Sleepless in Colorado
Uceris side effects
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Uceris side effects
I've been on Uceris now for three weeks now and I'm having a horrible time trying to sleep at night, and I'm up having to urinate 2-3 times a night. Driving me crazy - I'm exhausted! I'm due to start weaning off Uceris with 6 mg of entocort for 2 weeks and then 3 mg for two more weeks. I'm supposed to take Uceris for a couple more weeks but don't think I can make it. Has anyone experienced sleeplessness and frequent urination due to Uceris?
Sleepless in Colorado
Sleepless in Colorado
Been there, done that. You are almost surely magnesium deficient. Magnesium deficiency can cause symptoms very similar to diabetes (frequent urination urge, always thirsty, etc.).
You were probably magnesium deficient before you started taking the Uceris, but you weren't yet critically low. Corticosteroids deplete magnesium (so do antibiotics and many other medications). So when you began taking the Uceris it quickly finished off your remaining magnesium reserves.
During the day, you get some magnesium from your meals, but during the night your body runs out of magnesium so you begin having symptoms (and the symptoms you describe are a perfect fit). If you check your blood pressure you will find that in the mornings it will probably be very low (because you are dehydrated), and as the day wears on your BP will climb as you rehydrate. But it will tend to be too high at times during the day, because magnesium is a critical electrolyte, so your body will have a difficult time regulating BP, heart rate, breathing, and other functions controlled by your autonomic nervous system because of the irregular availability of magnesium.
It typically takes months to rebuild magnesium supplies (magnesium is stored in muscle cells), and the Uceris will also be depleting it 24x7, so in addition to taking magnesium following meals, take at least 100 mg just before bedtime so that you don't run out during the night. Corticosteroids tend to make many/most people hyper anyway, but a magnesium deficiency greatly magnifies the effect. Magnesium may not completely prevent your symptoms (because of the extra cortisol boost by the Uceris) but it should certainly help to reduce the effect.
And please update us on how well (or whether) this works to resolve your symptoms.
Tex
You were probably magnesium deficient before you started taking the Uceris, but you weren't yet critically low. Corticosteroids deplete magnesium (so do antibiotics and many other medications). So when you began taking the Uceris it quickly finished off your remaining magnesium reserves.
During the day, you get some magnesium from your meals, but during the night your body runs out of magnesium so you begin having symptoms (and the symptoms you describe are a perfect fit). If you check your blood pressure you will find that in the mornings it will probably be very low (because you are dehydrated), and as the day wears on your BP will climb as you rehydrate. But it will tend to be too high at times during the day, because magnesium is a critical electrolyte, so your body will have a difficult time regulating BP, heart rate, breathing, and other functions controlled by your autonomic nervous system because of the irregular availability of magnesium.
It typically takes months to rebuild magnesium supplies (magnesium is stored in muscle cells), and the Uceris will also be depleting it 24x7, so in addition to taking magnesium following meals, take at least 100 mg just before bedtime so that you don't run out during the night. Corticosteroids tend to make many/most people hyper anyway, but a magnesium deficiency greatly magnifies the effect. Magnesium may not completely prevent your symptoms (because of the extra cortisol boost by the Uceris) but it should certainly help to reduce the effect.
And please update us on how well (or whether) this works to resolve your symptoms.
Tex
Magnesium
You mentioned taking it after meals, what is the recommended dosage? This just started happening after I started back on the Uceris - didn't notice it when I was off medication. I'm starting on magnesium today - after I take a nap! Thanks again Tex.
I don't recall if it actually matters whether or not it's taken on an empty stomach. I just always take meds and supplements after meals (except for thyroid treatments) because the body evolved to absorb nutrients from meals.
The RDA is about 400 mg per day, but it's impossible to make up for deficiencies at the RDA, because the RDA specified is typically the minimum amount for average people (who do not have a deficiency). We're not average (because IBDs and many of the medications we use deplete magnesium, and we have MC).
I usually take about 300 mg after breakfast, another 100 mg after lunch, and another 100 mg before bedtime. Chelated magnesium (magnesium glycinate) is the only form of oral magnesium not known to cause D in larger doses. Be sure you understand the label, because most magnesium labels show the total "normal" dose amount on the front label, but when you look at the back label it mentions that a dose is 2 tablets. Therefore each tablet only contains half the amount shown on the front label.
