My "good" doctor, during my recent physical, suggested that I research butyrate. Anyone familiar? It comes in supplement form.
Here are two sites, one scientific, the other paleo.
Susan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816278/
https://paleoleap.com/butyrate-anti-inflammatory-fat/
Butyrate
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Butyrate and resistant starch
I am new to your forum, but not to lymphocytic colitis or multiple autoimmune diseases. This is my first post, so I hope it is appropriate. If not, let me know.
My belief is to try to heal my body to where it can perform the processes that it was originally designed to do. Butyrate is naturally produced by a healthy microbiome. However, getting that established is not as easy as it sounds. Over several years, I have learned that if you focus on both the prebiotics and probiotics, this can be accomplished with consistency and patience. After a round of antibiotics or other medications manage to terrorize the microbiome, the same routine can quickly reestablish the microbiome. Here are a few articles and some excerpts that have proven beneficial to me. While there are many methods and techniques, my preference is the unmodified potato starch as a prebiotic. This cannot be accomplished by eating a raw potato, because potatoes are an inflammatory food. Also, here is a WARNING: If you start including any prebiotic/resistant starch in your diet, ask your doctor first, and most important start with very small quantities, as it has a potential to give you very explosive gas until your body levels out. Healthy microbacteria/microbiome includes gas production as a bi-product. If you start with a bang and over indulge, you will know it.
Here are some advantages of increasing the butyrate production: http://www.frontiersin.org/files/Articl ... 9-t001.jpg
http://www.sciencedirect.com/science/ar ... 4402001310
PDF: https://www.researchgate.net/profile/Fr ... lution.pdf
In normal cells butyrate has been shown to induce proliferation at the crypt base, enhancing a healthy tissue turnover and maintenance. In inflamed mucosa butyrate stimulates the regeneration of the diseased lining of the gut.
For years we have heard about probiotics and the microbiome to maintain a healthy gut. Probiotics are microorganisms introduced into the body to promote a health microbiome through colonization. Prebiotics on the other hand are the "food ingredients which promote the growth and colonization of the bacteria. Without some form of nutrients or resistant starch, the microorganisms cannot make it through the digestive system to the colon to establish colonies or to balance the nircrobiome. Prebiotics actually feed the bacteria.
Once the colonies get established and healthy, they begin building short-chain fatty acids, which include butyrate. The SCFA are produced by beneficial colonic bacteria (probiotics) that feed on, or ferment prebiotics, which are plant products that contain adequate amounts of dietary fiber.
http://www.fermented-foods.com/resistan ... -prebiotic
On the short term, taking a probiotic supplement is absolutely the best course of action; it targets with precision the condition, it has the fastest results, and it has the least side effects. However, on a long term you would probably want to get rid of the supplements. This means you need to start restoring your natural intestinal microbiota to its original composition and numbers. For some people, this might be impossible, depending on health issues, age, and lifestyle. For those who want to live healthy and to not rely on supplements, the approach is to feed the bacteria in your guts. This is achieved by ensuring a healthy dose of prebiotics in our daily diet.
Prebiotics and Prebiotic Types
Prebiotics are food ingredients, non-digestible, that promote the growth and well being of the intestinal microbiota. They are not digested, hence pass the small intestine intact, and they feed the beneficial bacteria in colon. They are also known as soluble fiber, although not all prebiotics are soluble fiber. More about fiber here
(link is external)
… There are a few types of prebiotics, the most notable ones are inulins, fructo-oligosaccharides, galacto-oligosaccharides and beta glucans. Soluble fiber is the most common name of non-digestible prebiotic sugars. One of the most recent discoveries points to resistant starch as a great prebiotic. There is not enough research to fully understand the relationship between resistant starch and microflora, but there is enough research and anecdotal evidence to point it as one of the most powerful prebiotics.
What Is Resistant Starch
Resistant starch is called so because it is not digested, it resists stomach acids and bile, thus passing the stomach and small intestine unchanged. It is also called indigestible starch in the medical world. It’s also called the third fiber, alongside soluble and insoluble fiber. In many ways, it acts like the soluble fiber, but is also brings some of the benefits of insoluble fiber. On the other hand, the regular starch is very rapidly digested and absorbed, providing our body with a boost of energy in a short time. Resistant starch, because is not digested by our body, does not provide us any energy. The fantastic thing about it is that it feeds gut bacteria, like soluble fiber. Although there is little research in the field, it looks like the prebiotic effects of resistant starch are a little different than other prebiotics. Indigestible starch is very rich in Amylose, which is a polysaccharide that is very hard to digest, because our enzyme cannot break them down in the small intestine. There are four types of resistant starches:
* the type found in legumes, and seeds, RS1
* the type found in some raw foods, such as green bananas and raw potato, RS2
* and resistant starch obtained through cooking and cooling rich-starch foods, (potatoes, rice, and pasta).
