23 and me / methylation profile

Dhorne2275 · Post by **Dhorne2275** » Sat Jun 11, 2016 5:59 pm

Following is my methylation profile from genetic genie from my 23andme results. I would really appreciate any input on my results. Thanks you guys!

Gene & Variation rsID Alleles Result

COMT V158M rs4680 AG +/-

COMT H62H rs4633 CT +/-

COMT P199P rs769224 GG -/-

VDR Bsm rs1544410 TT +/+

VDR Taq rs731236 GG -/-

MAO-A R297R rs6323 GT +/-

ACAT1-02 rs3741049 AG +/-

MTHFR C677T rs1801133 GG -/-

MTHFR 03 P39P rs2066470 GG -/-

MTHFR A1298C rs1801131 TT -/-

MTR A2756G rs1805087 AA -/-

MTRR A66G rs1801394 GG +/+

MTRR H595Y rs10380 __ no call

MTRR K350A rs162036 AA -/-

MTRR R415T rs2287780 __ no call

MTRR A664A rs1802059 GG -/-

BHMT-02 rs567754 CC -/-

BHMT-04 rs617219 __ no call

BHMT-08 rs651852 CC -/-

AHCY-01 rs819147 TT -/-

AHCY-02 rs819134 __ no call

AHCY-19 rs819171 TT -/-

CBS C699T rs234706 AG +/-

CBS A360A rs1801181 -- no call

Gabes-Apg · Post by **Gabes-Apg** » Sat Jun 11, 2016 6:55 pm

NB: I am no expert, it is only what i have learnt along the way..
this is layperson key points type summary

COMT 158
- critical that homocysteine is not elevated
- limit estrogen supplemenation

your COMT status and VDR Taq status
you are susceptible to iodine and lithium depletion as you detoxify.
best to NOT have quercetin. And do not have a diet high in tyrosine.
may lead to decreased emotional resilience
often leads to decreased pain threshold

Mao - breaks down serotonin - defects in this have been associated with mood and neurological disorders (predisposes to generalised anxiety)
as you are +/_ you have 30-40% reduction in this functionality

ACAT - is involved in cholesterol and energy metabolism. ACAT dysfunction can lead to B12 deficiency
again as you are +/- you are only have 30-40% reduction in functionality.

MTRR - generates methyl B12. Blood B12 levels may be normal but with your +/+ status the methyl B12 will be compromised, methylation will be compromised.

The combo of your MTRR status with COMT status - you may benefit more using the Hydroxy B12 and then later transition to methyl B12

CBS - this is linked to trans-sulfuration pathway. excess sulfur break down products (sulfite and sulfate which stimulate cortisol - fight or flight response) hydrogen sulfide (which produces brain fog) and too much ammonia (which depletes BH4, leading to insufficient dopamine and serotonin production)

molybdenum can help with excess sulfur and following eating plan with decrease in high sulfur foods helps some patients

- the deficiency in BH4 can mean additional free radicals - predisposing you to hypertension and inflammatory disease.
- long term oxidative stress (Free radicals) and inflammation (leaky gut etc) it will impact methylation and compromise the ability to recycle homocysteine back into SAMe.

long term oxidative stress and inflammation leads to accelerated aging.

- if you have too much ammonia, charcoal is a good way to absorb it. (taken at bedtime)
this with magnesium and Vit C will promote normal Gi tract motility (adjust doses to obtain a balance between ammonia neutralisation and proper GI Function) too much magnesium or vitamin C pulls water into the intestines

- your CBS status confirms that P5P (active form of B6) is a better fit for you.

Dhorne2275 · Post by **Dhorne2275** » Sat Jun 11, 2016 7:52 pm

Thank you so much Gabes! You are a wealth of knowledge and I thank you so much for sharing it with me!

So here are my questions:

1) so I should have my homocysteine levels checked?

2) I'm confused about the VDR bsm vs. taq? In currently taking 5000 iu/day. My last level was 64. Do I need to do anything differently now that I have this information?

3) should I be tested for ammonia? Or try the charcoal and see what happens?

I will look into the b12 suggestions and all of your other great advice! Thank you!!!

Gabes-Apg · Post by **Gabes-Apg** » Sat Jun 11, 2016 8:56 pm

you are welcome, and I am not a wealth of knowledge, just know the places to look things up!

1. it might be worth getting homocysteine levels checked - how high or low they are can tell us a bit more

2. VDR Taq is the one linked to needing more it D3 - you have +/+ for VDR BSM
it is the combo of your COMT and VDR Taq that provided indicators regarding iodine and lithium

3. I would do some reading on the ammonia and CBS.

Keep in mind, these results are indicators of 'possible issues' it doesnt mean you have the issue.
listening to your body, and what symptoms you are having is our best indicator of whether it is active or not (does that make sense)

and my experience is that CBS is one of those areas of methylation that has some differing interpretations by the experts.

some starting points for reading
https://metabolichealing.com/metabolic- ... utathione/
http://mthfrsupport.weebly.com/articles ... r-protocol
https://mthfrsupport.com/2013/05/other- ... -protocol/

what i have figured out - alot of what we do for our MC eating plan - minimises the ammonia issues, ie avoiding processed foods and low histamine etc..

Dhorne2275 · Post by **Dhorne2275** » Sun Jun 12, 2016 5:19 am

Well you are certainly priceless to this forum! Thanks again and I will proceed with your suggested readings. I'm still working through the rest of my 23andme results so I will likely be adding more posts for advice! It can be a little overwhelming so I'm taking it slowly.