Avoid cheap magnesium forms, such as "buffered" chelated magnesium (sold by Vitacost, for example), because it is "buffered" with dirt-cheap magnesium oxide. Magnesium oxide is poorly absorbed, and when it is absorbed it is a very common cause of D. Spray on magnesium or Epsom salt soaks can be used without any risk of causing D.
You're very welcome,
Tex
The RDA is about 400 mg per day, but it's impossible to make up for deficiencies at the RDA, because the RDA specified is typically the minimum amount for average people (who do not have a deficiency). We're not average (because IBDs and many of the medications we use deplete magnesium, and we have MC).
I usually take about 300 mg after breakfast, another 100 mg after lunch, and another 100 mg before bedtime. Chelated magnesium (magnesium glycinate) is the only form of oral magnesium not known to cause D in larger doses. Be sure you understand the label, because most magnesium labels show the total "normal" dose amount on the front label, but when you look at the back label it mentions that a dose is 2 tablets. Therefore each tablet only contains half the amount shown on the front label.
Avoid cheap magnesium forms, such as "buffered" chelated magnesium (sold by Vitacost, for example), because it is "buffered" with dirt-cheap magnesium oxide. Magnesium oxide is poorly absorbed, and when it is absorbed it is a very common cause of D. Spray on magnesium or Epsom salt soaks can be used without any risk of causing D.
You're very welcome,
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Gabes-Apg
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the 400mg that Tex talks about is 'ELEMENTAL magnesium' check the fine print of any magnesium product
for example: it will say that each dose (and a dose can be multiple tablets) has 250mg of magnesium that equates to 180mg of elemental magnesium
many here have been caught out by either the dose requires multiple tablets and/or they are not getting enough Elemental magnesium to fix the deficiency.
it can also take time to fix the deficiency - copy of some text i wrote yesterday for ALoha
Time wise for fixing deficiencies the following applies for minerals vitamins etc;
Mild deficiency 6-10 weeks
Medium level deficiency 10-20 weeks
Severely deficient 20- 30 weeks. (Or more)
Keep in mind, to fix a deficiency your daily intake needs to be well above your daily usage.
The daily RDI for normal person for magnesium is 400mg ELEMENTAL magnesium per day
For those with health issues, medications or other factors that deplete magnesium the RDI would be about 600-700mg ELEMENTAL magnesium per day...
for example: it will say that each dose (and a dose can be multiple tablets) has 250mg of magnesium that equates to 180mg of elemental magnesium
many here have been caught out by either the dose requires multiple tablets and/or they are not getting enough Elemental magnesium to fix the deficiency.
it can also take time to fix the deficiency - copy of some text i wrote yesterday for ALoha
Time wise for fixing deficiencies the following applies for minerals vitamins etc;
Mild deficiency 6-10 weeks
Medium level deficiency 10-20 weeks
Severely deficient 20- 30 weeks. (Or more)
Keep in mind, to fix a deficiency your daily intake needs to be well above your daily usage.
The daily RDI for normal person for magnesium is 400mg ELEMENTAL magnesium per day
For those with health issues, medications or other factors that deplete magnesium the RDI would be about 600-700mg ELEMENTAL magnesium per day...
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Magnesium
The magnesium I have is "Nature's Life", it has magnesium and vit B6. One capsule has 500 mg magnesium (magnesium oxide, citrate, malate) and 5 mg bit B6. I have this in the house so I'll try this. I read all the fine print and didn't see anything about "Elemental." I might soak in epsom salts. Looking into magnesium spray - never hear of it. Thanks for the input from you both.
Magnesium
Tex, I've been taking 500 mg of magnesium and spraying magnesium oil on at night. Sleeping better and not running to bathroom 3 times a night. I have reduced then entocort to 6 mg from 9 as well. The oil stings a little but I also add an oil to it. Thanks so much.
I purchased Life-Flo Pure Magnesium Oil.....why does it sting and make the skin red? It's worse if I put it on after my shower.
On the bottle it says that it is Magnesium Chloride Brine...provides 66 mg of elemental magnesium for every 4 sprays or 560mg per teaspoon (for bath or foot soak).
