23andMe/interesting article about CC genes

Tor · Post by **Tor** » Sun Nov 08, 2015 3:51 pm

I received my 23andMe-report a few days ago. I wasn't very surprised to find that I was HLA-DQ2.5 homozygot. 24-28 % of HLA-DQ2.5 homozygots have celiac disease, and who nows how many has NCGS. This fits nicely with my serum IgA against gliadin at 6 times normal levels. It also fits well with unspesific gastroduodenal inflammation, anemia, osteopenia, a positive response to gluten free diet and several autoimmune conditions. "It fits", as doctor House would say.

As a coincidence, I received a warning about a new article yesterday from a solid group of researchers who has reproduced some of Kenneth Fines findings in a large genome wide study of CC. Guess what: CC links heavy to HLA-DQ2.5. The researchers even hints at that gluten may have a patogenic role in CC. This does not happen every day. I think Tex will be interested in this: http://gut.bmj.com/content/early/2015/1 ... 015-309934.

--Tor

Post by **tex** » Sun Nov 08, 2015 4:48 pm

Hi Tor,

That's some very helpful information. I was wondering if any other researchers were ever going to take an interest in that line of research and support Ken Fine's work.

Many thanks for the link.

Tex

Sheila · Post by **Sheila** » Mon Nov 09, 2015 2:28 pm

It would be great to have corroboration, for sure.

Over the summer I downloaded all of my 23andme data to a site that interpreted same. There were lots of genes for Crohns, nothing for MC. I suspect MC is not a well known IBD and those of us with MC are lumped into the Crohns camp. It was eye opening to see genetic confirmation of my various AI disorders; celiac, Sjogrens, GI issues, allergies etc.

Sheila W

TaiaK · Post by **TaiaK** » Mon Nov 09, 2015 6:36 pm

Thought I'd jump on this thread as I've been toying with doing this 23andme test. I see the cost has recently gone up to $199 US and after the back and forth with the FDA, reports/updates will now be included to help the customer better understand their results. I also started to see commercials for it on TV.

For those that have done this test-are you glad you did? Did you find the information beneficial? I guess I'm trying to determine what and how much I want to know. I'm hoping it's not like "you have a 6 times higher risk for cancer" or is it like that?? Any feedback would be appreciated-just curious. Thanks!

Taia

Post by **tex** » Mon Nov 09, 2015 7:11 pm

Taia,

Yes, I've found the information to be very helpful. Not only did it clarify which metholation problems I have, but I now know which diseases might be a higher risk than others, and I discovered that I am unable to properly metabolize caffeine (which is why I have to be careful not to overdo it, or it interferes with my sleep). The results also showed that I'm unable to properly metabolize Plavix (which I take for stroke prevention), and I'm immune to Creutzfeldt-Jakob disease (the human equivalent of mad cow disease). IOW, I could eat mad cow brains and not have to worry about catching the disease. I can absolutely guarantee you that I will never intentionally do that, but it's nice to know that if any mad cow brains ever accidentally turned up in my ground beef, it wouldn't matter at all.

The results will list all known single nucleotide polymorphisms (snps) that you have that predispose to various forms of cancer, but it will also list mutations you have that are protective of the various types of cancer. So interpretation is everything.

For the information provided, IMO it's an incredible bargain.

Tex

Sheila · Post by **Sheila** » Mon Nov 09, 2015 7:49 pm

I agree with Tex. Well worth it.

Sheila W

Zizzle · Post by **Zizzle** » Mon Nov 09, 2015 11:09 pm

I'm hetero HLA DQ 2.5. Knowing this and referring to my LC, Dr. Alessio Fasano (the famous celiac doc), basically told me that LC is celiac of the large intestine. "We used to think celiac was confined to the small intestine...now we know better."

