Lou-Ann
Leaky gut is caused by multiple things, gluten is a big offender, as is dairy, sugar, alcohol.
Long story short, ongoing inflammation damages the villi of the gut, this impacts digestion but it also allows the lining of the gut to become 'leaky'. When the gut is leaky, toxins, parasites, etc instead of being passed as waste, can get through these leaks and get into the blood stream.
This is why MC symptoms can be whole of body, with joint pain, foggy brain etc. toxins and particles that should be excreted as waste, end up in our blood stream.
This is also why we talk about protein, good nutrients, and home made bone broth so much.
medications will help to reduce inflammation but don't contribute to the healing process of the gut to the large extent that protein, amino acids, and other goodies in the home made bone broth are proven to do.
This is also why when the MC settles down, people should avoid highly inflammatory items like gluten, sugar, alcohol etc. you may not have a mc reaction but it wil still impact the villi, and leaky gut can occur.
As we age, the bodies ability to heal reduces/slows down....
Hope this helps.
Need to vent
Moderators: Rosie, Stanz, Jean, CAMary, moremuscle, JFR, Dee, xet, Peggy, Matthew, Gabes-Apg, grannyh, Gloria, Mars, starfire, Polly, Joefnh
-
Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
Not really.
It is not really acknowledged by mainstream... comes under the broad group of IBS.
Functional medicine have a test, but mostly the best indicator is listen to your body.
If you have a high trigger item and feel like shite after, you have leaky gut!
It is not really acknowledged by mainstream... comes under the broad group of IBS.
Functional medicine have a test, but mostly the best indicator is listen to your body.
If you have a high trigger item and feel like shite after, you have leaky gut!
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Lou Ann,
To expand on what Gabes posed, here is a more detailed description of how leaky gut develops. The guys in the white coats call leaky gut "increased intestinal permeability". This is taken from pages 4–7 of my next book (but those page numbers may change before I finish the book).
5. Drago, S., El Asmar, R., Di Pierro, M., Grazia, C. M., Tripathi, A., Sapone, A., . . . Fasano, A. (2006). Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scandinavian Journal of Gastroenterology, 41(4), 408–19. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/16635908
6. Fasano, A. (2012). Zonulin, regulation of tight junctions, and autoimmune diseases. Annals of the New York Academy of Sciences, 1258(1), 25–33. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384703/
7. Uhde, M., Ajamian, M., Caio, G., De Giorgio, R., Indart, A., Green, P. H., . . . Alaedini, A. (2016). Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Gut, pii, gutjnl-2016-311964. Retrieved from http://gut.bmj.com/content/early/2016/0 ... 11964.full
Tex
To expand on what Gabes posed, here is a more detailed description of how leaky gut develops. The guys in the white coats call leaky gut "increased intestinal permeability". This is taken from pages 4–7 of my next book (but those page numbers may change before I finish the book).
Here are references 5, 6, and 7 from that quote:In order to be absorbed into the bloodstream, nutrients must be allowed to pass through the inner lining of the intestine.
This lining consists of a single layer of columnar (tall and relatively narrow) cells and it's known as the epithelium. Both the small and large intestine contain an epithelial layer. The epithelium is actually the top of several layers of the intestinal lining known as the mucosa. The second layer is known as the lamina propria, and the third layer is known as the muscularis mucosae. The lamina propria and the muscularis mucosae provide support and resources for the epithelium. For example, the lamina propria contains numerous lymphocytes provided by the immune system to help prevent pathogens from entering the bloodstream.
The epithelium is the critical link in the interface between the food flowing through the digestive system and the rest of the body (via the bloodstream). It's vitally important that the integrity of the epithelial barrier must be maintained because this is where nutrients are allowed to pass into the bloodstream, and this must be done while blocking the passage of pathogens, incompletely digested food, and other foreign items that could cause serious harm if allowed into the bloodstream. The junctions between these epithelial cells are known as the tight junctions and they normally remain tightly closed. As food is digested, and nutrients become available for absorption, the tight junctions open wide enough to allow the passage of nutrients, such as amino acids, without allowing undigested molecules or medium-length peptides to pass through. Peptides are the result of incomplete digestion. They are partially-digested segments of protein molecules, consisting of medium-length strings of amino acids.
But if the tight junctions open too widely, or stay open too long, these peptides and other undesirable contents of the intestine can pass through. This is known as increased intestinal permeability. It's also called leaky gut, and leaky gut is bad news for health in general because it can lead to many miserable symptoms. When leaky gut allows peptides and other foreign matter into the bloodstream, they tend to be transported to various organs and dumped. When they end up in joints they cause arthritic-like inflammation and pain. When they end up in various organs they can cause inflammation that interferes with the proper functioning of those organs.
