A couple things here, this is what my DNA says about my VitD ability as far as my genes go:
Vitamin D Insufficiency
rs2282679(A;C)
Magnitude: 1
Frequency: 43.4%
Repute:Bad
References:23
somewhat lower vitamin D levels
DESCRIPTION:
rs2282679, located in the group-specific component (vitamin D binding protein) GC gene on chromosome 4p12, has been linked by several studies to vitamin D serum concentrations. In both studies, the allele associated with lower vitamin D, and thus the potential for vitamin D insufficiency, is rs2282679(C). Carriers of two such alleles have lower vitamin D than carriers of one allele, who in turn on average have lower vitamin D levels than rs2282679(A;A) individuals. A near-perfect proxy (i.e. substitute) for rs2282679 is reported to be rs4588. [GWAS:Vitamin D levels]
And here are the first few genes listed as far as Methylation goes:
Gene & Variation rsID Alleles Result
COMT V158M rs4680 AG +/-
COMT H62H rs4633 CT +/-
COMT P199P rs769224 GG -/-
VDR Bsm rs1544410 TT +/+
VDR Taq rs731236 GG -/-
MAO A R297R rs6323 TT +/+
After reading Tex's VitD book twice now it would appear that I may not have enough VDR receptors to take care of my immune needs.
How do I increase my VDR receptors? What dose of Vit D and how long to get them activated properly?
If a woman's estrogen starts dropping is there another hormone that picks up what it used to do so that adequate VDR receptors are in play?
It appears I didn't start to have my MC symptoms until my estrogen started having wild swings beginning when I was 40 (I have kept a hormone diary for almost 8 years, due to migraines, on again off again monthly cycles). BUT when I tried to give my body a helping hand with bio-identical hormones it whacked it out even more so.....probably due to the soy that I was having reaction to and didn't know it at the time. But I'm betting I probably needed to have a very hefty dose of VitD these last 8 years and didn't know it!
Does this mean that by increasing my VitD3 I might activate nuclear receptors and that may give better expression to more genes to start doing the right thing?
Perhaps a higher VitD level will ultimately up or down regulate some of my genes to help them better perform and therefore the healing in the gut will maintain and I can hope for less flares down the road?
I also looked at my genes and my body does not report having any BIRC5 or Survivin and I would have an increased chance of surviving a bout of meningitis....
In my case would a corticosteroid help to express my VDR's better so that it would enhance the effectiveness of the elevated Vitamin D I am taking? If so what could be a potential dosage for maintenance based on my genes expression showing probable low VDR receptors?
Getting my body to heal, not quickly but proactively, is what I'm trying to gain here with all these questions and I was moved by the information in your book Tex, and I would like to implement what I can if anything at this point.
I have so many questions now that I have read this book twice!
Hugs
Erica
Vitamin D, VDR, Survivin - Tex's book is very insightful
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Vitamin D, VDR, Survivin - Tex's book is very insightful
To Succeed you have to Believe in something with such a passion that it becomes a Reality - Anita Roddick
Dx LC April 2012 had symptoms since Aug 2007
Dx LC April 2012 had symptoms since Aug 2007
-
Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
magnesium!!
in the Magnesium sticky you will find a post that talks about VDR's and magnesium
http://www.perskyfarms.com/phpBB2/viewtopic.php?t=19888 (this one)
(it was that post that started me on the research journey about Magnesium)
It is also the one of the main reasons I mention Magnesium SOOOO Much to new MC'ers..
we need magnesium for the Vit D to be used properly!
in the Magnesium sticky you will find a post that talks about VDR's and magnesium
http://www.perskyfarms.com/phpBB2/viewtopic.php?t=19888 (this one)
(it was that post that started me on the research journey about Magnesium)
It is also the one of the main reasons I mention Magnesium SOOOO Much to new MC'ers..
we need magnesium for the Vit D to be used properly!
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Erica,
As far as I can tell, no one really knows how to increase the expression of vitamin D receptors. If I were going to try budesonide I would try 3 mg to see if it makes a noticeable difference. But you have to have adequate vitamin D available and you have to be able to convert it into the active form in order to see results. The active form (if I recall correctly) is about 10,000 times more potent than the inactive form.
What's your current vitamin D level?
