Hello all I hope I find you all well, while awaiting the results of my latest endoscopy which I've been told they will be looking at Mast cell activation syndrome and several other things , I noticed that I was urinating less and had some more pains around my abdomen. I therefore went to hospital to get checked out. The blood tests they done suggested that my kidney function was down, they inserted a catheter and straight away I started passing plenty of water and within hours my kidney function had returned to baseline normal (they kept me in hospital for 3 nights because of it, only got out yesterday) . However simultaneously my pancreas had been playing up with plenty of pale and floaty stools. Whether this is a coincidence I doubted, I'd kind've convinced myself that this was some kind of autoimmune reaction or attack , which possibly explains not just this but everything. However there is a couple of flaws in my plan, firstly the pancreas has never presented itself in a way that it would typically If there had been an AI attack, more seriously though is an issue brought up by several doctors, with autoimmune attacks and dissorders such as Lupus for instance you would have raised inflammatory markers (CRP & ESR) , in my case however the inflammatory markers are if anything on the low side. The mystery therefore deepens.
Last week independently of all else that had happened I'd had my first gastroentorology appointment on the NHS and I'd managed to talk the doctor into doing an IgG4 blood test , the result of which I await. This was just due to my EPI and was before my kidney episode.
Autoimmune conundrum
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
Hi Jim,
It's good to hear that you have some test results coming that should be helpful. There are several clues in your post.
1. mast cell issues
2 urine blockage
3. reduced kidney function indicated by a below-range EGFR result or an elevated creatinine level
4. compromised pancreatic functioning
5. the absence of an increase in the markers of inflammation (CRP, etc.)
I'm beginning to sound like a broken record, but here is why I believe that all of those issues are associated with a chronic magnesium deficiency:
I'm not going to cite all the references here because I'm a bit short of time, but I can cite medical references for all of these if you need them.
1. Magnesium deficiency has been shown to cause mast cell activation issues.
2. This would almost surely be caused by a magnesium deficiency (by causing malfunction of the clinching action of the prostate on the ureter). Magnesium deficiency interferes with the proper functioning of smooth muscle tissue, and can cause it to spasm or contract.
3. As my magnesium deficiency became worse, my EGFR headed south as my creatinine level increased. Increased magnesium intake quickly resolved the problem.
4. Compromised pancreatic functioning is known to be associated with magnesium deficiency.
5. Because the problem is caused by a nutrient deficiency (magnesium), all this can occur without increased inflammation markers.
I hope that some of this is helpful.
Tex
It's good to hear that you have some test results coming that should be helpful. There are several clues in your post.
1. mast cell issues
2 urine blockage
3. reduced kidney function indicated by a below-range EGFR result or an elevated creatinine level
4. compromised pancreatic functioning
5. the absence of an increase in the markers of inflammation (CRP, etc.)
I'm beginning to sound like a broken record, but here is why I believe that all of those issues are associated with a chronic magnesium deficiency:
I'm not going to cite all the references here because I'm a bit short of time, but I can cite medical references for all of these if you need them.
1. Magnesium deficiency has been shown to cause mast cell activation issues.
2. This would almost surely be caused by a magnesium deficiency (by causing malfunction of the clinching action of the prostate on the ureter). Magnesium deficiency interferes with the proper functioning of smooth muscle tissue, and can cause it to spasm or contract.
3. As my magnesium deficiency became worse, my EGFR headed south as my creatinine level increased. Increased magnesium intake quickly resolved the problem.
4. Compromised pancreatic functioning is known to be associated with magnesium deficiency.
5. Because the problem is caused by a nutrient deficiency (magnesium), all this can occur without increased inflammation markers.
I hope that some of this is helpful.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
It's quite strange you should mention magnesium . I'd noticed over a period of a month that my urine became dark or fluorescent at a certain time of the day, it was suggested to me that it may have been a vitamin or mineral I was taking, so I stopped the lot. On top of the D3, Chelated Magnesium and B12 , I was taking bioglan and a multivitamin tablet. It was during this period that I experienced the unusual pains that I'd only experienced at the very beginning of my problem a year ago and also the reduction of urine. I was meaning to restart the magnesium and d3. You may well have a point Tex. Do you think that these two are kidney safe?
Many thanks as usual for your special insights.
Many thanks as usual for your special insights.
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Gabes-Apg
- Emperor Penguin
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- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
Jim
4 years ago I was in similar situation to you. (mast cells, kidney issues etc)
I can reiterate that fixing key deficiencies will minimise these issues.
I would suggest upgrading to a better quality (more absorbable form) of magnesium
the Dr Dean ReMag product is very good. and using topical magnesium
hope this helps
4 years ago I was in similar situation to you. (mast cells, kidney issues etc)
I can reiterate that fixing key deficiencies will minimise these issues.
