Hello All,
I received the diagnosis of Microscopic Lymphocytic Colitis in the late winter of 2013. All together I had full blown diarrhea for 18 months. I had it for 10 months when diagnosed. Lost 40 pounds, could not leave the house, without great apprehension. I was weak, aging fast and miserable.
There was some pain, but mostly food was running through me in about 6-7 hours.
The gastro office had 17 specialists in it. I saw three of them. They tested for everything humanly possible, found nothing pathogen wise or allergy wise. However, I stopped dairy and wheat, corn, oats, rye, on my own. Also stopped raw foods. Nut butters made no difference. Nothing I did altered the course of the disease.
To complicated it, I had a traumatic brain injury, which was completely ignored for almost 5 years. So, other parts of my life were impacted by that, notably my pituitary was damaged and I became extremely hypothyroid due to greatly diminished production of ACTH. Thyroid hormone can not enter the cells without proper amounts of adrenal hormones. No one addressed this issue, until it nearly killed me. I saw 13 different doctors, none cared. So, eventually went into adrenal crisis and now taking Cortef. The generic form made me more ill, only can tolerate the brand name.
The gastro doctors ordered Enterocort. It was nearly $2,000 a month, did not work for me, because I have allergic reaction to that much or kind of cellulose. So, after about a week on it, with violent headaches, stomach pains and vomiting, I tossed it. The only other option from them was huge doses of Pepto Bismol. Fearing bismuth poisoning, I did not attempt its use.
Went on line and began to read everything I could find, including ordering Wayne's fabulous book. The side effects of the drugs which you explained, rather put me off. Have grown my own food for years, basically organic in most of what I eat, taking those chemicals sounded wrong for me. Was having enough trouble without adding more. And, they seemed to be an on going thing! Enterocort on average, only gives one 29 days before relapse when discontinue! No cure there!
Fortunately, I can tolerate probiotics, I know not every one can. In reading all I could find, found that certain probiotics will increase mobility of the gut, did not want them. It took about four or five months of taking four brands of particular probiotics and some fibers before the diarrhea stopped and has not returned, in six months. I still maintain the diet, still take the probiotics daily. Slowly adding a little raw food and whole nuts well chewed. Colon seems pretty much normal, at this point, or perhaps, only slightly more active, than before the diarrhea started.
Below is the information I gathered. Some of this came from ConsumersLabs.com Some from other sites. I do hope it will help at least one person, who is enduring the misery and isolation of MC. Will send you a separate note which includes all the info I kept on the different stains of probiotics, just incase you find something there that may be useful.
I wish to express my gratitude for all those who shared their experiences on the blog and to you for your on going effort on behalf of those of us, who are isolated, sad and miserable in dealing with this situation. It is a real compassion generator and I send love and support to all of those who offered their experiences for people, such as myself… much gratitude…you all made a huge difference!
I have a histamine issue and Interstitial Cystitis so histamine was also a problem. Probiotic strains which increase histamine and therefore gut mobility are …Lactobacillus casei, Lactobacillus reuteri, Lactobacillus plantarum [especially bad for increasing histamine], Lactobacillus lactis, Enterococcus faecalis and various types of E. coli. Many of these strains are in probiotics commonly available!
Probiotics which seem to degrade histamine and calm the intestines are many of the Bifidobacteria, in particular Bifidobacterium infantis [subspecies of longum], Bifidobacterium longum, Lactobacillus rhamnosus [Culturelle is all rhamnosus] , Lactobacillus salvarius, sponogenes and Lactobacillus gasser.
Lactobacillus helveticus is great for the colon, is used in making Swiss cheese, increases bone density, reduces artery stiffness, helps prevent infections, reduces BP, helps to reduce or prevent the growth of unhealthy bacteria within the body, improves overall health.
http://www.probiotic.org/lactobacillus-helveticus.htm
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500876/
The Probiotic Sticks from Jamieson have the Bifido longum R0175 and the Lactobacillus helveticus R0052. According to Consumer Labs reporting on French research, taken during or just after breakfast for 30 days, in healthy individuals, found significant improvements in day to day depression, anger, anxiety as lower levels of stress hormone cortisol, as compared to placebo. VSL #3 is similar but pricey. They are also great for a healthy gut flora!
YoPlus and Dannon Activia both cause FASTER transit of food through the bowel!! NOT good!
Certain fibers helped me also, slippery elm bark was good, Marshmallow root helped, but lowered my blood sugar , discontinued.
Inulin was the best fiber and the last thing I added, which completely stopped the diarrhea. Very inexpensive, from Belgium not from China, available from Swanson Vitamins.
Butyrate complex, from Amazon, two a day, helps feed damaged cells on gut lining. Then dropped back to one a day, no longer need them. Butyrate is the sour smell in emesis and is nurturing to the lining of the colon, which I am sure you know.
Brands and sources of probiotics which helped me and I am still taking, because probiotics do not always set up cultures in our intestine, as I thought they would and must be taken on a continuing basis:
Jamieson Probiotic Straws and Jamieson 30 Billion Active Cells available from feelbest.com, in Canada. Your credit card company may call, to make sure the foreign order is made by you.