Tex
As far as I can tell, no one really knows how to increase the expression of vitamin D receptors. If I were going to try budesonide I would try 3 mg to see if it makes a noticeable difference. But you have to have adequate vitamin D available and you have to be able to convert it into the active form in order to see results. The active form (if I recall correctly) is about 10,000 times more potent than the inactive form.
What's your current vitamin D level?
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
over lunch I also had the lightbulb moment.. Zinc and B6
Zinc and B6 are linked to estrogen stuff - cell health etc..
The high copper would be impacting effective zinc usage in your cells...
(also - if you have any other excess metals like Lead, Cadmium, Mercury etc they would be impacting Zinc, B6 and magnesium usage)
Zinc and B6 are linked to estrogen stuff - cell health etc..
The high copper would be impacting effective zinc usage in your cells...
(also - if you have any other excess metals like Lead, Cadmium, Mercury etc they would be impacting Zinc, B6 and magnesium usage)
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
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Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
This article may help:
https://selfhacked.com/2016/01/13/natur ... xpression/
Natural Ways to Increase Calcitrol and Vitamin D Receptor Gene Expression
Exercise (R)- increases calcitriol, but not aerobic exercise (R).
RXR ( and retinol) is needed to produce proteins with the VDR (R). 1,25D3 binds to the VDR, which then combines with RXR to activate gene expression. (Not all VDR dependent genes need RXR.)
Parathyroid hormone (PTH) – increases Calcitriol/1,25 D3 (R),
PTH-related peptide (R),
SIRT1 -potentiates VDR (R, R2) – acetylation of VDR lessens 1,25D/VDR signaling. SIRT1 increased the ability of VDR to associate with RXR.
PGC-1a (R) – potentiates VDR. It is a coactivator of the VDR, but it still needs 1,25D3.
Dopamine (R) –Mucuna (AMZN) or Mucuna (IHERB)
Bile – specifically Lithocholic acid or LCA (R),
The VDR evolved from its ancient role as a detoxification nuclear receptor. LCA is produced from the gut bacteria (metabolizing liver derived chenodeoxycholic acid). LCA travels to the colon, where the VDR binds to LCA or 1,25 D and activates the CYP3A4 and SULT2A genes facilitates disposal from the cell via the ABC efflux transporter (R).
Omega-3:DHA, EPA (R), – Fish oil/DHA (AMZN) or Fish Oil/DHA (IHERB)
Omega-6:Linolenic acid, Arachidonic acid (R),
Curcumin (R) – Curcumin is more active than LCA/Bile in driving VDR-mediated
transcription and that it binds to VDR with approximately the same affinity as LCA.
Resveratrol (R) – Potentiates VDR by: (1) potentiating 1,25D binding to VDR; (2) activating RXR; (3) stimulating SIRT1.
Forskolin (AMZN) (95%) or Forskolin (IHERB) (R), – increases 1,25D3 from 25D3 in-vitro.
Gamma Tocotrienol (R)- Tocotrienols or Tocopherols (IHERB)
Vitamin E/alpha-tocopherol (R)- doesn’t compete with calcitriol for the VDR.
Dexamethasone (R) – doesn’t compete with 1,25
Interferon gamma -IFN-γ treatment inhibited 1,25D3 induction of 24-hydroxylase, the enzyme that breaks down 1,25 D3. This means 1,25D3 increased. (Technical: IFNy did not change the base level activity of the promoter, or change 1,25D binding to the VDR or nuclear VDR levels. IFN-γ impairs VDR-RXR binding to VDRE through a Stat1-mediated mechanism) (R),
Estradiol – increases VDR expression (R, R2),
Phytoestrogens (R),
Testosterone (R),
Prostaglandins (R),
Bisphosphonates (R),
DHA, EPA, linoleic acid and arachidonic acid are all 10,000X less capable than 1,25 D3 at activating the VDR (R).
Curcumin is 1,000X less capable than 1,25 D3 in inducing VDR gene expression (R).
Curcumin and bile have similar binding ability to the VDR and similar levels of gene expression (R).
Curcumin, Bile, DHA, EPA, Arachidonic acid all compete with 1,25 D3 for binding. Dexamethasone and alpha-tocopherol don’t compete (R).
A natural question to pose would be that if these are competitive binders and have much lower binding capacity for the VDR, are they of use? The answer seems to be yes.
High concentrations of PUFAs could occur in select cells or tissues and exert bioactivity (R).