Gluten is a primary cause of leaky gut.
While food allergies can have other origins, the basic cause of food intolerances can be traced to the fact that gluten causes increased intestinal permeability — for everyone, not just for celiacs (Drago et al., 2006).5 But people who have genes that predispose them to gluten sensitivity tend to experience a greater intestinal permeability problem when exposed to gluten, so they are more likely to develop clinical symptoms, and they are more likely to develop symptoms earlier in life.
Research shows that the opening of the tight junctions is controlled by an enzyme known as zonulin, and certain peptides resulting from the incomplete digestion of gluten and glutelin proteins in wheat, rye, and barley promote the production of zonulin (Fasano, 2012).6 Repeated exposures to these peptides leads to increased production of zonulin. And as the process is repeated over and over again with virtually every meal, the tight junctions tend to open wider and stay open longer, allowing larger particles and an increasing amount of inappropriate material to enter the bloodstream.
And this problem (increased intestinal permeability) exists not only for gluten sensitivity associated with celiac genes, but it's also present with non-celiac gluten sensitivity (Uhde et al., 2016).7 For decades the medical community mistakenly denied the existence of non-celiac gluten sensitivity. But Uhde et al. (2016) proved that even when celiac disease and wheat allergy are ruled out, some patients still show the markers of gluten sensitivity, including increased intestional permeability.
When partially-digested chains of amino acids or other particles that are normally excluded are allowed to pass through into the bloodstream, the immune system immediately recognizes that those invaders shouldn't be there. It marks them for destruction and begins to produce antibodies against them. This primes the immune system so that the next time those peptides appear in the blood, antibody production will be stepped up and an assortment of inflammatory agents will be released in an attempt to destroy the invaders.
With repeated exposures, this leads to a condition where anytime that particular protein is identified within the digestive system, an immune system reaction against it is triggered. And once the production of antibodies is triggered, then that particular protein will always provoke an immune system reaction whenever it is ingested, and a reaction will occur regardless of whether or not leaky gut is present at the time. In other words, once a protein is registered as an antigen by the immune system, a reaction will always be initiated as soon as the immune system identifies the protein, even if digestion of the protein is currently proceeding normally, and the tight junctions are functioning normally.
This is part of the adaptive immune system, the same system that provides immunity to a disease in response to a vaccine. A vaccine prompts the immune system to begin producing antibodies against a specific pathogen so that in the future, any exposure to that pathogen will result in a flood of antibodies that promote the release of additional immune system defense mechanisms designed to destroy the pathogen.
Vaccines work because esposures to antigens of this type are normally discrete events. That is to say, an exposure occurs, the immune system launches an attack and destroys the invading bacteria or virus, and that's the end of it.
But if the antigen is part of the diet, then re-exposure will be a frequent or regular occurrence. That means that the immune system is faced with a never-ending job that it was never designed to have to deal with.
5. Drago, S., El Asmar, R., Di Pierro, M., Grazia, C. M., Tripathi, A., Sapone, A., . . . Fasano, A. (2006). Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scandinavian Journal of Gastroenterology, 41(4), 408–19. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/16635908
6. Fasano, A. (2012). Zonulin, regulation of tight junctions, and autoimmune diseases. Annals of the New York Academy of Sciences, 1258(1), 25–33. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384703/
7. Uhde, M., Ajamian, M., Caio, G., De Giorgio, R., Indart, A., Green, P. H., . . . Alaedini, A. (2016). Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Gut, pii, gutjnl-2016-311964. Retrieved from http://gut.bmj.com/content/early/2016/0 ... 11964.full
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Thanks Gabes and Tex!
The symptoms of leaky gut are sure similar to MC from what I'm reading.....now I'm even more confused...if that's possible lol. I guess either way it comes down to the diet. It suggested to take digestive enzymes, which I've done many times, never seemed to make a difference....and also L-glutamine. Never heard of it. Tex, do you know anything about it ? And congrats on yet another book....kudos to you !!!!!! Never to late to go to med school !!
Lou Ann
The symptoms of leaky gut are sure similar to MC from what I'm reading.....now I'm even more confused...if that's possible lol. I guess either way it comes down to the diet. It suggested to take digestive enzymes, which I've done many times, never seemed to make a difference....and also L-glutamine. Never heard of it. Tex, do you know anything about it ? And congrats on yet another book....kudos to you !!!!!! Never to late to go to med school !!