Incidentally, when I am glutened now, I rarely get an obvious reaction upon ingestion or even in the first few hours. I seems like the gluten must make it's way down to a certain level of my intestines to turn on the reaction.

louis · Post by **louis** » Tue Nov 10, 2015 3:01 am

Do you guys know, if you get the same amount of data, if you Order the package for 99 dollar and not 199 dollar. In the 199 is health information included but for 99 dollar only the ancestry, but is it basiclly the same data, so
one just have to let it interpret from a third party? I ask because its not possible to get the health information in germany.

Gabes-Apg · Post by **Gabes-Apg** » Tue Nov 10, 2015 10:13 am

Louis,
12 months ago I did the $99 usd package of data only. With international courier costs each way it cost me about $199 usd. Outside of the USA, you have to use their DHL courier process.

One of the best investments I have done on my journey to wellness.

TaiaK · Post by **TaiaK** » Tue Nov 10, 2015 3:07 pm

Thanks for the feedback-seems you feel the test was a good investment. However, from what I'm seeing people are now mad because the cost has gone up from $99 to $199 and there are reviews saying you don't get as much info as you used to. Some are feeling it used to be a better value. I think this change occurred very recently-like October of this year-kind of a "re-launch" after the back and forth with the FDA. I also noticed a 23andme UK site that sends to various countries in Europe. I'm going to sift thought the reviews on this current change a bit more and then decide.

Oh and Tex-I can't believe you found out you were immune to mad cow disease! Wow.

Taia

Erica P-G · Post by **Erica P-G** » Tue Nov 10, 2015 5:09 pm

I just ordered the 23andMe today....

I'm kinda a science junky when it comes to my genes....plus it is scientific information that my family/kids can't dispute. If there is anything in this report that needs to be known and passed down to my children then I sure hope they listen.

Gabes-Apg · Post by **Gabes-Apg** » Tue Nov 10, 2015 5:20 pm

Erica,
I found the information very interesting....
The things that I seem to be having the most issue with, those issues are snps from both parents....

For years my mother was in a bit of denial about things and was trying to blame dad for most of my health stuff. She was not happy that I had some scientific evidence that it came from both!!!

My advice is, Use discernment. I am not sure what sort of reporting will come with your results under the new FDA approved reporting set up. Some of the third party reports can seem a bit scary at first read. Don't get wrapped up in the could be's and maybes. You will not get every condition illness that you have a risk factor for....
I have used the information to look at my current issues and know how maybe to resolve them better. ( methylation etc )

Gabes-Apg · Post by **Gabes-Apg** » Tue Nov 10, 2015 5:22 pm

And books like 'biology of belief' etc remind us that we are not locked into/trapped by our genes...

Erica P-G · Post by **Erica P-G** » Tue Nov 10, 2015 5:41 pm

I agree Gabes, not all alleles produce themselves they are just there, part of the make up. I am interested in the histamine/mast cell/gluten ratio about myself the other stuff will be 'just scientific extras' as far as I am concerned. I'm really not sure what other kinds of things I will get to know, it should be interesting to match up things I have had a liking to as compared to things I have not and why perhaps I am who I am .

I want to know just how intricate I really am, I am a member of Ancestry.com and it will be interesting to see some of those similarities should they shine thru with anyone. I've always been curious how much of each side of my family I have taken on. My son resembles sooo much like my grandpa that raised me that it's kinda spooky, he does have some of my Ex's attributes too so it isn't 100%, but enough that my son looks like my grandpa did in his later 20's, so for me I already have a grasp of how my son will look in his later years, very handsome

and he will age gracefully.

Thankfully if I have any questions it appears enough people have gotten this testing that I can ask questions here

Gabes-Apg · Post by **Gabes-Apg** » Tue Nov 10, 2015 5:54 pm

My excitement as I read the results and did research was not shared by family friends etc
It was a bit like your post about magnesium a few weeks back....

I will be interested to hear /see what type of reports you get..... As mentioned by Louis, those outside of USA do not get access to report package.
I kinda like that I have my data and can use it at any time in the future as other providers reporting/research info etc becomes available.