4XPro-B Digestive Care Probiotics, were a great benefit, comes in foil packed supply 2.5 X more cells and far less expensive than Align. Purchased from Costco on line.
Culturelle, much studied and helpful… is rhamnosus, they call it GC. On line or in Costco store, amazon. Some things are at drugstore.com at better price than amazon. They no longer import the Jamieson products.
Saccharomyces boulardii, Jarrow from amazon.com.
L-Glutmmine helps gut lining, as does L-Threonine, and L-Threanine. They also impact mood in a postiive way, something that people with MC can use!
Summary if what worked for me:
Up to 20 Gm. if L-Glutamine a day, divided ..ordered in bulk at amazon helps heal gut lining
L-Threonine 1/4 tsp. twice a day ..ordered in bulk at amazon helps heal gut lining
L-Theonine 1/4 tsp. twice a day.. ordered in bulk at amazon helps heal gut lining
Butyrate complex 1 daily, feeds cells on gut lining [no longer need]..amazon.com
1 scoop of Inulin twice a day..Swanson Vitamins on line
1 tsp Slipper elm bark daily in juice diluted..Frontier Herbs on line
Jamieson Probiotic Sticks. a.m. and p.m. with meal .. feelbest.com [Canada], amaazon.com
Culturelle 1 morning and evening...amazon.com
Jarrow Saccharomyces boulardi 1 daily...amazon.com
4X Pro-B Digestive Care Natural Probiotics 1 daily .. amazon.com, costco.com
That is it… took awhile to figure it out, but people who can not tolerate probiotics, could possibly have taken the strains that actually make MC worse! I know that not many doctors can be trusted to do much, expect dispense what the reps want them to!
Thank you for reading.
Tokala
New Member Using Probiotics
Moderators: Rosie, JFR, Gabes-Apg, grannyh, Gloria, starfire, Polly, Joefnh
In case this can be of some use for someone… D
What I used to stop the colitis… Jamieson Probotic sticks, 4XPro-B. probiotic. Jamieson 30 Billion Active Cells probiotic, Culturelle, Sac, boulardi [Jarrow] More info on these below, plus some references. Plus 20 Gms. L-Glutamine divided, 1/4 tsp L-threonine BID, 1/4 tsp. TMG, BID, psysillum seed husk powder 1/2 - 1 tsp BID, Inulin.. one scoop BID.
************************************
Some bacteria harm those with colitis, some help. Histamine producers increase mobility of the gut tissues… not good with colitis.
The histamine-producing category is Lactobacillus casei, Lactobacillus reuteri, Lactobacillus plantarum Lactococcus lactis, Enterococcus faecalis, and various types of E. coli.
The probioitics that seem to degrade histamine and be beneficial are lots of bifidobacteria species, but particularly Bifidobacterium infantis [subspecies of longum], Lactobacillus rhamnosus [Culturelle is all rhamnosus] and Lactobacillus salivarius and sporogenes and Lactobacillus gasser.
Lactobacillus plantarum.. bad for histamine issues.
*****************************************
L. helveticus used in making swiss cheese and widely used in Europe to increase bone density, reduce artery stiffness, prevent infections,reduce BP, help reduce or prevent growth of unhealthy bacteria within body, improving overall health.
http://www.probiotic.org/lactobacillus-helveticus.htm
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500876/
http://www.drperlmutter.com/study/benef ... olunteers/ [effects on stress, compulsive, anxiety issues, depression besides other positive effects.]
L. helveticus available with B. longum in Jamieson Probiotic Sticks$14.99drugstore.com.
***********************************************************************************
Lists of most commercially available probiotics and what contents are and use.. pharmacists reference.
http://www.eastbayfp.com/pdf/Comparison ... oducts.pdf
************************************************************************************
Verduetal.Gastroenterology20041273826-837.pdf …..In mice studies: "Our results raise the possibility that L. paracasei could be useful in attenuating Post Infection gut dysfunction in humans and in treating PI-IBS.'
B. infantis http://www.powerofprobiotics.com/Bifido ... antis.html
in 4X Pro-B. Purchased best price Costco on line -foil packs
List of the Jamieson Labs. 30 Billion Active Cells, is below. This really helped me,
All of these bacteria decrease mobility of the gut… all good bacteria.
ConsumersReports site Jamieson products many times for quality and the strains they use.
Supplement Facts
Serving Size:
1 Capsule
Servings Per Container:
30
30 Billion live cells
Probiotic Blend 30 Billion CFU
Bifidobacterium Bifidum HA-132
Bifidobacterium Breve HA-129
Bifidobacterium Longum HA-135
Lactobacillus Acidophilus HA-122
Lactobacillus Paracasei HA-196
Lactobacillus Rhamnosus HA-111
Lactobacillus Rhamnosus B HA-114
Lactobacillus Salivarius HA-118
****************************************
Costco on line sells 4X Pro-B Digestive Care Probiotics, also helped me… $22.99 for 63 .. comes packed for one week supply, in foil. 2.5 x more cells than the expensive Align.. Helped a great deal!