* The fourth type is chemically modified starch in order to render it non-digestible.
OK, some of you might think, “another type of fiber, another prebiotic on a long list, what’s so exciting about it, and what’s with all the hype around resistant starches?” That’s what I initially though too. There are a few facts that might change your mind, and convince you that this is huge, and the more prebiotic types we find the better we can improve our health.
This article has many food selections listed about halfway down the page: http://www.fermented-foods.com/resistan ... -prebiotic
https://en.m.wikipedia.org/wiki/Resistant_starch
Resistant starch (RS) is starch, including its degradation products, that escapes from digestionin the small intestine of healthy individuals.[1][2] Resistant starch occurs naturally in foods but is also added to foods by the addition of isolated or manufactured types of resistant starch.[3]
Some types of resistant starch (RS1, RS2 and RS3) are fermented by the large intestinal microbiota, conferring benefits to human health through the production of short-chain fatty acids, increased bacterial mass, and promotion of butyrate-producing bacteria.[4]
Resistant starch in various ways has similar physiologic effect as dietary fiber,[5] which is why it functions as a mild laxative and why consuming it can lead to flatulence at high dose.
If someone is looking for more scientific information, it is out there to find:
http://journal.frontiersin.org/article/ ... 00979/full
https://en.m.wikipedia.org/wiki/Butyrate
http://www.aprifel.com/article-resistan ... 11910.html
My belief is to try to heal my body to where it can perform the processes that it was originally designed to do. Butyrate is naturally produced by a healthy microbiome. However, getting that established is not as easy as it sounds. Over several years, I have learned that if you focus on both the prebiotics and probiotics, this can be accomplished with consistency and patience. After a round of antibiotics or other medications manage to terrorize the microbiome, the same routine can quickly reestablish the microbiome. Here are a few articles and some excerpts that have proven beneficial to me. While there are many methods and techniques, my preference is the unmodified potato starch as a prebiotic. This cannot be accomplished by eating a raw potato, because potatoes are an inflammatory food. Also, here is a WARNING: If you start including any prebiotic/resistant starch in your diet, ask your doctor first, and most important start with very small quantities, as it has a potential to give you very explosive gas until your body levels out. Healthy microbacteria/microbiome includes gas production as a bi-product. If you start with a bang and over indulge, you will know it.
Here are some advantages of increasing the butyrate production: http://www.frontiersin.org/files/Articl ... 9-t001.jpg
http://www.sciencedirect.com/science/ar ... 4402001310
PDF: https://www.researchgate.net/profile/Fr ... lution.pdf
In normal cells butyrate has been shown to induce proliferation at the crypt base, enhancing a healthy tissue turnover and maintenance. In inflamed mucosa butyrate stimulates the regeneration of the diseased lining of the gut.
For years we have heard about probiotics and the microbiome to maintain a healthy gut. Probiotics are microorganisms introduced into the body to promote a health microbiome through colonization. Prebiotics on the other hand are the "food ingredients which promote the growth and colonization of the bacteria. Without some form of nutrients or resistant starch, the microorganisms cannot make it through the digestive system to the colon to establish colonies or to balance the nircrobiome. Prebiotics actually feed the bacteria.
Once the colonies get established and healthy, they begin building short-chain fatty acids, which include butyrate. The SCFA are produced by beneficial colonic bacteria (probiotics) that feed on, or ferment prebiotics, which are plant products that contain adequate amounts of dietary fiber.
http://www.fermented-foods.com/resistan ... -prebiotic
On the short term, taking a probiotic supplement is absolutely the best course of action; it targets with precision the condition, it has the fastest results, and it has the least side effects. However, on a long term you would probably want to get rid of the supplements. This means you need to start restoring your natural intestinal microbiota to its original composition and numbers. For some people, this might be impossible, depending on health issues, age, and lifestyle. For those who want to live healthy and to not rely on supplements, the approach is to feed the bacteria in your guts. This is achieved by ensuring a healthy dose of prebiotics in our daily diet.
Prebiotics and Prebiotic Types
Prebiotics are food ingredients, non-digestible, that promote the growth and well being of the intestinal microbiota. They are not digested, hence pass the small intestine intact, and they feed the beneficial bacteria in colon. They are also known as soluble fiber, although not all prebiotics are soluble fiber. More about fiber here
(link is external)
… There are a few types of prebiotics, the most notable ones are inulins, fructo-oligosaccharides, galacto-oligosaccharides and beta glucans. Soluble fiber is the most common name of non-digestible prebiotic sugars. One of the most recent discoveries points to resistant starch as a great prebiotic. There is not enough research to fully understand the relationship between resistant starch and microflora, but there is enough research and anecdotal evidence to point it as one of the most powerful prebiotics.