Lou Ann
Lou Ann,
Everyone who has food sensitivities has leaky gut (not necessarily at all times, but they had to have leaky gut to develop the food sensitivities, and whenever we have an MC flare, we have leaky gut). Leaky gut is the cause of all of the symptoms associated with MC. So yes, leaky gut is very closely associated with MC. It's possible to have leaky gut without having MC, but I doubt that it is possible to have MC without having leaky gut. I hope I haven't further confused the issue.
L-glutamine is used by body builders to help build muscles. In bodybuilding one builds increased strength by overworking muscles until they are damaged. Then when they heal, they are rebuilt to be stronger than they were previously. L-glutamine is claimed to help muscles heal.
Some people believe that this also applies to intestinal damage, since the intestines contain smooth muscle. However, if you look at my post above (and my description of the layers of the intestinal mucosa), you will see that this can only apply to Crohn's disease and UC. Why? Because the smooth muscle in the intestines begins with the muscularis mucosae, which is the third (bottom) layer of the mucosa, and of course there is smooth muscle below that, in the walls of the intestines. With Crohn's disease and UC, damage can occur to all layers of the intestinal walls from the epithelium all the way out to the serosa (the outermost layer). But with MC, intestinal damage only involves the top 2 (innermost) layers, the epithelium and the lamina propria. Neither the epithelium nor the lamina propria contain any muscle tissue. Because of that, I'm skeptical about claims that L-glutamine speeds up intestinal healing for MC patients. If it does, it does so by some unknown mechanism, not by the claims typically attributed to it.
Thanks for the encouragement, but I'm pretty sure that it's too late for me to go to med school.
Tex
Everyone who has food sensitivities has leaky gut (not necessarily at all times, but they had to have leaky gut to develop the food sensitivities, and whenever we have an MC flare, we have leaky gut). Leaky gut is the cause of all of the symptoms associated with MC. So yes, leaky gut is very closely associated with MC. It's possible to have leaky gut without having MC, but I doubt that it is possible to have MC without having leaky gut. I hope I haven't further confused the issue.
L-glutamine is used by body builders to help build muscles. In bodybuilding one builds increased strength by overworking muscles until they are damaged. Then when they heal, they are rebuilt to be stronger than they were previously. L-glutamine is claimed to help muscles heal.
Some people believe that this also applies to intestinal damage, since the intestines contain smooth muscle. However, if you look at my post above (and my description of the layers of the intestinal mucosa), you will see that this can only apply to Crohn's disease and UC. Why? Because the smooth muscle in the intestines begins with the muscularis mucosae, which is the third (bottom) layer of the mucosa, and of course there is smooth muscle below that, in the walls of the intestines. With Crohn's disease and UC, damage can occur to all layers of the intestinal walls from the epithelium all the way out to the serosa (the outermost layer). But with MC, intestinal damage only involves the top 2 (innermost) layers, the epithelium and the lamina propria. Neither the epithelium nor the lamina propria contain any muscle tissue. Because of that, I'm skeptical about claims that L-glutamine speeds up intestinal healing for MC patients. If it does, it does so by some unknown mechanism, not by the claims typically attributed to it.
Thanks for the encouragement, but I'm pretty sure that it's too late for me to go to med school.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Thank you Tex! I will absolutely take your word for it and not waste a dime on that supplement. That's why I appreciate your knowledge...if I didn't have somewhere to go to ask questions I would have a cupboard full of unneeded garbage. The Internet is a great tool, but every website you go to someone's trying to sell you something, and desperate people will try anything!
Lou Ann
Lou Ann
-
Gabes-Apg
- Emperor Penguin
- Posts: 8332
- Joined: Mon Dec 21, 2009 3:12 pm
- Location: Hunter Valley NSW Australia
home made bone broth is one of the best options to heal the gut, it has multiple things that are proven gut healers, it is cheaper than supplements, and better absorbed, as the nutrients are in a readily absorb-able form
the other key thing that helps heal leaky gut (that is not frequently mentioned as people can not make money from it) is fixing dental issues, if you have troublesome teeth (bacteria in root canals or temporary fillings etc) every time you eat or drink these are going into the gut and if you have leaky gut, it makes it harder to heal.
despite years of focussed diet and supps i struggled to heal leaky gut, then I got all my dental issues fixed and viola! great results
the other key thing that helps heal leaky gut (that is not frequently mentioned as people can not make money from it) is fixing dental issues, if you have troublesome teeth (bacteria in root canals or temporary fillings etc) every time you eat or drink these are going into the gut and if you have leaky gut, it makes it harder to heal.
despite years of focussed diet and supps i struggled to heal leaky gut, then I got all my dental issues fixed and viola! great results
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Lou Ann,
You have to remember that what I wrote is just my opinion. A lot of people swear by L-glutamine and consider it to be almost a miracle supplement.