Bifidobacterium infantis 10 mg.
B. infantis strain SD-5845
Probiotic blend..B. Lactis, B. longum, B. bifidum 15 mg.
Total live probiotic cells 5 billion
***********************************
Anxiety Reduction
Chronic gut disorders are associated with higher rates of anxiety and depression. A well-publicized study in mice suggested a possible role for probiotics in reducing anxiety associated with gut inflammation (Bercik, Neurogatroenterol Motil 2011). Mice in the study had a chemically-induced inflammation of their gut and exhibited anxiety-like behavior. Giving 1 billion cells of Bifidobacterium longum NCC3001 for 1 week normalized their behavior. The probiotic did not reduce inflammation in the gut but appeared to act by reducing the excitability of nerves in the gut which connect, through the vagus nerve, with the central nervous system. Similarly, French researchers evaluated a combination of Bifidobacterium longum R0175 and Lactobacillus helveticus R0052 (3 billion organisms total — sold in Canada by Jamieson as Probiotic Sticks with 1 billion cells per stick) taken during or just after breakfast for 30 days in healthy individuals, finding significant improvements in day-to-day depression, anger, anxiety, as well as lower levels of the stress hormone cortisol in those taking the probiotic compared to those taking placebo -- although some improvement also occurred in the placebo group (Messaoudi, Br J Nutr 2011).
.com.
VSL#3 is similar but is pricey. Some insurance pays for Rx VSL#3, start very slowly. High power.
Do not eat YoPlus or Dannon Activia, those bacteria cause faster transit of food through bowel! Bad for colitis!
Cholesterol-lowering
Some probiotics may be helpful in modestly lowering cholesterol, particularly by lowering LDL cholesterol. A study with Lactobacillus reuteri NCIMB 30242 (sold as Cardioviva) in men and women with high cholesterol showed that those who took a capsule containing 2 billion cells with breakfast and another with dinner for nine weeks had average reductions in both LDL and total cholesterol of about 6% while these levels increased by a few percent among people taking placebo. There was no effect on HDL cholesterol nor triglycerides. (Jones, Eur J Clin Nutr 2012). A longer study (56 weeks) using a different probiotic, E. faecium M-74, found that giving 2 billion cells once daily lead to a 12% reduction in total cholesterol, with a 20% drop in LDL cholesterol -- although total cholesterol and LDL levels also fell in the placebo group by 5.5% and 8.3%, respectively, perhaps due to the fact that participants in both groups began eating healthier during the study (Hlivak, Bratisl Lek Listy 2005). Lactobacillus reuteri NCIMB 30242 may be the safer of the two probiotics as it is generally recognized as safe by the FDA, while E. faecium has not gained this status and some strains of this species are human pathogens (DiRienzo, Nutrition Reviews 2013).
http://www.medscape.com/viewarticle/722838_3 ! L. salvarius.. decrease inflammation in bowel. Want strain UCC118
B. infantis and Sac. boulardi, proven to help…L. rhamnosus and Bifido longum… beneficial. Part of what ended my severe colitis!
L. reuteri reduces TNF-a, also Increase histamine!! NOT GOOD.
Culturelle,, L.GG [rhamnosus] improves barrier function by inhibiting apoptosis of intestinal cells.
Intestinal bacteria, generally decrease inflammatory cytokines, enhanced barrier
function.
Foods with inulin and oliofructose that help probiotics:
* Chicory root: 41.6 g inulin, 22.9 g oligofructose
* Jerusalem artichoke: 18.0 g inulin, 13.5 g oligofructose
* Dandelion greens: 13.5 g inulin, 10.8 g oligofructose
* Garlic: 12.5 g inulin, 5.0 g oligofructose
* Leek: 6.5 g inulin, 5.2 g oligofructose
* Asparagus: 2.5 g inulin, 2.5 g oligofructose
* Wheat bran: 2.5 g inulin, 2.5 g oligofructose
* Wheat flour, baked: 2.4 g inulin, 2.4 g oligofructose
* Banana: 0.5 g inulin, 0.5 oligofructose
* plus jimaca, agave, wild yam, onions
Lactobacillus helveticus is a very interesting probiotic that has studies showing it can reduce blood pressure. Widely used in Switzerland, it is one of the choice starter cultures for Swiss cheeses!
L. Helveticus Benefits
* (for hypertensive patients) reduces blood pressure
* improves sleep quality/duration
* increases perception of one’s health
* increase levels of serum calcium in blood (see here)
* decrease PTH (associated with bone loss)
* normalize microflora colonization composition for infants fed formula
* assist in ACE-inhibitor production
Helviticus is in probiotic straws… Jamieson Probiotic Straws… made in Canada.