What Is Resistant Starch
Resistant starch is called so because it is not digested, it resists stomach acids and bile, thus passing the stomach and small intestine unchanged. It is also called indigestible starch in the medical world. It’s also called the third fiber, alongside soluble and insoluble fiber. In many ways, it acts like the soluble fiber, but is also brings some of the benefits of insoluble fiber. On the other hand, the regular starch is very rapidly digested and absorbed, providing our body with a boost of energy in a short time. Resistant starch, because is not digested by our body, does not provide us any energy. The fantastic thing about it is that it feeds gut bacteria, like soluble fiber. Although there is little research in the field, it looks like the prebiotic effects of resistant starch are a little different than other prebiotics. Indigestible starch is very rich in Amylose, which is a polysaccharide that is very hard to digest, because our enzyme cannot break them down in the small intestine. There are four types of resistant starches:
* the type found in legumes, and seeds, RS1
* the type found in some raw foods, such as green bananas and raw potato, RS2
* and resistant starch obtained through cooking and cooling rich-starch foods, (potatoes, rice, and pasta).
* The fourth type is chemically modified starch in order to render it non-digestible.
OK, some of you might think, “another type of fiber, another prebiotic on a long list, what’s so exciting about it, and what’s with all the hype around resistant starches?” That’s what I initially though too. There are a few facts that might change your mind, and convince you that this is huge, and the more prebiotic types we find the better we can improve our health.
This article has many food selections listed about halfway down the page: http://www.fermented-foods.com/resistan ... -prebiotic
https://en.m.wikipedia.org/wiki/Resistant_starch
Resistant starch (RS) is starch, including its degradation products, that escapes from digestionin the small intestine of healthy individuals.[1][2] Resistant starch occurs naturally in foods but is also added to foods by the addition of isolated or manufactured types of resistant starch.[3]
Some types of resistant starch (RS1, RS2 and RS3) are fermented by the large intestinal microbiota, conferring benefits to human health through the production of short-chain fatty acids, increased bacterial mass, and promotion of butyrate-producing bacteria.[4]
Resistant starch in various ways has similar physiologic effect as dietary fiber,[5] which is why it functions as a mild laxative and why consuming it can lead to flatulence at high dose.
If someone is looking for more scientific information, it is out there to find:
http://journal.frontiersin.org/article/ ... 00979/full
https://en.m.wikipedia.org/wiki/Butyrate
http://www.aprifel.com/article-resistan ... 11910.html
Eternally hopeful and optimistic
Making progress untangling a web of autoimmune disease and illness.
Making progress untangling a web of autoimmune disease and illness.
Butyrate
I have taken 2 tabs of Butyrate a day for 4 months now (pre-LLMC) and find it helps tremendously with inflammation (no more cramping, nauseous stomach.) Also take L-Glutamine powder twice a day with water.
https://www.healthline.com/health/diges ... #overview1
https://www.healthline.com/health/diges ... #overview1
Hi,
As to probiotics. How do we know what kind of good bacteria we lack? There are so many different kinds, and in order to know what I lack, I would have to get my poop analyzed. If such a test exists.
I believe in fermented foods, and trust that my body knows how to extract what it needs from those fermented foods. But, one cannot be sure
Lilja
As to probiotics. How do we know what kind of good bacteria we lack? There are so many different kinds, and in order to know what I lack, I would have to get my poop analyzed. If such a test exists.
I believe in fermented foods, and trust that my body knows how to extract what it needs from those fermented foods. But, one cannot be sure
Lilja
Collagenous Colitis diagnosis in 2010
Psoriasis in 1973, symptom free in 2014
GF, CF and SF free since April, 2013
Psoriasis in 1973, symptom free in 2014
GF, CF and SF free since April, 2013
I believe you are right, that's probably the best we can do at present. Even if we could identify exactly which bacteria we have, and figure out which ones we need (for our diet), no lab on earth would be able to supply a probiotic that would work because bacteria cannot attach (stick to the walls of our intestines and reproduce) unless they have been raised inside a human gut. Raised in a lab, they will never be able to colonize our gut — they will go down the toilet instead.Lilja wrote:I believe in fermented foods, and trust that my body knows how to extract what it needs from those fermented foods. But, one cannot be sure
Tex
It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
I had my gut Microbiome tested through Genova Labs via a stool sample, showing the heathy and bad gut bacteria/diversity. I was in the RED zone. Total inflammation! Pre MC diagnosis!
Be happy to post results if needed. Some people need it, some people don’t, as is the case with a lot of what Tex gives guidance to on this forum. If our colon/large intestine is inflamed, it probably needs help via a probiotic, as that’s part of why our digestion system is in a chaotic state anyway. Mine was NSAD induced from years of Excedrine Migraine use.
Be happy to post results if needed. Some people need it, some people don’t, as is the case with a lot of what Tex gives guidance to on this forum. If our colon/large intestine is inflamed, it probably needs help via a probiotic, as that’s part of why our digestion system is in a chaotic state anyway. Mine was NSAD induced from years of Excedrine Migraine use.