Feel free to discuss any topic of general interest, so long as nothing you post here is likely to be interpreted as insulting, and/or inflammatory, nor clearly designed to provoke any individual or group. Please be considerate of others feelings, and they will be considerate of yours.
It is so frustrating, when you have looked at your DNA analysis and poked and prodded every gene sequence, but you still can't come up with any reason to not be eating gluten.
When the only reason you know you shouldn't is because you've done the dang stool test with Enterolab it makes a person feel even more frustrated. I sure hope the DNA analysis catches up with this area of the body sooner and figures out which SNP is the cause if there is one that our bodies react to gluten in the manner that they do.
On all HLA-DQ sequences I am a +/- neither does it say I am at risk nor does it say I am fine....LOL, I'm gonna go insane. Even my HLA-DQ8 says that I'm not predisposed to ulcerative colitis
Albeit...I do feel tons better by not eating my four offensive foods, it still makes me wonder why we react the way we do. Our genes are funny little ticking time bombs
Is there another way of saying gluten intolerance....I know that sounds lame but maybe I'm not looking at a specific gene sequence that I should be.
To Succeed you have to Believe in something with such a passion that it becomes a Reality - Anita Roddick
Dx LC April 2012 had symptoms since Aug 2007
It's actually the gliadin and glutenin (glutelin) protein fractions of gluten that trigger gluten sensitivity. EnteroLab offers a DNA test that specifically checks for gluten sensitivity.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Thanks Tex,
I poked around Promethease more and found my gene Gs221 says:...."Autoimmune disorder risk in Europeans This genoset tags the DQ2.2 haplotype in Europeans, and thus increased risk gluten intolerance and for autoimmune disorders such as celiac disease." The pie chart associated with the risk was filled in 1/3 with red and the rest was grey, no green.
Ok....so I think that pretty sums it up that I have gluten intolerance, and my risk is fairly up there in the rating. I actually found some of this info on Livewello too. I opted for a yearly subscription to get a better understanding and more thorough explanation of some SNP's. A person has to get info in three different ways practically for it to bonk ya on the head as to what it might be referring to. With out a geneticist who specializes in this you need to be very open to interpretation and not let any of it bother you, some of it is very plain in the face though, such as this was but I wasn't reading it right until now. I think I read too much and let my brain go in to many directions trying to absorb the information...lets face it I'm not a computer, lol.
To Succeed you have to Believe in something with such a passion that it becomes a Reality - Anita Roddick
Dx LC April 2012 had symptoms since Aug 2007
Yes, that's the main celiac gene. I have it too, FWIW. I haven't spent very much time digging into my results. So many of them are confusing, because some mutations predispose to certain conditions, while others protect against the same condition. I was afraid I'd become cross-eyed if I spent too much time studying all that information.
I have a rather unique SNP that supposedly protects me from Creutzfeldt-Jakob disease (CJD). IOW I could eat the infected brains of a cow with Bovine spongiform encephalopathy (BSE) (aka mad cow disease) and not have to worry about developing the disease. Needless to say I probably won't be testing that one out, since I don't particularly crave to munch on cow brains, anyway.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Erica
keep in mind that the medical diagnosis of 'non celiac gluten intolerance' is only relatively new. and linking this issue to genetic markers will take a few years.
the other thing to be mindful of, my pondering regarding MC and genetic info is,
the type of inflammation reactions we have with MC is a bit unique (hence why MC is not understood well by the medical world) MC is different to the other IBD's, and the type of reaction that a MC'er has to things like Gluten has not been studied, therefore the information available linking genetic snps to our type of issues is not there...
what we do know is that inflammation (be it food, environmental, stress etc) are triggers. Anything that increases inflammation levels should be avoided as much as possible.
I think Livewello has a report about inflammation related SNP's
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Thanks Tex,
Yes your unique gene expression I'm sure made you look twice when you first learned about it, LOL.
Thanks Gabes,
I'm feeling with this DNA info comes brand new or virgin analysis of many things and I am starting to notice Gluten, Inflammation, or Microscopic Colitis is in the very young infant stages of discovery. When they start to discover more about the HLA gene perhaps we will understand more, but until that time comes it is trial and error. (Big Sigh) Don't get me wrong, there is still plenty to ponder when doing the DNA test, just not enough in the area that I want more answers....LOL, as I am sure everyone else that does it wishes the same thing too.
I will poke around with more of the reports in Livewello.
Hugs
E
To Succeed you have to Believe in something with such a passion that it becomes a Reality - Anita Roddick
Dx LC April 2012 had symptoms since Aug 2007
My experience is (i have had my DNA results for 14 months) and what I have read and researched over the past 12 months or so, there is no exact science or proven process regarding the root causes of health issues. There is such a complex matrix of things that;
a) 'contribute' to an illness starting,
b) impacts/factors to make it chronic and
c) cause ongoing issues/symptoms despite years of 'best effort' to heal and get well
The various impacts that can affect health vary from town to city, state to state, country to country.
Just today I read an article (that is the starting point for more research and wider reasearch) is that 'WiFied' society is making mold growth worse. WiFi networks permanently on in homes, workplaces, along with multiple mobile phones, digital radios etc
people having major illness due to mold (or multiple conditions linked to mold) was rar-ish 15 years ago - whereas now, it is more common (and is one of the suspected links as to why people may get sick from Lyme)
without getting too full on
although there are some elements of the factors of you in America and Me in Australia getting the same illness (whether that be genetics, medications, gut issues during childhood etc) there are many other factors that will be way different between our locations and lifestyles etc.
IMO the studies that do look at genetic SNP's and linkage to illness and root causes, unless it is done across multiple countries and noting key differences between participants of different countries then the results have limited scope of application.
Long story short - I dont believe we will get all the answers in our lifetime... ( i dont mean to sound morbid, just being realistic)
like our lives with MC and blind faith, we have to live with minimal expectations and be at peace that we may not ever get all the answers...
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Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
I agree Gabes... lots of info yet to be found out in the DNA world.
It has helped me to understand that most of my colitis issues have stemmed from my Danish side of the family and I'm pretty sure those genetics have travelled from Northwestern Europe for a while in my family for me to get such a grand amount of them predisposed in my genetic makeup. Yay me!
To Succeed you have to Believe in something with such a passion that it becomes a Reality - Anita Roddick
Dx LC April 2012 had symptoms since Aug 2007