Excess Bile/LCA given to rats caused the same effect that 1,25D3 would cause (in particular calcium transport activation) (R).
Kidney glandular might contain some 1,25 vitamin D.
What Inhibits The Vitamin D Receptor (VDR) or Calcitriol
Caffeine decreases VDR production (R),
Cortisol/Glucocorticoids decreases VDR production (R),
Prolactin (R),
Thyroid hormones repress VDR activation (R),
TGF-beta reduces the activation of VDR/RXR combination, which results in VDR-mediated gene expression (R).
TNF (R) (inhibits osteocalcin interaction with VDR, but not osteopontin)
Corticosteroids decrease calcitriol (R),
Phosphatonin, Ketoconazole, Heparin and Thiazides decrease calcitriol (R).
Ubiquitin (R) – autophagy stops this
Pathogens That Inhibit The Vitamin D Receptor
Many pathogens inhibit some aspect of the vitamin D system – either the VDR, the ability of molecules to bind to it or the ability of VDR to cause gene expression.
These are some examples, but I’m sure I haven’t covered all of them known to the body of science.
P. aeruginosa (often hospital acquired). Produces “Sulfonolipid ligand capnine.”(R) Antibiotics don’t work well (R).
H. pylori (responsible for stomach ulcers). 50% of the global population has this. Produces “Sulfonolipid ligand capnine.”(R)
Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes) and “dead” Borrelia reduces it by 8 times (R) – This could explain why people develop autoimmune conditions after lyme infection.
Tuberculosis – Reduces VDR 3.3-fold. (R)
“Gliding” biofilm bacteria have been shown to create Capnine – Capnine (Cytophaga, Capnocytophaga, Sporocytophaga, and Flexibacter)
Chlamydia (trachomatis)
Shigella – bacteria in stool and causes intestinal problems and diarrhea. It increases Caspase-3, which is protein which breaks apart the VDR structure and thus limits the ability of VDR to perform gene transcription. (R)
Mycobacterium leprase – produces mir-21 to target multiple genes associated with the VDR. (R)
Epstein-Barr virus (EBV) – Decreases VDR by a factor of about five (R) EBV also blocks the ability of VDR to produce products. (R)
HIV – binds to the VDR (R) and inhibits conversion to active D (R)
Aspergillus fumigatus – In cystic fibrosis patients, the fungus A. fumigatus has been shown to secrete gliotoxin, a toxin which dose-dependently decreases VDR.
Cytomegalovirus – CMV decreases VDR 2.2 fold. (R)
Hepatitis C virus – Inhibits CYP24A1, the enzyme responsible for breaking down excess 1,25-D. (R)
https://selfhacked.com/2016/01/13/natur ... xpression/
Natural Ways to Increase Calcitrol and Vitamin D Receptor Gene Expression
Exercise (R)- increases calcitriol, but not aerobic exercise (R).
RXR ( and retinol) is needed to produce proteins with the VDR (R). 1,25D3 binds to the VDR, which then combines with RXR to activate gene expression. (Not all VDR dependent genes need RXR.)
Parathyroid hormone (PTH) – increases Calcitriol/1,25 D3 (R),
PTH-related peptide (R),
SIRT1 -potentiates VDR (R, R2) – acetylation of VDR lessens 1,25D/VDR signaling. SIRT1 increased the ability of VDR to associate with RXR.
PGC-1a (R) – potentiates VDR. It is a coactivator of the VDR, but it still needs 1,25D3.
Dopamine (R) –Mucuna (AMZN) or Mucuna (IHERB)
Bile – specifically Lithocholic acid or LCA (R),
The VDR evolved from its ancient role as a detoxification nuclear receptor. LCA is produced from the gut bacteria (metabolizing liver derived chenodeoxycholic acid). LCA travels to the colon, where the VDR binds to LCA or 1,25 D and activates the CYP3A4 and SULT2A genes facilitates disposal from the cell via the ABC efflux transporter (R).
Omega-3:DHA, EPA (R), – Fish oil/DHA (AMZN) or Fish Oil/DHA (IHERB)
Omega-6:Linolenic acid, Arachidonic acid (R),
Curcumin (R) – Curcumin is more active than LCA/Bile in driving VDR-mediated
transcription and that it binds to VDR with approximately the same affinity as LCA.