Experimental colitis
More than 20 animal models of IBD are available[64] and have been widely used to study the efficacy and mechanisms of probiotics in ameliorating inflammation in order to provide support for human clinical trials. In IL-10 knockout mice, L. plantarum 299v[65], L. reuteri[46], L. salivarius subspecies salivarius 433118, B. infantis 35624[66], L. salivarius subspecies salivarius UCC118[67] and VSL#3[49] have all been shown to successfully attenuate intestinal inflammation. L. GG prevents recurrent colitis in HLA-B27 transgenic rats after antibiotic treatment, whereas L. plantarum has no effect[68]. Both VSL#3 and L. GG significantly ameliorate sulfhydryl-blocker iodoacetamide-induced colitis in rats, whereas they have no effect on dinitrobenzene sulfonic acid-induced colitis[69]. Improved inflammation in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis has also been demonstrated after oral administration of L. salivarius ssp. salivarius CECT5713 and L. plantarum NCIMB8826[70,71]. Dextran sulphate sodium (DSS)-induced colitis in mice is ameliorated by soluble bacterial antigens extracted from E. coli (strain Laves) or by Bifidobacterium strains breve, catenulatum, and longum[72,73]. Daily administration of live but not heat-killed auto-aggregating L. crispatus reduces the severity of DSS-colitis in mice[74]. L. reuteri significantly reduces the colonic inflammation caused by both acetic acid and methotrexate in rats[75,76]. Interestingly, DNA from VSL#3 has been reported to reduce colonic inflammation, thus improving intestinal barrier function in IL-10 KO mice and DSS-induced colitis[41,77].
Ulcerative colitis
Numerous studies have investigated the use of probiotics for maintenance of remission of UC in humans. A small study investigating the use of non-pathogenic E. coli Nissle 1917 versus low-dose mesalamine showed that it can maintain remission of quiescent UC, with a relapse rate of 16%-67% in those treated with E.coli versus 11%-73% in the mesalamine group[81]. In a double-blind, randomized trial involving 327 patients, Kruis et al[82] compared the effectiveness of an oral preparation of E. coli Nissle 1917 with mesalamine for maintaining remission of UC, and found that at the end of the 12-mo study, there is no significant difference between the two study groups, with relapses occurring in 36.4% of the E. coli Nissle 1917 group and 33.9% of the mesalamine group (significant equivalence, P = 0.003). Recently, Zocco et al[83] investigated the efficacy of L. GG in maintaining remission of UC and found that there is no difference in relapse rate between the 3 groups after 6 and 12 mo. However, L. GG [Culturelle ]is more effective than standard mesalamine treatment in prolonging relapse-free time (P < 0.05). An open-label study of VSL#3 showed that 15/20 UC patients remain in remission after 1 year[8
http://www.wjgnet.com/1007-9327/12/5941.asp
Oligofructocse in obese mice increased the abundance of A. muciniphilia..found lacking in type 2 diabetes and obesity.
http://drbganimalpharm.blogspot.com
Unlike Resistant Starch, Oligofructose and Inulin-like Fructans Cause Miraculous Body Fat Loss and Weight Loss
Yes. Many fibers induce fat loss, but resistant starch is not one imho.
Inulin and oligofructose often are. Humans and rodent model research.
Inulin and oligos are naturally found abundantly in onions, leeks (French stay skinny on leek soup), asparagus, sunchokes, etc. It's sweet tasting with little energy/calories for us but plentiful for the intestinal flora.
I believe it's body fat reducing characteristics are related to A. muciniphila and many of our co-evolved ancestral core microbiota which have co-adapted to eating the diverse spectrum of plant polysaccharides on Earth that we feed them (oligos, inulin, xylan, arabinoxylan, lignin, arabinogalactan, beta-glucan, hemicelluloses, pectin, glucomannan, etc). They have diversified above and beyond raw resistant starch. You don't need a lot. Oligofructose and inulin-like fructans are the second most abundant 'fiber' on the planet, found in over 36,000 plants in our global ecosystem in roots, tubers, legumes, leaves, grains, agave, cacti, and stems. Tiny amounts go a LOOOOONG way.
FRom article…
In humans, A. muciniphila is 'missing' in the gut fingerprint of obesity, T2 diabetes and IBD, to name just a few post-industrial conditions. When I look at a gut profile, what I see matches the studies; in obese/weight-challenged, A muciniphila is low. In lean, abundant.
"In the article that appeared on 13 May in the journal Proceedings of the National Academy of Sciences, the research team concluded that the bacteria are less frequent in mice with induced obesity and with type 2 (adult-onset) diabetes. Furthermore, administering rather indigestible fibres such as oligofructose, known for its advantageous effect on intestinal biota, resulted in a recovery of the Akkermansia population in mice. The presence of the bacteria strengthens the intestinal barrier and is also inversely correlated with weight increase (fat storage), inflammation reactions in fatty tissues and insulin resistance.