As far as Magnesium Glycinate orally, should I chance that as I'm trying to heal?
Thanks,
Terre
On the bottle it says that it is Magnesium Chloride Brine...provides 66 mg of elemental magnesium for every 4 sprays or 560mg per teaspoon (for bath or foot soak).
As far as Magnesium Glycinate orally, should I chance that as I'm trying to heal?
Thanks,
Terre
Your skin may be more sensitive than normal. You may need to dilute the oil.
Unless you take a tremendous amount of magnesium glycinate, which isn't generally advisable, because it's possible to OD with any mineral supplement, it shouldn't cause any digestive problems. Supplementation in the range of 300-500 mg shouldn't cause problems for anyone except those who have very low blood pressure (because magnesium can lower BP) and those who have kidney function issues (because the kidneys purge excess amounts of magnesium from the body). Research shows that the more we take, the lower the percentage that's actually absorbed, so high dosage rates will cause a lot of waste, and create a bigger workload for the kidneys. As I mentioned above, the RDA for magnesium is around 400 mg on the average (from all sources, including diet). Of course if we have a magnesium deficiency we need to take more if we hope to ever rebuild any reserves.
Magnesium reserves are stored in muscle tissue, and that fact is what makes topically-applied magnesium so beneficial. But if it irritates your skin, then oral supplementation is the next best option. Maybe another brand might work better. Can you tolerate Epsom salt foot salts? Or maybe adding some Epsom salts to bath water might work for you.
Tex
Side Effects and Dangers of Magnesium OilIf you have fair skin, the kind of skin that ‘everything makes you break out’, magnesium oil could sting and tingle. It’s not necessarily the magnesium. in magnesium oil that does it. Any of the salts in the oil can have this effect. There is a full 3,000 mg of magnesium chloride in just a teaspoon (5 ml) of magnesium oil, and even more of various other naturally occurring mineral salts.
If spraying magnesium oil on your skin irritates it, try diluting the oil with water. Magnesium ‘oil’ isn’t really oil, it’s a concentrated salt solution. So it mixes very well with water. Just dilute your magnesium oil with water 10 to 1 and use it in your aerosol spray.
Magnesium can trigger a detoxifying reaction that temporarily causes irritation to the skin. This is most likely to happen when people have mercury amalgam fillings, or when they have rosacea. The skin reaction does not last very long, typically one to two weeks, and may go away faster if you take oral bentonite to absorb toxins released, or are no longer absorbed through your gut.
Unless you take a tremendous amount of magnesium glycinate, which isn't generally advisable, because it's possible to OD with any mineral supplement, it shouldn't cause any digestive problems. Supplementation in the range of 300-500 mg shouldn't cause problems for anyone except those who have very low blood pressure (because magnesium can lower BP) and those who have kidney function issues (because the kidneys purge excess amounts of magnesium from the body). Research shows that the more we take, the lower the percentage that's actually absorbed, so high dosage rates will cause a lot of waste, and create a bigger workload for the kidneys. As I mentioned above, the RDA for magnesium is around 400 mg on the average (from all sources, including diet). Of course if we have a magnesium deficiency we need to take more if we hope to ever rebuild any reserves.
Magnesium reserves are stored in muscle tissue, and that fact is what makes topically-applied magnesium so beneficial. But if it irritates your skin, then oral supplementation is the next best option. Maybe another brand might work better. Can you tolerate Epsom salt foot salts? Or maybe adding some Epsom salts to bath water might work for you.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Well, that pretty much explains it:
Fair skin - yes
Very sensitive skin - yes
Amalgam fillings - yes
Rosacea - yes
I've not tried foot soaking and I'm not a bath person....so may be looking into the foot soak. When I was using Magnesium gel on the bottoms of my feet....they got really dry.....my guess is the salt.
I think I will at least explore the oral magnesium. Thanks!
Terre[/i]
Fair skin - yes
Very sensitive skin - yes
Amalgam fillings - yes
Rosacea - yes
I've not tried foot soaking and I'm not a bath person....so may be looking into the foot soak. When I was using Magnesium gel on the bottoms of my feet....they got really dry.....my guess is the salt.
I think I will at least explore the oral magnesium. Thanks!
Terre[/i]