Resveratrol (R) – Potentiates VDR by: (1) potentiating 1,25D binding to VDR; (2) activating RXR; (3) stimulating SIRT1.
Forskolin (AMZN) (95%) or Forskolin (IHERB) (R), – increases 1,25D3 from 25D3 in-vitro.
Gamma Tocotrienol (R)- Tocotrienols or Tocopherols (IHERB)
Vitamin E/alpha-tocopherol (R)- doesn’t compete with calcitriol for the VDR.
Dexamethasone (R) – doesn’t compete with 1,25
Interferon gamma -IFN-γ treatment inhibited 1,25D3 induction of 24-hydroxylase, the enzyme that breaks down 1,25 D3. This means 1,25D3 increased. (Technical: IFNy did not change the base level activity of the promoter, or change 1,25D binding to the VDR or nuclear VDR levels. IFN-γ impairs VDR-RXR binding to VDRE through a Stat1-mediated mechanism) (R),
Estradiol – increases VDR expression (R, R2),
Phytoestrogens (R),
Testosterone (R),
Prostaglandins (R),
Bisphosphonates (R),
DHA, EPA, linoleic acid and arachidonic acid are all 10,000X less capable than 1,25 D3 at activating the VDR (R).
Curcumin is 1,000X less capable than 1,25 D3 in inducing VDR gene expression (R).
Curcumin and bile have similar binding ability to the VDR and similar levels of gene expression (R).
Curcumin, Bile, DHA, EPA, Arachidonic acid all compete with 1,25 D3 for binding. Dexamethasone and alpha-tocopherol don’t compete (R).
A natural question to pose would be that if these are competitive binders and have much lower binding capacity for the VDR, are they of use? The answer seems to be yes.
High concentrations of PUFAs could occur in select cells or tissues and exert bioactivity (R).
Excess Bile/LCA given to rats caused the same effect that 1,25D3 would cause (in particular calcium transport activation) (R).
Kidney glandular might contain some 1,25 vitamin D.
What Inhibits The Vitamin D Receptor (VDR) or Calcitriol
Caffeine decreases VDR production (R),
Cortisol/Glucocorticoids decreases VDR production (R),
Prolactin (R),
Thyroid hormones repress VDR activation (R),
TGF-beta reduces the activation of VDR/RXR combination, which results in VDR-mediated gene expression (R).
TNF (R) (inhibits osteocalcin interaction with VDR, but not osteopontin)
Corticosteroids decrease calcitriol (R),
Phosphatonin, Ketoconazole, Heparin and Thiazides decrease calcitriol (R).
Ubiquitin (R) – autophagy stops this
Pathogens That Inhibit The Vitamin D Receptor
Many pathogens inhibit some aspect of the vitamin D system – either the VDR, the ability of molecules to bind to it or the ability of VDR to cause gene expression.
These are some examples, but I’m sure I haven’t covered all of them known to the body of science.
P. aeruginosa (often hospital acquired). Produces “Sulfonolipid ligand capnine.”(R) Antibiotics don’t work well (R).
H. pylori (responsible for stomach ulcers). 50% of the global population has this. Produces “Sulfonolipid ligand capnine.”(R)
Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes) and “dead” Borrelia reduces it by 8 times (R) – This could explain why people develop autoimmune conditions after lyme infection.
Tuberculosis – Reduces VDR 3.3-fold. (R)
“Gliding” biofilm bacteria have been shown to create Capnine – Capnine (Cytophaga, Capnocytophaga, Sporocytophaga, and Flexibacter)
Chlamydia (trachomatis)
Shigella – bacteria in stool and causes intestinal problems and diarrhea. It increases Caspase-3, which is protein which breaks apart the VDR structure and thus limits the ability of VDR to perform gene transcription. (R)
Mycobacterium leprase – produces mir-21 to target multiple genes associated with the VDR. (R)
Epstein-Barr virus (EBV) – Decreases VDR by a factor of about five (R) EBV also blocks the ability of VDR to produce products. (R)
HIV – binds to the VDR (R) and inhibits conversion to active D (R)
Aspergillus fumigatus – In cystic fibrosis patients, the fungus A. fumigatus has been shown to secrete gliotoxin, a toxin which dose-dependently decreases VDR.
