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from all the reading I have done re B6 / P5P - there is only risk of issues with high dose B6 if it is done continually for 12-24 months
and it is over the 100mg per day level
However, chronic administration of 1–6 g oral pyridoxine per day for 12–40 months can cause severe and progressive sensory neuropathy characterized by ataxia (loss of control of bodily movements) [7,29-32]. Symptom severity appears to be dose dependent, and the symptoms usually stop if the patient discontinues the pyridoxine supplements as soon as the neurologic symptoms appear. Other effects of excessive vitamin B6 intakes include painful, disfiguring dermatological lesions; photosensitivity; and gastrointestinal symptoms, such as nausea and heartburn [1,2,29].
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
If we are deficient in vitamin B-2 (riboflavin) we are unable to properly utilize the energy in fats (and other nutrients). Riboflavin is necessary for metabolizing (converting) the energy in protein, fat, and carbs into a form of energy that the body can use - ATP.
B-2 deficiency is not necessarily known (by the medical community) to be common with IBDs, but since it's very common with anorexia and alcoholism, that suggests to me that it may be an overlooked problem. IMO any IBD that's associated with watery diarrhea is certainly a potential cause of B-2 deficiency. I would also point out that fatigue and low energy are very common complaints with MC.
And I note that migraines are somewhat common with MC (they were a major problem for me). Migraines have been shown by recent research to be associated with deficiencies in magnesium, vitamin D, co-enzyme Q10, and vitamin B-2.
The Thorne Methyl Guard Plus contains B-2.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Erica
saw my 'womens health' doctor today and we talked about my supp protocol and we talked about B6 dosage, given it was top of mind based on this conversation today
the 1000mg it talks about is B6 form (not P5P).
She said so long as you are not doing doses above 400mg of either B6 or P5P then there is no concern about neuropathy. doses around the 100mg for the long term, especially if a) we are not absorbing ALL of that dose due to some inflammation and b) and we are using what we are taking due to the histamine levels or in my case the histamine and Pyrrole
the other aspect to usage by the body is hormones, interestingly the RDA is increased for women who are lactating but they don't make mention of usage rates for other hormone events.
hope this helps
Gabes Ryan
"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
Tex, I have a question regarding the Thorne Methyl-Guard Plus. If a person doesn't have methylation issues (or doesn't know), is it safe to take this product since it is more concentrated? I looked at the original Methyl-Guard, but it does not contain B-2.
Funny (but sad) story: I called customer service to inquire about the Methyl-Guard Plus and she told me that B-2 was methycolbalamin and I told her that would be B-12, then she told me B-2 was Niacin and I told her, no that would be B-3......she then paused and came back and said she looked online and that it was Riboflavin. This was the person that was supposed to answer my questions!
I use Dr. Deans ReAline capsules from RNAreset.com. Check it out, It has methylated B's and amino acids. Also methionine which is the precursor to Glutathione. I've had no trouble with it and I do not have methylation issues. Its safe to use, your body will still utilize.....
As long as you don't also take the inactive forms of those vitamins, taking the active forms shouldn't cause any problems, regardless of methylation issues. The main difference is that anyone who has certain methylation problems may not be able to convert adequate amounts of the inactive forms into the active forms that the body needs in order to function properly. Taking megadoses would not be advisable, but taking a minimum dose (1 capsule per day) shouldn't carry any risk of overdosing.
Note that anytime we are taking methylcobalamin (rather than cyanocobalamin) for example, unless we stop taking it about a week before the blood draw (when testing blood B-12 levels), the test results will be high. This is because of a relatively long half-life (about 6 days). If we stop taking it a week before the blood draw, the results should be accurate.
Terre wrote:Funny (but sad) story: I called customer service to inquire about the Methyl-Guard Plus and she told me that B-2 was methycolbalamin and I told her that would be B-12, then she told me B-2 was Niacin and I told her, no that would be B-3......she then paused and came back and said she looked online and that it was Riboflavin. This was the person that was supposed to answer my questions!
Wow! That is sad. They must be desperate for customer service reps. You should have asked her if there was anything else she needed to know while you were still on the line.
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
Erica
saw my 'womens health' doctor today and we talked about my supp protocol and we talked about B6 dosage, given it was top of mind based on this conversation today
the 1000mg it talks about is B6 form (not P5P).
She said so long as you are not doing doses above 400mg of either B6 or P5P then there is no concern about neuropathy. doses around the 100mg for the long term, especially if a) we are not absorbing ALL of that dose due to some inflammation and b) and we are using what we are taking due to the histamine levels or in my case the histamine and Pyrrole
the other aspect to usage by the body is hormones, interestingly the RDA is increased for women who are lactating but they don't make mention of usage rates for other hormone events.
hope this helps
Thanks Gabes....so I think 100mg P5P a day along with everything else I am taking, for a while should help aid me I hope....I did not take an antihistamine today and I think I will hold off a few more days to see if the B6 will be substantial enough, if I need to take a benedryl at night for a few more evenings (since I have remnants of that respiratory flu) I will do that. I am sure my Mag is low due to this virus too.
To Succeed you have to Believe in something with such a passion that it becomes a Reality - Anita Roddick
Dx LC April 2012 had symptoms since Aug 2007
If nothing else works or causes you problems, you can try the multi-vitamin patches. They also have B-vitamin patches. I may be jumping to conclusions but since I've started these, my histamine intolerance seems to be getting better....I'll definitely see in the next month when the pollen covers my yard.
Martha E.
Philippians 4:13
Jul 2008 took Clindamycin for a Sinus infection that forever changed my life
Dec 2014 MC Dx
Jul 15, 2015 Elimination Diet
Aug 17, 2015 Enterolab Test
Dec 2015 Reflux
Sept 2016 IC
I know Vitk2 mk4 was discussed in our forum to help with our bones. I can't find it in the archives. Just need to know what brand is safe. Drs. Best has rosemary extract. Even though it says no soy.
You should have asked her if there was anything else she needed to know while you were still on the line. 
.