Aloha - I have a couple of quick questions. 1. What do IGG and IGA levels mean? I just looked at tests I had 1-16. The IGG was 689.0 mg/dl & usual range is 751-1561. IGA is 69.8 when range is 69-309. IGM is 61.5 with range of 48-274. Is there something that I should talk with my GI doc about who ordered the tests?
2. I went to a talk by a GI MD in Honolulu last night sponsored by CCFA. He is in town while in the Army & is very well informed. He stresses treating the inflammation in the colon & for MC mentioned lialda & uceris. He draws the distinction between feeling good and looking at the gut to prove the progress. I have not taken anything other than Xifaxan for a couple of weeks a year ago. I have an eye condition, episcleritis, now which I wonder whether it is tied to the inflammation in my body/gut. This MD (I did not tell him what eye condition I have other than 'red eyes.') wondered if it could be related to deficient vitamins or minerals. Anyway, is there a down side to take lialda or uceris when I am not suffering with D - only getting really tired of having a severely restricted diet for the past 11 months. Thanks in advance for any input!
IGG and meds
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
IGG and meds
LC, strong reaction to cola, squash and D & C Orange #4; moderate reaction to sugar cane, sulfite, sardine, flaxseed, coriander, black-eyed peas and FD & C Blue #1. Enterolab Anti-gliadin IgA 6 units.
IgG, IgA, and IgM are all Immunoglobulins that represent different types of antibody reactions. IgE is the most common and it's associated with the production of histamines and other proinflammatory agents related to upper respiratory system allergies and most skin allergy reactions. IgG is similar to IgE except that it represents longer-term reactions whereas IgE antibodies are produced within a matter of seconds after exposure to an allergen. IgG antibodies usually take days or weeks to show up in quantity.
IgA are the type of reactions associated with MC reactions in the gut and they typically begin to show effects roughly 3–6 hours or longer after a food sensitivity is ingested. IgM antibodies are usually used mostly to detect infections, and they're not usually associated with MC reactions.
Your results are all fine, so there is nothing to be concerned about there. Your doctor checked them to make sure that any celaic screening tests he does on your blood can show valid results. The celiac screening tests (blood tests) used by doctors look for elevated levels of IgA and IgG antibodies as markers of celiac disease. But if a patient's ability to produce normal quantities of IgA and IgG is compromised, then those celiac tests may yield false negative results. Low IgA production is called "selective IgA deficiency". About 1 in 500 people in the general population have selective IgA deficiency. I don't recall the names of the other conditions associated with low immunoglobulin production sydromes, but that's irrelevant to your question, anyway.
Yes, episcleritis is definicely associated with IBDs, as are several other eye conditions caused by inflammation, including uveitis, and more specifically, iritis. Retinal detachment is also a possibility in some cases.
The main problem with taking an anti-inflammatory medication such as Lialda or Uceris when D is absent is the relatively high risk of constipation.
It takes most members here over a year (sometimes 2 years or more) to completely resolve the fatigue problem associated with MC after they adopt a non-inflammatory diet.
You're very welcome,
Tex
IgA are the type of reactions associated with MC reactions in the gut and they typically begin to show effects roughly 3–6 hours or longer after a food sensitivity is ingested. IgM antibodies are usually used mostly to detect infections, and they're not usually associated with MC reactions.
Your results are all fine, so there is nothing to be concerned about there. Your doctor checked them to make sure that any celaic screening tests he does on your blood can show valid results. The celiac screening tests (blood tests) used by doctors look for elevated levels of IgA and IgG antibodies as markers of celiac disease. But if a patient's ability to produce normal quantities of IgA and IgG is compromised, then those celiac tests may yield false negative results. Low IgA production is called "selective IgA deficiency". About 1 in 500 people in the general population have selective IgA deficiency. I don't recall the names of the other conditions associated with low immunoglobulin production sydromes, but that's irrelevant to your question, anyway.
Yes, episcleritis is definicely associated with IBDs, as are several other eye conditions caused by inflammation, including uveitis, and more specifically, iritis. Retinal detachment is also a possibility in some cases.
The main problem with taking an anti-inflammatory medication such as Lialda or Uceris when D is absent is the relatively high risk of constipation.
It takes most members here over a year (sometimes 2 years or more) to completely resolve the fatigue problem associated with MC after they adopt a non-inflammatory diet.
You're very welcome,
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
-
Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
.It takes most members here over a year (sometimes 2 years or more) to completely resolve the fatigue problem associated with MC after they adopt a non-inflammatory diet
agreed, and for a small percentage it can take longer
I am 6+ years post Dx and following my bland low inflammation plan
good wellness only started when I fixed major deficiencies, it has been almost three years of focused supplementation protocol to clear excess toxins, fix methylation cycle and correct nutritional imbalances. the past fortnight I have 'near perfect poop' every day for two weeks, first time in over 20 years.
in this time it has been lots of 2 steps forward, 1 step back (sometimes 2 steps back), and at times you do question if all the effort is worth it. it is, hang in there, be patient. it is early days for you using the B6 etc.. give it a few months. the body needs time to regenerate healthy cells once it has the right nutrients.
hope this helps
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama