Hey celia-
What test did you take that said you have genetic marker for the seronegative spondylarthropies which includes UC and Crohns? Was that the stool test for acute/chronic colitis? Do your results mean that you either have crohns or UC? Do you have MC? Do you follow a diet that helps you with your symptoms?
Any suggestions on my GI visit?
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Terps,
It's a blood test for HLA B27. For awhile I thought I had ankylosing spondylitis (a type of arthritis) because I had extreme stiffness in the night and pain in my hips and lower back. I researched it and asked my doctor to do the above blood test since HLA B27 is a marker for AS. Incidentally, I learned that it is also a marker for UC and Crohn's.
But like Tex says, having a marker doesn't necessarily mean you will get the disease. When we found out that the marker is indeed positive, I had a CT scan of the SI joints to determine if there were the charasteristic indications of AS. There aren't so I don't have AS.
Interestingly, a great deal of the stiffness (and it was extreme) disappeared once I stopped eating wheat.
Researching AS turned me on to the London AS (no starch diet) which I tried. Through the diet, I came to realize that starch is one of the main triggers of my symptoms. That includes:
-all grains (even whole grains) and legumes; no pasta, bread...
-all starchy vegetables (potatoes, yams, parsnips, yucca root, etc.)
-all processed foods for the most part.
Sugar is the other big trigger for me, which includes fruit.
Starch is hidden in many things. For example, garlic and onions have a difficult to digest starch called inulin as do bananas. Garlic also has ten different kinds of sugar including glucose. And the skin on a walnut has starch even though the meat doesn't.
Right now my naturopath has me on an anti-inflammation diet. If you are interested, I could email it to you but I would have to ask my husband to scan it. Basically, I eat very simply:
-poultry and deep ocean fish, red meat occassionally
-lower carbohydrate vegetables (nothing raw)
-almonds
You can eat more on the anti inflam diet like a cup of brown rice per day, but I can't tolerate that myself. At the moment I am also only drinking water as even decaf green tea seems to be a problem.
If I stick to the diet, I don't have the vast majority of my symptoms. I never have D or loose stools. It might seem a little radical, but the reality is I can't tolerate the carbohydrates. Matthew is one other person on this site that has this same extreme problem with carbs.
Conventionally speaking, both lactose and cafeine are not recommended for MC. So as a start, you might consider removing those two from your diet and gluten as well. Even if you are not lactose intolerant, dairy products are an irritant for MC.
And yes, I have mild LC, just diagnosed in Jan. I do not have Crohns or UC, even thought I have that marker. I beleive all my progressive diet changes is what has made the LC mild!
Hope that helps! Good luck, Celia
It's a blood test for HLA B27. For awhile I thought I had ankylosing spondylitis (a type of arthritis) because I had extreme stiffness in the night and pain in my hips and lower back. I researched it and asked my doctor to do the above blood test since HLA B27 is a marker for AS. Incidentally, I learned that it is also a marker for UC and Crohn's.
But like Tex says, having a marker doesn't necessarily mean you will get the disease. When we found out that the marker is indeed positive, I had a CT scan of the SI joints to determine if there were the charasteristic indications of AS. There aren't so I don't have AS.
Interestingly, a great deal of the stiffness (and it was extreme) disappeared once I stopped eating wheat.
Researching AS turned me on to the London AS (no starch diet) which I tried. Through the diet, I came to realize that starch is one of the main triggers of my symptoms. That includes:
-all grains (even whole grains) and legumes; no pasta, bread...
-all starchy vegetables (potatoes, yams, parsnips, yucca root, etc.)
-all processed foods for the most part.
Sugar is the other big trigger for me, which includes fruit.
Starch is hidden in many things. For example, garlic and onions have a difficult to digest starch called inulin as do bananas. Garlic also has ten different kinds of sugar including glucose. And the skin on a walnut has starch even though the meat doesn't.
Right now my naturopath has me on an anti-inflammation diet. If you are interested, I could email it to you but I would have to ask my husband to scan it. Basically, I eat very simply:
-poultry and deep ocean fish, red meat occassionally
-lower carbohydrate vegetables (nothing raw)
-almonds
You can eat more on the anti inflam diet like a cup of brown rice per day, but I can't tolerate that myself. At the moment I am also only drinking water as even decaf green tea seems to be a problem.
If I stick to the diet, I don't have the vast majority of my symptoms. I never have D or loose stools. It might seem a little radical, but the reality is I can't tolerate the carbohydrates. Matthew is one other person on this site that has this same extreme problem with carbs.