To check that, the researchers administered Akkermansia bacteria to ordinary mice on various diets. With a normal diet, no effect was noticed but in mice that became overweight as a result of a high-fat diet, the Akkermansia bacteria caused a reduction in fat development and associated metabolic defects, without affecting food intake. After the administration of Akkermansia bacteria, there was an increase in endocannabinoid levels, a substance that ensures blood glucose remains at the correct level. In addition, the intestinal barrier function was strengthened. Only intact, living bacteria produced these results; the researchers noticed that bacteria that had been heated beforehand had no effect." Sciencedaily
"The athletes are an exceptional group in terms of their dietary intake, fitness/endurance and now we know, in relation to their gut microbiota! This high diversity is particularly linked with exercise and protein consumption and suggests that eating specific proteins and/or exercise can provide a means of increasing microbial diversity in the gut.
This is the first report that exercise increases microbial diversity in humans. While we and others have previously shown that diet influences microbial diversity, we can now report that protein consumption, in particular, positively correlates with microbial diversity." Source
From same source Animal Pharm as above notes
Antidepressant Microbes In Soil: How Dirt Makes You Happy
"Soil Microbes and Human Health: Did you know that there’s a natural antidepressant in soil? It’s true. Mycobacterium vaccae is the substance under study and has, indeed, been found to mirror the effect on neurons that drugs like Prozac provide. The bacterium is found in soil and may stimulate serotonin production, which makes you relaxed and happier. Studies were conducted on cancer patients and they reported a better quality of life and less stress.
Serotonin has been linked to such problems as depression, anxiety, obsessive compulsive disorder and bipolar problems. The bacterium appears to be a natural antidepressant in soil and has no adverse health effects. These antidepressant microbes in soil may be as easy to use as just playing in the dirt.
Most avid gardeners will tell you that their landscape is their “happy place” and the actual physical act of gardening is a stress reducer and mood lifter. The fact that there is some science behind it adds additional credibility to these garden addicts’ claims. The presence of a soil bacteria antidepressant is not a surprise to many of us who have experienced the phenomenon ourselves. Backing it up with science is fascinating, but not shocking, to the happy gardener.
Mycrobacterium antidepressant microbes in soil are also being investigated for improving cognitive function, Crohn’s disease and even rheumatoid arthritis.
Mycobacterium vaccae. Soil organism.. for happy head!!
What I used to stop the colitis… Jamieson Probotic sticks, 4XPro-B. probiotic. Jamieson 30 Billion Active Cells probiotic, Culturelle, Sac, boulardi [Jarrow] More info on these below, plus some references. Plus 20 Gms. L-Glutamine divided, 1/4 tsp L-threonine BID, 1/4 tsp. TMG, BID, psysillum seed husk powder 1/2 - 1 tsp BID, Inulin.. one scoop BID.
************************************
Some bacteria harm those with colitis, some help. Histamine producers increase mobility of the gut tissues… not good with colitis.
The histamine-producing category is Lactobacillus casei, Lactobacillus reuteri, Lactobacillus plantarum Lactococcus lactis, Enterococcus faecalis, and various types of E. coli.
The probioitics that seem to degrade histamine and be beneficial are lots of bifidobacteria species, but particularly Bifidobacterium infantis [subspecies of longum], Lactobacillus rhamnosus [Culturelle is all rhamnosus] and Lactobacillus salivarius and sporogenes and Lactobacillus gasser.
Lactobacillus plantarum.. bad for histamine issues.
*****************************************
L. helveticus used in making swiss cheese and widely used in Europe to increase bone density, reduce artery stiffness, prevent infections,reduce BP, help reduce or prevent growth of unhealthy bacteria within body, improving overall health.
http://www.probiotic.org/lactobacillus-helveticus.htm
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500876/
http://www.drperlmutter.com/study/benef ... olunteers/ [effects on stress, compulsive, anxiety issues, depression besides other positive effects.]
L. helveticus available with B. longum in Jamieson Probiotic Sticks$14.99drugstore.com.
***********************************************************************************
Lists of most commercially available probiotics and what contents are and use.. pharmacists reference.
http://www.eastbayfp.com/pdf/Comparison ... oducts.pdf
************************************************************************************
Verduetal.Gastroenterology20041273826-837.pdf …..In mice studies: "Our results raise the possibility that L. paracasei could be useful in attenuating Post Infection gut dysfunction in humans and in treating PI-IBS.'
B. infantis http://www.powerofprobiotics.com/Bifido ... antis.html
in 4X Pro-B. Purchased best price Costco on line -foil packs
List of the Jamieson Labs. 30 Billion Active Cells, is below. This really helped me,
All of these bacteria decrease mobility of the gut… all good bacteria.
ConsumersReports site Jamieson products many times for quality and the strains they use.
Supplement Facts
Serving Size:
1 Capsule
Servings Per Container:
30
30 Billion live cells
Probiotic Blend 30 Billion CFU
Bifidobacterium Bifidum HA-132
Bifidobacterium Breve HA-129
Bifidobacterium Longum HA-135
Lactobacillus Acidophilus HA-122
Lactobacillus Paracasei HA-196
Lactobacillus Rhamnosus HA-111
Lactobacillus Rhamnosus B HA-114
Lactobacillus Salivarius HA-118
****************************************
Costco on line sells 4X Pro-B Digestive Care Probiotics, also helped me… $22.99 for 63 .. comes packed for one week supply, in foil. 2.5 x more cells than the expensive Align.. Helped a great deal!