Cytomegalovirus – CMV decreases VDR 2.2 fold. (R)
Hepatitis C virus – Inhibits CYP24A1, the enzyme responsible for breaking down excess 1,25-D. (R)
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
-
Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
Study (on rats) about zinc deficiency and the VDR
http://www.ncbi.nlm.nih.gov/pubmed/16623997
CONCLUSIONS:
Zinc deficiency, by changing the activity of VDR, changes the protein expression of VDR, and thus affects the transcription of the target gene CaBP, resulting in the absorption of calcium that causes allo-osteogenesis.
http://www.ncbi.nlm.nih.gov/pubmed/16623997
CONCLUSIONS:
Zinc deficiency, by changing the activity of VDR, changes the protein expression of VDR, and thus affects the transcription of the target gene CaBP, resulting in the absorption of calcium that causes allo-osteogenesis.
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Tex my Vit D is 45 only up 2 from last year at this time.What's your current vitamin D level?
Wow Gabes,
Some of the natural ways would be ideal to increase VDR's. It's a catch 22 finding the right combo in that list, exercise, VitE, and of course Estriadiol!! That pesky hormone that I am starting to become more depleted in as time marches on.
I don't think I have to worry about the pathogens, after having been tested well in that area last year, that is very impressive and interesting info. I will keep pondering over it more.
The inhibitors of the VDR I suppose could be looked at a bit more, but I'm not ingesting a lot of caffeine in my diet and I'm not currently on any medication.
I seem to have a good report with Budesonide as far as my genes go...as far as inhaling it perhaps not so good and I don't have asthma, but the response to in in general looks like it could have potential for me. Of course I would need good levels of VitD and continue to maintain good or better levels while on it, even at a low dose.
Budesonide
rs37973(A;G)
Magnitude: 1.8
Frequency: 56.2%
Repute:Bad
References:3
Among asthmatics, 1.5x more likely to show less response to inhaled glucocorticoids
rs2240017(G;G)
Magnitude: 0
Frequency: 100.0%
Repute:Good
References:2
ambig
common
(hide)
This SNP encodes a variation in the 33rd amino acid of the protein encoded by the TBX21 gene. Although 95% or so of all Caucasians carry two copies of the rs2240017(G) allele, as oriented in dbSNP orientation, and are thus rs2240017(G;G) homozygotes, a few individuals are rs2240017(C;G) heterozygotes. These heterozgotes are reported to improve better over time in response to corticosteroid treatment for asthma than the rs2240017(G;G) homozygotes. So far, studies have not linked, however, this SNP to any change in the overall risk of asthma itself. Although the effect observed was strong, in that treating rs2240017(C;G) heterozygotes ultimately (over 4 years) yields average airway responsiveness in the normal range (i.e. in the same range as for nonasthmatics), the authors point out that th...
I've not gotten completely back on track as I was before March came along and the change in weather sparked environment changes. This set back has my mind in a spin about how to deal with it. I've done everything including backing off all foods, stopping supplements eating as bland as possible and I can't pinpoint what my deal is. I haven't even done anything new as far as soap, or makeup...nothing. If I'm a chronic stress person then I may not ever get myself in check, I know this part is up to me. I must not deal very well with daily issues anymore. I used to be able to conquer everything in my path...now I sidestep around lots of stuff.
I took to this new information with great passion, because it is natural, doable and not unrealistic to obtain I am hoping.
What's been the consensus with others when a flare just can't seem to be figured out? I get to travel in 2 days, and I'm not in the least bit excited about it, as I was a couple months ago. Pepto doesn't even seem to kick in very well either it takes care of stomach ailments but not the on again off again WD. Imodium does absolutely zero for me too.
I know I'm in a tough spot, and there is probably not a whole lot anyone can say that will get my body back from the brink of WD land in a timely manner, but I'm always open for suggestions as my brain is just about dead coming up with my own ideas for now.
Hugs
Erica
To Succeed you have to Believe in something with such a passion that it becomes a Reality - Anita Roddick
Dx LC April 2012 had symptoms since Aug 2007
Dx LC April 2012 had symptoms since Aug 2007
-
Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
Erica
as we have discussed - with no easy affordable testing to ascertain these issues, it tends to be a bit of trial and error...
we have to look at our biggest risk based on our lives to this point - if you are confident that pathogens and virus are not the issue, and you dont think there are any high risk inhibitors, my suggestion is O3, O6, soy free Vit E, the zinc to help balance the hormones.
