Wayne - Gabes - Help Please

[tex]

Suzy,

From pages 25–26 of Pancreatic Cancer — A Guidebook for Prevention:

But this leads us to the magnesium connection again.
As mentioned in the previous chapter, magnesium deficiency plays an important role in the development of insulin resistance and type 2 diabetes. Researchers have shown that both hypertension and type 2 diabetes involve low intracellular magnesium levels (Takaya, Higashino, & Kobayashi, 2004).26 In the research article cited, Takaya, Higashino, and Kobayashi (2004) concluded that because magnesium is necessary for the proper utilization of glucose, and it's also used for insulin signaling, an intracellular magnesium deficiency may alter glucose availability and contribute to the development of insulin resistance.

Magnesium and insulin are co-dependent.
One cannot function properly without the other. And this is a 2-way street in many regards. Not only does a magnesium deficiency cause insulin resistance in the cells of the body, and reduced insulin production by the pancreas, but there is a reciprocal effect. Insulin is responsible for the transport of nutrients to locations where they can either be immediately utilized or stored for future use. When the availability and effectiveness of insulin is compromised, extra magnesium in the blood cannot be properly stored, so most of it may be wasted, instead (Sircus, 2009).27

This can dramatically increase the odds that diabetes patients may develop a magnesium deficiency. And of course as the magnesium deficiency becomes worse, insulin resistance may increase and insulin production by the pancreas may decline even further.

But even stronger evidence of the association between magnesium deficiency and diabetes has been found by researchers. Research published by Hruby et al. (2014) found that higher magnesium intake reduces the risk of insulin resistance and the risk of progression from a prediabetic condition to diabetes.28 In that study, people who had the highest magnesium intake had only about half the risk (53 %) of metabolic interference or diabetes development compared with those who had the lowest magnesium intake. This information is especially important for those who have been told by their physicians that their blood test results indicate that they are at a stage known as prediabetes.

Here are references 26–28 from that quote:

26. Takaya, J., Higashino, H., & Kobayashi, Y. (2004). Intracellular magnesium and insulin resistance. Magnesium Research, 17(2), 126-136. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/15319146

27. Sircus, M. (2009, December 8). The Insulin Magnesium Story [Web log message]. Retrieved from http://drsircus.com/medicine/magnesium/ ... um-story-2

28. Hruby, A., Meigs, J. B., O’Donnell, C. J., Jacques, P. F., & McKeown, N. M. (2014). Higher Magnesium Intake Reduces Risk of Impaired Glucose and Insulin Metabolism and Progression From Prediabetes to Diabetes in Middle-Aged Americans. Diabetes Care, 37(2), 419-427. Retrieved from http://care.diabetesjournals.org/content/37/2/419

You can download a digital copy of the book free of charge at Smashwords, Barnes&Noble, the Apple Bookstore, and other booksellers. Apple charges 99 cents for a digital download, or $3.85 for a printed copy. Chapter 2 discusses magnesium, and chapter 3 discusses diabetes/insulin resistance.

Tex

[Suzy]

Wow I had no idea magnesium helps insulin. Amazing. Thanks so much.

[tex]

Suzy,

Incidentally, if you're not already taking it, there is some evidence that vitamin K2 is helpful for preventing the progression of insulin resistance. It also works synergistically with vitamin D to improve other health issue outcomes. But don't take vitamin K supplements if you are taking a blood thinner, or if you have a known ischemic stroke risk, because vitamin K enhances clotting.

Beneficial role of vitamin K supplementation on insulin sensitivity, glucose metabolism, and the reduced risk of type 2 diabetes: A review.

What is vitamin K?

I'm not aware of an official RDA for vitamin K, but The National Institutes of Health lists the "Adequate Intake" for vitamin K at 90 mcg (micrograms) for women, 120 mcg for men.

Tex

[Gabes-Apg]

my nutrient text books has RDA as the following;

RDA - 700-1500mcg or 1mcg per kg of weight
for deficiency - 2-20 mg

[Suzy]

Thank you!

[brandy]

Suzy,

K2 is also really good for bone health. It puts the calcium in the bones. (simplistic explanation.)

I've been taking K2-MK7 Doctors Best 45 mcg for 12 months. It is soy free. There is discussion about taking 90 mcg on the Osteo forums. I've never tried the higher dose.

I also have K2 MK-4 in my cupboard, Carlson brand 5mg. I have not tried this yet.

Both versions are discussed on the Osteo forums. The MK-4 version seems to have more studies for bone health behind it. (Japanese studies.)

K-2 is also supposed to help with dental health. Less plaque is deposited on the teeth with K-2 supplementation.

[tex]

RDA - 700-1500mcg or 1mcg per kg of weight

Isn't there something wrong with the "700–1500mcg" part of that statement? At 1 mcg per kg of weight, that would indicate an RDA of 75 mcg for a person weighing 75 kg. That seems correct. But 700–1500 mcg is a mighty big dose, IMO.

Tex

[Suzy]

Is it possible to get enough vitamin K for diet alone? (I feel like I'm taking so many supplements)...