Bifidobacterium infantis 10 mg.
B. infantis strain SD-5845
Probiotic blend..B. Lactis, B. longum, B. bifidum 15 mg.
Total live probiotic cells 5 billion
***********************************
Anxiety Reduction
Chronic gut disorders are associated with higher rates of anxiety and depression. A well-publicized study in mice suggested a possible role for probiotics in reducing anxiety associated with gut inflammation (Bercik, Neurogatroenterol Motil 2011). Mice in the study had a chemically-induced inflammation of their gut and exhibited anxiety-like behavior. Giving 1 billion cells of Bifidobacterium longum NCC3001 for 1 week normalized their behavior. The probiotic did not reduce inflammation in the gut but appeared to act by reducing the excitability of nerves in the gut which connect, through the vagus nerve, with the central nervous system. Similarly, French researchers evaluated a combination of Bifidobacterium longum R0175 and Lactobacillus helveticus R0052 (3 billion organisms total — sold in Canada by Jamieson as Probiotic Sticks with 1 billion cells per stick) taken during or just after breakfast for 30 days in healthy individuals, finding significant improvements in day-to-day depression, anger, anxiety, as well as lower levels of the stress hormone cortisol in those taking the probiotic compared to those taking placebo -- although some improvement also occurred in the placebo group (Messaoudi, Br J Nutr 2011).
.com.
VSL#3 is similar but is pricey. Some insurance pays for Rx VSL#3, start very slowly. High power.
Do not eat YoPlus or Dannon Activia, those bacteria cause faster transit of food through bowel! Bad for colitis!
Cholesterol-lowering
Some probiotics may be helpful in modestly lowering cholesterol, particularly by lowering LDL cholesterol. A study with Lactobacillus reuteri NCIMB 30242 (sold as Cardioviva) in men and women with high cholesterol showed that those who took a capsule containing 2 billion cells with breakfast and another with dinner for nine weeks had average reductions in both LDL and total cholesterol of about 6% while these levels increased by a few percent among people taking placebo. There was no effect on HDL cholesterol nor triglycerides. (Jones, Eur J Clin Nutr 2012). A longer study (56 weeks) using a different probiotic, E. faecium M-74, found that giving 2 billion cells once daily lead to a 12% reduction in total cholesterol, with a 20% drop in LDL cholesterol -- although total cholesterol and LDL levels also fell in the placebo group by 5.5% and 8.3%, respectively, perhaps due to the fact that participants in both groups began eating healthier during the study (Hlivak, Bratisl Lek Listy 2005). Lactobacillus reuteri NCIMB 30242 may be the safer of the two probiotics as it is generally recognized as safe by the FDA, while E. faecium has not gained this status and some strains of this species are human pathogens (DiRienzo, Nutrition Reviews 2013).
http://www.medscape.com/viewarticle/722838_3 ! L. salvarius.. decrease inflammation in bowel. Want strain UCC118
B. infantis and Sac. boulardi, proven to help…L. rhamnosus and Bifido longum… beneficial. Part of what ended my severe colitis!
L. reuteri reduces TNF-a, also Increase histamine!! NOT GOOD.
Culturelle,, L.GG [rhamnosus] improves barrier function by inhibiting apoptosis of intestinal cells.
Intestinal bacteria, generally decrease inflammatory cytokines, enhanced barrier
function.
Foods with inulin and oliofructose that help probiotics:
* Chicory root: 41.6 g inulin, 22.9 g oligofructose
* Jerusalem artichoke: 18.0 g inulin, 13.5 g oligofructose
* Dandelion greens: 13.5 g inulin, 10.8 g oligofructose
* Garlic: 12.5 g inulin, 5.0 g oligofructose
* Leek: 6.5 g inulin, 5.2 g oligofructose
* Asparagus: 2.5 g inulin, 2.5 g oligofructose
* Wheat bran: 2.5 g inulin, 2.5 g oligofructose
* Wheat flour, baked: 2.4 g inulin, 2.4 g oligofructose
* Banana: 0.5 g inulin, 0.5 oligofructose
* plus jimaca, agave, wild yam, onions
Lactobacillus helveticus is a very interesting probiotic that has studies showing it can reduce blood pressure. Widely used in Switzerland, it is one of the choice starter cultures for Swiss cheeses!
L. Helveticus Benefits
* (for hypertensive patients) reduces blood pressure
* improves sleep quality/duration
* increases perception of one’s health
* increase levels of serum calcium in blood (see here)
* decrease PTH (associated with bone loss)
* normalize microflora colonization composition for infants fed formula
* assist in ACE-inhibitor production
Helviticus is in probiotic straws… Jamieson Probiotic Straws… made in Canada.