I would suggest upgrading to a better quality (more absorbable form) of magnesium
the Dr Dean ReMag product is very good. and using topical magnesium
hope this helps
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Jim,
If you know that you have a kidney disease then you have to be careful taking supplemental magnesium because any excess magnesium that you absorb into your bloodstream, but cannot use, has to be eliminated by the kidneys in order to prevent the blood level of magnesium from becoming too high. Normally, extra magnesium in the blood is transported to the cells for storage in case the body needs it in the future when the diet is deficient in magnesium. But a chronic magnesium deficiency can cause insulin resistance and reduced insulin production by the pancreas. Insulin is necessary to transport the extra magnesium in the blood into the cells, so insulin resistance or reduced insulin supply can limit the amount of magnesium that we can move into storage.
IOW, if we have the signs of insulin resistance we may have to start slowly rebuilding the magnesium reserves to allow the pancreas and insulin some time to begin working normally again. But if there are no signs of insulin resistance, and the kidneys are working fine, then we can safely handle up to about twice the RDA for magnesium, provided that we use a form that is absorbed well and we can tolerate that much magnesium (if we take much more than we can absorb, it remains in our intestines and can act as a laxative).
It can be a balancing act at first. Vitamin D should also be taken if we are taking magnesium because magnesium regulates calcium and uses vitamin D to move the calcium into our bones. If we don't take vitamin D, it can become quickly depleted if there is plenty of calcium and magnesium in our diet/blood.
I hope I haven't just confused the issue.
Tex
If you know that you have a kidney disease then you have to be careful taking supplemental magnesium because any excess magnesium that you absorb into your bloodstream, but cannot use, has to be eliminated by the kidneys in order to prevent the blood level of magnesium from becoming too high. Normally, extra magnesium in the blood is transported to the cells for storage in case the body needs it in the future when the diet is deficient in magnesium. But a chronic magnesium deficiency can cause insulin resistance and reduced insulin production by the pancreas. Insulin is necessary to transport the extra magnesium in the blood into the cells, so insulin resistance or reduced insulin supply can limit the amount of magnesium that we can move into storage.
IOW, if we have the signs of insulin resistance we may have to start slowly rebuilding the magnesium reserves to allow the pancreas and insulin some time to begin working normally again. But if there are no signs of insulin resistance, and the kidneys are working fine, then we can safely handle up to about twice the RDA for magnesium, provided that we use a form that is absorbed well and we can tolerate that much magnesium (if we take much more than we can absorb, it remains in our intestines and can act as a laxative).
It can be a balancing act at first. Vitamin D should also be taken if we are taking magnesium because magnesium regulates calcium and uses vitamin D to move the calcium into our bones. If we don't take vitamin D, it can become quickly depleted if there is plenty of calcium and magnesium in our diet/blood.
I hope I haven't just confused the issue.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Hi Gabes hope your well, I'm awaiting my results for mast cell activation syndrome which were done on my recent endoscopy. I will have to look into what is available in the UK. Hope you are keeping well.
Tex I currently have Doctors Best Chelated would you say these are OK for the time being and if so what dose (if I recall correctly these were the ones you were taking some time back.)
Many thanks to both of you
Tex I currently have Doctors Best Chelated would you say these are OK for the time being and if so what dose (if I recall correctly these were the ones you were taking some time back.)
Many thanks to both of you
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Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
Jim
not sure that the mast cell issues CAUSED the kidney or vice versa (no way of knowing) but they are definately linked and each makes the other worse.
to simplify things, and inline with topics we have previously discussed; ongoing inflammation impacts the body, all organs, etc. and this ongoing inflammation depletes key nutrients which exacerbates other health issues and puts pressure on digestion system etc.
the kidney function has been back to normal with three key things
- fixing magnesium deficiency
- balancing mast cell issues (zinc, B6, Vit C, magnesium)
- looking at full methylation cycle requirements. (active B6, active B12 etc)
not sure that the mast cell issues CAUSED the kidney or vice versa (no way of knowing) but they are definately linked and each makes the other worse.
to simplify things, and inline with topics we have previously discussed; ongoing inflammation impacts the body, all organs, etc. and this ongoing inflammation depletes key nutrients which exacerbates other health issues and puts pressure on digestion system etc.
