Coffee And The Risk of Alzheimer's and Parkinson's Disease

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tex
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Coffee And The Risk of Alzheimer's and Parkinson's Disease

Post by tex »

The news just gets better and better for coffee drinkers. Here's why drinking dark roast coffee is more helpful for reducing the risk of developing Alzheimer's or Parkinson's than drinking light roast coffee, even if it's decaffeinated:
Recent studies have shown that being a regular coffee drinker can reduce your risk of all kinds of ailments, including heart attack and stroke. Now, a new research effort reveals that dark roast coffee is particularly good at warding off some nasty brain conditions, including Alzheimer’s and Parkinson’s disease. The findings were published in Frontiers in Neuroscience.

The study, which focused on a specific group of compounds called phenylindanes, emphasizes the benefits of specifying the type of roast you go with for your morning brew. Dark roast, even in its decaffeinated form, is packed with the compounds, which are thought to inhibit the production of a type of protein that is linked to Alzheimer’s and Parkinson’s.
Coffee can help reduce risk of Alzheimer’s, Parkinson’s

Here's a link to the original research article:

Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by brandy »

Thank you for posting.
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Post by brandy »

Hi Tex,

I found reading the original study pretty hard to follow, i.e. it was tough for me to understand the measurements. If I drank a 2 ounce dark roast cappucino (2 ounce of darkroast expresso plus almond milk foam ) in the morning that should offer some brain protection?

I really need all the brain help I can get but I really don't like coffee....i.e. it would be tough for me to drink an 8 ounce
drip coffee but I think I could get a shot of 2 ounce cappucino down plus I would feel Italian. :grin:

I guess 2 ounce of dark roast per day would be better than 0 ounce that I'm currently getting now?
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Post by AliciaM »

Good news! Thank you for sharing!

I’ve been off coffee since being diagnosed in July because the caffeine irritated my stomach. I’m considering trying a waterpress method decaf because I miss my coffee so much. I enjoy the taste and if it’s healthy why not? Can anyone recommend a good decaf brand that’s specifically done with the waterpress method?
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Coffee

Post by dolson »

I can't live without my dark coffee. A little almond milk and honey, and I'm good to go! It's something I can't give up and will never stop. I'm sub-human until I get coffee into my system. The stronger, the darker, the better! Plus it wards off disease. Yea, for COFFEE!
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Post by tex »

Brandy,

Yes, that's a very difficult, confusing article to read. The discussions seems to be about active components (especially phenylindane) in quantitative terms, with the mentions of coffee only in relative terms (except that the concentrations specified are above 100 μg/mL). So yes, some coffee is better than none, with dark roast better than the other types. I believe these are the most important takeaways:
  • All instant coffee extracts inhibit fibrillization of Aβ and tau, and promote α-synuclein oligomerization at concentrations above 100 μg/mL.

    Dark roast coffee extracts are more potent inhibitors of Aβ oligomerization

    pure caffeine (1) has no effect on Aβ, tau or α-synuclein aggregation

    Coffee components 2(chlorogenic acid), 4(caffeic acid), and 5(quercetin) inhibit the fibrillization of Aβ at 100 μM concentration, yet only 5(quercetin) inhibits Aβ oligomerization

    1–5 have no effect on tau fibrillization

    Coffee component 6(phenylindane), however, is a potent inhibitor of both Aβ and tau fibrillization, and also inhibits Aβ oligomerization

    Coffee components 4(caffeic acid) and 5(quercetin) promote the aggregation of α-synuclein at concentrations above 100 μM; no other coffee components affect α-synuclein oligomerization

    While the neuroprotective effect of coffee consumption is likely due to a combination of factors, our data suggest that inhibition Aβ and tau aggregation by 6phenylindane (formed during the roasting of coffee beans, higher quantities found in dark roast coffees) is a plausible mechanism by which coffee may provide neuroprotection.
Incidentally, did you notice this line (regarding the treatment of Alzheimer's disease)?
We have recently reported that components of Canadian maple syrup can reduce the aggregation of amyloidogenic Aβ and tau (Hawco et al., 2016),
Here's a link to the article:

A Maple Syrup Extract Prevents β-Amyloid Aggregation

Tex
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It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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Post by carolm »

Thanks for the post Tex. It was a happy day for me when I found I could tolerate coffee again.

AliciaM- I can’t recommend a roast for waterpress methods, but I found that while I was recovering a low acid coffee was very helpful and allowed me to enjoy coffee again. The brand I ordered was Healthwise and they had decaf as well. It might be worth a look.

Best wishes,
Carol
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Post by brandy »

I bought a Nespresso so I can make cappuccino and espressos. I really don't like coffee but I thought I could
get a small shot of coffee in a day in the form of cappuccino or espresso.

My Citiz Nespresso also came with the aerocino milk frother :grin:

I could not get Califia almond milk to foam but NEW BARN Barista almond milk makes great milk foam
in the aerocino. I'm able to find the NEW BARN Barista almond milk at Whole Foods and Earth Fair.
It is not calcium fortified.

Best of all I pulled out great grandma's demitasse cups and demitasse spoons and am using them.

Mom is late stage alzheimers and about 15 years into the disease. She still walks about 1/2 mile a day with caregivers.
I have her eating essentially high fat/low carb paleo. It is stressful on me and I realized I need to take
care of myself.
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Post by carolm »

I’m sorry to hear about your Mom, Brandy. I’m glad you are trying to take care of yourself. The small, simple pleasures can go a long way.

Carol
“.... people will forget what you said, people will forget what you did, but people will never forget how you made them feel.” Maya Angelou
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