Experimental colitis
More than 20 animal models of IBD are available[64] and have been widely used to study the efficacy and mechanisms of probiotics in ameliorating inflammation in order to provide support for human clinical trials. In IL-10 knockout mice, L. plantarum 299v[65], L. reuteri[46], L. salivarius subspecies salivarius 433118, B. infantis 35624[66], L. salivarius subspecies salivarius UCC118[67] and VSL#3[49] have all been shown to successfully attenuate intestinal inflammation. L. GG prevents recurrent colitis in HLA-B27 transgenic rats after antibiotic treatment, whereas L. plantarum has no effect[68]. Both VSL#3 and L. GG significantly ameliorate sulfhydryl-blocker iodoacetamide-induced colitis in rats, whereas they have no effect on dinitrobenzene sulfonic acid-induced colitis[69]. Improved inflammation in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis has also been demonstrated after oral administration of L. salivarius ssp. salivarius CECT5713 and L. plantarum NCIMB8826[70,71]. Dextran sulphate sodium (DSS)-induced colitis in mice is ameliorated by soluble bacterial antigens extracted from E. coli (strain Laves) or by Bifidobacterium strains breve, catenulatum, and longum[72,73]. Daily administration of live but not heat-killed auto-aggregating L. crispatus reduces the severity of DSS-colitis in mice[74]. L. reuteri significantly reduces the colonic inflammation caused by both acetic acid and methotrexate in rats[75,76]. Interestingly, DNA from VSL#3 has been reported to reduce colonic inflammation, thus improving intestinal barrier function in IL-10 KO mice and DSS-induced colitis[41,77].
Ulcerative colitis
Numerous studies have investigated the use of probiotics for maintenance of remission of UC in humans. A small study investigating the use of non-pathogenic E. coli Nissle 1917 versus low-dose mesalamine showed that it can maintain remission of quiescent UC, with a relapse rate of 16%-67% in those treated with E.coli versus 11%-73% in the mesalamine group[81]. In a double-blind, randomized trial involving 327 patients, Kruis et al[82] compared the effectiveness of an oral preparation of E. coli Nissle 1917 with mesalamine for maintaining remission of UC, and found that at the end of the 12-mo study, there is no significant difference between the two study groups, with relapses occurring in 36.4% of the E. coli Nissle 1917 group and 33.9% of the mesalamine group (significant equivalence, P = 0.003). Recently, Zocco et al[83] investigated the efficacy of L. GG in maintaining remission of UC and found that there is no difference in relapse rate between the 3 groups after 6 and 12 mo. However, L. GG [Culturelle ]is more effective than standard mesalamine treatment in prolonging relapse-free time (P < 0.05). An open-label study of VSL#3 showed that 15/20 UC patients remain in remission after 1 year[8
http://www.wjgnet.com/1007-9327/12/5941.asp
Oligofructocse in obese mice increased the abundance of A. muciniphilia..found lacking in type 2 diabetes and obesity.
http://drbganimalpharm.blogspot.com
Unlike Resistant Starch, Oligofructose and Inulin-like Fructans Cause Miraculous Body Fat Loss and Weight Loss
Yes. Many fibers induce fat loss, but resistant starch is not one imho.
Inulin and oligofructose often are. Humans and rodent model research.
Inulin and oligos are naturally found abundantly in onions, leeks (French stay skinny on leek soup), asparagus, sunchokes, etc. It's sweet tasting with little energy/calories for us but plentiful for the intestinal flora.
I believe it's body fat reducing characteristics are related to A. muciniphila and many of our co-evolved ancestral core microbiota which have co-adapted to eating the diverse spectrum of plant polysaccharides on Earth that we feed them (oligos, inulin, xylan, arabinoxylan, lignin, arabinogalactan, beta-glucan, hemicelluloses, pectin, glucomannan, etc). They have diversified above and beyond raw resistant starch. You don't need a lot. Oligofructose and inulin-like fructans are the second most abundant 'fiber' on the planet, found in over 36,000 plants in our global ecosystem in roots, tubers, legumes, leaves, grains, agave, cacti, and stems. Tiny amounts go a LOOOOONG way.
FRom article…
In humans, A. muciniphila is 'missing' in the gut fingerprint of obesity, T2 diabetes and IBD, to name just a few post-industrial conditions. When I look at a gut profile, what I see matches the studies; in obese/weight-challenged, A muciniphila is low. In lean, abundant.
"In the article that appeared on 13 May in the journal Proceedings of the National Academy of Sciences, the research team concluded that the bacteria are less frequent in mice with induced obesity and with type 2 (adult-onset) diabetes. Furthermore, administering rather indigestible fibres such as oligofructose, known for its advantageous effect on intestinal biota, resulted in a recovery of the Akkermansia population in mice. The presence of the bacteria strengthens the intestinal barrier and is also inversely correlated with weight increase (fat storage), inflammation reactions in fatty tissues and insulin resistance.