the kidney function has been back to normal with three key things
- fixing magnesium deficiency
- balancing mast cell issues (zinc, B6, Vit C, magnesium)
- looking at full methylation cycle requirements. (active B6, active B12 etc)
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
-
Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
Jim
i was reminded via an article i shared with Martha (crevin) today
the other key thing that helped me was CoQ10 which i still take today
purchasing soy free version of CoQ10 is expensive but definately worth the outlay
https://www.rejuvenation-science.com/n_ ... ilure.html
http://www.lifesourcevitamins.com/kidne ... sku288.htm
i was reminded via an article i shared with Martha (crevin) today
the other key thing that helped me was CoQ10 which i still take today
purchasing soy free version of CoQ10 is expensive but definately worth the outlay
https://www.rejuvenation-science.com/n_ ... ilure.html
http://www.lifesourcevitamins.com/kidne ... sku288.htm
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Gabes I have always been happy to try new vitamins and minerals, do you think that without testing they would be safe to take for the kidney. I've got so many problems , including pancreas but because they are a new experience to me I'm naively I'm bliss with them, however my father had complete renal failure and was on dialysis for about 11 years , this has left a bitter taste in my mouth so to speak and I'm frightened of going the same way. This attitude has made me scared to act one way or another. If you feel that they are kidney safe then your word is good with me.
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Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
not only is CoQ10 safe for kidney they are recommended treatment for kidney issues
did you read the links I provided?
From the first link
did you read the links I provided?
From the first link
the bold highlight was done by me81% Positive Response to Coenzyme Q10 Treatment for Chronic Kidney Failure
Ninety-seven patients (mean age, 48 years) with chronic renal failure (serum creatinine > 5 mg/dl), with a history of declining renal function for at least 12 weeks, were randomly assigned to receive, in double-blind fashion, water-soluble coenzyme Q10 (CoQ10; 60 mg, 3 times per day orally) (Q-Gel) or placebo for 12 weeks.
The 45 patients who were receiving hemodialysis at the start of the study were encouraged to decrease the frequency or stop dialysis if there was an increase in urine output and a decrease in serum creatinine of more than 2 mg/dl. In the patients receiving hemodialysis and CoQ10, the mean serum creatinine concentration decreased from 9.5 to 6.7 mg/dl; mean BUN decreased from 88.2 to 79.8 mg/dl; mean creatinine clearance increased from 40 to 54.9 ml/min; and 24-hour urine output increased from 1,300 to 1,920 ml. Renal function tended to worsen in hemodialysis patients receiving placebo, and the differences in the changes between groups were significant (p < 0.01 to p < 0.001).
Significant improvements in each of these parameters relative to the placebo group were also seen in the non-dialysis patients treated with CoQ10. The number of patients receiving dialysis decreased from 21 to 12 in the CoQ10 group, and remained unchanged at 24 in the placebo group (p < 0.02). Eighty-one percent of the patients receiving CoQ10 had a positive response to treatment.
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
-
Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
doesnt take much google searching to find more articles supporting it
http://www.wellnessresources.com/health ... _pressure/
http://www.allvita.net/kidney.htm
http://onlinelibrary.wiley.com/doi/10.1 ... .12485/pdf
http://www.wellnessresources.com/health ... _pressure/
http://www.allvita.net/kidney.htm
http://onlinelibrary.wiley.com/doi/10.1 ... .12485/pdf
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Jim,
If you have a family history of renal issues, be careful when taking magnesium supplements. The reason is that any magnesium absorbed into the bloodstream but not utilized by the body (or transported to cells for storage) must be removed from circulation by the kidneys (in order to keep the blood level of magnesium in the normal range). If we supplement with way too much magnesium (that is, way more than we can actually use) filtering out the excess magnesium and disposing of it can overwork the kidneys. It's a balancing act because the only time in my life when I had compromised kidney function (and high creatinine levels) was when I was magnesium deficient. IOW, magnesium deficiency can cause kidney disease, but way too much magnesium can overwork the kidneys.
In that situation, taking the RDA for magnesium (400 mg) should be safe, but I would be reluctant to suggest taking twice the RDA, because of the risk of overworking the kidneys for no good reason.
Tex
If you have a family history of renal issues, be careful when taking magnesium supplements. The reason is that any magnesium absorbed into the bloodstream but not utilized by the body (or transported to cells for storage) must be removed from circulation by the kidneys (in order to keep the blood level of magnesium in the normal range). If we supplement with way too much magnesium (that is, way more than we can actually use) filtering out the excess magnesium and disposing of it can overwork the kidneys. It's a balancing act because the only time in my life when I had compromised kidney function (and high creatinine levels) was when I was magnesium deficient. IOW, magnesium deficiency can cause kidney disease, but way too much magnesium can overwork the kidneys.
In that situation, taking the RDA for magnesium (400 mg) should be safe, but I would be reluctant to suggest taking twice the RDA, because of the risk of overworking the kidneys for no good reason.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Nice to see something from someone else in th UK. I have CC and am just coming to the end of the first month of treatment with Budesonide. It has dramatically improved my life but seems to have the effect of giving me cystitis. I have had to give up having a glass of wine as the combination makes me dash to the loo to spend a penny. My GFR just before my diagnosis had gone down to 42. I think that that was because I was so dehydrated. Next week I am to have a gastroscopy to see if I am coeliac as well. I already have RD.