Keep in mind that resolving these issues takes time months not weeks..
the body focusses on healing first, then cell rebuild.
in finding these articles, and reading their content, it reminded me that blocking acid reduces VDR...
another long term impact of PPI's etc.
as we have discussed - with no easy affordable testing to ascertain these issues, it tends to be a bit of trial and error...
we have to look at our biggest risk based on our lives to this point - if you are confident that pathogens and virus are not the issue, and you dont think there are any high risk inhibitors, my suggestion is O3, O6, soy free Vit E, the zinc to help balance the hormones.
Keep in mind that resolving these issues takes time months not weeks..
the body focusses on healing first, then cell rebuild.
in finding these articles, and reading their content, it reminded me that blocking acid reduces VDR...
another long term impact of PPI's etc.
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Thanks Gabes, I know you are right of course 
what is the O3 and O6, are those B-vits?
I am only one year into this healing business...and I know it may take up to 5 years to get good complete healing...just so much life to live and too many obstacles with this MC that get in the way. It makes it kinda hard to say no to doing certain things that one would really like to be doing instead of rearranging outings based on bathroom stops along the way.
what is the O3 and O6, are those B-vits?I am only one year into this healing business...and I know it may take up to 5 years to get good complete healing...just so much life to live and too many obstacles with this MC that get in the way. It makes it kinda hard to say no to doing certain things that one would really like to be doing instead of rearranging outings based on bathroom stops along the way.
To Succeed you have to Believe in something with such a passion that it becomes a Reality - Anita Roddick
Dx LC April 2012 had symptoms since Aug 2007
Dx LC April 2012 had symptoms since Aug 2007
-
Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
Omega 3, Omega 6
(another reminder why animal protein is important for healing)
There are some MC safe options for this...Omega-3:DHA, EPA (R), – Fish oil/DHA (AMZN) or Fish Oil/DHA (IHERB)
Omega-6:Linolenic acid, Arachidonic acid (R),
(another reminder why animal protein is important for healing)
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Ah-ha....Thank you!
What if my highest intolerances in the meat dept of Enterolab were Tuna and Beef...does this Omega situation get iffy for me then?
What if my highest intolerances in the meat dept of Enterolab were Tuna and Beef...does this Omega situation get iffy for me then?
To Succeed you have to Believe in something with such a passion that it becomes a Reality - Anita Roddick
Dx LC April 2012 had symptoms since Aug 2007
Dx LC April 2012 had symptoms since Aug 2007
Thank you Gabes....my mind has been trying to go in too many directions lately. Of course there are perfectly good other options for O3 and O6 out there...just a bit brain dead last few days.
Had a trip of three days to make sure I was prepared enough to go on, Graduation gift in order, mail taken care of while gone (and it has gotten to the close 100 degree mark in our Pacific Northwest area so was concerned about garden and yard)....it all adds up to reminding myself I am only one person and can only do so much.
On a lighter note, I did OK on the trip....wasn't perfect, but I didn't have any bad road emergencies either. I may have gotten into a bad food situation on the last day but I think I will smooth out in the next couple days on my safer foods now that I am home again. I am still not at the Norman stage yet and it has been a strong week again....maybe with things quieting down for a little while I can get back on track better.
I need to gain ground again as my husband and I are going to a KISS concert 45 miles from where we live middle of July.....I am so excited
We don't hardly ever get to do this kind of thing.
Had a trip of three days to make sure I was prepared enough to go on, Graduation gift in order, mail taken care of while gone (and it has gotten to the close 100 degree mark in our Pacific Northwest area so was concerned about garden and yard)....it all adds up to reminding myself I am only one person and can only do so much.
On a lighter note, I did OK on the trip....wasn't perfect, but I didn't have any bad road emergencies either. I may have gotten into a bad food situation on the last day but I think I will smooth out in the next couple days on my safer foods now that I am home again. I am still not at the Norman stage yet and it has been a strong week again....maybe with things quieting down for a little while I can get back on track better.
I need to gain ground again as my husband and I are going to a KISS concert 45 miles from where we live middle of July.....I am so excited
We don't hardly ever get to do this kind of thing.To Succeed you have to Believe in something with such a passion that it becomes a Reality - Anita Roddick
Dx LC April 2012 had symptoms since Aug 2007
Dx LC April 2012 had symptoms since Aug 2007