Unofficial survey question - calcium channel blockers?

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JaneTX
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Unofficial survey question - calcium channel blockers?

Post by JaneTX »

A couple trivia questions popped up in my research into MC and thought I'd toss them out and see what y'all might have to say about it -

Does anyone with MC also take a calcium channel blocker for high blood pressure (like Norvasc/Amlopidine)? If so, does it help/hurt or not affect MC symptoms?

Does anyone taking a magnesium supplement find it helps with MC symptoms?

Is anyone with MC taking oral Ketotifen, and if so, does it help/hurt or not affect MC symptoms?

I've been reading up on voltage-gated calcium channels in cells, and the 3-year-old in me started asking what, why, how ...
TXBrenda
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Post by TXBrenda »

I am not currently taking Norvasc/Amlodipine. When I did, it did not seem to affect my MC symptoms.
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Post by persevere »

I was taking calcium channel blocker. It messed with b12 levels.(even as I supplemented). Gave hideous swollen ankles. It was also a time of escalating LC. I was also taking Eliquis, which I think was the contributor. Eventually Got onto a low dose beta blocker, off the Eliquis.
Sometimes I think this condition is the sum of many little parts.
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Erica P-G
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Post by Erica P-G »

Does anyone with MC also take a calcium channel blocker for high blood pressure (like Norvasc/Amlopidine)? If so, does it help/hurt or not affect MC symptoms?

Does anyone taking a magnesium supplement find it helps with MC symptoms?

Is anyone with MC taking oral Ketotifen, and if so, does it help/hurt or not affect MC symptoms?
Never took a CCB

An unequivocal YES to Magnesium....it's been one of my most helpful aides with LC

Never took Ketotifen
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Dx LC April 2012 had symptoms since Aug 2007
JaneTX
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Post by JaneTX »

Thanks y'all for your input. Reason I was asking was that I was looking into why Ketotifen is a mast cell stabilizer and I ran across a discussion how it may be a calcium channel blocker - it blocks calcium from going into mast cells, and mast cells need calcium to degranulate. I saw more info suggesting calcium is needed to activate lymphocytes. So I was puzzling if CCBs act like Ketotifen on the immune system, and if CCBs or Ketotifen might help tame down lymphocytes in MC. CCBs are well known to reduce aldosterone and get the body to eliminate sodium and reduce blood pressure. From what I understand, cells are constantly trying to balance their sodium and potassium levels through calcium channels, and magnesium is needed for that, plus magnesium is needed to help balance calcium. So I guess CCBs aren't a possibly useful tool against MC.
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tex
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Post by tex »

Jane,

Some researchers claim that calcium channel blockers are one of the group of medications associated with an increased risk of developing MC, but other research that I have seen claims that no one has established definite proof of such a connection, so if there is a risk, it's only relatively slight.

Tex
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