a day for restless leg. It is working very well but is causing constipation. Is this unusual? If I take less, the restless leg comes back.
Thanks,
Sheila W