Conventionally speaking, both lactose and cafeine are not recommended for MC. So as a start, you might consider removing those two from your diet and gluten as well. Even if you are not lactose intolerant, dairy products are an irritant for MC.
And yes, I have mild LC, just diagnosed in Jan. I do not have Crohns or UC, even thought I have that marker. I beleive all my progressive diet changes is what has made the LC mild!
Hope that helps! Good luck, Celia
I beleive in magic!
Celia,
That is interesting as many people we've read about in this group and our old one, have mentioned having seronegative arthritis.
Your genotype just means the one you got from your mama, and the one you got from your papa -- a pair, in other words. For instance, those of us who did the cheek swab with enterolab know whether or not we have HLA CD 2 or HLA CD 8, but we also know which of the other CD genes we have that might also predispose us to M.C. and gluten sensitivity. I happen to have one CD2 from Mom, and one M.C./gs gene from Dad.
Looks to me as though it's almost impossible not to have one of them if one lives in the USA. What sets the autoimmunity in motion is a horse of another color, I'm afraid. This is a multifactorial condition, no doubt.
By the way, your phenotype is the way you turned out, for instance, if your eye color is brown, your genotype could be either two brown genes or it could be one brown and one recessive gene, like blue, for instance. In other words, the brown is dominant over the blue in this case. I'm not sure I know how the dominant/recessive element figures in with our genes, but come to think of it, I can't remember a single person not having both be a "celiac gene" or else one of the other gs/M.C. genes with it, or else two of the gs/M.C. genes.. Anyone want to comment on this?
Interesting about your 27 gene. Have you learned anymore about it besides the fact that the UC and Crohn's is possible with it? Any other non-gut related diseases other than the sero-negative spondyl.?
Yours, Luce
That is interesting as many people we've read about in this group and our old one, have mentioned having seronegative arthritis.
Your genotype just means the one you got from your mama, and the one you got from your papa -- a pair, in other words. For instance, those of us who did the cheek swab with enterolab know whether or not we have HLA CD 2 or HLA CD 8, but we also know which of the other CD genes we have that might also predispose us to M.C. and gluten sensitivity. I happen to have one CD2 from Mom, and one M.C./gs gene from Dad.
Looks to me as though it's almost impossible not to have one of them if one lives in the USA. What sets the autoimmunity in motion is a horse of another color, I'm afraid. This is a multifactorial condition, no doubt.
By the way, your phenotype is the way you turned out, for instance, if your eye color is brown, your genotype could be either two brown genes or it could be one brown and one recessive gene, like blue, for instance. In other words, the brown is dominant over the blue in this case. I'm not sure I know how the dominant/recessive element figures in with our genes, but come to think of it, I can't remember a single person not having both be a "celiac gene" or else one of the other gs/M.C. genes with it, or else two of the gs/M.C. genes.. Anyone want to comment on this?
Interesting about your 27 gene. Have you learned anymore about it besides the fact that the UC and Crohn's is possible with it? Any other non-gut related diseases other than the sero-negative spondyl.?
Yours, Luce
Luce,
Alice, Dee, Polly, and CAMary don't have any celiac genes. CAMary, in fact, has only a single GS gene, and it is non-celiac.
Tex
Alice, Dee, Polly, and CAMary don't have any celiac genes. CAMary, in fact, has only a single GS gene, and it is non-celiac.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Thanks for clarifying that Wayne. I edited that a little, probably after you'd already read it, but I just read it again, and it's still not too clear what I meant to say. Should've just scrubbed it and started over again.
Thanks again for making that clear. I didn't mean that everyone had a "celiac gene", but just meant that I didn't remember anyone not having two that could predispose to gluten sensitivity. Interesting about Mary's ONE gs gene! I hadn't realized that. What was her other one, by the way?
Yours, Luce
Thanks again for making that clear. I didn't mean that everyone had a "celiac gene", but just meant that I didn't remember anyone not having two that could predispose to gluten sensitivity. Interesting about Mary's ONE gs gene! I hadn't realized that. What was her other one, by the way?
Yours, Luce
Yep, I see it has been changed, since I read it.
Mary doesn't have another one--she only has one. In her own words: Well, I only have one- HLA-DQ1 involving DQB1 0501 subtype...
And, she apparently has no food intolerances other than gluten.
Wayne
Mary doesn't have another one--she only has one. In her own words: Well, I only have one- HLA-DQ1 involving DQB1 0501 subtype...
And, she apparently has no food intolerances other than gluten.
Wayne
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.