Tex
You have to remember that what I wrote is just my opinion. A lot of people swear by L-glutamine and consider it to be almost a miracle supplement.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Tex-
My mean value of 11 Antigenic foods was 41 units...sorry so long to get back to this. I've been doing real well the past week. Added some mahi mahi into the protein rotation the past few days and seems to be good.
Started Remag and am upping that slowly.
Laine
My mean value of 11 Antigenic foods was 41 units...sorry so long to get back to this. I've been doing real well the past week. Added some mahi mahi into the protein rotation the past few days and seems to be good.
Started Remag and am upping that slowly.
Laine
"Do what you can, with what you have, where you are"-Teddy Roosevelt
Laine,
That's a relatively high result, so be careful with the 2+ and 3 + foods. It's not impossible that you might be able to tolerate one or more of the 2+ foods, but with a score that high, it's very unlikely.
It's nice to see that you're doing so much better. I hope your recovery continues.
Thanks for the update.
Tex
That's a relatively high result, so be careful with the 2+ and 3 + foods. It's not impossible that you might be able to tolerate one or more of the 2+ foods, but with a score that high, it's very unlikely.
It's nice to see that you're doing so much better. I hope your recovery continues.
Thanks for the update.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Tex....
Those 2 and 3's are out...I can cut my diet down to the minimum really and be ok with it. I just cant go back to where I was before..I basically am living on turkey, elk, lamb, overcooked veggies (yellow/green squash, carrots, butternut squash), a banana a day, small serving of apple sauce, some mushed up avocado and root chips.. Have done a little sunflower seed butter.....had been doing the beef/corn (as in chips..) as they were the least reactive but cut them out a few weeks ago too.
Haven't had diarrhea for weeks...have cut down the cholestryamine and have lost the rumbles...still bloaty at times but that is way better. I probably could cut the cholestyramine down further but that scares me and I am pooping daily so I feel like thats good.
Upped the Vit D to 10,000 a week or so ago and have been hitting the magnesium oil/lotion hard. I started ReMag on Tuesday night and am slowly upping that. Have to work all this around the cholestryamine...
I went to the PCP's office Tuesday morning due to elevated heart rate...maybe I'm slow but it took me a while to pick up on this...haven't slept well for a long time and it was really bad recently with the churning guts..but that had settled and then I wasn't sleeping because my heart was just pounding in my chest. I work in a hospital..been taking my vitals during the middle of the day as I'm just sitting charting on computer...blood pressures have been normal at like 112/75 but heart rate at rest 106...so first thing that pops into my head is thyroid issues. They pulled blood (made them do more for thyroid than just TSH), did an EKG which was fine and have referred me for a cardiac monitor which is being sent to me...
So, there we are. I would pay good money to just sleep...really that is the big thing at this point. Guts are going in right direction...Is this all magnesium related? Have read it messes with your sleep if you are deficient..I am working on that..really I am!!
Laine
Those 2 and 3's are out...I can cut my diet down to the minimum really and be ok with it. I just cant go back to where I was before..I basically am living on turkey, elk, lamb, overcooked veggies (yellow/green squash, carrots, butternut squash), a banana a day, small serving of apple sauce, some mushed up avocado and root chips.. Have done a little sunflower seed butter.....had been doing the beef/corn (as in chips..) as they were the least reactive but cut them out a few weeks ago too.
Haven't had diarrhea for weeks...have cut down the cholestryamine and have lost the rumbles...still bloaty at times but that is way better. I probably could cut the cholestyramine down further but that scares me and I am pooping daily so I feel like thats good.
Upped the Vit D to 10,000 a week or so ago and have been hitting the magnesium oil/lotion hard. I started ReMag on Tuesday night and am slowly upping that. Have to work all this around the cholestryamine...
I went to the PCP's office Tuesday morning due to elevated heart rate...maybe I'm slow but it took me a while to pick up on this...haven't slept well for a long time and it was really bad recently with the churning guts..but that had settled and then I wasn't sleeping because my heart was just pounding in my chest. I work in a hospital..been taking my vitals during the middle of the day as I'm just sitting charting on computer...blood pressures have been normal at like 112/75 but heart rate at rest 106...so first thing that pops into my head is thyroid issues. They pulled blood (made them do more for thyroid than just TSH), did an EKG which was fine and have referred me for a cardiac monitor which is being sent to me...
So, there we are. I would pay good money to just sleep...really that is the big thing at this point. Guts are going in right direction...Is this all magnesium related? Have read it messes with your sleep if you are deficient..I am working on that..really I am!!
Laine
"Do what you can, with what you have, where you are"-Teddy Roosevelt