Allegra or Claritin Red-tabs are not "doing the job" for me. Still having an issue with stuffiness and lots of WD, despite a very restricted diet. Has anyone had experience
with adding a DAO enzyme, ie hesperidin or diosmin or other to get the histamines under control? I'm concerned about the rapid heartbeat 60 minutes after eating. From the website reading it seems as though it must be mast cells degranulating.
I would greatly appreciate any input, thanks.
Christina
Using DAO enzymes in addition to antihistamines
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christinafriberg
- Adélie Penguin
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- Joined: Tue Dec 29, 2015 12:13 pm
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Christina,
In theory, DAO supplements should be beneficial, but to date at least, I'm not aware of anyone who has tried a DAO supplement and been able to tell that it was helpful. However, most members here who have tried a supplement were trying to control their MC symptoms, not reduce other physiological (classic allergic response) effects of histamine. It's possible that you might be able to see some benefits though, since you would be able to tell almost immediately if it reduced your tachycardia symptoms after eating.
But if you want to prevent mast cells from degranulating, that is an entirely different process from purging excess histamine from the body (DAO supplements help to purge excess histamine from the body). Currently, the most popular product for stabilizing mast cells (preventing them from degranulating) is cromolyn sodium, but apparently it's very expensive. Here's a link to a recent research article that discusses such products:
Twenty-first century mast cell stabilizers
It's normal for one's heart rate to increase after a meal. However, such increases should be limited to roughly the 10–20 % range or so. If you are noticing significant tachycardia soon after a meal, you may be having either a classic allergic reaction (including anaphylaxis), or you may have a form of mastocytosis. But unfortunately, I'm not aware of any physicians in the PNW who are qualified to treat mast cell issues, especially when they are associated with MC. Most of those specialists are located in the NE, because most of them were trained under the supervision of Dr. Maria Castells at the Brigham and Women's Hospital in Boston. But maybe your PCP is aware of someone in your area qualified to diagnose and treat mast cell issues.
This issue has come up before (post prandial tachycardia). You might be interested in the thread at the following link:
Increased heart rate after eating
IOW, you might try an H2 antihistamine rather than an H1 antihistamine, to see if it may be more effective. But be aware that this discussion took place before we realized how common mast cell issues seem to be associated with MC.
Tex
In theory, DAO supplements should be beneficial, but to date at least, I'm not aware of anyone who has tried a DAO supplement and been able to tell that it was helpful. However, most members here who have tried a supplement were trying to control their MC symptoms, not reduce other physiological (classic allergic response) effects of histamine. It's possible that you might be able to see some benefits though, since you would be able to tell almost immediately if it reduced your tachycardia symptoms after eating.
But if you want to prevent mast cells from degranulating, that is an entirely different process from purging excess histamine from the body (DAO supplements help to purge excess histamine from the body). Currently, the most popular product for stabilizing mast cells (preventing them from degranulating) is cromolyn sodium, but apparently it's very expensive. Here's a link to a recent research article that discusses such products:
Twenty-first century mast cell stabilizers
It's normal for one's heart rate to increase after a meal. However, such increases should be limited to roughly the 10–20 % range or so. If you are noticing significant tachycardia soon after a meal, you may be having either a classic allergic reaction (including anaphylaxis), or you may have a form of mastocytosis. But unfortunately, I'm not aware of any physicians in the PNW who are qualified to treat mast cell issues, especially when they are associated with MC. Most of those specialists are located in the NE, because most of them were trained under the supervision of Dr. Maria Castells at the Brigham and Women's Hospital in Boston. But maybe your PCP is aware of someone in your area qualified to diagnose and treat mast cell issues.
This issue has come up before (post prandial tachycardia). You might be interested in the thread at the following link:
Increased heart rate after eating
IOW, you might try an H2 antihistamine rather than an H1 antihistamine, to see if it may be more effective. But be aware that this discussion took place before we realized how common mast cell issues seem to be associated with MC.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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christinafriberg
- Adélie Penguin
- Posts: 84
- Joined: Tue Dec 29, 2015 12:13 pm
- Location: oregon
Christina,
You're right of course that not everyone can tolerate the H2 antihistamines at certain times. But the receptors in the stomach are type H2, so that's why an H2 antihistamine should be the most effective there. Histamine is used as a messenger to activate the H2 receptors to prompt the parietal cells to produce more gastric acid. Sometimes there can be more histamine than is needed. And yes it's quite a challenge because as you pointed out, so much of it tends to be trial and error.
You're very welcome. I hope it helps.
Tex
You're right of course that not everyone can tolerate the H2 antihistamines at certain times. But the receptors in the stomach are type H2, so that's why an H2 antihistamine should be the most effective there. Histamine is used as a messenger to activate the H2 receptors to prompt the parietal cells to produce more gastric acid. Sometimes there can be more histamine than is needed. And yes it's quite a challenge because as you pointed out, so much of it tends to be trial and error.
You're very welcome. I hope it helps.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
I'm trying the L-methionine right now myself. Taking 500 mg daily, been about 2 weeks so far. I've yet to notice any difference but it may take longer, going to stick to it. I've had a lot of gas and D, even with my safe foods. I've attributed it to the pollen overtaking my area right now, maybe you could try that too.
Martha E.
Philippians 4:13
Jul 2008 took Clindamycin for a Sinus infection that forever changed my life
Dec 2014 MC Dx
Jul 15, 2015 Elimination Diet
Aug 17, 2015 Enterolab Test
Dec 2015 Reflux
Sept 2016 IC
Philippians 4:13
Jul 2008 took Clindamycin for a Sinus infection that forever changed my life
Dec 2014 MC Dx
Jul 15, 2015 Elimination Diet
Aug 17, 2015 Enterolab Test
Dec 2015 Reflux
Sept 2016 IC
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christinafriberg
- Adélie Penguin
- Posts: 84
- Joined: Tue Dec 29, 2015 12:13 pm
- Location: oregon