To check that, the researchers administered Akkermansia bacteria to ordinary mice on various diets. With a normal diet, no effect was noticed but in mice that became overweight as a result of a high-fat diet, the Akkermansia bacteria caused a reduction in fat development and associated metabolic defects, without affecting food intake. After the administration of Akkermansia bacteria, there was an increase in endocannabinoid levels, a substance that ensures blood glucose remains at the correct level. In addition, the intestinal barrier function was strengthened. Only intact, living bacteria produced these results; the researchers noticed that bacteria that had been heated beforehand had no effect." Sciencedaily
"The athletes are an exceptional group in terms of their dietary intake, fitness/endurance and now we know, in relation to their gut microbiota! This high diversity is particularly linked with exercise and protein consumption and suggests that eating specific proteins and/or exercise can provide a means of increasing microbial diversity in the gut.
This is the first report that exercise increases microbial diversity in humans. While we and others have previously shown that diet influences microbial diversity, we can now report that protein consumption, in particular, positively correlates with microbial diversity." Source
From same source Animal Pharm as above notes
Antidepressant Microbes In Soil: How Dirt Makes You Happy
"Soil Microbes and Human Health: Did you know that there’s a natural antidepressant in soil? It’s true. Mycobacterium vaccae is the substance under study and has, indeed, been found to mirror the effect on neurons that drugs like Prozac provide. The bacterium is found in soil and may stimulate serotonin production, which makes you relaxed and happier. Studies were conducted on cancer patients and they reported a better quality of life and less stress.
Serotonin has been linked to such problems as depression, anxiety, obsessive compulsive disorder and bipolar problems. The bacterium appears to be a natural antidepressant in soil and has no adverse health effects. These antidepressant microbes in soil may be as easy to use as just playing in the dirt.
Most avid gardeners will tell you that their landscape is their “happy place” and the actual physical act of gardening is a stress reducer and mood lifter. The fact that there is some science behind it adds additional credibility to these garden addicts’ claims. The presence of a soil bacteria antidepressant is not a surprise to many of us who have experienced the phenomenon ourselves. Backing it up with science is fascinating, but not shocking, to the happy gardener.
Mycrobacterium antidepressant microbes in soil are also being investigated for improving cognitive function, Crohn’s disease and even rheumatoid arthritis.
Mycobacterium vaccae. Soil organism.. for happy head!!
Tokala,
This was an awful lot of information to digest. I haven't read it all, but found the Lactobacillus Helveticus interesting. Some probiotic are said to enhance the gut flora, and some do the opposite.
But, I don't have the courage to try it. Maybe sometime if/when I reach full remission.
Lilia
This was an awful lot of information to digest. I haven't read it all, but found the Lactobacillus Helveticus interesting. Some probiotic are said to enhance the gut flora, and some do the opposite.
But, I don't have the courage to try it. Maybe sometime if/when I reach full remission.
Lilia
Collagenous Colitis diagnosis in 2010
Psoriasis in 1973, symptom free in 2014
GF, CF and SF free since April, 2013
Psoriasis in 1973, symptom free in 2014
GF, CF and SF free since April, 2013
GERD
[quote="Lilja"]Tokala,
This was an awful lot of information to digest. I haven't read it all, but found the Lactobacillus Helveticus interesting. Some probiotic are said to enhance the gut flora, and some do the opposite.
But, I don't have the courage to try it. Maybe sometime if/when I reach full remission.
Lilia[/quote]
This was an awful lot of information to digest. I haven't read it all, but found the Lactobacillus Helveticus interesting. Some probiotic are said to enhance the gut flora, and some do the opposite.
But, I don't have the courage to try it. Maybe sometime if/when I reach full remission.
Lilia[/quote]
GERD
[quote="Lilja"]Tokala,
This was an awful lot of information to digest. I haven't read it all, but found the Lactobacillus Helveticus interesting. Some probiotic are said to enhance the gut flora, and some do the opposite.
But, I don't have the courage to try it. Maybe sometime if/when I reach full remission.
Lilia[/quote]
This was an awful lot of information to digest. I haven't read it all, but found the Lactobacillus Helveticus interesting. Some probiotic are said to enhance the gut flora, and some do the opposite.
But, I don't have the courage to try it. Maybe sometime if/when I reach full remission.
Lilia[/quote]
Just did a search and found this in the database....good info for those in a situation that have to take probiotics.
Just wanted to share...
Just wanted to share...
Martha E.
Philippians 4:13
Jul 2008 took Clindamycin for a Sinus infection that forever changed my life
Dec 2014 MC Dx
Jul 15, 2015 Elimination Diet
Aug 17, 2015 Enterolab Test
Dec 2015 Reflux
Sept 2016 IC
Philippians 4:13
Jul 2008 took Clindamycin for a Sinus infection that forever changed my life
Dec 2014 MC Dx
Jul 15, 2015 Elimination Diet
Aug 17, 2015 Enterolab Test
Dec 2015 Reflux
Sept 2016 IC
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jmarksberry
- Posts: 6
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